The G protein-coupled receptor 17 (GPR17) was first identified in samples extracted from the central nervous system. This protein belongs to the G protein-coupled receptor (GPCR) protein family, whose members serve as important regulators of oligodendrocyte development.
Oligodendrocytes are the cells that mainly provide support and electrically insulate axons in the brain by forming the myelin sheath. During development, these cells progress from oligodendrocyte precursor cells to myelinating mature oligodendrocytes.
GPR17, in particular is an oligodendroglial maturation inhibitor since its stimulation arrests mouse oligodendrocytes at a less differentiated stage...Read more