To fold or to degrade? Proteins have to be folded to its native structure in order to perform its designated tasks and a failure to do so leads to deleterious effects. Chaperones as the name suggest prevents improper interactions and ensures proper functioning of the proteome...Read more

"Movember" marks the time of the year when men around the world grow their moustaches to raise awareness for men's health issues, such as prostate cancer, the second most common cancer in men and one of the leading causes of death in men worldwide. (Rawla et al, 2019)..Read more

The winners of the 2019 Nobel Prize in Physiology or Medicine were announced here in Stockholm last week. William G. Kaelin Jr., Sir Peter J. Ratcliffe and Gregg L. Semenza were jointly awarded for their discoveries of how cells sense and adapt to oxygen availability...Read more

Intermediate filaments are part of a dynamic protein network, called the cytoskeleton, that provides shape, structural organization and mechanical resilience to human cells and tissues. Indeed, intermediate filaments have been proven to be very strong, while at the same time remaining flexible and elastic (Kreplak et al, 2005). Remarkably, they seem to stiffen when subjected to high mechanical force (Janmey et al, 1991), making them important contributors to integrity of cells, especially in tissues subjected to pronounced mechanical stress, such as our skin...Read more

Soon it is time for the summer holiday! But before you can take that well-deserved vacation there are many things that have to be done. Speaking of the need of multitasking, that is what many proteins have to do every day to keep your body up and running...Read more