Protein detected in human plasma by immunoassays
In this chapter the estimated protein concentrations of proteins detected in human plasma using immunoasays is presented. Reference plasma concentrations for 440 proteins actively secreted to blood were collected based on published research articles where immunoassays had been used to measure the target proteins. The concentrations of the proteins for which reference values could be obtained ranged over 10 orders of magnitude from 40 mg/ml for human serum albumin down to 4 pg/ml for interleukin 5.
Figure 2. Violin plots showing the distribution of plasma concentrations for 22 different groups based on their main protein function.
Apolipoprotein, enzyme inhibitors and proteins involved in transport generally show high plasma concentrations above 1 ug/ml. In contrast, chemokines and cytokines, especially interleukins and interferons, are found in the lower end of the concentration range below 1 ng/ml together with hormones, neuropeptides and growth factors.
Table 1. Concentrations for proteins secreted to blood. Measured by immunoassays.