A bit more than two decades ago, the first Diablo game was released to the world. A game about a lone hero tasked with bringing down Diablo, one of the lords of Hell. This month we highlight a namesake to this hellish lord of terror, the protein DIABLO...Read more
Immunohistochemistry was first described by Coons et al. in the beginning of the 1940s, where the authors used fluorescein-labeled antibodies to visualize bacterial antigens in infected tissues. Today, IHC plays a pivotal role in diagnostics and serves as an essential tool in research...Read more
Testicular cancer is a rare type of cancer. Most testis cancers are curable, even at an advanced stage. The cancer can be divided into essentially two categories: Seminoma and Non-seminomatous germ cell tumors. Based on transcriptomics data and clinical metadata we have been able to determine 57 genes associated with either favorable or unfavorable prognosis in testis cancer...Read more
Head and neck cancer arises in the epithelium of the nasal cavity, sinuses, lips, mouth, salivary glands, throat, or larynx. By using a systems level approach to analyze the head and neck cancer proteome based on clinical metadata and genome-wide transcriptomics data, 792 genes were found to be associated with prognostic outcome...Read more
The pituitary gland plays a crucial role in human physiology, and together with the hypothalamus this highly conserved and elegant system form a link between the nervous and endocrine system, by controlling the functions of the thyroid, adrenal glands, and the gonads, and also regulating growth, lactation, and water preservation.
This gland, also called hypophysis, consists of two separate lobes with dual embryonic origin; the anterior (adeno) pituitary gland originates from the oral cavity, and the posterior (neural) pituitary gland develops from the neural plate...Read more