Approximately 11% of the human proteins are defined as missing proteins. These proteins lack experimental data on the protein level. In an investigation led by Sjöstedt et al, an integrated omics approach was applied to explore and identify missing proteins...Read more
Located on top of the kidneys like two tiny caps, the adrenal glands play a fundamental role in the endocrine system. We have previously described the human adrenal gland proteome and now it is time to shed light on proteins specific for the medullary compartment of the adrenal gland. These proteins are essential for the synthesis of two major stress coping hormones - adrenaline and noradrenaline...Read more
Previous news articles featured the history and technology behind two powerful tools for visualizing proteins in tissues: immunohistochemistry and microscopy. These tools are applied to investigate and answer a wide range of questions, both in healthcare and research. This article focuses on two applications related to lung cancer: diagnostics in clinical pathology and discovery of genes associated with prognosis...Read more
Immunohistochemistry was first described by Coons et al. in the beginning of the 1940s, where the authors used fluorescein-labeled antibodies to visualize bacterial antigens in infected tissues. Today, IHC plays a pivotal role in diagnostics and serves as an essential tool in research...Read more
Testicular cancer is a rare type of cancer. Most testis cancers are curable, even at an advanced stage. The cancer can be divided into essentially two categories: Seminoma and Non-seminomatous germ cell tumors. Based on transcriptomics data and clinical metadata we have been able to determine 57 genes associated with either favorable or unfavorable prognosis in testis cancer...Read more
March 28, 2019 - March 29, 2019
On March 29th, 2019, Mathias Uhlén will give a keynote on "The Human Protein Atlas - implications for human biology, drug development and precision medicine" at the International Rouen P2M Symposium on Precision Medicine "Pathways to Precision Medicine".