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PLBD2 expression profiles.
Gene data  
 
 Description:  Phospholipase B domain containing 2
Source acc: 27283 (HGNC Symbol)  
 Chromosome:  12:q24.13 
 EnsEMBL ID:  ENSG00000151176 
 
    Protein Ensembl ID   Transcript Ensembl ID   No of aa  Mw
 Splice variant 1:  ENSP00000280800  ENST00000280800  589  65 kDa 
 
Normal Tissues - IHC  
Nasopharynx respiratory epithelial cells 
Bronchus respiratory epithelial cells 
Lung alveolar cells 
macrophages 
Oral mucosa squamous epithelial cells 
Salivary gland glandular cells 
Esophagus squamous epithelial cells 
Stomach 1 glandular cells 
Stomach 2 glandular cells 
Duodenum glandular cells 
Small intestine glandular cells 
Colon glandular cells 
Rectum glandular cells 
Appendix glandular cells 
lymphoid tissue 
Liver bile duct cells 
hepatocytes 
Gall bladder glandular cells 
Pancreas exocrine glandular cells 
islet cells 
Thyroid gland glandular cells 
Parathyroid gland glandular cells 
Adrenal gland cortical cells 
Kidney cells in glomeruli 
cells in tubules 
Urinary bladder urothelial cells 
Vagina squamous epithelial cells 
Vulva/anal skin squamous epithelial cells 
Skin adnexal cells 
epidermal cells 
Ovary follicle cells 
ovarian stromal cells 
Fallopian tube glandular cells 
Corpus, uterine 1 cells in endometrial stroma 
glandular cells 
Corpus, uterine 2 cells in endometrial stroma 
glandular cells 
Cervix, uterine glandular cells 
squamous epithelial cells 
Placenta decidual cells 
trophoblastic cells 
Breast glandular cells 
Testis cells in seminiferus ducts 
leydig cells 
Epididymis glandular cells 
Seminal vesicle glandular cells 
Prostate glandular cells 
Cerebral cortex glial cells 
neuronal cells 
Cerebellum cells in granular layer 
cells in molecular layer 
purkinje cells 
Hippocampus glial cells 
neuronal cells 
Lateral ventricle glial cells 
neuronal cells 
Spleen cells in red pulp 
cells in white pulp 
Lymph node lymphoid cells outside reaction centra 
reaction center cells 
Tonsil lymphoid cells outside reaction centra 
reaction center cells 
squamous epithelial cells 
Bone marrow bone marrow poietic cells 
Heart muscle myocytes 
Smooth muscle smooth muscle cells 
Skeletal muscle myocytes 
Soft tissue 1 mesenchymal cells 
Soft tissue 2 mesenchymal cells 
 
Annotation Summary - IHC  
Most of the normal tissues displayed moderate granular cytoplasmic positivity. Strong staining was seen in adrenal cortical cells, leydig cells and cells of cerebellum and cerebral cortex. Liver and myocytes were generally negative. Malignant tissues exhibited weak to moderate cytoplasmic immunoreactivity with a granular pattern. Many cases of lymphomas, testicular and pancreatic cancers were negative.
Cancer Tissues - IHC  
Colorectal cancer  
Breast cancer  
Prostate cancer  
Ovarian cancer  
Cervical cancer  
Endometrial cancer  
Malignant carcinoid  
Head & neck cancer  
Thyroid cancer  
Malignant glioma  
Malignant lymphoma  
Lung cancer  
Malignant melanoma  
Skin cancer  
Testis cancer  
Urothelial cancer  
Renal cancer  
Stomach cancer  
Pancreatic cancer  
Liver cancer  
 
Cell lines - IF  
A-431
U-2 OS
U-251MG
 
Annotation summary:
Staining of centrosomes and nuclei but not nucleoli in all three cell lines.
 
Validation:
Subcellular localization not consistent with literature.
 
  
 
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Validation Summary
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IF
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Protein expression
 Strong
 Moderate
 Weak
 Negative
 Not representative
 
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