The pituitary gland plays a crucial role in human physiology, and together with the hypothalamus this highly conserved and elegant system form a link between the nervous and endocrine system, by controlling the functions of the thyroid, adrenal glands, and the gonads, and also regulating growth, lactation, and water preservation.
This gland, also called hypophysis, consists of two separate lobes with dual embryonic origin; the anterior (adeno) pituitary gland originates from the oral cavity, and the posterior (neural) pituitary gland develops from the neural plate...Read more
Mitochondria harbors an own genome that renders key proteins involved in production of energy through oxidation of various substrates. Majority of the disorders associated with mitochondrial function are caused by impaired expression of the proteins encoded in the mitochondrial genome. One of these proteins is the translational activator of cytochrome c oxidase 1 (TACO1).
Experimental results reveal that TACO1 is expressed in all tissues within the human body. The protein is detected mainly in the cytoplasm and more precise inside mitochondria. Explore expression and subcellular localization of TACO1 in the Cell Atlas...Read more
Renal cell cancer is a relatively common form of human cancer. Tumors develop in the kidney and have a tendency to grow into renal veins and metastasize to distant organs without the spread to regional lymph nodes as is common for many other tumor types.
This particular case shows a papillary form of renal cell cancer that grows with papillary excrescences into cyst formations and with areas of necrosis. The tumor has been stained with an antibody (HPA005785) that recognizes the CD44 protein.
CD44 is a cell-surface glycoprotein and a receptor for hyaluronic acid that is involved in cell-cell interactions, cell adhesion and migration...Read more
Today, it is time for the first image of the week from the Cancer Atlas!
Lung cancer is one of the deadliest and most common forms of human cancer. Different forms of lung cancer exist and non-small cell lung cancer is the most common form. The cancer image this week is selected from such a lung cancer that has been immunohistochemically stained for the proliferation marker Ki-67 (MKI67). Ki-67 is the most commonly used immunohistochemical marker in rutin cancer diagnostics. The Ki-67 antigen is expressed in all cell nuclei that are active in the cell cycle and thus positive staining in a tumor cell population reflects the level of proliferation in that particular cancer...Read more
In 2017, February 28th will be the day that in Sweden is known as "Fettisdagen", (lit. "Fat Tuesday"), in other countries known as "Mardi Gras", "Faschingsdienstag" or "Shrove Tuesday". This day was originally celebrated in the Christian tradition as the last day of a three day feast to prepare for the forty day long fasting period before Easter. Today it has been popularized and in many places around the world this day is now known for its carnivals.
In Sweden together with some other northern European countries we like to eat "semlor" on Fat Tuesday...Read more
January 8, 2018
Prof. Sophia Hober will present the latest advances regarding engineering of protein A, for Ca-mediated purification of antibodies. Her talk is scheduled on January 9, during one of the largest annual events focusing on protein science, the PepTalk conference.
January 8, 2018 - January 12, 2018
Development of the Human Protein Atlas, protein production pipeline will be highlighted in the upcoming PepTalk conference in a talk given by PhD Hanna Tegel.