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Protein Classes

Main classes
Protein class	No of genes	Code	No of genes with tissue profiles	Source
Kinases	504	Ki	367	UniProt
CD markers	360	Cd	252	UniProt
Blood group antigen proteins	29	Ba	15	UniProt
Transporters	461	Tr	243	TCDB
Ribosomal proteins	161	Ri	50	UniProt
Peptidases	515	Pe	311	UniProt/Merops
GPCRs excl olfactory receptors	392	Gp	181	UniProt
Transcription factors	1416	Tf	652	DBD
Enzymes	2594	Ez	1503	ENZYME
SH2-domain containing proteins	108	Sh	76	InterPro
SH3-domain containing proteins	219	Sd	131	InterPro
Voltage-gated ion channels	132	Ic	63	IUPHAR-DB
Membrane proteins predicted by MDM	5590	Mb	2347	MDM

Project related classes
Protein class	No of genes	Code	No of genes with tissue profiles	Source
Candidate cancer biomarkers	1052	Cb	802	Plasma Proteome Institute
Plasma proteins	649	Pp	452	Plasma Proteome Institute
Candidate cardiovascular disease genes	157	Cc	124	Plasma Proteome Institute
UniProt - no evidence at protein level	6464	Up	1766	UniProt
Mutated genes in cancer	378	Cm	261	Cancer genome project

Kinases
Protein class	No of genes	Code	No of genes with tissue profiles	Source
Kinases	504	Ki	367	UniProt
AGC Ser/Thr protein kinases	57	Kg	45	UniProt
CAMK Ser/Thr protein kinases	73	Kc	47	UniProt
CK1 Ser/Thr protein kinases	12	Kk	7	UniProt
CMGC Ser/Thr protein kinases	61	Km	47	UniProt
NEK Ser/Thr protein kinases	11	Kn	5	UniProt
RGC receptor guanylate cyclase kinases	5	Kr	3	UniProt
STE Ser/Thr protein kinases	55	Ks	41	UniProt
TKL Ser/Thr protein kinases	34	Kl	25	UniProt
Tyr protein kinases	90	Kt	73	UniProt
Atypical kinases	25	Ka	19	UniProt

Transporters
Protein class	No of genes	Code	No of genes with tissue profiles	Source
Transporters	461	Tr	243	TCDB
Transporter channels and pores	163	Tc	85	TCDB
Electrochemical Potential-driven transporters	129	Te	61	TCDB
Primary Active Transporters	101	Tp	64	TCDB
Transport Electron Carriers	8	Tt	4	TCDB
Accessory Factors Involved in Transport	27	Ta	14	TCDB

Peptidases
Protein class	No of genes	Code	No of genes with tissue profiles	Source
Peptidases	515	Pe	311	UniProt/Merops
Aspartic-type peptidases	16	Pa	14	UniProt/Merops
Cysteine-type peptidases	140	Pc	86	UniProt/Merops
Metallopeptidases	173	Pm	104	UniProt/Merops
Serine-type peptidases	167	Ps	95	UniProt/Merops
Threonine-type peptidases	19	Pt	12	UniProt/Merops

G-protein coupled receptors
Protein class	No of genes	Code	No of genes with tissue profiles	Source
G-protein coupled receptors	773	Gr	188	UniProt
Adenosine and adenine nucleotide receptors	17	Ga	10	UniProt
Chemokines and chemotactic factors receptors	29	Gh	20	UniProt
Lysolipids receptors	14	Gl	6	UniProt
Odorant/olfactory and gustatory receptors	381	Go	7	UniProt
Opsins	10	Gi	1	UniProt
Serotonin receptors	12	Gs	8	UniProt
Family 2 (B) receptors	49	Gb	24	UniProt
Family T2R receptors (taste receptor GPCRs)	21	Gt	1	UniProt
Family fz/smo receptors	11	Gf	5	UniProt
GPCRs excl olfactory receptors	392	Gp	181	UniProt

Enzymes
Protein class	No of genes	Code	No of genes with tissue profiles	Source
Enzymes	2594	Ez	1503	ENZYME
Oxidoreductases	355	Eo	179	ENZYME
Transferases	1129	Et	669	ENZYME
Hydrolases	830	Eh	493	ENZYME
Lyases	104	Ey	75	ENZYME
Isomerase	95	Ei	51	ENZYME
Ligase	125	El	66	ENZYME

Voltage-gated ion channels
Protein class	No of genes	Code	No of genes with tissue profiles	Source
Voltage-gated ion channels	132	Ic	63	IUPHAR-DB
Calcium-Activated Potassium Channels	7	Id	0	IUPHAR-DB
CatSper and Two-Pore Channels	4	Ie	1	IUPHAR-DB
Cyclic Nucleotide-Regulated Channels	9	If	2	IUPHAR-DB
Inwardly Rectifying Potassium Channels	15	Ig	10	IUPHAR-DB
Transient Receptor Potential Channels	24	Ih	13	IUPHAR-DB
Two-P Potassium Channels	14	Ii	4	IUPHAR-DB
Voltage-Gated Calcium Channels	10	Ij	3	IUPHAR-DB
Voltage-Gated Potassium Channels	40	Ik	26	IUPHAR-DB
Voltage-Gated Sodium Channels	9	Il	4	IUPHAR-DB

Potential transmembrane proteins
Protein class	No of genes	Code	No of genes with tissue profiles	Source
Potential transmembrane proteins	10297	Ma	4376	HPA publication
Membrane proteins predicted by MDM	5590	Mb	2347	MDM
MEMSAT3 predicted membrane proteins	7344	Md	3078	MEMSAT3
MEMSAT-SVM predicted membrane proteins	6371	Me	2754	MEMSAT-SVM
Phobius predicted membrane proteins	5871	Mf	2431	Phobius
SCAMPI predicted membrane proteins	6395	Mg	2679	SCAMPI
SPOCTOPUS predicted membrane proteins	7828	Mh	3341	SPOCTOPUS
THUMBUP predicted membrane proteins	7333	Mi	3077	THUMBUP
TMHMM predicted membrane proteins	5564	Mj	2403	TMHMM
GPCRHMM predicted membrane proteins	845	Mk	199	GPCRHMM
1TM proteins predicted by MDM	2996	Mq	1406	MDM
2TM proteins predicted by MDM	841	Mr	310	MDM
3TM proteins predicted by MDM	477	Ms	142	MDM
4TM proteins predicted by MDM	532	Mt	177	MDM
5TM proteins predicted by MDM	312	Mu	98	MDM
6TM proteins predicted by MDM	308	Mv	112	MDM
7TM proteins predicted by MDM	950	Mx	250	MDM
8TM proteins predicted by MDM	168	My	57	MDM
9TM proteins predicted by MDM	133	Mz	40	MDM
>9TM proteins predicted by MDM	492	Mo	193	MDM

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