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TMPRSS2 expression profiles.
Gene data  
 
 Description:  Transmembrane protease, serine 2
Source acc: 11876 (HGNC Symbol)  
 Chromosome:  21:q22.3 
 EnsEMBL ID:  ENSG00000184012 
 
    Protein Ensembl ID   Transcript Ensembl ID   No of aa  Mw
 Splice variant 1:  ENSP00000330330  ENST00000332149  492  54 kDa 
 Splice variant 2:  ENSP00000381588  ENST00000398585  492  54 kDa 
 Splice variant 3:  ENSP00000389006  ENST00000454499  489  54 kDa 
 Splice variant 4:  ENSP00000391216  ENST00000458356  492  54 kDa 
 
Normal Tissues - IHC  
Adrenal gland cortical cells 
Appendix glandular cells 
lymphoid tissue 
Bone marrow bone marrow poietic cells 
Breast glandular cells 
Bronchus respiratory epithelial cells 
Cerebellum cells in granular layer 
cells in molecular layer 
purkinje cells 
Cerebral cortex glial cells 
neuronal cells 
Cervix, uterine glandular cells 
squamous epithelial cells 
Colon glandular cells 
Corpus, uterine 1 cells in endometrial stroma 
glandular cells 
Corpus, uterine 2 cells in endometrial stroma 
glandular cells 
Duodenum glandular cells 
Epididymis glandular cells 
Esophagus squamous epithelial cells 
Fallopian tube glandular cells 
Gall bladder glandular cells 
Heart muscle myocytes 
Hippocampus glial cells 
neuronal cells 
Kidney cells in glomeruli 
cells in tubules 
Lateral ventricle glial cells 
neuronal cells 
Liver bile duct cells 
hepatocytes 
Lung alveolar cells 
macrophages 
Lymph node lymphoid cells outside reaction centra 
reaction center cells 
Nasopharynx respiratory epithelial cells 
Oral mucosa squamous epithelial cells 
Ovary follicle cells 
ovarian stromal cells 
Pancreas exocrine glandular cells 
islet cells 
Parathyroid gland glandular cells 
Placenta decidual cells 
trophoblastic cells 
Prostate glandular cells 
Rectum glandular cells 
Salivary gland glandular cells 
Seminal vesicle glandular cells 
Skeletal muscle myocytes 
Skin adnexal cells 
epidermal cells 
Small intestine glandular cells 
Smooth muscle smooth muscle cells 
Soft tissue 1 mesenchymal cells 
Soft tissue 2 mesenchymal cells 
Spleen cells in red pulp 
cells in white pulp 
Stomach 1 glandular cells 
Stomach 2 glandular cells 
Testis cells in seminiferus ducts 
leydig cells 
Thyroid gland glandular cells 
Tonsil lymphoid cells outside reaction centra 
reaction center cells 
squamous epithelial cells 
Urinary bladder urothelial cells 
Vagina squamous epithelial cells 
Vulva/anal skin squamous epithelial cells 
 
Annotation Summary - IHC  
This antibody stained cytoplasm of most normal tissues moderately in a granular pattern. Strong positivity was observed in hepatocytes, renal tubules and their malignant counterparts. The remaining malignant tissues displayed variable staining intensities, however displayed the malignant gliomas generally stronger intensities compared to normal glial cells.
Cancer Tissues - IHC  
Breast cancer  
Cervical cancer  
Colorectal cancer  
Endometrial cancer  
Head & neck cancer  
Liver cancer  
Lung cancer  
Malignant carcinoid  
Malignant glioma  
Malignant lymphoma  
Malignant melanoma  
Ovarian cancer  
Pancreatic cancer  
Prostate cancer  
Renal cancer  
Skin cancer  
Stomach cancer  
Testis cancer  
Thyroid cancer  
Urothelial cancer  
 
Cell lines - IHC  
Myeloid
HEL
HL-60
HMC-1
K-562
NB-4
THP-1
U-937
Lymphoid
Daudi
HDLM-2
Karpas-707
KM3
LP-1
MOLT-4
RPMI-8226
U-266/70
U-266/84
U-698
Brain
D341 Med
SH-SY5Y
U-138MG
U-251MG
U-87MG
Lung
A-549
SCLC-21H
Abdominal
CACO-2
CAPAN-2
Hep-G2
Breast, female reproductive system
AN3-CA
EFO-21
HeLa
MCF-7
SiHa
SK-BR-3
Urinary, male reproductive system
NTERA-2
PC-3
RT-4
Skin
A-431
HaCaT
SK-MEL-30
WM-115
Sarcoma
RH-30
U-2 OS
U-2197
Miscellaneous
BEWO
HEK 293
HTh 83
TIME
 
Cells - IHC  
Leukemia, AML
Leukemia, AML
Leukemia, B-ALL
Leukemia, B-CLL subtype 1
Leukemia, B-CLL subtype 2
Leukemia, B-CLL subtype 3
Leukemia, B-CLL subtype 4
Leukemia, CML
Leukemia, CML
Leukemia, T-ALL
PBMC
PBMC
 
Cell Expression Diagram - IHC  
Cell lines - IF  
A-431
U-2 OS
U-251MG
 
Annotation summary:
Staining of plasma membrane and cytoplasm in all three cell lines.
 
Validation:
Subcellular localization supported by literature.
 
  
 
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Validation Summary
IH
IF
PA
WB
 
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Protein expression
 Strong
 Moderate
 Weak
 Negative
 Not representative
 
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