SUN2 (Sad1 and UNC84 domain containing 2), found in the nuclear membrane of cells, is an essential protein for many cellular processes. SUN plays a large role in the organization of multi-nucleated muscle cells, and dysregulation of SUN can cause muscular dystrophy among other diseases...Read more
Autophagosomes play a crucial role in recycling, by degrading cellular components and providing building blocks for renewal och cell components. Last year, we published a post about autophagy, which was the subject of the 2016 Nobel Prize in Physiology and Medicine.
We show, for the first time, images of HPA antibodies that co-localize with the autophagosomes. These membrane bound vesicles are involved in degradation of cellular constituents through a process called autophagy. The protein detected is localized to the autophagosomes (green) in SH-SY5Y cells, a human neuroblastoma cell line from neural tissue...Read more
Diurnal cycle influence biological processes in all organisms, on a molecular level, through regulators of the circadian clock. The Nuclear factor interleukin-3-regulated protein is a component of the circadian clock in humans that also fluctuates with the seasons. The Human Protein Atlas team has stained in A-431 cells NFIL3 (green) in nuclear bodies with DNA (blue) and microtubules (red)...Read more
Distinct mitotic substages have been identified during cell cycle progression. The different subphases are characterised by variation in protein abundance and degree of phosphorylation...Read more
The importance of mapping the human cell has become recognized as one of the key challenges in modern biology. Image-based assays offer a data-rich medium of studying cells and their proteins in situ. As such, several large-scale initiatives for studying cellular biology using image-based assays have been founded in recent years...Read more
December 8, 2018 - December 12, 2018
The Human Protein Atlas will be exhibiting at the 2018 ASCB EMBO meeting in San Diego. In booth number #624 you will meet the Cell Atlas team Emma Lundberg, Christian Gnann, Lovisa Åkesson and Peter Thul. They will also present four posters. Preliminary programme
March 28, 2019 - March 29, 2019
On March 29th, 2019, Mathias Uhlén will give a keynote on "The Human Protein Atlas - implications for human biology, drug development and precision medicine" at the International Rouen P2M Symposium on Precision Medicine "Pathways to Precision Medicine".