Gene "Gene synonym" Ensembl "Gene description" Uniprot Chromosome Position "Protein class" "Biological process" "Molecular function" "Disease involvement" Evidence "HPA evidence" "UniProt evidence" "NeXtProt evidence" "RNA tissue specificity" "RNA tissue distribution" "RNA tissue specificity score" "RNA tissue specific nTPM" "RNA single cell type specificity" "RNA single cell type distribution" "RNA single cell type specificity score" "RNA single cell type specific nTPM" "RNA cancer specificity" "RNA cancer distribution" "RNA cancer specificity score" "RNA cancer specific FPKM" "RNA brain regional specificity" "RNA brain regional distribution" "RNA brain regional specificity score" "RNA brain regional specific nTPM" "RNA blood cell specificity" "RNA blood cell distribution" "RNA blood cell specificity score" "RNA blood cell specific nTPM" "RNA blood lineage specificity" "RNA blood lineage distribution" "RNA blood lineage specificity score" "RNA blood lineage specific nTPM" "RNA cell line specificity" "RNA cell line distribution" "RNA cell line specificity score" "RNA cell line specific nTPM" "RNA tissue cell type enrichment" "RNA mouse brain regional specificity" "RNA mouse brain regional distribution" "RNA mouse brain regional specificity score" "RNA mouse brain regional specific nTPM" "RNA pig brain regional specificity" "RNA pig brain regional distribution" "RNA pig brain regional specificity score" "RNA pig brain regional specific nTPM" Antibody "Reliability (IH)" "Reliability (Mouse Brain)" "Reliability (IF)" "Subcellular location" "Secretome location" "Secretome function" "CCD Protein" "CCD Transcript" "Blood concentration - Conc. blood IM [pg/L]" "Blood concentration - Conc. blood MS [pg/L]" "Blood expression cluster" "Tissue expression cluster" "Brain expression cluster" "Cell line expression cluster" "Single cell expression cluster" Interactions "Subcellular main location" "Subcellular additional location" "Antibody RRID" "Pathology prognostics - Breast cancer" "Pathology prognostics - Cervical cancer" "Pathology prognostics - Colorectal cancer" "Pathology prognostics - Endometrial cancer" "Pathology prognostics - Glioma" "Pathology prognostics - Head and neck cancer" "Pathology prognostics - Liver cancer" "Pathology prognostics - Lung cancer" "Pathology prognostics - Melanoma" "Pathology prognostics - Ovarian cancer" "Pathology prognostics - Pancreatic cancer" "Pathology prognostics - Prostate cancer" "Pathology prognostics - Renal cancer" "Pathology prognostics - Stomach cancer" "Pathology prognostics - Testis cancer" "Pathology prognostics - Thyroid cancer" "Pathology prognostics - Urothelial cancer" KCNMA1 "KCa1.1, mSLO1, SLO" ENSG00000156113 "Potassium calcium-activated channel subfamily M alpha 1" Q12791 10 76869601-77638369 "Disease related genes, FDA approved drug targets, Human disease related genes, Predicted intracellular proteins, Predicted membrane proteins, Transporters, Voltage-gated ion channels" "Ion transport, Potassium transport, Transport" "Ion channel, Potassium channel, Voltage-gated channel" "Disease variant, Epilepsy, FDA approved drug targets" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "endometrium 1: 134.1" "Cell type enhanced" "Detected in many" "Astrocytes: 446.8;Bipolar cells: 485.5;Excitatory neurons: 989.5;Inhibitory neurons: 610.3;Oligodendrocyte precursor cells: 664.6" "Low cancer specificity" "Detected in many" "Low region specificity" "Detected in all" "Immune cell enhanced" "Detected in some" "intermediate monocyte: 2.5;non-classical monocyte: 1.7" "Lineage enhanced" "Detected in single" "monocytes: 2.5" "Low cancer specificity" "Detected in many" "Adipose subcutaneous - Smooth muscle cells, Adipose visceral - Smooth muscle cells, Heart muscle - Smooth muscle cells, Prostate - Smooth muscle cells, Testis - Early spermatids, Testis - Late spermatids, Thyroid - Smooth muscle cells" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA054648 Approved NA NA "Cluster 40: Monocytes - Innate immune response" "Cluster 41: Smooth muscle tissue - ECM organization" "Cluster 40: Astrocytes - Astrocyte-neuron interactions" "Cluster 72: Neuronal - Signal transduction" "Cluster 34: Neurons - Neuronal signaling" "HPA054648: AB_2682556" "unprognostic (1.25e-1)" "unprognostic (2.23e-2)" "unprognostic (1.86e-2)" "unprognostic (5.29e-2)" "unprognostic (9.43e-2)" "unprognostic (2.25e-1)" "unprognostic (1.77e-1)" "unprognostic (2.81e-2)" "unprognostic (1.87e-1)" "unprognostic (1.34e-1)" "unprognostic (4.12e-3)" "unprognostic (1.20e-1)" "unprognostic (2.26e-2)" "unprognostic (1.42e-2)" "unprognostic (5.19e-2)" "unprognostic (1.42e-2)" "unprognostic (3.99e-3)" KCNN1 "hSK1, KCa2.1" ENSG00000105642 "Potassium calcium-activated channel subfamily N member 1" Q92952 19 17951293-18000085 "FDA approved drug targets, Predicted membrane proteins, Transporters, Voltage-gated ion channels" "Ion transport, Transport" "Calmodulin-binding, Ion channel" "FDA approved drug targets" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Tissue enriched" "Detected in some" 49 "brain: 106.5" "Cell type enhanced" "Detected in some" "Excitatory neurons: 12.4;Langerhans cells: 18.1" "Cancer enhanced" "Detected in some" "testis cancer: 3.5" "Low region specificity" "Detected in all" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cancer enhanced" "Detected in some" "Bone cancer: 16.2" "Testis - Spermatogonia" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA065938 Approved "Actin filaments,Cytosol" Yes No "Cluster 33: Brain - Neuronal signaling" "Cluster 51: Neurons - Mixed function" "Cluster 12: Bone cancer - Neuronal signaling" "Cluster 28: Dendritic cells - Antigen presentation" "Actin filaments, Cytosol" "HPA065938: AB_2685582" "unprognostic (7.55e-2)" "unprognostic (4.03e-2)" "unprognostic (1.82e-1)" "unprognostic (7.80e-2)" "unprognostic (1.90e-1)" "unprognostic (8.94e-5)" "unprognostic (3.92e-3)" "unprognostic (1.01e-1)" "unprognostic (8.42e-2)" "unprognostic (3.59e-1)" "unprognostic (2.71e-3)" "unprognostic (3.38e-1)" "unprognostic (5.21e-3)" "unprognostic (2.70e-2)" "unprognostic (1.14e-1)" "unprognostic (7.24e-3)" "unprognostic (3.24e-1)" KCNN2 "hSK2, KCa2.2" ENSG00000080709 "Potassium calcium-activated channel subfamily N member 2" Q9H2S1 5 114055926-114496500 "Disease related genes, FDA approved drug targets, Human disease related genes, Plasma proteins, Predicted membrane proteins, Transporters, Voltage-gated ion channels" "Ion transport, Transport" "Calmodulin-binding, Ion channel" "Disease variant, Dystonia, FDA approved drug targets, Intellectual disability" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "adrenal gland: 20.1;liver: 31.1" "Cell type enhanced" "Detected in many" "Astrocytes: 34.4;Excitatory neurons: 145.1;Inhibitory neurons: 93.0;Oligodendrocyte precursor cells: 59.4;Prostatic glandular cells: 30.0" "Group enriched" "Detected in some" 7 "glioma: 3.5;melanoma: 3.2;prostate cancer: 12.6" "Low region specificity" "Detected in all" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cancer enhanced" "Detected in some" "prostate cancer: 28.6;skin cancer: 8.3" "Heart muscle - Cardiomyocytes, Liver - Hepatocytes, Testis - Spermatogonia" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA038221 Uncertain Uncertain "Nucleoplasm,Plasma membrane" NA NA "Cluster 69: Liver - Oxidoreductase activity" "Cluster 29: Forebrain - Mixed function" "Cluster 14: Myeloid leukemia - Innate immune response" "Cluster 65: Neurons - Synaptic function" 1 "Nucleoplasm, Plasma membrane" "HPA038221: AB_10673044" "unprognostic (9.22e-3)" "unprognostic (1.90e-1)" "unprognostic (2.04e-1)" "unprognostic (5.65e-2)" "unprognostic (1.43e-1)" "unprognostic (1.40e-1)" "unprognostic (2.94e-1)" "unprognostic (1.42e-1)" "unprognostic (1.11e-2)" "unprognostic (1.56e-1)" "unprognostic (1.09e-1)" "unprognostic (1.15e-1)" "unprognostic (1.66e-1)" "unprognostic (1.23e-2)" "unprognostic (4.61e-1)" "unprognostic (3.16e-1)" "unprognostic (4.25e-1)" KCNN3 "hSK3, KCa2.3, SKCA3" ENSG00000143603 "Potassium calcium-activated channel subfamily N member 3" Q9UGI6 1 154697455-154870281 "Disease related genes, FDA approved drug targets, Human disease related genes, Predicted membrane proteins, Transporters, Voltage-gated ion channels" "Ion transport, Transport" "Calmodulin-binding, Ion channel" "Disease variant, FDA approved drug targets" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "brain: 14.3" "Cell type enhanced" "Detected in many" "Astrocytes: 160.1;Ciliated cells: 28.9;Lymphatic endothelial cells: 51.8;Plasma cells: 40.5;Skeletal myocytes: 84.9" "Cancer enhanced" "Detected in many" "glioma: 5.8" "Low region specificity" "Detected in all" "Immune cell enhanced" "Detected in some" "basophil: 4.7;memory B-cell: 2.6" "Group enriched" "Detected in many" 12 "B-cells: 2.6;granulocytes: 4.7;monocytes: 1.4" "Group enriched" "Detected in some" 5 "lymphoma: 18.8;Myeloma: 37.2" "Adipose subcutaneous - Smooth muscle cells, Colon - Enteric glia cells, Heart muscle - Fibroblasts" "Low region specificity" "Detected in many" "Low region specificity" "Detected in all" "HPA017990, HPA057127" Enhanced Approved "Plasma membrane,Cytosol" NA NA "Cluster 23: B-cells - Immunoglobulins" "Cluster 33: Brain - Neuronal signaling" "Cluster 19: Astrocytes - Mixed function" "Cluster 51: Myeloma - Immunoglobulins" "Cluster 54: Lymphatic endothelial cells - Lymph vessel development" "Plasma membrane, Cytosol" "HPA017990: AB_2669730, HPA057127: AB_2683345" "unprognostic (2.09e-1)" "unprognostic (2.91e-2)" "unprognostic (3.41e-2)" "unprognostic (1.04e-1)" "unprognostic (7.22e-2)" "unprognostic (4.06e-2)" "unprognostic (2.19e-2)" "unprognostic (2.03e-1)" "unprognostic (3.43e-2)" "unprognostic (9.51e-2)" "unprognostic (4.07e-3)" "unprognostic (4.89e-2)" "prognostic unfavorable (1.97e-4)" "unprognostic (1.71e-2)" "unprognostic (1.54e-1)" "unprognostic (6.93e-2)" "unprognostic (1.80e-2)" KCNN4 "hIKCa1, hKCa4, hSK4, IK, KCa3.1" ENSG00000104783 "Potassium calcium-activated channel subfamily N member 4" O15554 19 43766533-43780976 "Disease related genes, FDA approved drug targets, Human disease related genes, Predicted intracellular proteins, Predicted membrane proteins, Transporters, Voltage-gated ion channels" "Immunity, Ion transport, Transport" "Calmodulin-binding, Ion channel" "Disease variant, FDA approved drug targets, Hereditary hemolytic anemia" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "salivary gland: 122.7" "Group enriched" "Detected in many" 5 "Cytotrophoblasts: 223.3;Syncytiotrophoblasts: 783.0" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in many" "Low lineage specificity" "Detected in many" "Low cancer specificity" "Detected in many" "Breast - Breast glandular cells (progenitors), Skin - Eccrine sweat gland cells, Stomach - Gastric mucous cells" "Region enhanced" "Detected in single" "olfactory bulb: 1.9" "Not detected" "Not detected" "HPA013367, HPA053841, HPA059622" Approved Approved "Plasma membrane,Cytosol" NA NA "Cluster 14: Non-specific - Unknown function" "Cluster 48: Stomach - Proteolysis" "Cluster 20: Macrophages & Microglia - Immune response" "Cluster 69: Skin cancer - ECM organization" "Cluster 27: Syncytiotrophoblasts - Pregnancy" 7 "Plasma membrane, Cytosol" "HPA013367: , HPA053841: AB_2682278, HPA059622: AB_2684085" "unprognostic (1.23e-2)" "unprognostic (3.22e-2)" "unprognostic (4.29e-1)" "unprognostic (3.74e-3)" "prognostic unfavorable (2.68e-4)" "unprognostic (1.98e-2)" "unprognostic (7.33e-2)" "unprognostic (1.42e-2)" "unprognostic (2.48e-3)" "unprognostic (4.12e-2)" "prognostic unfavorable (4.56e-4)" "unprognostic (9.96e-3)" "prognostic unfavorable (1.05e-14)" "unprognostic (3.70e-2)" "unprognostic (2.17e-2)" "unprognostic (7.50e-2)" "prognostic favorable (1.75e-4)" KCNT1 "KCa4.1, KIAA1422, SLACK, Slo2.2" ENSG00000107147 "Potassium sodium-activated channel subfamily T member 1" Q5JUK3 9 135702185-135795508 "Disease related genes, Human disease related genes, Potential drug targets, Predicted membrane proteins, Transporters, Voltage-gated ion channels" "Ion transport, Potassium transport, Transport" "Ion channel, Potassium channel" "Disease variant, Epilepsy" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in some" "brain: 44.5;lymphoid tissue: 15.3;skeletal muscle: 12.9" "Group enriched" "Detected in some" 6 "Excitatory neurons: 58.0;Inhibitory neurons: 52.7" "Cancer enhanced" "Detected in single" "ovarian cancer: 0.8" "Low region specificity" "Detected in all" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cancer enriched" "Detected in single" 6 "Neuroblastoma: 5.6" "Heart muscle - Cardiomyocytes, Thyroid - Smooth muscle cells" "Low region specificity" "Detected in all" "Region enhanced" "Detected in all" "cerebellum: 56.2" HPA059880 Uncertain NA NA "Cluster 22: Brain - Synaptic signal transduction" "Cluster 53: Neurons - Mixed function" "Cluster 17: Neuroblastoma - Neuronal signaling" "Cluster 8: Neurons - Neuronal signaling" "HPA059880: AB_2684149" "unprognostic (1.50e-3)" "unprognostic (1.72e-2)" "unprognostic (2.07e-3)" "unprognostic (2.98e-13)" "unprognostic (9.26e-2)" "unprognostic (7.73e-2)" "unprognostic (9.60e-2)" "unprognostic (1.67e-1)" "unprognostic (1.15e-1)" "unprognostic (1.30e-3)" "unprognostic (9.89e-2)" "unprognostic (6.20e-2)" "unprognostic (4.89e-7)" "unprognostic (9.15e-2)" "unprognostic (2.70e-1)" "unprognostic (2.26e-1)" "unprognostic (1.66e-2)" KCNT2 "KCa4.2, SLICK, SLO2.1" ENSG00000162687 "Potassium sodium-activated channel subfamily T member 2" Q6UVM3 1 196225779-196609225 "Disease related genes, Human disease related genes, Potential drug targets, Predicted intracellular proteins, Predicted membrane proteins, Transporters, Voltage-gated ion channels" "Ion transport, Potassium transport, Transport" "Ion channel, Potassium channel" "Disease variant, Epilepsy" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in some" "ovary: 3.6" "Group enriched" "Detected in some" 4 "Excitatory neurons: 212.4;Inhibitory neurons: 229.3;Oligodendrocyte precursor cells: 291.5" "Cancer enhanced" "Detected in some" "renal cancer: 1.4" "Low region specificity" "Detected in all" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cancer enhanced" "Detected in some" "Neuroblastoma: 4.0" "Adipose visceral - Mesothelial cells, Heart muscle - Fibroblasts, Prostate - Fibroblasts, Skin - Endothelial cells, Testis - Early spermatids" "Low region specificity" "Detected in many" "Low region specificity" "Detected in all" HPA051218 Uncertain Approved Vesicles NA NA "Cluster 83: Liver - Metabolism" "Cluster 14: Neurons - Synaptic function" "Cluster 16: Thyroid cancer - Neuronal signaling" "Cluster 69: Neurons - Neuronal signaling" Vesicles "HPA051218: AB_2681392" "unprognostic (5.06e-2)" "unprognostic (2.94e-2)" "unprognostic (8.01e-2)" "unprognostic (5.10e-6)" "unprognostic (1.22e-3)" "unprognostic (1.30e-2)" "unprognostic (1.07e-1)" "unprognostic (3.03e-2)" "unprognostic (5.90e-2)" "unprognostic (2.18e-1)" "unprognostic (9.56e-3)" "unprognostic (2.61e-1)" "prognostic unfavorable (1.67e-5)" "unprognostic (3.30e-4)" "unprognostic (2.95e-2)" "unprognostic (4.75e-1)" "unprognostic (1.72e-3)"