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ADAM10 expression profiles.
Gene data  
 
 Description:  ADAM metallopeptidase domain 10
Source acc: 188
(HGNC Symbol)  
 Chromosome:  15:q21.3 
 EnsEMBL ID:  ENSG00000137845 
 
    Protein Ensembl ID   Transcript Ensembl ID   No of aa  Mw
 Splice variant 1:  ENSP00000379444  ENST00000396140  747  84 kDa 
 Splice variant 2:  ENSP00000391994  ENST00000443434  55  6 kDa 
 Splice variant 3:  ENSP00000391930  ENST00000439637  125  15 kDa 
 Splice variant 4:  ENSP00000386056  ENST00000402627  71  7 kDa 
 Splice variant 5:  ENSP00000379440  ENST00000396136  567  63 kDa 
 Splice variant 6:  ENSP00000260408  ENST00000260408  748  84 kDa 
 
Normal Tissues - IHC  
Adrenal gland cortical cells 
Appendix glandular cells 
lymphoid tissue 
Bone marrow bone marrow poietic cells 
Breast glandular cells 
Bronchus respiratory epithelial cells 
Cerebellum cells in granular layer 
cells in molecular layer 
purkinje cells 
Cerebral cortex glial cells 
neuronal cells 
Cervix, uterine glandular cells 
squamous epithelial cells 
Colon glandular cells 
Corpus, uterine 1 cells in endometrial stroma 
glandular cells 
Corpus, uterine 2 cells in endometrial stroma 
glandular cells 
Duodenum glandular cells 
Epididymis glandular cells 
Esophagus squamous epithelial cells 
Fallopian tube glandular cells 
Gall bladder glandular cells 
Heart muscle myocytes 
Hippocampus glial cells 
neuronal cells 
Kidney cells in glomeruli 
cells in tubules 
Lateral ventricle glial cells 
neuronal cells 
Liver bile duct cells 
hepatocytes 
Lung alveolar cells 
macrophages 
Lymph node lymphoid cells outside reaction centra 
reaction center cells 
Nasopharynx respiratory epithelial cells 
Oral mucosa squamous epithelial cells 
Ovary follicle cells 
ovarian stromal cells 
Pancreas exocrine glandular cells 
islet cells 
Parathyroid gland glandular cells 
Placenta decidual cells 
trophoblastic cells 
Prostate glandular cells 
Rectum glandular cells 
Salivary gland glandular cells 
Seminal vesicle glandular cells 
Skeletal muscle myocytes 
Skin adnexal cells 
epidermal cells 
Small intestine glandular cells 
Smooth muscle smooth muscle cells 
Soft tissue 1 mesenchymal cells 
Soft tissue 2 mesenchymal cells 
Spleen cells in red pulp 
cells in white pulp 
Stomach 1 glandular cells 
Stomach 2 glandular cells 
Testis cells in seminiferus ducts 
leydig cells 
Thyroid gland glandular cells 
Tonsil lymphoid cells outside reaction centra 
reaction center cells 
squamous epithelial cells 
Urinary bladder urothelial cells 
Vagina squamous epithelial cells 
Vulva/anal skin squamous epithelial cells 
 
Annotation Summary - IHC  
Most glandular epithelia showed cytoplasmic positivity. Squamous epithelium less positive. Urothelial cells positive in both nucleus and cytoplasm. Most adenocarcinomas showed a slight cytoplasmic staining, in tumour cells as well as in surrounding stroma. In breast cancer a nuclear staining was also seen, sometimes also a cytoplasmic membrane staining. Ovarian carcinomas sometimes showed nuclear staining. Otherwise genital tract carcinomas were weakly positive or negative. Varying positivity in other carcinoma types. Gliomas and lymphomas generally negative.
Cancer Tissues - IHC  
Breast cancer  
Cervical cancer  
Colorectal cancer  
Endometrial cancer  
Head & neck cancer  
Liver cancer  
Lung cancer  
Malignant carcinoid  
Malignant glioma  
Malignant lymphoma  
Malignant melanoma  
Ovarian cancer  
Pancreatic cancer  
Prostate cancer  
Renal cancer  
Skin cancer  
Stomach cancer  
Testis cancer  
Thyroid cancer  
Urothelial cancer  
 
Cell lines - IHC  
Myeloid
HEL
HL-60
HMC-1
K-562
NB-4
THP-1
U-937
Lymphoid
Daudi
HDLM-2
Karpas-707
KM3
LP-1
MOLT-4
RPMI-8226
U-266/70
U-266/84
U-698
Brain
D341 Med
SH-SY5Y
U-138MG
U-251MG
U-87MG
Lung
A-549
SCLC-21H
Abdominal
CACO-2
CAPAN-2
Hep-G2
Breast, female reproductive system
AN3-CA
EFO-21
HeLa
MCF-7
SiHa
SK-BR-3
Urinary, male reproductive system
NTERA-2
PC-3
RT-4
Skin
A-431
HaCaT
SK-MEL-30
WM-115
Sarcoma
RH-30
U-2 OS
U-2197
Miscellaneous
BEWO
HEK 293
HTh 83
TIME
 
Cells - IHC  
Leukemia, AML
Leukemia, AML
Leukemia, B-ALL
Leukemia, B-CLL subtype 1
Leukemia, B-CLL subtype 2
Leukemia, B-CLL subtype 3
Leukemia, B-CLL subtype 4
Leukemia, CML
Leukemia, CML
Leukemia, T-ALL
PBMC
PBMC
 
Cell Expression Diagram - IHC  
  
 
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Protein expression
 Strong
 Moderate
 Weak
 Negative
 Not representative
 
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