Transcription factor landscape - Immune cell - NK-cells

Transcriptome analysis shows that 45% (n=9166) of all human proteins (n=20162) are detected in nk-cells and 276 of these genes show an elevated expression in any nk-cells compared to other cell type groups. Learn more about genes with elevated expression here.

In-depth analysis of transcription factor genes expressed in nk-cells highlights 22 transcription factors with elevated expression in nk-cells compared to other immune lineages. In total, 5 transcription factors are classified as enriched in nk-cells.

Here we provide the expression overview of all transcription factors that show enriched expression levels in nk-cells compared to other cell types. The gene expression overview, across different cell types is accopanied by the top 3 nearest neighbours based on single cell RNA expression and correlation in the clustering analysis.

Enriched transcription factors

Gene

Expression

Expression clustering

PRDM16

Lineage enriched (Nk-cells)

3 nearest neighbours based on single cell RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
TNFRSF11A	TNF receptor superfamily member 11a	1.0000	15
SPRY2	Sprouty RTK signaling antagonist 2	1.0000	15
RNF165	Ring finger protein 165	1.0000	15

NR1I2

Lineage enriched (Nk-cells)

3 nearest neighbours based on single cell RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
N/A

SALL4

Lineage enriched (Nk-cells)

3 nearest neighbours based on single cell RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
N/A

HOXA7

Lineage enriched (Nk-cells)

3 nearest neighbours based on single cell RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
N/A

ZNF324B

Lineage enriched (Nk-cells)

3 nearest neighbours based on single cell RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
MOK	MOK protein kinase	0.9762	33
IPO7	Importin 7	0.9762	33
C6orf136	Chromosome 6 open reading frame 136	0.9762	33

Enriched transcription factors

Gene

Expression

Expression clustering

EOMES

Group enriched (Nk-cells, T-cells)

3 nearest neighbours based on single cell RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
KIR3DL1	Killer cell immunoglobulin like receptor, three Ig domains and long cytoplasmic tail 1	1.0000	15
TRGC1	T cell receptor gamma constant 1	1.0000	15
TRGJP2	T cell receptor gamma joining P2	1.0000	15

GATA3

Group enriched (Nk-cells, T-cells)

3 nearest neighbours based on single cell RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
ZNF831	Zinc finger protein 831	1.0000	1
XPOT	Exportin for tRNA	1.0000	1
SH2D1A	SH2 domain containing 1A	1.0000	1

TCF7

Group enriched (Nk-cells, T-cells)

3 nearest neighbours based on single cell RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
BCL9	BCL9 transcription coactivator	1.0000	43
TRAJ61	T cell receptor alpha joining 61 (non-functional)	1.0000	43
GPRASP1	G protein-coupled receptor associated sorting protein 1	1.0000	43

HOPX

Group enriched (Nk-cells, T-cells)

3 nearest neighbours based on single cell RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
XCL2	X-C motif chemokine ligand 2	1.0000	15
TBXT	T-box transcription factor T	1.0000	15
ZNF333	Zinc finger protein 333	1.0000	15

TBX21

Group enriched (Nk-cells, T-cells)

3 nearest neighbours based on single cell RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
XCL2	X-C motif chemokine ligand 2	1.0000	15
TBXT	T-box transcription factor T	1.0000	15
ZNF333	Zinc finger protein 333	1.0000	15

HOXA9

Group enriched (Dendritic cells, Granulocytes, Nk-cells)

3 nearest neighbours based on single cell RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
POLR3G	RNA polymerase III subunit G	1.0000	32
ZNF559-ZNF177	ZNF559-ZNF177 readthrough	1.0000	32
TAPBP	TAP binding protein	1.0000	32

MAFF

Group enriched (Granulocytes, Nk-cells)

3 nearest neighbours based on single cell RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
STK26	Serine/threonine kinase 26	1.0000	32
LNPEP	Leucyl and cystinyl aminopeptidase	0.9762	32
SAMD9	Sterile alpha motif domain containing 9	0.9762	32

STAT4

Group enriched (Nk-cells, T-cells)

3 nearest neighbours based on single cell RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
SPEF2	Sperm flagellar 2	1.0000	1
DPP4	Dipeptidyl peptidase 4	1.0000	1
GZMM	Granzyme M	1.0000	1

HOXA10

Group enriched (Granulocytes, Nk-cells)

3 nearest neighbours based on single cell RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
TNFSF11	TNF superfamily member 11	0.9762	15
XCL1	X-C motif chemokine ligand 1	0.9762	15
PRDM16	PR/SET domain 16	0.9762	15

IKZF2

Group enriched (Granulocytes, Nk-cells, T-cells)

3 nearest neighbours based on single cell RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
TMEM87A	Transmembrane protein 87A	1.0000	5
WDR44	WD repeat domain 44	0.9762	5
RPA1	Replication protein A1	0.9762	5

TOX

Group enriched (Granulocytes, Nk-cells, T-cells)

3 nearest neighbours based on single cell RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
DSCC1	DNA replication and sister chromatid cohesion 1	1.0000	16
TMEM244	Transmembrane protein 244	1.0000	16
RGPD2	RANBP2 like and GRIP domain containing 2	1.0000	16

TSC22D1

Group enriched (Dendritic cells, Granulocytes, Nk-cells)

3 nearest neighbours based on single cell RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
WIPF2	WAS/WASL interacting protein family member 2	1.0000	41
RMND5A	Required for meiotic nuclear division 5 homolog A	1.0000	41
PPIP5K2	Diphosphoinositol pentakisphosphate kinase 2	1.0000	41

ZBTB16

Group enriched (B-cells, Nk-cells, T-cells)

3 nearest neighbours based on single cell RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
SEPTIN7	Septin 7	1.0000	24
ZNF625	Zinc finger protein 625	1.0000	24
TRDV3	T cell receptor delta variable 3	1.0000	24

ZNF600

Group enriched (Nk-cells, T-cells)

3 nearest neighbours based on single cell RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
EOMES	Eomesodermin	1.0000	15
TRGC1	T cell receptor gamma constant 1	1.0000	15
TRGJP2	T cell receptor gamma joining P2	1.0000	15

ZNF726

Group enriched (Granulocytes, Nk-cells)

3 nearest neighbours based on single cell RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
ASNS	Asparagine synthetase (glutamine-hydrolyzing)	0.9762	43
ARHGEF35	Rho guanine nucleotide exchange factor 35	0.9762	43
TRBJ2-3	T cell receptor beta joining 2-3	0.9762	43

SATB1

Group enriched (Nk-cells, T-cells)

3 nearest neighbours based on single cell RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
ZC4H2	Zinc finger C4H2-type containing	1.0000	24
ERICH6	Glutamate rich 6	1.0000	24
CCDC28B	Coiled-coil domain containing 28B	1.0000	24

ZNF549

Group enriched (B-cells, Nk-cells, T-cells)

3 nearest neighbours based on single cell RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
MZF1	Myeloid zinc finger 1	1.0000	24
SYNRG	Synergin gamma	1.0000	24
ATP6V1G2	ATPase H+ transporting V1 subunit G2	1.0000	24