Transcription factor landscape - Immune cell - B-cells

Transcriptome analysis shows that 48% (n=9625) of all human proteins (n=20162) are detected in b-cells and 280 of these genes show an elevated expression in any b-cells compared to other cell type groups. Learn more about genes with elevated expression here.

In-depth analysis of transcription factor genes expressed in b-cells highlights 28 transcription factors with elevated expression in b-cells compared to other immune lineages. In total, 9 transcription factors are classified as enriched in b-cells.

Here we provide the expression overview of all transcription factors that show enriched expression levels in b-cells compared to other cell types. The gene expression overview, across different cell types is accopanied by the top 3 nearest neighbours based on single cell RNA expression and correlation in the clustering analysis.

Enriched transcription factors

Gene

Expression

Expression clustering

ZNF860

Lineage enriched (B-cells)

3 nearest neighbours based on single cell RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
SOX5	SRY-box transcription factor 5	1.0000	17
RASSF6	Ras association domain family member 6	1.0000	17
BTNL9	Butyrophilin like 9	1.0000	17

PAX5

Lineage enriched (B-cells)

3 nearest neighbours based on single cell RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
PIK3C2B	Phosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 beta	1.0000	34
SLC38A11	Solute carrier family 38 member 11	1.0000	34
APBB2	Amyloid beta precursor protein binding family B member 2	1.0000	34

TEAD2

Lineage enriched (B-cells)

3 nearest neighbours based on single cell RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
EBF1	EBF transcription factor 1	1.0000	23
IGLV6-57	Immunoglobulin lambda variable 6-57	1.0000	23
IGLV4-60	Immunoglobulin lambda variable 4-60	1.0000	23

EBF1

Lineage enriched (B-cells)

3 nearest neighbours based on single cell RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
GNG3	G protein subunit gamma 3	1.0000	23
IGLV6-57	Immunoglobulin lambda variable 6-57	1.0000	23
IGLV4-60	Immunoglobulin lambda variable 4-60	1.0000	23

BHLHE41

Lineage enriched (B-cells)

3 nearest neighbours based on single cell RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
SOX5	SRY-box transcription factor 5	1.0000	17
RASSF6	Ras association domain family member 6	1.0000	17
BTNL9	Butyrophilin like 9	1.0000	17

E2F5

Lineage enriched (B-cells)

3 nearest neighbours based on single cell RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
SOX5	SRY-box transcription factor 5	1.0000	17
RASSF6	Ras association domain family member 6	1.0000	17
BTNL9	Butyrophilin like 9	1.0000	17

ZBTB32

Lineage enriched (B-cells)

3 nearest neighbours based on single cell RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
CCR9	C-C motif chemokine receptor 9	1.0000	14
AIM2	Absent in melanoma 2	1.0000	14
POF1B	POF1B actin binding protein	1.0000	14

SOX5

Lineage enriched (B-cells)

3 nearest neighbours based on single cell RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
E2F5	E2F transcription factor 5	1.0000	17
RASSF6	Ras association domain family member 6	1.0000	17
BTNL9	Butyrophilin like 9	1.0000	17

TAL2

Lineage enriched (B-cells)

3 nearest neighbours based on single cell RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
IGF1	Insulin like growth factor 1	1.0000	17
IGKV1OR2-108	Immunoglobulin kappa variable 1/OR2-108 (non-functional)	1.0000	17
IGKJ1	Immunoglobulin kappa joining 1	1.0000	17

Enriched transcription factors

Gene

Expression

Expression clustering

SPIB

Group enriched (B-cells, Dendritic cells)

3 nearest neighbours based on single cell RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
BLNK	B cell linker	0.9762	12
TXNDC5	Thioredoxin domain containing 5	0.9762	12
MZB1	Marginal zone B and B1 cell specific protein	0.9762	12

ID3

Group enriched (B-cells, T-cells)

3 nearest neighbours based on single cell RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
ENSG00000281179	Novel gene identicle to IGHV1OR15-1	1.0000	43
IGHV1OR15-1	Immunoglobulin heavy variable 1/OR15-1 (non-functional)	1.0000	43
H3C3	H3 clustered histone 3	0.9762	43

MSC

Group enriched (B-cells, Dendritic cells, T-cells)

3 nearest neighbours based on single cell RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
PTTG1	PTTG1 regulator of sister chromatid separation, securin	1.0000	16
TNFRSF19	TNF receptor superfamily member 19	0.9762	16
PCLAF	PCNA clamp associated factor	0.9762	16

TCF4

Group enriched (B-cells, Dendritic cells)

3 nearest neighbours based on single cell RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
KCNK10	Potassium two pore domain channel subfamily K member 10	1.0000	44
ETV2	ETS variant transcription factor 2	1.0000	44
PTPRS	Protein tyrosine phosphatase receptor type S	1.0000	44

TFEC

Group enriched (B-cells, Dendritic cells, Monocytes)

3 nearest neighbours based on single cell RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
CRIP3	Cysteine rich protein 3	1.0000	2
GPR33	G protein-coupled receptor 33	0.9762	2
PKIB	CAMP-dependent protein kinase inhibitor beta	0.9762	2

BCL11A

Group enriched (B-cells, Dendritic cells)

3 nearest neighbours based on single cell RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
CYB561A3	Cytochrome b561 family member A3	1.0000	12
SPIB	Spi-B transcription factor	0.9762	12
MTG1	Mitochondrial ribosome associated GTPase 1	0.9762	12

THRB

Group enriched (B-cells, Granulocytes)

3 nearest neighbours based on single cell RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
ACIN1	Apoptotic chromatin condensation inducer 1	0.9762	20
CDK12	Cyclin dependent kinase 12	0.9762	20
KIAA1958	KIAA1958	0.9762	20

ZNF239

Group enriched (B-cells, T-cells)

3 nearest neighbours based on single cell RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
CTH	Cystathionine gamma-lyase	1.0000	43
RPSAP58	Ribosomal protein SA pseudogene 58	1.0000	43
PDE7A	Phosphodiesterase 7A	1.0000	43

IRF5

Group enriched (B-cells, Dendritic cells, Monocytes)

3 nearest neighbours based on single cell RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
STAC3	SH3 and cysteine rich domain 3	1.0000	38
AIFM3	Apoptosis inducing factor mitochondria associated 3	1.0000	38
FGD6	FYVE, RhoGEF and PH domain containing 6	1.0000	38

HSF5

Group enriched (B-cells, T-cells)

3 nearest neighbours based on single cell RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
METAP1D	Methionyl aminopeptidase type 1D, mitochondrial	1.0000	43
ST6GAL1	ST6 beta-galactoside alpha-2,6-sialyltransferase 1	1.0000	43
EIF4A2	Eukaryotic translation initiation factor 4A2	0.9762	43

IKZF3

Group enriched (B-cells, T-cells)

3 nearest neighbours based on single cell RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
MTBP	MDM2 binding protein	1.0000	24
SLC9B2	Solute carrier family 9 member B2	1.0000	24
TMOD1	Tropomodulin 1	1.0000	24

IRF4

Group enriched (B-cells, Dendritic cells, T-cells)

3 nearest neighbours based on single cell RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
NPIPA9	Nuclear pore complex interacting protein family, member A9	1.0000	23
TLR10	Toll like receptor 10	1.0000	23
PARM1	Prostate androgen-regulated mucin-like protein 1	1.0000	23

JDP2

Group enriched (B-cells, Granulocytes, Monocytes)

3 nearest neighbours based on single cell RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
CALHM6	Calcium homeostasis modulator family member 6	1.0000	40
MTSS1	MTSS I-BAR domain containing 1	1.0000	40
RASL11A	RAS like family 11 member A	1.0000	40

MEF2C

Group enriched (B-cells, Dendritic cells, Monocytes)

3 nearest neighbours based on single cell RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
OLFML1	Olfactomedin like 1	1.0000	23
RUBCNL	Rubicon like autophagy enhancer	1.0000	23
UVRAG	UV radiation resistance associated	0.9762	23

ZBTB16

Group enriched (B-cells, Nk-cells, T-cells)

3 nearest neighbours based on single cell RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
SEPTIN7	Septin 7	1.0000	24
ZNF625	Zinc finger protein 625	1.0000	24
TRDV3	T cell receptor delta variable 3	1.0000	24

LYL1

Group enriched (B-cells, Granulocytes, Monocytes)

3 nearest neighbours based on single cell RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
SLC29A1	Solute carrier family 29 member 1 (Augustine blood group)	1.0000	45
NBPF1	NBPF member 1	1.0000	45
GTF2E2	General transcription factor IIE subunit 2	1.0000	45

ZNF549

Group enriched (B-cells, Nk-cells, T-cells)

3 nearest neighbours based on single cell RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
MZF1	Myeloid zinc finger 1	1.0000	24
SYNRG	Synergin gamma	1.0000	24
ATP6V1G2	ATPase H+ transporting V1 subunit G2	1.0000	24

ZNF563

Group enriched (B-cells, T-cells)

3 nearest neighbours based on single cell RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
RPS29	Ribosomal protein S29	1.0000	43
TMEM121	Transmembrane protein 121	1.0000	43
PHGDH	Phosphoglycerate dehydrogenase	1.0000	43

Enriched transcription factors

Gene

Expression

Expression clustering

ZNF711

Lineage enhanced (B-cells)

3 nearest neighbours based on single cell RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
N/A