Previous news articles featured the history and technology behind two powerful tools for visualizing proteins in tissues: immunohistochemistry and microscopy. These tools are applied to investigate and answer a wide range of questions, both in healthcare and research. This article focuses on two applications related to lung cancer: diagnostics in clinical pathology and discovery of genes associated with prognosis...Read more
Immunohistochemistry was first described by Coons et al. in the beginning of the 1940s, where the authors used fluorescein-labeled antibodies to visualize bacterial antigens in infected tissues. Today, IHC plays a pivotal role in diagnostics and serves as an essential tool in research...Read more
Testicular cancer is a rare type of cancer. Most testis cancers are curable, even at an advanced stage. The cancer can be divided into essentially two categories: Seminoma and Non-seminomatous germ cell tumors. Based on transcriptomics data and clinical metadata we have been able to determine 57 genes associated with either favorable or unfavorable prognosis in testis cancer...Read more
Head and neck cancer arises in the epithelium of the nasal cavity, sinuses, lips, mouth, salivary glands, throat, or larynx. By using a systems level approach to analyze the head and neck cancer proteome based on clinical metadata and genome-wide transcriptomics data, 792 genes were found to be associated with prognostic outcome...Read more
Although thyroid cancer is fairly common, it has a relatively good prognosis compared to other cancers. Survival varies depending on type of thyroid cancer, with papillary carcinoma, the most common type, having the highest survival rate. By using a systems level approach to analyze the thyroid cancer proteome based on clinical metadata and genome-wide transcriptomics data, 374 genes were found to be associated with prognostic outcome...Read more
September 30, 2018 - October 3, 2018
HPA Presence at HUPO 2018On Sunday Sept 30 (11am-12pm), Jochen Schwenk will be hosting a session on Antibody Validation.On Monday October 1, Cristina Al-Khalili Szigyarto will present "Antibodypedia - an open access resource of validated antibodies".On Wednesday October 3, Ragna Häussler will give a talk on "Elucidating changes in plasma protein profiles related to bariatric surgery: an IMI DIRECT study." At 10.30 am Emma Lundberg will present "Dissecting the spatiotemporal subcellular distribution of the human proteome".Peter Nilsson presents "Autoantigen Anoctamin 2 associates with increased risk for multiple sclerosis".At 14.30 pm Cecilia Lindskog Bergström will present "Integrated omics for spatial mapping of the human proteome - understanding the molecular repertoire in health and disease".
March 28, 2019 - March 29, 2019
On March 29th, 2019, Mathias Uhlén will give a keynote on "The Human Protein Atlas - implications for human biology, drug development and precision medicine" at the International Rouen P2M Symposium on Precision Medicine "Pathways to Precision Medicine".