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Image of the week - CDC42 and actin filaments

497_A12_1_blue_red_green_CDC42.jpg

This week HPA image of the week, I've decided to highlight two of my favorite things, the cell cycle and actin filaments!

The protein labeled in Fig 1. is an image of Cell division cycle 42 effector protein (Rho GTPase binding) 4 (CDC42EP4). In addition to being quite a mouthful, this protein resides in the cytoplasm and is associated with the actin filaments. In this image, CDC42EP4 is seen in U-2 OS human osteosarcoma cells.

As the name suggests, the CDC42EP4 is a protein associated with CDC42, which helps regulate the transition from G1 to S (in which DNA is replicated), and is essential for proper cell cycle progression (Yasuda S et al. 2006)...Read more


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International Rouen P2M Symposium on Precision Medicine

March 28, 2019 - March 29, 2019

On March 29th, 2019, Mathias Uhlén will give a keynote on "The Human Protein Atlas - implications for human biology, drug development and precision medicine" at the International Rouen P2M Symposium on Precision Medicine "Pathways to Precision Medicine".