The primary data page shows the detailed antibody staining in 76 different cell types for each analyzed antibody. In addition, for each cell type, a knowledge-based annotated protein expression score based on all analyzed antibodies is displayed furthest to the right. The images and annotations can be accessed by clicking on the tissue name or score bar. More information can be found in Assays & Annotation.
The tissues and cell types can be ordered by organ, cell type or alphabetically. If ordered by organ, the tissues are presented in groups according to functional features. If ordered by cell type, the cells are presented in groups related to origin.
This score describes the level of antibody staining observed in the annotated cell types as not detected (n), low (l), medium (m) or high (h). It is based on the staining intensity and fraction of stained cells. The images and annotations can be accessed by clicking on the tissue name or score bar. More information can be found in Assays & Annotation.
This score describes a knowledge-based best estimate of the protein expression in the annotated cell types as not detected (n), low (l), medium (m) or high (h). It is a result of stringent evaluation of immunohistochemical staining pattern, RNA data from internal and external sources and available protein/gene characterization data. More information can be found in Assays & Annotation.
Summarizing texts describe the staining pattern for each antibody based on staining intensity, fraction of stained cells and subcellular localization. More information can be found in Assays & Annotation.
Normal cells displayed weak to moderate cytoplasmic immunoreactivity in most cases. The upper parts of the intestine, duodenum and the small intestine, displayed strong staining of basal cells in crypts of Lieberkuhn. The lower parts of the intestine, colon, appendix and rectum, showed distinct staining in cytoplasm and membranes. Strong cytoplasmic positivity was also observed in placental trophoblastic cells and glandular cells in epididymis and seminal vesicle.
Most of the normal tissues were negative. Strong cytoplasmic positivity was observed in liver hepatocytes, gall bladder, bronchus, Paneth and enteroendocrine cells in gastrointestinal tract. Cells in seminiferous ducts of testis showed moderate nuclear positivity.