Human Protein Atlas

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The HPA program

The Swedish Human Protein Atlas (HPA) program, funded by the Knut and Alice Wallenberg Foundation, has been set up to allow for a systematic exploration of the human proteome using Antibody-Based Proteomics. This is accomplished by combining high-throughput generation of affinity-purified (mono-specific) antibodies with protein profiling in a multitude of tissues/celltypes assembled in tissue microarrays. The program is run by Proteome Resource (HPR) Center located in Stockholm and Uppsala, Sweden.

The HPR Center

The Swedish Human Proteome Resource (HPR) Center is located at the AlbaNova University center at the Royal Institute of Technology, Stockholm and at the Rudbeck Laboratory, Uppsala University, Uppsala. The main objective of the resource centre is to produce specific antibodies to human target proteins using a high-throughput method involving the cloning and protein expression of Protein Epitope Signature Tags (PrESTs). The antibodies are subsequently used to study expression profiles in cells and tissues and for functional analysis of the corresponding proteins in a wide range of assay platforms.

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