Transcription factor landscape - Immune cell - granulocytes

Transcriptome analysis shows that 53% (n=10608) of all human proteins (n=20162) are detected in granulocytes and 640 of these genes show an elevated expression in any granulocytes compared to other cell type groups. Learn more about genes with elevated expression here.

In-depth analysis of transcription factor genes expressed in granulocytes highlights 98 transcription factors with elevated expression in granulocytes compared to other immune lineages. In total, 59 transcription factors are classified as enriched in granulocytes.

Here we provide the expression overview of all transcription factors that show enriched expression levels in granulocytes compared to other cell types. The gene expression overview, across different cell types is accopanied by the top 3 nearest neighbours based on single cell RNA expression and correlation in the clustering analysis.

Enriched transcription factors

Gene

Expression

Expression clustering

GATA2

Lineage enriched (Granulocytes)

3 nearest neighbours based on single cell RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
ZNF638	Zinc finger protein 638	1.0000	46
ITGB8	Integrin subunit beta 8	1.0000	46
CABP5	Calcium binding protein 5	1.0000	46

GATA1

Lineage enriched (Granulocytes)

3 nearest neighbours based on single cell RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
DCAF15	DDB1 and CUL4 associated factor 15	1.0000	22
TEPSIN	TEPSIN adaptor related protein complex 4 accessory protein	1.0000	22
HSPA4L	Heat shock protein family A (Hsp70) member 4 like	1.0000	22

CEBPE

Lineage enriched (Granulocytes)

3 nearest neighbours based on single cell RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
GADD45A	Growth arrest and DNA damage inducible alpha	1.0000	19
PPP1R1B	Protein phosphatase 1 regulatory inhibitor subunit 1B	1.0000	19
F12	Coagulation factor XII	1.0000	19

OLIG2

Lineage enriched (Granulocytes)

3 nearest neighbours based on single cell RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
GADD45A	Growth arrest and DNA damage inducible alpha	1.0000	19
PPP1R1B	Protein phosphatase 1 regulatory inhibitor subunit 1B	1.0000	19
F12	Coagulation factor XII	1.0000	19

KLF5

Lineage enriched (Granulocytes)

3 nearest neighbours based on single cell RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
SEMA3C	Semaphorin 3C	1.0000	46
ITGB8	Integrin subunit beta 8	1.0000	46
CABP5	Calcium binding protein 5	1.0000	46

OTX1

Lineage enriched (Granulocytes)

3 nearest neighbours based on single cell RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
ELAPOR1	Endosome-lysosome associated apoptosis and autophagy regulator 1	1.0000	4
SLPI	Secretory leukocyte peptidase inhibitor	1.0000	4
FAM209A	Family with sequence similarity 209 member A	1.0000	4

MXD1

Lineage enriched (Granulocytes)

3 nearest neighbours based on single cell RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
UBE2B	Ubiquitin conjugating enzyme E2 B	1.0000	35
SULT1A2	Sulfotransferase family 1A member 2	1.0000	35
STAT3	Signal transducer and activator of transcription 3	1.0000	35

TWIST2

Lineage enriched (Granulocytes)

3 nearest neighbours based on single cell RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
N/A

NFIL3

Lineage enriched (Granulocytes)

3 nearest neighbours based on single cell RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
ENSG00000287856	Novel protein	1.0000	41
CA13	Carbonic anhydrase 13	1.0000	41
TNRC18	Trinucleotide repeat containing 18	1.0000	41

PRDM5

Lineage enriched (Granulocytes)

3 nearest neighbours based on single cell RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
FBXL13	F-box and leucine rich repeat protein 13	1.0000	21
H4C1	H4 clustered histone 1	0.9762	21
ZNF586	Zinc finger protein 586	0.9762	21

EPAS1

Lineage enriched (Granulocytes)

3 nearest neighbours based on single cell RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
ZNF638	Zinc finger protein 638	1.0000	46
ITGB8	Integrin subunit beta 8	1.0000	46
CABP5	Calcium binding protein 5	1.0000	46

GFI1B

Lineage enriched (Granulocytes)

3 nearest neighbours based on single cell RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
FAM228B	Family with sequence similarity 228 member B	1.0000	22
MLYCD	Malonyl-CoA decarboxylase	1.0000	22
TOR4A	Torsin family 4 member A	1.0000	22

GATA6

Lineage enriched (Granulocytes)

3 nearest neighbours based on single cell RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
N/A

NKX3-1

Lineage enriched (Granulocytes)

3 nearest neighbours based on single cell RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
TCF23	Transcription factor 23	1.0000	20
ANKRD49	Ankyrin repeat domain 49	1.0000	20
FBXW7	F-box and WD repeat domain containing 7	0.9762	20

SOX6

Lineage enriched (Granulocytes)

3 nearest neighbours based on single cell RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
N/A

E2F6

Lineage enriched (Granulocytes)

3 nearest neighbours based on single cell RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
N/A

FOXI1

Lineage enriched (Granulocytes)

3 nearest neighbours based on single cell RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
N/A

OLIG1

Lineage enriched (Granulocytes)

3 nearest neighbours based on single cell RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
DCAF15	DDB1 and CUL4 associated factor 15	1.0000	22
TEPSIN	TEPSIN adaptor related protein complex 4 accessory protein	1.0000	22
HSPA4L	Heat shock protein family A (Hsp70) member 4 like	1.0000	22

HES2

Lineage enriched (Granulocytes)

3 nearest neighbours based on single cell RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
N/A

ZNF658

Lineage enriched (Granulocytes)

3 nearest neighbours based on single cell RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
CNN2	Calponin 2	1.0000	21
WBP2	WW domain binding protein 2	1.0000	21
TUBA4A	Tubulin alpha 4a	0.9762	21

HES4

Lineage enriched (Granulocytes)

3 nearest neighbours based on single cell RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
GADD45A	Growth arrest and DNA damage inducible alpha	1.0000	19
PPP1R1B	Protein phosphatase 1 regulatory inhibitor subunit 1B	1.0000	19
F12	Coagulation factor XII	1.0000	19

ZBTB42

Lineage enriched (Granulocytes)

3 nearest neighbours based on single cell RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
DCAF15	DDB1 and CUL4 associated factor 15	1.0000	22
TEPSIN	TEPSIN adaptor related protein complex 4 accessory protein	1.0000	22
HSPA4L	Heat shock protein family A (Hsp70) member 4 like	1.0000	22

ZSCAN31

Lineage enriched (Granulocytes)

3 nearest neighbours based on single cell RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
ZNF292	Zinc finger protein 292	0.9524	24
ZC3H6	Zinc finger CCCH-type containing 6	0.9286	24
TARS3	Threonyl-tRNA synthetase 3	0.9286	24

RFX2

Lineage enriched (Granulocytes)

3 nearest neighbours based on single cell RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
LRRC75A	Leucine rich repeat containing 75A	1.0000	21
ARHGEF40	Rho guanine nucleotide exchange factor 40	0.9762	21
SLC22A4	Solute carrier family 22 member 4	0.9762	21

GRHL1

Lineage enriched (Granulocytes)

3 nearest neighbours based on single cell RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
N/A

HES1

Lineage enriched (Granulocytes)

3 nearest neighbours based on single cell RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
MOB3C	MOB kinase activator 3C	1.0000	45
ZDHHC13	Zinc finger DHHC-type palmitoyltransferase 13	1.0000	45
SART1	Spliceosome associated factor 1, recruiter of U4/U6.U5 tri-snRNP	1.0000	45

CREB5

Lineage enriched (Granulocytes)

3 nearest neighbours based on single cell RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
GPX3	Glutathione peroxidase 3	1.0000	21
EYS	Eyes shut homolog	1.0000	21
FCAR	Fc alpha receptor	1.0000	21

HES6

Lineage enriched (Granulocytes)

3 nearest neighbours based on single cell RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
CHKA	Choline kinase alpha	1.0000	45
NBPF1	NBPF member 1	1.0000	45
GTF2E2	General transcription factor IIE subunit 2	1.0000	45

HIF1A

Lineage enriched (Granulocytes)

3 nearest neighbours based on single cell RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
MT-ND1	Mitochondrially encoded NADH:ubiquinone oxidoreductase core subunit 1	0.9762	21
ZNF396	Zinc finger protein 396	0.9762	21
ZNF646	Zinc finger protein 646	0.9762	21

NR6A1

Lineage enriched (Granulocytes)

3 nearest neighbours based on single cell RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
ENSG00000285938	BCL6 antisense 1	1.0000	21
NBPF26	NBPF member 26	1.0000	21
PPP1R12B	Protein phosphatase 1 regulatory subunit 12B	1.0000	21

PROX2

Lineage enriched (Granulocytes)

3 nearest neighbours based on single cell RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
MARK2	Microtubule affinity regulating kinase 2	0.9762	21
TBKBP1	TBK1 binding protein 1	0.9762	21
ZNF33A	Zinc finger protein 33A	0.9762	21

BCL3

Lineage enriched (Granulocytes)

3 nearest neighbours based on single cell RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
ENSG00000284956	Novel protein	1.0000	21
SEMA4D	Semaphorin 4D	1.0000	21
COL18A1	Collagen type XVIII alpha 1 chain	1.0000	21

FOS

Lineage enriched (Granulocytes)

3 nearest neighbours based on single cell RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
RAB3D	RAB3D, member RAS oncogene family	1.0000	21
SDCBP	Syndecan binding protein	1.0000	21
PRRG4	Proline rich and Gla domain 4	0.9762	21

GLI1

Lineage enriched (Granulocytes)

3 nearest neighbours based on single cell RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
SETX	Senataxin	1.0000	35
ENSG00000289051	Novel protein	0.9762	35
UEVLD	UEV and lactate/malate dehyrogenase domains	0.9762	35

NFE2

Lineage enriched (Granulocytes)

3 nearest neighbours based on single cell RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
TOX4	TOX high mobility group box family member 4	1.0000	41
RSRP1	Arginine and serine rich protein 1	1.0000	41
EMILIN2	Elastin microfibril interfacer 2	0.9762	41

SHOX

Lineage enriched (Granulocytes)

3 nearest neighbours based on single cell RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
PRDM2	PR/SET domain 2	0.9762	22
RNPC3	RNA binding region (RNP1, RRM) containing 3	0.9524	21
NUPR1	Nuclear protein 1, transcriptional regulator	0.9524	21

ZNF516

Lineage enriched (Granulocytes)

3 nearest neighbours based on single cell RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
UBL5	Ubiquitin like 5	0.9762	36
LRCH4	Leucine rich repeats and calponin homology domain containing 4	0.9524	21
MYL6	Myosin light chain 6	0.9524	36

ZNF552

Lineage enriched (Granulocytes)

3 nearest neighbours based on single cell RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
H2BC4	H2B clustered histone 4	1.0000	35
KATNBL1	Katanin regulatory subunit B1 like 1	1.0000	35
SLC25A37	Solute carrier family 25 member 37	1.0000	35

ZNF713

Lineage enriched (Granulocytes)

3 nearest neighbours based on single cell RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
CR1	Complement C3b/C4b receptor 1 (Knops blood group)	1.0000	20
ATP6V0D2	ATPase H+ transporting V0 subunit d2	1.0000	20
NMNAT3	Nicotinamide nucleotide adenylyltransferase 3	0.9762	20

ZNF746

Lineage enriched (Granulocytes)

3 nearest neighbours based on single cell RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
TMEM167B	Transmembrane protein 167B	1.0000	35
SELL	Selectin L	1.0000	35
HAL	Histidine ammonia-lyase	1.0000	35

HEY1

Lineage enriched (Granulocytes)

3 nearest neighbours based on single cell RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
LILRA2	Leukocyte immunoglobulin like receptor A2	1.0000	37
MAPRE3	Microtubule associated protein RP/EB family member 3	1.0000	37
TLR1	Toll like receptor 1	1.0000	37

HLX

Lineage enriched (Granulocytes)

3 nearest neighbours based on single cell RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
ZFC3H1	Zinc finger C3H1-type containing	1.0000	35
GAB2	GRB2 associated binding protein 2	0.9762	35
PLEKHM1	Pleckstrin homology and RUN domain containing M1	0.9762	35

ID1

Lineage enriched (Granulocytes)

3 nearest neighbours based on single cell RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
HNRNPC	Heterogeneous nuclear ribonucleoprotein C	0.9762	21
FABP2	Fatty acid binding protein 2	0.9524	35
PRR33	Proline rich 33	0.9524	35

NR5A2

Lineage enriched (Granulocytes)

3 nearest neighbours based on single cell RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
N/A

RUNX1

Lineage enriched (Granulocytes)

3 nearest neighbours based on single cell RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
ZBTB48	Zinc finger and BTB domain containing 48	1.0000	22
PIGM	Phosphatidylinositol glycan anchor biosynthesis class M	1.0000	22
CD63	CD63 molecule	1.0000	22

SPI1

Lineage enriched (Granulocytes)

3 nearest neighbours based on single cell RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
GADD45A	Growth arrest and DNA damage inducible alpha	1.0000	19
PPP1R1B	Protein phosphatase 1 regulatory inhibitor subunit 1B	1.0000	19
F12	Coagulation factor XII	1.0000	19

TFDP1

Lineage enriched (Granulocytes)

3 nearest neighbours based on single cell RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
ZNF610	Zinc finger protein 610	1.0000	5
THAP3	THAP domain containing 3	0.9762	5
ZNF273	Zinc finger protein 273	0.9762	5

ZFP57

Lineage enriched (Granulocytes)

3 nearest neighbours based on single cell RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
N/A

ZNF396

Lineage enriched (Granulocytes)

3 nearest neighbours based on single cell RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
H4C8	H4 clustered histone 8	1.0000	21
HIF1A	Hypoxia inducible factor 1 subunit alpha	0.9762	21
TMOD2	Tropomodulin 2	0.9762	21

ZNF467

Lineage enriched (Granulocytes)

3 nearest neighbours based on single cell RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
GPR141	G protein-coupled receptor 141	1.0000	38
FOLR3	Folate receptor gamma	0.9762	21
DCTN4	Dynactin subunit 4	0.9762	21

ZNF565

Lineage enriched (Granulocytes)

3 nearest neighbours based on single cell RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
PIGBOS1	PIGB opposite strand 1	1.0000	42
SSH3	Slingshot protein phosphatase 3	1.0000	42
RRAGA	Ras related GTP binding A	1.0000	42

ZNF597

Lineage enriched (Granulocytes)

3 nearest neighbours based on single cell RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
C11orf98	Chromosome 11 open reading frame 98	1.0000	36
RCHY1	Ring finger and CHY zinc finger domain containing 1	1.0000	36
SSU72	SSU72 homolog, RNA polymerase II CTD phosphatase	1.0000	36

ELK4

Lineage enriched (Granulocytes)

3 nearest neighbours based on single cell RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
SRRD	SRR1 domain containing	1.0000	24
MAP3K4	Mitogen-activated protein kinase kinase kinase 4	1.0000	24
ZNF525	Zinc finger protein 525	0.9762	24

MAF

Lineage enriched (Granulocytes)

3 nearest neighbours based on single cell RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
SRPK1	SRSF protein kinase 1	1.0000	42
BRPF3	Bromodomain and PHD finger containing 3	1.0000	42
RHBDD2	Rhomboid domain containing 2	1.0000	42

MAFG

Lineage enriched (Granulocytes)

3 nearest neighbours based on single cell RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
ENSG00000267740	Novel protein	0.9762	10
HSD17B4	Hydroxysteroid 17-beta dehydrogenase 4	0.9762	10
ADPGK	ADP dependent glucokinase	0.9762	10

SMAD5

Lineage enriched (Granulocytes)

3 nearest neighbours based on single cell RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
ZNF808	Zinc finger protein 808	1.0000	32
ZSCAN21	Zinc finger and SCAN domain containing 21	1.0000	32
TEC	Tec protein tyrosine kinase	1.0000	32

TCF23

Lineage enriched (Granulocytes)

3 nearest neighbours based on single cell RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
ANKRD49	Ankyrin repeat domain 49	1.0000	20
NKX3-1	NK3 homeobox 1	1.0000	20
FBXW7	F-box and WD repeat domain containing 7	0.9762	20

ZNF440

Lineage enriched (Granulocytes)

3 nearest neighbours based on single cell RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
RASSF1	Ras association domain family member 1	1.0000	32
AP3M1	Adaptor related protein complex 3 subunit mu 1	1.0000	32
MEX3C	Mex-3 RNA binding family member C	1.0000	32

ZNF66

Lineage enriched (Granulocytes)

3 nearest neighbours based on single cell RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
ZNF8	Zinc finger protein 8	0.9762	20
CCL22	C-C motif chemokine ligand 22	0.9762	20
CAPN15	Calpain 15	0.9762	20

Enriched transcription factors

Gene

Expression

Expression clustering

CEBPA

Group enriched (Dendritic cells, Granulocytes, Monocytes)

3 nearest neighbours based on single cell RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
DRAM1	DNA damage regulated autophagy modulator 1	1.0000	40
SPA17	Sperm autoantigenic protein 17	0.9762	10
SEZ6L	Seizure related 6 homolog like	0.9762	40

THRB

Group enriched (B-cells, Granulocytes)

3 nearest neighbours based on single cell RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
ACIN1	Apoptotic chromatin condensation inducer 1	0.9762	20
CDK12	Cyclin dependent kinase 12	0.9762	20
KIAA1958	KIAA1958	0.9762	20

CEBPB

Group enriched (Granulocytes, Monocytes)

3 nearest neighbours based on single cell RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
NPHP3-ACAD11	NPHP3-ACAD11 readthrough (NMD candidate)	1.0000	45
SMARCC2	SWI/SNF related, matrix associated, actin dependent regulator of chromatin subfamily c member 2	1.0000	45
LPCAT2	Lysophosphatidylcholine acyltransferase 2	1.0000	45

VDR

Group enriched (Dendritic cells, Granulocytes, Monocytes)

3 nearest neighbours based on single cell RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
STX12	Syntaxin 12	1.0000	40
RYR1	Ryanodine receptor 1	1.0000	40
PRR16	Proline rich 16	1.0000	40

ZNF687

Group enriched (Granulocytes, Monocytes)

3 nearest neighbours based on single cell RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
ARHGEF2	Rho/Rac guanine nucleotide exchange factor 2	1.0000	7
TMLHE	Trimethyllysine hydroxylase, epsilon	0.9762	7
CDC123	Cell division cycle 123	0.9762	7

BCL6

Group enriched (Granulocytes, Monocytes)

3 nearest neighbours based on single cell RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
IL1B	Interleukin 1 beta	1.0000	28
H2BC15	H2B clustered histone 15	1.0000	28
MX2	MX dynamin like GTPase 2	1.0000	28

EGR1

Group enriched (Granulocytes, Monocytes)

3 nearest neighbours based on single cell RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
STAT6	Signal transducer and activator of transcription 6	1.0000	38
SBF2	SET binding factor 2	1.0000	38
HMGCR	3-hydroxy-3-methylglutaryl-CoA reductase	0.9762	38

ETS2

Group enriched (Dendritic cells, Granulocytes, Monocytes)

3 nearest neighbours based on single cell RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
MTF1	Metal regulatory transcription factor 1	1.0000	38
FTH1	Ferritin heavy chain 1	1.0000	38
NPTN	Neuroplastin	1.0000	38

VENTX

Group enriched (Dendritic cells, Granulocytes, Monocytes)

3 nearest neighbours based on single cell RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
MARCO	Macrophage receptor with collagenous structure	1.0000	40
TCN2	Transcobalamin 2	1.0000	40
TMEM255B	Transmembrane protein 255B	1.0000	40

BATF2

Group enriched (Granulocytes, Monocytes)

3 nearest neighbours based on single cell RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
CERT1	Ceramide transporter 1	1.0000	37
GPCPD1	Glycerophosphocholine phosphodiesterase 1	1.0000	37
MFN2	Mitofusin 2	1.0000	37

HOXA9

Group enriched (Dendritic cells, Granulocytes, Nk-cells)

3 nearest neighbours based on single cell RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
POLR3G	RNA polymerase III subunit G	1.0000	32
ZNF559-ZNF177	ZNF559-ZNF177 readthrough	1.0000	32
TAPBP	TAP binding protein	1.0000	32

MAFF

Group enriched (Granulocytes, Nk-cells)

3 nearest neighbours based on single cell RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
STK26	Serine/threonine kinase 26	1.0000	32
LNPEP	Leucyl and cystinyl aminopeptidase	0.9762	32
SAMD9	Sterile alpha motif domain containing 9	0.9762	32

MITF

Group enriched (Dendritic cells, Granulocytes, Monocytes)

3 nearest neighbours based on single cell RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
GPR162	G protein-coupled receptor 162	0.9762	38
RNF130	Ring finger protein 130	0.9762	38
RPN1	Ribophorin I	0.9762	38

ZNF521

Group enriched (Dendritic cells, Granulocytes)

3 nearest neighbours based on single cell RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
PLAC8	Placenta associated 8	0.9762	8
ENSG00000286264	Novel protein	0.9762	8
KLRF2	Killer cell lectin like receptor F2	0.9762	8

ZNF710

Group enriched (Dendritic cells, Granulocytes, Monocytes)

3 nearest neighbours based on single cell RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
CMTM6	CKLF like MARVEL transmembrane domain containing 6	0.9762	37
GNGT2	G protein subunit gamma transducin 2	0.9762	37
CALM2	Calmodulin 2	0.9762	37

CEBPD

Group enriched (Granulocytes, Monocytes)

3 nearest neighbours based on single cell RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
ENSG00000285938	BCL6 antisense 1	1.0000	21
NBPF26	NBPF member 26	1.0000	21
PPP1R12B	Protein phosphatase 1 regulatory subunit 12B	1.0000	21

HOXA10

Group enriched (Granulocytes, Nk-cells)

3 nearest neighbours based on single cell RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
TNFSF11	TNF superfamily member 11	0.9762	15
XCL1	X-C motif chemokine ligand 1	0.9762	15
PRDM16	PR/SET domain 16	0.9762	15

IKZF2

Group enriched (Granulocytes, Nk-cells, T-cells)

3 nearest neighbours based on single cell RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
TMEM87A	Transmembrane protein 87A	1.0000	5
WDR44	WD repeat domain 44	0.9762	5
RPA1	Replication protein A1	0.9762	5

JDP2

Group enriched (B-cells, Granulocytes, Monocytes)

3 nearest neighbours based on single cell RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
CALHM6	Calcium homeostasis modulator family member 6	1.0000	40
MTSS1	MTSS I-BAR domain containing 1	1.0000	40
RASL11A	RAS like family 11 member A	1.0000	40

JUNB

Group enriched (Granulocytes, Monocytes)

3 nearest neighbours based on single cell RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
LILRA2	Leukocyte immunoglobulin like receptor A2	1.0000	37
MAPRE3	Microtubule associated protein RP/EB family member 3	1.0000	37
TLR1	Toll like receptor 1	1.0000	37

MYB

Group enriched (Dendritic cells, Granulocytes)

3 nearest neighbours based on single cell RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
C11orf58	Chromosome 11 open reading frame 58	1.0000	41
STMP1	Short transmembrane mitochondrial protein 1	1.0000	41
MFAP3L	Microfibril associated protein 3 like	1.0000	41

NANOG

Group enriched (Dendritic cells, Granulocytes)

3 nearest neighbours based on single cell RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
PAPLN	Papilin, proteoglycan like sulfated glycoprotein	0.9762	2
BRD3	Bromodomain containing 3	0.9762	2
ENKD1	Enkurin domain containing 1	0.9524	2

NFKBIZ

Group enriched (Granulocytes, Monocytes)

3 nearest neighbours based on single cell RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
PECAM1	Platelet and endothelial cell adhesion molecule 1	1.0000	37
MCTP1	Multiple C2 and transmembrane domain containing 1	1.0000	37
PILRA	Paired immunoglobin like type 2 receptor alpha	1.0000	37

PPARA

Group enriched (Dendritic cells, Granulocytes)

3 nearest neighbours based on single cell RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
ORAI3	ORAI calcium release-activated calcium modulator 3	1.0000	22
EIF5	Eukaryotic translation initiation factor 5	1.0000	22
FZR1	Fizzy and cell division cycle 20 related 1	1.0000	22

PRDM1

Group enriched (Granulocytes, T-cells)

3 nearest neighbours based on single cell RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
BTN3A2	Butyrophilin subfamily 3 member A2	1.0000	1
RASA3	RAS p21 protein activator 3	0.9762	1
NFYB	Nuclear transcription factor Y subunit beta	0.9762	1

RXRA

Group enriched (Granulocytes, Monocytes)

3 nearest neighbours based on single cell RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
STX11	Syntaxin 11	1.0000	37
SERPINA2	Serpin family A member 2 (gene/pseudogene)	1.0000	37
PLEKHO2	Pleckstrin homology domain containing O2	1.0000	37

SMAD1

Group enriched (Granulocytes, Monocytes)

3 nearest neighbours based on single cell RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
ISG20L2	Interferon stimulated exonuclease gene 20 like 2	1.0000	42
ZSWIM8	Zinc finger SWIM-type containing 8	1.0000	42
VPS39	VPS39 subunit of HOPS complex	1.0000	42

SOX4

Group enriched (Dendritic cells, Granulocytes, Monocytes)

3 nearest neighbours based on single cell RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
RC3H2	Ring finger and CCCH-type domains 2	1.0000	10
ATAT1	Alpha tubulin acetyltransferase 1	1.0000	10
RFT1	RFT1 homolog	1.0000	10

TOX

Group enriched (Granulocytes, Nk-cells, T-cells)

3 nearest neighbours based on single cell RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
DSCC1	DNA replication and sister chromatid cohesion 1	1.0000	16
TMEM244	Transmembrane protein 244	1.0000	16
RGPD2	RANBP2 like and GRIP domain containing 2	1.0000	16

TSC22D1

Group enriched (Dendritic cells, Granulocytes, Nk-cells)

3 nearest neighbours based on single cell RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
WIPF2	WAS/WASL interacting protein family member 2	1.0000	41
RMND5A	Required for meiotic nuclear division 5 homolog A	1.0000	41
PPIP5K2	Diphosphoinositol pentakisphosphate kinase 2	1.0000	41

ZNF726

Group enriched (Granulocytes, Nk-cells)

3 nearest neighbours based on single cell RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
ASNS	Asparagine synthetase (glutamine-hydrolyzing)	0.9762	43
ARHGEF35	Rho guanine nucleotide exchange factor 35	0.9762	43
TRBJ2-3	T cell receptor beta joining 2-3	0.9762	43

BACH1

Group enriched (Granulocytes, Monocytes)

3 nearest neighbours based on single cell RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
GGT1	Gamma-glutamyltransferase 1	1.0000	28
ACSL4	Acyl-CoA synthetase long chain family member 4	0.9762	28
RAB7A	RAB7A, member RAS oncogene family	0.9762	28

ETV7

Group enriched (Granulocytes, Monocytes, T-cells)

3 nearest neighbours based on single cell RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
TNFRSF9	TNF receptor superfamily member 9	0.9762	33
GPR19	G protein-coupled receptor 19	0.9762	33
TAB2	TGF-beta activated kinase 1 (MAP3K7) binding protein 2	0.9524	33

LYL1

Group enriched (B-cells, Granulocytes, Monocytes)

3 nearest neighbours based on single cell RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
SLC29A1	Solute carrier family 29 member 1 (Augustine blood group)	1.0000	45
NBPF1	NBPF member 1	1.0000	45
GTF2E2	General transcription factor IIE subunit 2	1.0000	45

TFE3

Group enriched (Granulocytes, Monocytes)

3 nearest neighbours based on single cell RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
SLC31A2	Solute carrier family 31 member 2	1.0000	37
SERPINA2	Serpin family A member 2 (gene/pseudogene)	1.0000	37
PLEKHO2	Pleckstrin homology domain containing O2	1.0000	37

ZXDC

Group enriched (Dendritic cells, Granulocytes, Monocytes)

3 nearest neighbours based on single cell RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
BICD2	BICD cargo adaptor 2	0.9762	7
TMLHE	Trimethyllysine hydroxylase, epsilon	0.9524	7
LIMK1	LIM domain kinase 1	0.9524	7

Enriched transcription factors

Gene

Expression

Expression clustering

HIC1

Lineage enhanced (Granulocytes)

3 nearest neighbours based on single cell RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
MOB3C	MOB kinase activator 3C	1.0000	45
ZDHHC13	Zinc finger DHHC-type palmitoyltransferase 13	1.0000	45
SART1	Spliceosome associated factor 1, recruiter of U4/U6.U5 tri-snRNP	1.0000	45

HOXA6

Lineage enhanced (Granulocytes)

3 nearest neighbours based on single cell RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
N/A

POU5F1B

Lineage enhanced (Granulocytes)

3 nearest neighbours based on single cell RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
ZNF638	Zinc finger protein 638	1.0000	46
ITGB8	Integrin subunit beta 8	1.0000	46
CABP5	Calcium binding protein 5	1.0000	46