FZD1 DKFZp564G072

uncertain adrenal gland glandular cells moderate appendix glandular cells moderate appendix lymphoid tissue moderate bone marrow hematopoietic cells strong breast adipocytes negative breast glandular cells moderate breast myoepithelial cells moderate bronchus respiratory epithelial cells strong cerebellum cells in granular layer weak cerebellum cells in molecular layer moderate cerebellum Purkinje cells moderate cerebral cortex endothelial cells weak cerebral cortex glial cells weak cerebral cortex neuronal cells weak cerebral cortex neuropil weak cervix, uterine glandular cells moderate cervix, uterine squamous epithelial cells moderate colon endothelial cells weak colon glandular cells moderate colon peripheral nerve/ganglion moderate duodenum glandular cells moderate epididymis glandular cells moderate esophagus squamous epithelial cells moderate fallopian tube glandular cells moderate gallbladder glandular cells moderate heart muscle myocytes moderate hippocampus glial cells weak hippocampus neuronal cells moderate kidney cells in glomeruli moderate kidney cells in tubules moderate lateral ventricle glial cells weak lateral ventricle neuronal cells moderate liver bile duct cells moderate liver hepatocytes strong lung macrophages strong lung pneumocytes moderate lymph node germinal center cells moderate lymph node non-germinal center cells weak nasopharynx respiratory epithelial cells moderate oral mucosa squamous epithelial cells moderate ovary ovarian stroma cells weak pancreas exocrine glandular cells moderate pancreas islets of Langerhans moderate placenta trophoblastic cells strong prostate glandular cells moderate rectum glandular cells moderate salivary gland glandular cells moderate seminal vesicle glandular cells moderate skeletal muscle myocytes moderate skin fibroblasts weak skin keratinocytes moderate skin Langerhans moderate skin melanocytes weak small intestine glandular cells strong smooth muscle smooth muscle cells moderate soft tissue 1 adipocytes negative soft tissue 1 fibroblasts negative soft tissue 2 adipocytes negative soft tissue 2 fibroblasts negative spleen cells in red pulp moderate spleen cells in white pulp negative stomach, lower glandular cells moderate stomach, upper glandular cells moderate testis cells in seminiferus ducts moderate testis Leydig cells moderate thyroid gland glandular cells moderate tonsil germinal center cells moderate tonsil non-germinal center cells moderate tonsil squamous epithelial cells strong urinary bladder urothelial cells moderate uterus, post-menopause cells in endometrial stroma weak uterus, post-menopause glandular cells moderate uterus, pre-menopause cells in endometrial stroma moderate uterus, pre-menopause glandular cells moderate vagina squamous epithelial cells moderate vulva/anal skin epidermal cells weak

MCF-7 Medium RT-4 Medium U-2 OS Medium HEK 293 Medium U-251 MG Low A-549 Low CACO-2 Low Hep-G2 Low HeLa Low PC-3 Low A-431 Low

low adrenal gland glandular cells medium appendix glandular cells low appendix lymphoid tissue none bone marrow hematopoietic cells low breast adipocytes none breast glandular cells low breast myoepithelial cells low bronchus respiratory epithelial cells none cerebellum cells in granular layer none cerebellum cells in molecular layer low cerebellum Purkinje cells low cerebral cortex endothelial cells none cerebral cortex glial cells none cerebral cortex neuronal cells high cerebral cortex neuropil none cervix, uterine glandular cells low cervix, uterine squamous epithelial cells none colon endothelial cells low colon glandular cells high colon peripheral nerve/ganglion low duodenum glandular cells high epididymis glandular cells low esophagus squamous epithelial cells none fallopian tube glandular cells none gallbladder glandular cells medium heart muscle myocytes medium hippocampus glial cells low hippocampus neuronal cells low kidney cells in glomeruli none kidney cells in tubules medium lateral ventricle glial cells low lateral ventricle neuronal cells medium liver bile duct cells none liver hepatocytes medium lung macrophages low lung pneumocytes low lymph node germinal center cells none lymph node non-germinal center cells low nasopharynx respiratory epithelial cells low oral mucosa squamous epithelial cells none ovary follicle cells low ovary ovarian stroma cells none pancreas exocrine glandular cells high pancreas islets of Langerhans none parathyroid gland glandular cells low placenta decidual cells low placenta trophoblastic cells medium prostate glandular cells none rectum glandular cells low salivary gland glandular cells medium seminal vesicle glandular cells medium skeletal muscle myocytes medium skin fibroblasts none skin keratinocytes none skin Langerhans none skin melanocytes none small intestine glandular cells high smooth muscle smooth muscle cells low soft tissue 1 adipocytes none soft tissue 1 fibroblasts none soft tissue 1 peripheral nerve none soft tissue 2 adipocytes none soft tissue 2 fibroblasts none soft tissue 2 peripheral nerve none spleen cells in red pulp none spleen cells in white pulp none stomach, lower glandular cells high stomach, upper glandular cells medium testis cells in seminiferus ducts medium testis Leydig cells low thyroid gland glandular cells low tonsil germinal center cells low tonsil non-germinal center cells low tonsil squamous epithelial cells low urinary bladder urothelial cells low uterus, post-menopause cells in endometrial stroma none uterus, post-menopause glandular cells low uterus, pre-menopause cells in endometrial stroma none uterus, pre-menopause glandular cells low vagina squamous epithelial cells none vulva/anal skin epidermal cells none

medium nucleus but not nucleoli

HeLa Low RT-4 Low U-2 OS Low HEK 293 Low U-251 MG Not detected A-549 Not detected CACO-2 Not detected Hep-G2 Not detected MCF-7 Not detected PC-3 Not detected A-431 Not detected ERLNMDYWKILAAQHKCKMNNQTKTLDCLMAASI

uncertain adrenal gland glandular cells moderate appendix glandular cells weak appendix lymphoid tissue negative bone marrow hematopoietic cells weak breast adipocytes negative breast glandular cells negative breast myoepithelial cells negative bronchus respiratory epithelial cells negative cerebellum cells in granular layer negative cerebellum cells in molecular layer weak cerebellum Purkinje cells weak cerebral cortex endothelial cells negative cerebral cortex glial cells negative cerebral cortex neuronal cells moderate cerebral cortex neuropil negative cervix, uterine glandular cells weak cervix, uterine squamous epithelial cells negative colon endothelial cells negative colon glandular cells strong colon peripheral nerve/ganglion negative duodenum glandular cells strong epididymis glandular cells weak esophagus squamous epithelial cells negative fallopian tube glandular cells negative gallbladder glandular cells moderate heart muscle myocytes moderate hippocampus glial cells weak hippocampus neuronal cells weak kidney cells in glomeruli negative kidney cells in tubules moderate lateral ventricle glial cells weak lateral ventricle neuronal cells moderate liver bile duct cells negative liver hepatocytes moderate lung macrophages weak lung pneumocytes weak lymph node germinal center cells negative lymph node non-germinal center cells weak nasopharynx respiratory epithelial cells weak oral mucosa squamous epithelial cells negative ovary follicle cells weak ovary ovarian stroma cells negative pancreas exocrine glandular cells strong pancreas islets of Langerhans negative parathyroid gland glandular cells negative placenta trophoblastic cells moderate prostate glandular cells negative rectum glandular cells weak salivary gland glandular cells moderate seminal vesicle glandular cells moderate skeletal muscle myocytes moderate skin fibroblasts negative skin keratinocytes negative skin Langerhans negative skin melanocytes negative small intestine glandular cells strong smooth muscle smooth muscle cells negative soft tissue 1 adipocytes negative soft tissue 1 fibroblasts negative soft tissue 1 peripheral nerve negative soft tissue 2 adipocytes negative soft tissue 2 fibroblasts negative soft tissue 2 peripheral nerve negative spleen cells in red pulp negative spleen cells in white pulp negative stomach, lower glandular cells strong stomach, upper glandular cells moderate testis cells in seminiferus ducts weak testis Leydig cells weak thyroid gland glandular cells weak tonsil germinal center cells weak tonsil non-germinal center cells weak tonsil squamous epithelial cells weak urinary bladder urothelial cells weak uterus, post-menopause cells in endometrial stroma negative uterus, post-menopause glandular cells negative uterus, pre-menopause cells in endometrial stroma negative uterus, pre-menopause glandular cells negative vagina squamous epithelial cells negative vulva/anal skin epidermal cells negative breast cancer tumor cells negative carcinoid tumor cells negative cervical cancer tumor cells moderate weak negative colorectal cancer tumor cells negative endometrial cancer tumor cells weak negative glioma tumor cells weak negative head and neck cancer tumor cells negative liver cancer tumor cells moderate weak negative lung cancer tumor cells moderate weak negative lymphoma tumor cells weak negative melanoma tumor cells moderate weak negative ovarian cancer tumor cells moderate negative pancreatic cancer tumor cells moderate weak negative prostate cancer tumor cells weak negative renal cancer tumor cells weak negative skin cancer tumor cells negative stomach cancer tumor cells moderate weak negative testis cancer tumor cells negative thyroid cancer tumor cells weak negative urothelial cancer tumor cells weak negative uncertain U-251 MG uncertain weak nucleus but not nucleoli A-431 uncertain weak nucleus but not nucleoli U-2 OS uncertain weak nucleus but not nucleoli uncertain supportive KTLQSWQQVCSRRLKKKSRRKPASVITSGGIYKKAQHPQKTHHGKYEIPAQSPTCV

uncertain adrenal gland glandular cells weak appendix glandular cells weak appendix lymphoid tissue negative bone marrow hematopoietic cells negative breast adipocytes weak breast glandular cells weak breast myoepithelial cells weak cerebellum cells in granular layer weak cerebellum cells in molecular layer weak cerebellum Purkinje cells moderate cerebral cortex endothelial cells negative cerebral cortex glial cells negative cerebral cortex neuronal cells strong cerebral cortex neuropil moderate cervix, uterine squamous epithelial cells weak colon endothelial cells weak colon glandular cells moderate colon peripheral nerve/ganglion moderate duodenum glandular cells moderate epididymis glandular cells weak esophagus squamous epithelial cells weak fallopian tube glandular cells weak gallbladder glandular cells moderate heart muscle myocytes weak hippocampus glial cells negative hippocampus neuronal cells weak kidney cells in glomeruli negative kidney cells in tubules moderate lateral ventricle glial cells negative lateral ventricle neuronal cells weak liver bile duct cells negative liver hepatocytes moderate lung macrophages moderate lung pneumocytes weak lymph node germinal center cells weak lymph node non-germinal center cells weak nasopharynx respiratory epithelial cells moderate oral mucosa squamous epithelial cells weak ovary follicle cells moderate ovary ovarian stroma cells weak pancreas exocrine glandular cells moderate pancreas islets of Langerhans weak parathyroid gland glandular cells moderate placenta decidual cells weak placenta trophoblastic cells moderate prostate glandular cells moderate rectum glandular cells weak salivary gland glandular cells negative seminal vesicle glandular cells strong skeletal muscle myocytes weak skin fibroblasts moderate skin keratinocytes negative skin Langerhans weak skin melanocytes moderate small intestine glandular cells moderate smooth muscle smooth muscle cells weak soft tissue 1 adipocytes weak soft tissue 1 fibroblasts weak soft tissue 2 adipocytes weak soft tissue 2 fibroblasts weak soft tissue 2 peripheral nerve weak spleen cells in red pulp weak spleen cells in white pulp negative stomach, lower glandular cells weak stomach, upper glandular cells moderate testis cells in seminiferus ducts strong testis Leydig cells moderate thyroid gland glandular cells moderate tonsil germinal center cells weak tonsil non-germinal center cells weak tonsil squamous epithelial cells negative urinary bladder urothelial cells moderate uterus, post-menopause cells in endometrial stroma weak uterus, post-menopause glandular cells moderate uterus, pre-menopause cells in endometrial stroma weak uterus, pre-menopause glandular cells moderate vagina squamous epithelial cells negative vulva/anal skin epidermal cells negative breast cancer tumor cells moderate weak carcinoid tumor cells weak negative cervical cancer tumor cells moderate weak colorectal cancer tumor cells moderate weak endometrial cancer tumor cells moderate weak glioma tumor cells moderate weak head and neck cancer tumor cells moderate weak liver cancer tumor cells weak negative lung cancer tumor cells moderate weak lymphoma tumor cells weak negative melanoma tumor cells moderate weak ovarian cancer tumor cells moderate pancreatic cancer tumor cells moderate weak negative prostate cancer tumor cells moderate weak renal cancer tumor cells moderate weak negative skin cancer tumor cells moderate weak stomach cancer tumor cells weak negative testis cancer tumor cells moderate weak negative thyroid cancer tumor cells strong moderate urothelial cancer tumor cells moderate weak negative uncertain U-251 MG uncertain weak nucleus but not nucleoli U-2 OS uncertain weak nucleus but not nucleoli A-431 uncertain weak nucleus but not nucleoli uncertain supportive FZD3

supportive adrenal gland glandular cells strong appendix glandular cells strong appendix lymphoid tissue moderate bone marrow hematopoietic cells strong breast adipocytes negative breast glandular cells moderate breast myoepithelial cells moderate bronchus respiratory epithelial cells moderate cerebellum cells in granular layer negative cerebellum cells in molecular layer negative cerebellum Purkinje cells moderate cerebral cortex endothelial cells negative cerebral cortex glial cells moderate cerebral cortex neuronal cells moderate cerebral cortex neuropil negative cervix, uterine glandular cells moderate cervix, uterine squamous epithelial cells strong colon endothelial cells moderate colon glandular cells strong colon peripheral nerve/ganglion moderate duodenum glandular cells strong epididymis glandular cells moderate esophagus squamous epithelial cells strong fallopian tube glandular cells strong gallbladder glandular cells strong heart muscle myocytes strong hippocampus glial cells weak hippocampus neuronal cells strong kidney cells in glomeruli moderate kidney cells in tubules moderate lateral ventricle glial cells weak lateral ventricle neuronal cells strong liver bile duct cells negative liver hepatocytes moderate lung macrophages strong lung pneumocytes moderate lymph node germinal center cells strong lymph node non-germinal center cells strong nasopharynx respiratory epithelial cells strong oral mucosa squamous epithelial cells weak ovary follicle cells strong ovary ovarian stroma cells moderate pancreas exocrine glandular cells strong parathyroid gland glandular cells moderate placenta decidual cells strong placenta trophoblastic cells strong prostate glandular cells moderate rectum glandular cells strong salivary gland glandular cells moderate seminal vesicle glandular cells strong skeletal muscle myocytes moderate skin fibroblasts strong skin keratinocytes strong skin Langerhans strong skin melanocytes strong small intestine glandular cells strong smooth muscle smooth muscle cells moderate soft tissue 1 adipocytes strong soft tissue 1 fibroblasts strong soft tissue 1 peripheral nerve negative soft tissue 2 adipocytes weak soft tissue 2 fibroblasts moderate soft tissue 2 peripheral nerve negative spleen cells in red pulp moderate spleen cells in white pulp strong stomach, lower glandular cells strong stomach, upper glandular cells strong testis cells in seminiferus ducts moderate testis Leydig cells strong thyroid gland glandular cells strong tonsil germinal center cells strong tonsil non-germinal center cells strong tonsil squamous epithelial cells strong urinary bladder urothelial cells moderate uterus, post-menopause cells in endometrial stroma moderate uterus, post-menopause glandular cells moderate uterus, pre-menopause cells in endometrial stroma moderate uterus, pre-menopause glandular cells strong vagina squamous epithelial cells strong vulva/anal skin epidermal cells strong

MCF-7 Medium A-431 Medium U-2 OS Medium HEK 293 Medium U-251 MG Low A-549 Low CACO-2 Low Hep-G2 Low HeLa Low PC-3 Low RT-4 Low

uncertain adrenal gland glandular cells weak appendix glandular cells negative appendix lymphoid tissue negative bone marrow hematopoietic cells weak breast adipocytes negative breast glandular cells weak breast myoepithelial cells weak bronchus respiratory epithelial cells weak cerebellum cells in granular layer weak cerebellum cells in molecular layer negative cerebellum Purkinje cells weak cerebral cortex endothelial cells negative cerebral cortex glial cells negative cerebral cortex neuronal cells weak cerebral cortex neuropil negative cervix, uterine glandular cells weak cervix, uterine squamous epithelial cells moderate colon endothelial cells negative colon glandular cells weak duodenum glandular cells moderate epididymis glandular cells negative esophagus squamous epithelial cells strong fallopian tube glandular cells weak gallbladder glandular cells moderate heart muscle myocytes moderate hippocampus glial cells negative hippocampus neuronal cells negative kidney cells in glomeruli weak kidney cells in tubules moderate lateral ventricle glial cells negative lateral ventricle neuronal cells moderate liver bile duct cells weak liver hepatocytes moderate lung macrophages weak lung pneumocytes weak lymph node germinal center cells moderate lymph node non-germinal center cells moderate nasopharynx respiratory epithelial cells weak oral mucosa squamous epithelial cells strong ovary follicle cells negative ovary ovarian stroma cells negative pancreas exocrine glandular cells strong pancreas islets of Langerhans negative parathyroid gland glandular cells weak placenta decidual cells negative placenta trophoblastic cells moderate prostate glandular cells weak rectum glandular cells moderate salivary gland glandular cells weak seminal vesicle glandular cells weak skeletal muscle myocytes negative skin fibroblasts moderate skin keratinocytes moderate skin Langerhans weak skin melanocytes moderate small intestine glandular cells moderate smooth muscle smooth muscle cells negative soft tissue 1 adipocytes negative soft tissue 1 chondrocytes weak soft tissue 1 fibroblasts weak soft tissue 1 peripheral nerve negative soft tissue 2 adipocytes negative spleen cells in red pulp negative spleen cells in white pulp negative stomach, lower glandular cells moderate stomach, upper glandular cells moderate testis cells in seminiferus ducts negative testis Leydig cells weak thyroid gland glandular cells moderate tonsil germinal center cells negative tonsil non-germinal center cells negative tonsil squamous epithelial cells weak urinary bladder urothelial cells negative uterus, post-menopause cells in endometrial stroma negative uterus, post-menopause glandular cells negative uterus, pre-menopause cells in endometrial stroma negative uterus, pre-menopause glandular cells negative vagina squamous epithelial cells strong vulva/anal skin epidermal cells negative

uncertain nucleoli

Hep-G2 High PC-3 Medium RT-4 Medium U-251 MG Low A-549 Low CACO-2 Low HeLa Low MCF-7 Low A-431 Low U-2 OS Low HEK 293 Low SAKTLHTWQKCSNRLVNSGKVKREKRGNGWVKP

very low adrenal gland glandular cells low appendix glandular cells none bone marrow hematopoietic cells low breast adipocytes none breast glandular cells none breast myoepithelial cells none bronchus respiratory epithelial cells low cerebellum cells in granular layer none cerebellum cells in molecular layer none cerebellum Purkinje cells medium cerebral cortex endothelial cells none cerebral cortex glial cells none cerebral cortex neuronal cells low cerebral cortex neuropil none cervix, uterine glandular cells low cervix, uterine squamous epithelial cells none colon endothelial cells none colon glandular cells none colon peripheral nerve/ganglion none duodenum glandular cells low epididymis glandular cells low esophagus squamous epithelial cells none fallopian tube glandular cells none gallbladder glandular cells none heart muscle myocytes none hippocampus glial cells none hippocampus neuronal cells medium kidney cells in glomeruli none kidney cells in tubules none lateral ventricle glial cells none lateral ventricle neuronal cells medium liver bile duct cells none liver hepatocytes none lung macrophages none lung pneumocytes none lymph node germinal center cells none lymph node non-germinal center cells none nasopharynx respiratory epithelial cells none oral mucosa squamous epithelial cells none ovary follicle cells none ovary ovarian stroma cells none pancreas exocrine glandular cells high pancreas islets of Langerhans none parathyroid gland glandular cells none placenta decidual cells low placenta trophoblastic cells medium prostate glandular cells medium rectum glandular cells low salivary gland glandular cells low seminal vesicle glandular cells none skeletal muscle myocytes none skin fibroblasts none skin keratinocytes none skin Langerhans none skin melanocytes none small intestine glandular cells low smooth muscle smooth muscle cells none soft tissue 1 adipocytes none soft tissue 1 fibroblasts none soft tissue 1 peripheral nerve none soft tissue 2 adipocytes none soft tissue 2 fibroblasts none soft tissue 2 peripheral nerve none spleen cells in red pulp none spleen cells in white pulp none stomach, lower glandular cells low stomach, upper glandular cells low testis cells in seminiferus ducts medium testis Leydig cells low thyroid gland glandular cells medium tonsil germinal center cells low tonsil non-germinal center cells medium tonsil squamous epithelial cells none urinary bladder urothelial cells none uterus, post-menopause cells in endometrial stroma none uterus, post-menopause glandular cells none uterus, pre-menopause cells in endometrial stroma none uterus, pre-menopause glandular cells low vagina squamous epithelial cells none vulva/anal skin epidermal cells none

Hep-G2 High CACO-2 Medium RT-4 Medium HEK 293 Medium U-251 MG Low A-549 Low HeLa Low MCF-7 Low PC-3 Low A-431 Low U-2 OS Low WPERMSCDRLPVLGRDAEVLCMDYNRSEATTAPPRPFPAKPTLP

uncertain adrenal gland glandular cells weak appendix glandular cells negative bone marrow hematopoietic cells weak breast adipocytes negative breast glandular cells negative breast myoepithelial cells negative bronchus respiratory epithelial cells weak cerebellum cells in granular layer negative cerebellum cells in molecular layer negative cerebellum Purkinje cells moderate cerebral cortex endothelial cells negative cerebral cortex glial cells negative cerebral cortex neuronal cells weak cerebral cortex neuropil negative cervix, uterine glandular cells weak cervix, uterine squamous epithelial cells negative colon endothelial cells negative colon glandular cells negative colon peripheral nerve/ganglion negative duodenum glandular cells moderate epididymis glandular cells weak esophagus squamous epithelial cells negative fallopian tube glandular cells negative gallbladder glandular cells negative heart muscle myocytes negative hippocampus glial cells negative hippocampus neuronal cells moderate kidney cells in glomeruli negative kidney cells in tubules negative lateral ventricle glial cells negative lateral ventricle neuronal cells moderate liver bile duct cells negative liver hepatocytes negative lung macrophages negative lung pneumocytes negative lymph node germinal center cells negative lymph node non-germinal center cells negative nasopharynx respiratory epithelial cells negative oral mucosa squamous epithelial cells negative ovary follicle cells negative ovary ovarian stroma cells negative pancreas exocrine glandular cells strong pancreas islets of Langerhans negative parathyroid gland glandular cells negative placenta decidual cells weak placenta trophoblastic cells moderate prostate glandular cells moderate rectum glandular cells weak salivary gland glandular cells weak seminal vesicle glandular cells negative skeletal muscle myocytes negative skin fibroblasts negative skin keratinocytes negative skin Langerhans negative skin melanocytes negative small intestine glandular cells moderate smooth muscle smooth muscle cells negative soft tissue 1 adipocytes negative soft tissue 1 fibroblasts negative soft tissue 1 peripheral nerve negative soft tissue 2 adipocytes negative soft tissue 2 fibroblasts negative soft tissue 2 peripheral nerve negative spleen cells in red pulp negative spleen cells in white pulp negative stomach, lower glandular cells weak stomach, upper glandular cells weak testis cells in seminiferus ducts moderate testis Leydig cells weak thyroid gland glandular cells moderate tonsil germinal center cells weak tonsil non-germinal center cells moderate tonsil squamous epithelial cells negative urinary bladder urothelial cells negative uterus, post-menopause cells in endometrial stroma negative uterus, post-menopause glandular cells negative uterus, pre-menopause cells in endometrial stroma negative uterus, pre-menopause glandular cells weak vagina squamous epithelial cells negative vulva/anal skin epidermal cells negative breast cancer tumor cells weak negative carcinoid tumor cells negative cervical cancer tumor cells weak negative colorectal cancer tumor cells weak negative endometrial cancer tumor cells moderate weak negative glioma tumor cells negative head and neck cancer tumor cells weak negative liver cancer tumor cells moderate weak negative lung cancer tumor cells moderate weak negative lymphoma tumor cells moderate negative melanoma tumor cells weak negative ovarian cancer tumor cells weak negative pancreatic cancer tumor cells moderate weak negative prostate cancer tumor cells moderate weak negative renal cancer tumor cells negative skin cancer tumor cells negative stomach cancer tumor cells moderate weak negative testis cancer tumor cells weak negative thyroid cancer tumor cells negative urothelial cancer tumor cells moderate weak negative uncertain supportive GPFVCKCREPFVPILKESHPLYNKVRTGQVPNCAVPCYQPSFSADERTFATF

uncertain adrenal gland glandular cells negative appendix glandular cells moderate appendix lymphoid tissue moderate bone marrow hematopoietic cells weak breast adipocytes negative breast glandular cells negative breast myoepithelial cells negative bronchus respiratory epithelial cells weak cerebellum cells in granular layer negative cerebellum cells in molecular layer negative cerebellum Purkinje cells negative cerebral cortex endothelial cells negative cerebral cortex glial cells negative cerebral cortex neuronal cells negative cerebral cortex neuropil negative cervix, uterine glandular cells negative cervix, uterine squamous epithelial cells negative colon endothelial cells negative colon glandular cells strong colon peripheral nerve/ganglion weak duodenum glandular cells weak epididymis glandular cells strong esophagus squamous epithelial cells negative fallopian tube glandular cells negative gallbladder glandular cells weak heart muscle myocytes weak hippocampus glial cells negative hippocampus neuronal cells negative kidney cells in glomeruli negative kidney cells in tubules negative lateral ventricle glial cells negative lateral ventricle neuronal cells negative liver bile duct cells negative liver hepatocytes negative lung macrophages strong lung pneumocytes moderate lymph node germinal center cells strong lymph node non-germinal center cells strong nasopharynx respiratory epithelial cells moderate oral mucosa squamous epithelial cells negative ovary follicle cells moderate ovary ovarian stroma cells negative pancreas exocrine glandular cells negative pancreas islets of Langerhans negative parathyroid gland glandular cells negative placenta decidual cells negative placenta trophoblastic cells negative prostate glandular cells weak rectum glandular cells moderate salivary gland glandular cells negative seminal vesicle glandular cells negative skeletal muscle myocytes negative skin fibroblasts negative skin keratinocytes negative skin Langerhans negative skin melanocytes negative small intestine glandular cells moderate smooth muscle smooth muscle cells negative soft tissue 1 adipocytes negative soft tissue 1 fibroblasts moderate soft tissue 1 peripheral nerve negative soft tissue 2 adipocytes negative soft tissue 2 fibroblasts negative soft tissue 2 peripheral nerve negative spleen cells in red pulp moderate spleen cells in white pulp strong stomach, lower glandular cells weak stomach, upper glandular cells weak testis cells in seminiferus ducts negative testis Leydig cells strong thyroid gland glandular cells negative tonsil germinal center cells strong tonsil non-germinal center cells strong tonsil squamous epithelial cells moderate urinary bladder urothelial cells negative uterus, post-menopause cells in endometrial stroma negative uterus, post-menopause glandular cells negative uterus, pre-menopause cells in endometrial stroma negative uterus, pre-menopause glandular cells negative vagina squamous epithelial cells negative vulva/anal skin epidermal cells negative breast cancer tumor cells moderate negative carcinoid tumor cells negative cervical cancer tumor cells negative colorectal cancer tumor cells moderate weak negative endometrial cancer tumor cells moderate weak negative glioma tumor cells negative head and neck cancer tumor cells weak negative liver cancer tumor cells weak negative lung cancer tumor cells moderate negative lymphoma tumor cells strong moderate weak negative melanoma tumor cells negative ovarian cancer tumor cells weak negative pancreatic cancer tumor cells negative prostate cancer tumor cells weak negative renal cancer tumor cells negative skin cancer tumor cells negative stomach cancer tumor cells negative testis cancer tumor cells negative thyroid cancer tumor cells negative urothelial cancer tumor cells negative uncertain supportive FZD6 Hfz6

uncertain adrenal gland glandular cells strong appendix glandular cells strong appendix lymphoid tissue moderate bone marrow hematopoietic cells moderate breast adipocytes weak breast glandular cells strong breast myoepithelial cells moderate bronchus respiratory epithelial cells strong cerebellum cells in granular layer moderate cerebellum cells in molecular layer moderate cerebellum Purkinje cells moderate cerebral cortex endothelial cells moderate cerebral cortex glial cells weak cerebral cortex neuronal cells moderate cerebral cortex neuropil weak cervix, uterine glandular cells moderate cervix, uterine squamous epithelial cells strong colon endothelial cells moderate colon glandular cells strong colon peripheral nerve/ganglion weak duodenum glandular cells strong epididymis glandular cells moderate esophagus squamous epithelial cells strong fallopian tube glandular cells strong gallbladder glandular cells strong heart muscle myocytes strong hippocampus glial cells weak hippocampus neuronal cells moderate kidney cells in glomeruli weak kidney cells in tubules strong lateral ventricle glial cells negative lateral ventricle neuronal cells moderate liver bile duct cells moderate liver hepatocytes strong lung macrophages moderate lung pneumocytes weak lymph node non-germinal center cells negative nasopharynx respiratory epithelial cells strong oral mucosa squamous epithelial cells strong ovary follicle cells moderate ovary ovarian stroma cells weak pancreas exocrine glandular cells strong pancreas islets of Langerhans moderate parathyroid gland glandular cells strong placenta decidual cells strong placenta trophoblastic cells strong prostate glandular cells moderate rectum glandular cells moderate salivary gland glandular cells weak seminal vesicle glandular cells moderate skeletal muscle myocytes moderate skin fibroblasts weak skin keratinocytes moderate skin Langerhans weak skin melanocytes weak small intestine glandular cells strong smooth muscle smooth muscle cells strong soft tissue 1 adipocytes weak soft tissue 1 fibroblasts weak soft tissue 1 peripheral nerve weak soft tissue 2 adipocytes weak soft tissue 2 fibroblasts negative soft tissue 2 peripheral nerve weak spleen cells in red pulp negative spleen cells in white pulp moderate stomach, lower glandular cells strong stomach, upper glandular cells strong testis cells in seminiferus ducts moderate testis Leydig cells moderate thyroid gland glandular cells moderate tonsil germinal center cells moderate tonsil non-germinal center cells moderate tonsil squamous epithelial cells strong urinary bladder urothelial cells strong uterus, post-menopause cells in endometrial stroma negative uterus, post-menopause glandular cells strong uterus, pre-menopause cells in endometrial stroma moderate uterus, pre-menopause glandular cells strong vagina squamous epithelial cells strong vulva/anal skin epidermal cells strong

supportive plasma membrane

U-251 MG High MCF-7 High RT-4 High A-431 High U-2 OS High A-549 Medium CACO-2 Medium Hep-G2 Medium HeLa Medium PC-3 Medium HEK 293 Medium TSTGATANHGTSAVAITSHDYLGQETLTEIQTSPETSMREVKADGASTPRLREQDCGEPASPAASISRLSGEQVDGKGQAGSVSESARSEGRISPKSDITDTGLAQSNNLQVPSSSEPSSLKGSTSLLVHPVS

uncertain adrenal gland glandular cells weak appendix glandular cells negative appendix lymphoid tissue negative bone marrow hematopoietic cells moderate breast adipocytes negative breast glandular cells weak breast myoepithelial cells negative bronchus respiratory epithelial cells weak cerebellum cells in granular layer negative cerebellum cells in molecular layer negative cerebellum Purkinje cells moderate cerebral cortex endothelial cells negative cerebral cortex glial cells weak cerebral cortex neuronal cells weak cerebral cortex neuropil weak cervix, uterine glandular cells moderate cervix, uterine squamous epithelial cells negative colon endothelial cells negative colon glandular cells weak colon peripheral nerve/ganglion negative duodenum glandular cells moderate epididymis glandular cells negative esophagus squamous epithelial cells moderate fallopian tube glandular cells weak gallbladder glandular cells weak heart muscle myocytes negative hippocampus glial cells weak hippocampus neuronal cells negative kidney cells in glomeruli negative kidney cells in tubules moderate lateral ventricle glial cells negative lateral ventricle neuronal cells weak liver bile duct cells weak liver hepatocytes moderate lung macrophages moderate lung pneumocytes negative lymph node germinal center cells negative lymph node non-germinal center cells weak nasopharynx respiratory epithelial cells weak oral mucosa squamous epithelial cells negative ovary follicle cells negative ovary ovarian stroma cells negative pancreas exocrine glandular cells weak pancreas islets of Langerhans negative parathyroid gland glandular cells weak placenta decidual cells weak placenta trophoblastic cells weak prostate glandular cells negative rectum glandular cells moderate salivary gland glandular cells weak seminal vesicle glandular cells weak skeletal muscle myocytes negative skin fibroblasts negative skin keratinocytes weak skin Langerhans negative skin melanocytes negative small intestine glandular cells moderate smooth muscle smooth muscle cells negative soft tissue 1 adipocytes negative soft tissue 1 fibroblasts negative soft tissue 1 peripheral nerve negative soft tissue 2 adipocytes negative spleen cells in red pulp negative spleen cells in white pulp negative stomach, lower glandular cells negative stomach, upper glandular cells negative testis cells in seminiferus ducts moderate testis Leydig cells moderate thyroid gland glandular cells moderate tonsil germinal center cells negative tonsil non-germinal center cells weak tonsil squamous epithelial cells moderate urinary bladder urothelial cells weak uterus, post-menopause cells in endometrial stroma negative uterus, post-menopause glandular cells weak uterus, pre-menopause cells in endometrial stroma negative uterus, pre-menopause glandular cells weak vagina squamous epithelial cells weak vulva/anal skin epidermal cells negative

uncertain

PC-3 High U-251 MG Medium HEK 293 Medium A-549 Low CACO-2 Low Hep-G2 Low HeLa Low MCF-7 Low RT-4 Low U-2 OS Low A-431 Not detected GSLYSDVSTGLTWRSGTASSVSYPKQMPLSQV

uncertain adrenal gland glandular cells moderate appendix glandular cells weak appendix lymphoid tissue negative bone marrow hematopoietic cells weak breast adipocytes weak breast glandular cells negative breast myoepithelial cells moderate bronchus respiratory epithelial cells weak cerebellum cells in granular layer negative cerebellum cells in molecular layer negative cerebellum Purkinje cells weak cerebral cortex endothelial cells moderate cerebral cortex glial cells moderate cerebral cortex neuronal cells moderate cerebral cortex neuropil weak cervix, uterine squamous epithelial cells negative colon endothelial cells negative colon glandular cells moderate duodenum glandular cells moderate epididymis glandular cells moderate esophagus squamous epithelial cells weak fallopian tube glandular cells strong gallbladder glandular cells moderate heart muscle myocytes weak hippocampus glial cells negative hippocampus neuronal cells weak kidney cells in glomeruli negative kidney cells in tubules moderate lateral ventricle glial cells weak lateral ventricle neuronal cells moderate liver bile duct cells strong liver hepatocytes weak lung macrophages moderate lung pneumocytes negative lymph node germinal center cells negative lymph node non-germinal center cells negative nasopharynx respiratory epithelial cells weak oral mucosa squamous epithelial cells weak ovary ovarian stroma cells moderate pancreas exocrine glandular cells moderate pancreas islets of Langerhans moderate parathyroid gland glandular cells moderate placenta trophoblastic cells strong prostate glandular cells moderate rectum glandular cells weak salivary gland glandular cells moderate seminal vesicle glandular cells moderate skeletal muscle myocytes weak skin fibroblasts moderate skin keratinocytes weak skin Langerhans moderate skin melanocytes strong small intestine glandular cells moderate smooth muscle smooth muscle cells moderate soft tissue 1 adipocytes moderate soft tissue 2 adipocytes moderate spleen cells in red pulp negative spleen cells in white pulp negative stomach, lower glandular cells moderate stomach, upper glandular cells moderate testis cells in seminiferus ducts strong testis Leydig cells moderate thyroid gland glandular cells weak tonsil germinal center cells negative tonsil non-germinal center cells negative tonsil squamous epithelial cells weak urinary bladder urothelial cells weak uterus, post-menopause cells in endometrial stroma moderate uterus, post-menopause glandular cells negative uterus, pre-menopause cells in endometrial stroma moderate uterus, pre-menopause glandular cells weak vagina squamous epithelial cells weak vulva/anal skin epidermal cells weak

U-251 MG Medium A-549 Medium CACO-2 Medium Hep-G2 Medium U-2 OS Medium HEK 293 Medium HeLa Low PC-3 Low RT-4 Low A-431 Low MCF-7 Not detected