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KLKB1 expression profiles.

Gene data

Description:

Kallikrein B, plasma (Fletcher factor) 1
Source acc: 6371 (HGNC Symbol)

Chromosome:

4:q35.2

EnsEMBL ID:

ENSG00000164344

	Protein Ensembl ID	Transcript Ensembl ID	No of aa	Mw
Splice variant 1:	ENSP00000264690	ENST00000264690	638	71 kDa
Splice variant 2:	ENSP00000397470	ENST00000418715	514	58 kDa

Normal Tissues - IHC

alph. sort order

Adrenal gland	cortical cells
Appendix	glandular cells
	lymphoid tissue
Bone marrow	bone marrow poietic cells
Breast	glandular cells
Bronchus	respiratory epithelial cells
Cerebellum	cells in granular layer
	cells in molecular layer
	purkinje cells
Cerebral cortex	glial cells
	neuronal cells
Cervix, uterine	glandular cells
	squamous epithelial cells
Colon	glandular cells
Corpus, uterine 1	cells in endometrial stroma
	glandular cells
Corpus, uterine 2	cells in endometrial stroma
	glandular cells
Duodenum	glandular cells
Epididymis	glandular cells
Esophagus	squamous epithelial cells
Fallopian tube	glandular cells
Gall bladder	glandular cells
Heart muscle	myocytes
Hippocampus	glial cells
	neuronal cells
Kidney	cells in glomeruli
	cells in tubules
Lateral ventricle	glial cells
	neuronal cells
Liver	bile duct cells
	hepatocytes
Lung	alveolar cells
	macrophages

Lymph node	lymphoid cells outside reaction centra
	reaction center cells
Nasopharynx	respiratory epithelial cells
Oral mucosa	squamous epithelial cells
Ovary	follicle cells
	ovarian stromal cells
Pancreas	exocrine glandular cells
	islet cells
Parathyroid gland	glandular cells
Placenta	decidual cells
	trophoblastic cells
Prostate	glandular cells
Rectum	glandular cells
Salivary gland	glandular cells
Seminal vesicle	glandular cells
Skeletal muscle	myocytes
Skin	adnexal cells
	epidermal cells
Small intestine	glandular cells
Smooth muscle	smooth muscle cells
Soft tissue 1	mesenchymal cells
Soft tissue 2	mesenchymal cells
Spleen	cells in red pulp
	cells in white pulp
Stomach 1	glandular cells
Stomach 2	glandular cells
Testis	cells in seminiferus ducts
	leydig cells
Thyroid gland	glandular cells
Tonsil	lymphoid cells outside reaction centra
	reaction center cells
	squamous epithelial cells
Urinary bladder	urothelial cells
Vagina	squamous epithelial cells
Vulva/anal skin	squamous epithelial cells

Annotation Summary - IHC

Normal cells exhibited a moderate to strong cytoplasmic staining, often with a granular staining pattern. In CNS subtypes of glial cells showed strong immunoreactivity. Like most normal tissues, malignant tumors showed cytoplasmic staining. Tumors of the liver, pancreas, stomach and urinary bladder showed a weaker staining than their normal counterparts.

Cancer Tissues - IHC

alph. sort order

Breast cancer

Cervical cancer

Colorectal cancer

Endometrial cancer

Head & neck cancer

Liver cancer

Lung cancer

Malignant carcinoid

Malignant glioma

Malignant lymphoma

Malignant melanoma

Ovarian cancer

Pancreatic cancer

Prostate cancer

Renal cancer

Skin cancer

Stomach cancer

Testis cancer

Thyroid cancer

Urothelial cancer

Cell lines - IHC

Myeloid
HEL
HL-60
HMC-1
K-562
NB-4
THP-1
U-937
Lymphoid
Daudi
HDLM-2
Karpas-707
KM3
LP-1
MOLT-4
RPMI-8226
U-266/70
U-266/84
U-698
Brain
D341 Med
SH-SY5Y
U-138MG
U-251MG
U-87MG
Lung
A-549
SCLC-21H

Abdominal
CACO-2
CAPAN-2
Hep-G2
Breast, female reproductive system
AN3-CA
EFO-21
HeLa
MCF-7
SiHa
SK-BR-3
Urinary, male reproductive system
NTERA-2
PC-3
RT-4
Skin
A-431
HaCaT
SK-MEL-30
WM-115
Sarcoma
RH-30
U-2 OS
U-2197
Miscellaneous
BEWO
HEK 293
HTh 83
TIME

Cells - IHC

Cell Expression Diagram - IHC

Cell lines - IF

A-431
U-2 OS
U-251MG

Annotation summary: Staining of cytoplasm in all three cell lines.

Validation: Subcellular localization supported by literature.

Navigation

Home HPA005634
	Expression profiles - IHC
	Normal tissues
	Cancer tissues
	Cells
	Expression profiles - IF
	Cells
	Gene/Protein info
	Antigen/Antibody info

Validation Summary

Protein expression
	Strong
	Moderate
	Weak
	Negative

	Not representative

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