Transcription factor landscape - Single cell type - Endocrine cells

The human body has a slow and a fast type of systemic signaling system: the endocrine and the nervous system, respectively. The endocrine system communicates through the production and secretion of messenger biomolecules, called hormones, using the cardiovascular system. The cells in charge of the production and secretion of hormones are called endocrine cells and are distributed in many parts of the body in the form of major endocrine organs, such as the adrenal gland and thyroid gland, or organ-associated cells distributed throughout the human body, in for example the brain and the digestive system. Hormones regulate numerous functions of the body, including digestion, reproduction, and fight-and-flight response.

Transcriptome analysis shows that 67% (n=13603) of all human proteins (n=20162) are detected in endocrine cells and 2399 of these genes show an elevated expression in any endocrine cells compared to other cell type groups. Learn more about genes wih elevated expression here. In-depth analysis of transcription factor genes expressed in endocrine cells highlights 36 transcription factors with elevated expression in endocrine cells compared to other cell types. In total, 2 transcription factors are classified as enriched in endocrine cells.

Here we provide the expression overview of all transcription factors that show enriched expression levels in endocrine cells compared to other cell types. The gene expression overview, across different cell types is accopanied by the top 3 nearest neighbours based on single cell RNA expression and correlation in the clustering analysis.

Enriched transcription factors

Gene

Expression

Expression clustering

LHX5

Cell type enriched (Neuroendocrine cells)

3 nearest neighbours based on single cell RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
CHGA	Chromogranin A	0.6491	96
KRTAP5-11	Keratin associated protein 5-11	0.6155	109
MLN	Motilin	0.6145	96

PHOX2B

Cell type enriched (Adrenal medulla cells)

3 nearest neighbours based on single cell RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
DBH	Dopamine beta-hydroxylase	0.9585	18
PHOX2A	Paired like homeobox 2A	0.9358	18
DRGX	Dorsal root ganglia homeobox	0.5761	109

TBX19

Cell type enriched (Corticotrophs)

3 nearest neighbours based on single cell RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
POMC	Proopiomelanocortin	0.7468	59
FSHB	Follicle stimulating hormone subunit beta	0.6474	59
LHB	Luteinizing hormone subunit beta	0.6417	59

DRGX

Cell type enriched (Adrenal medulla cells)

3 nearest neighbours based on single cell RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
PHOX2B	Paired like homeobox 2B	0.5761	18
DBH	Dopamine beta-hydroxylase	0.5723	18
PVALB	Parvalbumin	0.5693	109

PHOX2A

Cell type enriched (Adrenal medulla cells)

3 nearest neighbours based on single cell RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
PHOX2B	Paired like homeobox 2B	0.9358	18
DBH	Dopamine beta-hydroxylase	0.8992	18
DRGX	Dorsal root ganglia homeobox	0.5660	109

TBXT

Cell type enriched (Somatotrophs)

3 nearest neighbours based on single cell RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
GH1	Growth hormone 1	0.7384	59
GHRHR	Growth hormone releasing hormone receptor	0.7240	59
PRL	Prolactin	0.7013	59

FEV

Cell type enriched (Neuroendocrine cells)

3 nearest neighbours based on single cell RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
TPH1	Tryptophan hydroxylase 1	0.9932	96
SLC18A1	Solute carrier family 18 member A1	0.9929	96
RXFP4	Relaxin family peptide/INSL5 receptor 4	0.9852	96

MKX

Cell type enriched (Gonadotrophs)

3 nearest neighbours based on single cell RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
TGFBR3L	Transforming growth factor beta receptor 3 like	0.6712	59
FSHB	Follicle stimulating hormone subunit beta	0.6670	59
LHB	Luteinizing hormone subunit beta	0.6635	59

Enriched transcription factors

Gene

Expression

Expression clustering

POU1F1

Group enriched (Lactotrophs, Somatotrophs, Thyrotrophs)

3 nearest neighbours based on single cell RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
PRL	Prolactin	0.9843	59
IRS4	Insulin receptor substrate 4	0.9819	59
GH1	Growth hormone 1	0.9728	59

NEUROD2

Group enriched (Brain excitatory neurons, Neuroendocrine cells)

3 nearest neighbours based on single cell RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
STXBP5L	Syntaxin binding protein 5L	0.8107	35
AKAIN1	A-kinase anchor inhibitor 1	0.7811	2
FGF5	Fibroblast growth factor 5	0.7399	46

NEUROD1

Group enriched (Neuroendocrine cells, Rod photoreceptor cells)

3 nearest neighbours based on single cell RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
TPH1	Tryptophan hydroxylase 1	0.9605	96
SLC18A1	Solute carrier family 18 member A1	0.9584	96
FEV	FEV transcription factor, ETS family member	0.9554	96

DLX1

Group enriched (Adrenal medulla cells, Brain inhibitory neurons, Conjunctival goblet cells, Megakaryocytes, Other brain neurons, Schwann cells, Tuft cells)

3 nearest neighbours based on single cell RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
CORT	Cortistatin	0.8302	109
GPR83	G protein-coupled receptor 83	0.8177	109
SP9	Sp9 transcription factor	0.7977	109

LMX1A

Group enriched (Choroid plexus epithelial cells, Corticotrophs, Neuroendocrine cells)

3 nearest neighbours based on single cell RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
TPH1	Tryptophan hydroxylase 1	0.7691	96
SLC18A1	Solute carrier family 18 member A1	0.7685	96
LCN15	Lipocalin 15	0.7641	96

NKX2-2

Group enriched (Bergmann glia, Neuroendocrine cells, Oligodendrocyte progenitor cells, Oligodendrocytes, Pancreatic islet cells, Somatotrophs)

3 nearest neighbours based on single cell RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
RFX6	Regulatory factor X6	0.8103	96
CRYBA2	Crystallin beta A2	0.8100	96
PCSK1N	Proprotein convertase subtilisin/kexin type 1 inhibitor	0.8080	96

LHX9

Group enriched (Leydig cells, Peritubular myoid cells, Retinal amacrine cells)

3 nearest neighbours based on single cell RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
PROK1	Prokineticin 1	0.8500	94
PRPS2	Phosphoribosyl pyrophosphate synthetase 2	0.8227	94
INSL3	Insulin like 3	0.8223	94

RFX6

Group enriched (Adrenal medulla cells, Neuroendocrine cells, Pancreatic islet cells)

3 nearest neighbours based on single cell RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
CRYBA2	Crystallin beta A2	0.9367	96
PCSK1N	Proprotein convertase subtilisin/kexin type 1 inhibitor	0.9002	96
GPR119	G protein-coupled receptor 119	0.8878	76

GLI1

Group enriched (Bergmann glia, Leydig cells, Peritubular myoid cells)

3 nearest neighbours based on single cell RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
INSL3	Insulin like 3	0.8184	94
PTGDS	Prostaglandin D2 synthase	0.7884	94
PRPS2	Phosphoribosyl pyrophosphate synthetase 2	0.7714	94

HOXB9

Group enriched (Endometrial secretory cells, Epididymal basal cells, Epididymal clear cells, Epididymal efferent duct absorptive cells, Epididymal efferent duct ciliated cells, Epididymal principal cells, Neuroendocrine cells, Tuft cells)

3 nearest neighbours based on single cell RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
HOXB8	Homeobox B8	0.7121	30
HOXD1	Homeobox D1	0.6226	54
TAS1R3	Taste 1 receptor member 3	0.5850	30

PAX4

Group enriched (Late spermatids, Neuroendocrine cells)

3 nearest neighbours based on single cell RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
FEV	FEV transcription factor, ETS family member	0.9060	96
SLC18A1	Solute carrier family 18 member A1	0.9012	96
RXFP4	Relaxin family peptide/INSL5 receptor 4	0.9000	96

Enriched transcription factors

Gene

Expression

Expression clustering

ISX

Cell type enhanced (Colonocytes, Enteric stem cells, Enteric transient amplifying cells, Enterocytes, Goblet cells, Neuroendocrine cells, Paneth cells, Podocytes, Tuft cells)

3 nearest neighbours based on single cell RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
CDX2	Caudal type homeobox 2	0.8827	54
CDX1	Caudal type homeobox 1	0.8787	54
NOX1	NADPH oxidase 1	0.7665	54

LEF1

Cell type enhanced (Adrenal cortex cells, Choroid plexus epithelial cells, Endometrial stromal cells, Ependymal cells, Melanocytes, Pituicytes/FSCs, Renal collecting duct intercalated cells, T-cells, Thymocytes, Vascular endothelial cells)

3 nearest neighbours based on single cell RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
TNFSF8	TNF superfamily member 8	0.6846	9
TCF7	Transcription factor 7	0.6687	9
ERFL	ETS repressor factor like	0.6619	9

FOXA3

Cell type enhanced (Colonocytes, Enteric stem cells, Enteric transient amplifying cells, Foveolar cells, Gastric chief cells, Gastric progenitor cells, Goblet cells, Hepatocytes, Mucous neck cells, Neuroendocrine cells, Pancreatic acinar cells, Paneth cells, Tuft cells)

3 nearest neighbours based on single cell RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
REP15	RAB15 effector protein	0.9062	70
BEST2	Bestrophin 2	0.8960	70
TFF3	Trefoil factor 3	0.8914	70

CDX1

Cell type enhanced (Colonocytes, Enteric stem cells, Enteric transient amplifying cells, Enterocytes, Goblet cells, Neuroendocrine cells, Paneth cells, Tuft cells)

3 nearest neighbours based on single cell RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
ISX	Intestine specific homeobox	0.8787	54
NOX1	NADPH oxidase 1	0.8582	54
CDX2	Caudal type homeobox 2	0.8529	54

UNCX

Cell type enhanced (Brain excitatory neurons, Brain inhibitory neurons, Loop of henle epithelial cells, Other brain neurons, Retinal horizontal cells, Somatotrophs, Thyrotrophs)

3 nearest neighbours based on single cell RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
BARHL1	BarH like homeobox 1	0.8791	2
FGF3	Fibroblast growth factor 3	0.8160	2
CBLN3	Cerebellin 3 precursor	0.7841	2

NEUROG3

Cell type enhanced (Neuroendocrine cells)

3 nearest neighbours based on single cell RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
FOXD4L3	Forkhead box D4 like 3	0.7328	35
PCDH20	Protocadherin 20	0.6871	35
OR2V1	Olfactory receptor family 2 subfamily V member 1	0.6709	35

HOXB13

Cell type enhanced (Basal prostatic cells, Colonocytes, Enteric stem cells, Enteric transient amplifying cells, Goblet cells, Neuroendocrine cells, Prostatic club cells, Prostatic glandular cells)

3 nearest neighbours based on single cell RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
PRAC1	PRAC1 small nuclear protein	0.8156	54
HOXD13	Homeobox D13	0.7899	54
CDX2	Caudal type homeobox 2	0.7083	54

NEUROD4

Cell type enhanced (Gonadotrophs, Lactotrophs, Retinal bipolar cells, Somatotrophs, Thyrotrophs)

3 nearest neighbours based on single cell RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
LACTBL1	Lactamase beta like 1	0.9507	86
GABRR3	Gamma-aminobutyric acid type A receptor subunit rho3	0.9128	86
KCNG4	Potassium voltage-gated channel modifier subfamily G member 4	0.9104	86

ETV3L

Cell type enhanced (Breast secretory cells, cDC, Gastric progenitor cells, Gonadotrophs, Kupffer cells, Macrophages, monocytes, pDCs, Prostatic club cells, Prostatic hillock cells, Thymocytes)

3 nearest neighbours based on single cell RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
GPR183	G protein-coupled receptor 183	0.8053	40
INSIG1	Insulin induced gene 1	0.8034	82
CXCL3	C-X-C motif chemokine ligand 3	0.7995	40

CDX2

Cell type enhanced (Colonocytes, Enteric stem cells, Enteric transient amplifying cells, Enterocytes, Goblet cells, Neuroendocrine cells, Paneth cells, Tuft cells)

3 nearest neighbours based on single cell RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
ISX	Intestine specific homeobox	0.8827	54
NXPE1	Neurexophilin and PC-esterase domain family member 1	0.8576	54
CDX1	Caudal type homeobox 1	0.8529	54

HOXD13

Cell type enhanced (Basal prostatic cells, Colonocytes, Enteric stem cells, Enteric transient amplifying cells, Goblet cells, Neuroendocrine cells, Prostatic club cells, Prostatic glandular cells, Prostatic hillock cells)

3 nearest neighbours based on single cell RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
PRAC1	PRAC1 small nuclear protein	0.9156	54
B3GNT7	UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 7	0.8325	54
NXPE1	Neurexophilin and PC-esterase domain family member 1	0.8264	54

NR0B1

Cell type enhanced (Adrenal cortex cells, Adrenal medulla cells, Corticotrophs, Epididymal efferent duct ciliated cells, Gonadotrophs, Oligodendrocyte progenitor cells, Pancreatic islet cells, Sertoli cells)

3 nearest neighbours based on single cell RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
CYP11B1	Cytochrome P450 family 11 subfamily B member 1	0.7690	18
MC2R	Melanocortin 2 receptor	0.7635	18
CYP17A1	Cytochrome P450 family 17 subfamily A member 1	0.7599	18

PAX6

Cell type enhanced (Astrocytes, Bergmann glia, Lacrimal acinar cells, Müller glia, Ocular epithelial cells, Pancreatic islet cells, Retinal amacrine cells, Retinal ganglion cells, Retinal horizontal cells)

3 nearest neighbours based on single cell RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
KRTAP4-5	Keratin associated protein 4-5	0.6784	100
MGARP	Mitochondria localized glutamic acid rich protein	0.6521	100
CLU	Clusterin	0.6505	100

HNF4G

Cell type enhanced (Cholangiocytes, Colonocytes, Enteric stem cells, Enteric transient amplifying cells, Enterocytes, Foveolar cells, Goblet cells, Neuroendocrine cells, Pancreatic acinar cells, Paneth cells, Proximal tubule cells, Tuft cells)

3 nearest neighbours based on single cell RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
MALRD1	MAM and LDL receptor class A domain containing 1	0.8404	1
TM4SF5	Transmembrane 4 L six family member 5	0.7487	1
CCL15	C-C motif chemokine ligand 15	0.7312	1

MLXIPL

Cell type enhanced (Adipocytes, Adrenal cortex cells, Cholangiocytes, Enterocytes, Epididymal principal cells, Hepatocytes, Microglia, Myonuclei, Neuroendocrine cells, Paneth cells, Proximal tubule cells, Sertoli cells)

3 nearest neighbours based on single cell RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
PC	Pyruvate carboxylase	0.6878	89
GPAM	Glycerol-3-phosphate acyltransferase, mitochondrial	0.6641	89
AQP7B	Aquaporin 7B	0.6489	89

ZNF541

Cell type enhanced (Adrenal cortex cells, Differentiating spermatogonia, Early primary spermatocytes, Early spermatids, Epididymal efferent duct absorptive cells, Late primary spermatocytes, Late spermatids, Retinal amacrine cells, Undifferentiated spermatogonia)

3 nearest neighbours based on single cell RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
SYCP1	Synaptonemal complex protein 1	0.8560	3
FTHL17	Ferritin heavy chain like 17	0.8482	3
DMRTC2	DMRT like family C2	0.8452	3

MAFA

Cell type enhanced (Endometrial secretory cells, Myonuclei, Neuroendocrine cells, Pancreatic islet cells, Thymic myoid cells)

3 nearest neighbours based on single cell RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
KCNK16	Potassium two pore domain channel subfamily K member 16	0.7806	76
GCG	Glucagon	0.7787	76
IAPP	Islet amyloid polypeptide	0.7739	76

NKX6-1

Cell type enhanced (Ependymal cells, Fibroblasts, Late primary spermatocytes, Pancreatic duct cells, Pancreatic islet cells)

3 nearest neighbours based on single cell RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
IAPP	Islet amyloid polypeptide	0.7554	76
KCNK16	Potassium two pore domain channel subfamily K member 16	0.7377	76
INS	Insulin	0.7217	76

NPAS4

Cell type enhanced (Gonadotrophs, Lactotrophs, Other brain neurons, Pancreatic islet cells, Retinal amacrine cells, Retinal ganglion cells, Retinal horizontal cells, Smooth muscle cells, Thyrotrophs)

3 nearest neighbours based on single cell RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
UNC13A	Unc-13 homolog A	0.8223	59
GCK	Glucokinase	0.6377	76
GPR148	G protein-coupled receptor 148	0.6192	109

ARX

Cell type enhanced (Brain inhibitory neurons, Ependymal cells, Leydig cells, Myonuclei, Neuroendocrine cells, Oocytes, Ovarian stromal cells, Pancreatic islet cells, Peritubular myoid cells, Respiratory ciliated cells)

3 nearest neighbours based on single cell RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
PROK1	Prokineticin 1	0.7335	94
WFIKKN2	WAP, follistatin/kazal, immunoglobulin, kunitz and netrin domain containing 2	0.7108	94
PRPS2	Phosphoribosyl pyrophosphate synthetase 2	0.6745	94

EGR4

Cell type enhanced (Breast secretory cells, Endometrial glandular cells, Endometrial secretory cells, Epididymal basal cells, Granulosa cells, Neuroendocrine cells, Pancreatic islet cells, Undifferentiated spermatogonia)

3 nearest neighbours based on single cell RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
PYY	Peptide YY	0.6032	96
INSL5	Insulin like 5	0.5984	96
GLYATL3	Glycine-N-acyltransferase like 3	0.5828	96

PDX1

Cell type enhanced (Cholangiocytes, Foveolar cells, Gastric chief cells, Gastric progenitor cells, Neuroendocrine cells, Pancreatic acinar cells, Pancreatic duct cells, Pancreatic islet cells)

3 nearest neighbours based on single cell RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
SST	Somatostatin	0.9388	76
KCNK16	Potassium two pore domain channel subfamily K member 16	0.9358	76
GCG	Glucagon	0.9358	76

RFX4

Cell type enhanced (Astrocytes, Bergmann glia, Early primary spermatocytes, Ependymal cells, Late primary spermatocytes, Pituitary stem cells, Somatotrophs)

3 nearest neighbours based on single cell RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
SERPINA3	Serpin family A member 3	0.8352	28
GFAP	Glial fibrillary acidic protein	0.8241	28
GTF2A1L	General transcription factor IIA subunit 1 like	0.8105	28

RORB

Cell type enhanced (Astrocytes, Cone photoreceptor cells, Corticotrophs, Decidual stromal cells, Endometrial stromal cells, Müller glia, Retinal amacrine cells, Retinal horizontal cells, Retinal pigment epithelial cells, Rod photoreceptor cells)

3 nearest neighbours based on single cell RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
HOXA11	Homeobox A11	0.7047	108
HOXD11	Homeobox D11	0.6595	108
GDF7	Growth differentiation factor 7	0.6170	108

SATB2

Cell type enhanced (Brain excitatory neurons, Choroid plexus epithelial cells, Colonocytes, Enteric stem cells, Enteric transient amplifying cells, Ependymal cells, Goblet cells, Neuroendocrine cells, Tuft cells)

3 nearest neighbours based on single cell RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
SLC6A7	Solute carrier family 6 member 7	0.7195	2
PRAC1	PRAC1 small nuclear protein	0.6918	54
HOXD13	Homeobox D13	0.6804	54

SIX6

Cell type enhanced (Cone photoreceptor cells, Lactotrophs, Müller glia, Pituicytes/FSCs, Pituitary stem cells, Retinal horizontal cells, Thyrotrophs)

3 nearest neighbours based on single cell RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
RAX	Retina and anterior neural fold homeobox	0.9285	11
CRABP1	Cellular retinoic acid binding protein 1	0.9086	11
NPVF	Neuropeptide VF precursor	0.8959	11

TCF23

Cell type enhanced (Breast lactating cells, Cardiomyocytes, Leydig cells, Ocular epithelial cells, Ovarian stromal cells, Pericytes, Peritubular myoid cells, Smooth muscle cells)

3 nearest neighbours based on single cell RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
TCEAL1	Transcription elongation factor A like 1	0.8345	94
PROK1	Prokineticin 1	0.8289	94
TCEAL4	Transcription elongation factor A like 4	0.8023	94

TOX

Cell type enhanced (Alveolar cells type 2, Bergmann glia, Gonadotrophs, Innate lymphoid cells, Neuroendocrine cells, NK-cells, Oligodendrocyte progenitor cells, Renal collecting duct principal cells, Renal connecting tubule cells, Sertoli cells, T-cells, Thymocytes)

3 nearest neighbours based on single cell RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
TMSB15B	Thymosin beta 15B	0.5508	76
TOX2	TOX high mobility group box family member 2	0.4968	92
CCR9	C-C motif chemokine receptor 9	0.4909	9

DMRTC1

Cell type enhanced (Brain excitatory neurons, Brain inhibitory neurons, Cone photoreceptor cells, Early primary spermatocytes, Gonadotrophs, Lactotrophs, Oligodendrocyte progenitor cells, Other brain neurons, Rod photoreceptor cells, Sertoli cells, Somatotrophs, Thyrotrophs)

3 nearest neighbours based on single cell RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
DZIP3	DAZ interacting zinc finger protein 3	0.5695	34
GAGE10	G antigen 10	0.5580	59
PRDM7	PR/SET domain 7	0.5563	3

HNF4A

Cell type enhanced (Colonocytes, Enteric stem cells, Enteric transient amplifying cells, Enterocytes, Foveolar cells, Gastric progenitor cells, Goblet cells, Hepatocytes, Neuroendocrine cells, Paneth cells, Proximal tubule cells, Tuft cells)

3 nearest neighbours based on single cell RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
NOX1	NADPH oxidase 1	0.7919	54
CDX1	Caudal type homeobox 1	0.7662	54
ISX	Intestine specific homeobox	0.7441	54

MNX1

Cell type enhanced (Colonocytes, Corticotrophs, Enteric stem cells, Enteric transient amplifying cells, Goblet cells, Neuroendocrine cells, Pancreatic duct cells, Pancreatic islet cells, Paneth cells, Tuft cells)

3 nearest neighbours based on single cell RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
GPR119	G protein-coupled receptor 119	0.7747	76
PDX1	Pancreatic and duodenal homeobox 1	0.7604	76
RFX6	Regulatory factor X6	0.7498	96

NR5A1

Cell type enhanced (Adrenal cortex cells, Adrenal medulla cells, Gonadotrophs, Granulosa cells, Leydig cells, Lymphatic endothelial cells, Ovarian stromal cells, Peritubular myoid cells, Platelets, Sertoli cells)

3 nearest neighbours based on single cell RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
MC2R	Melanocortin 2 receptor	0.8118	18
CYP17A1	Cytochrome P450 family 17 subfamily A member 1	0.8084	18
HSD3B2	Hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 2	0.7955	18

PGR

Cell type enhanced (Breast hormone-responsive cells, Cardiomyocytes, Decidual stromal cells, Endometrial ciliated cells, Endometrial stromal cells, Epididymal efferent duct absorptive cells, Fallopian secretory cells, Fallopian tube ciliated cells, Gonadotrophs, Smooth muscle cells)

3 nearest neighbours based on single cell RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
SFRP4	Secreted frizzled related protein 4	0.7538	108
ESR1	Estrogen receptor 1	0.7126	52
HOXA11	Homeobox A11	0.7077	108

PROX1

Cell type enhanced (Cardiomyocytes, Corticotrophs, Hepatocytes, Lymphatic endothelial cells, Myosatellite cells, Pancreatic duct cells, Respiratory ionocytes, Retinal bipolar cells, Retinal horizontal cells, Tuft cells)

3 nearest neighbours based on single cell RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
MMRN1	Multimerin 1	0.6190	32
CCL21	C-C motif chemokine ligand 21	0.5994	32
GJC2	Gap junction protein gamma 2	0.5596	32

TAL2

Cell type enhanced (B-cells, Differentiating spermatogonia, Distal convoluted tubule cells, Müller glia, Myonuclei, Other brain neurons, Somatotrophs)

3 nearest neighbours based on single cell RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
TNFRSF13C	TNF receptor superfamily member 13C	0.5154	87
QRSL1	Glutaminyl-tRNA amidotransferase subunit QRSL1	0.5068	87
BEND4	BEN domain containing 4	0.5063	87

ALX4

Cell type enhanced (Cardiomyocytes, Choroid plexus epithelial cells, Ependymal cells, Epicardial cells, Fibro-adipogenic progenitors, Fibroblasts, Leydig cells, Myosatellite cells, Vascular smooth muscle cells)

3 nearest neighbours based on single cell RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
TNN	Tenascin N	0.7508	108
APOD	Apolipoprotein D	0.6151	108
RTL3	Retrotransposon Gag like 3	0.5979	108

ASCL1

Cell type enhanced (Bergmann glia, Corticotrophs, Medullary thymic epithelial cells, Neuroendocrine cells, Oligodendrocyte progenitor cells, Pancreatic islet cells)

3 nearest neighbours based on single cell RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
CHGB	Chromogranin B	0.7201	76
NKX2-2	NK2 homeobox 2	0.7050	96
RAB3B	RAB3B, member RAS oncogene family	0.6665	76

BNC2

Cell type enhanced (Adipocytes, Epicardial cells, Fibro-adipogenic progenitors, Leydig cells, Mast cells, Melanocytes, Mesothelial cells, Microglia, Myonuclei, Ovarian stromal cells, Peritubular myoid cells, Pituitary stem cells, Proximal tubule cells)

3 nearest neighbours based on single cell RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
EVC2	EvC ciliary complex subunit 2	0.5419	108
PWWP3B	PWWP domain containing 3B	0.5232	94
MMP23B	Matrix metallopeptidase 23B	0.5165	94

CRAMP1

Cell type enhanced (Lactotrophs, Somatotrophs, Thyrotrophs)

3 nearest neighbours based on single cell RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
ZNF841	Zinc finger protein 841	0.4465	17
MSANTD2	Myb/SANT DNA binding domain containing 2	0.4389	50
TBCD	Tubulin folding cofactor D	0.4262	12

CREBL2

Cell type enhanced (Adrenal cortex cells, Kupffer cells)

3 nearest neighbours based on single cell RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
CSF1R	Colony stimulating factor 1 receptor	0.6093	72
C1QA	Complement C1q A chain	0.5909	74
GPR34	G protein-coupled receptor 34	0.5598	72

CSRNP3

Cell type enhanced (Brain excitatory neurons, Brain inhibitory neurons, Choroid plexus epithelial cells, Cone photoreceptor cells, Corticotrophs, Lacrimal acinar cells, Lactotrophs, Oligodendrocyte progenitor cells, Other brain neurons, Retinal pigment epithelial cells, Somatotrophs, Thyrotrophs)

3 nearest neighbours based on single cell RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
NBEA	Neurobeachin	0.5359	35
PLPPR5	Phospholipid phosphatase related 5	0.5316	35
SLC4A10	Solute carrier family 4 member 10	0.5291	101

DLX2

Cell type enhanced (Adrenal medulla cells, Brain inhibitory neurons, Breast hormone-responsive cells, Breast secretory cells, Conjunctival goblet cells, Early spermatids, Innate lymphoid cells, Melanocytes, Other brain neurons, Schwann cells, Tuft cells)

3 nearest neighbours based on single cell RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
DLX1	Distal-less homeobox 1	0.5987	109
UBE2S	Ubiquitin conjugating enzyme E2 S	0.5809	20
CER1	Cerberus 1, DAN family BMP antagonist	0.5638	109

DMBX1

Cell type enhanced (Brain inhibitory neurons, Corticotrophs, Differentiating spermatogonia, Early primary spermatocytes, Epicardial cells, Gastric progenitor cells, Oocytes, Retinal bipolar cells, Retinal ganglion cells, Undifferentiated spermatogonia, Urothelial cells)

3 nearest neighbours based on single cell RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
KCNG4	Potassium voltage-gated channel modifier subfamily G member 4	0.7078	86
CFC1B	Cripto, FRL-1, cryptic family 1B	0.6744	86
GSG1L2	GSG1 like 2	0.6670	86

DMRTA2

Cell type enhanced (Conjunctival goblet cells, Gonadotrophs, Late primary spermatocytes, Ocular epithelial cells, Pituitary stem cells, Respiratory basal cells, Respiratory deuterosomal cells, Respiratory ionocytes, Respiratory secretory cells, Submucosal glandular cells)

3 nearest neighbours based on single cell RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
GJB4	Gap junction protein beta 4	0.8405	100
ERICH5	Glutamate rich 5	0.8340	100
APOBEC3A	Apolipoprotein B mRNA editing enzyme catalytic subunit 3A	0.7970	100

DMRTC1B

Cell type enhanced (Adrenal medulla cells, Brain excitatory neurons, Brain inhibitory neurons, Choroid plexus epithelial cells, Gonadotrophs, Lactotrophs, Other brain neurons, Pituitary stem cells, Retinal amacrine cells, Somatotrophs, Thyrotrophs)

3 nearest neighbours based on single cell RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
SGSM1	Small G protein signaling modulator 1	0.7255	59
ZNF667	Zinc finger protein 667	0.6736	59
DGKK	Diacylglycerol kinase kappa	0.6632	59

DNMT3A

Cell type enhanced (Gonadotrophs, Myonuclei, Rod photoreceptor cells)

3 nearest neighbours based on single cell RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
GTF2IRD1	GTF2I repeat domain containing 1	0.5190	36
KANTR	KANTR integral membrane protein	0.4560	36
TOGARAM1	TOG array regulator of axonemal microtubules 1	0.4450	7

EBF1

Cell type enhanced (Adipocytes, B-cells, Fibro-adipogenic progenitors, Fibroblasts, Leydig cells, Pericytes, Peritubular myoid cells, Pituitary stem cells, Retinal ganglion cells, Vascular smooth muscle cells)

3 nearest neighbours based on single cell RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
LHCGR	Luteinizing hormone/choriogonadotropin receptor	0.6692	89
ADAMTS12	ADAM metallopeptidase with thrombospondin type 1 motif 12	0.6660	89
ADIPOQ	Adiponectin, C1Q and collagen domain containing	0.6399	89

EBF4

Cell type enhanced (Basal prostatic cells, Endometrial stromal cells, Oligodendrocyte progenitor cells, Somatotrophs)

3 nearest neighbours based on single cell RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
TSHZ3	Teashirt zinc finger homeobox 3	0.4996	108
GPR173	G protein-coupled receptor 173	0.4509	59
FOXL2	Forkhead box L2	0.4501	94

EGR3

Cell type enhanced (Breast secretory cells, Endometrial glandular cells, Endometrial luminal cells, Endometrial secretory cells, Epididymal basal cells, Epididymal efferent duct absorptive cells, Fallopian secretory cells, Mast cells, Neuroendocrine cells, Neutrophils, Salivary myoepithelial cells)

3 nearest neighbours based on single cell RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
BTBD19	BTB domain containing 19	0.7399	31
RILPL2	Rab interacting lysosomal protein like 2	0.7154	31
AQP9	Aquaporin 9	0.7146	31

ESR1

Cell type enhanced (Adipocytes, Breast hormone-responsive cells, Endometrial ciliated cells, Endometrial glandular cells, Endometrial luminal cells, Endometrial stromal cells, Epicardial cells, Epididymal efferent duct absorptive cells, Fallopian secretory cells, Gonadotrophs, Hepatocytes, Lactotrophs, Retinal horizontal cells)

3 nearest neighbours based on single cell RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
PGR	Progesterone receptor	0.7126	108
URGCP-MRPS24	URGCP-MRPS24 readthrough	0.6723	52
HOXA11	Homeobox A11	0.6063	108

ESR2

Cell type enhanced (Adrenal cortex cells, Cardiomyocytes, Epicardial cells, Myonuclei, Rod photoreceptor cells)

3 nearest neighbours based on single cell RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
ERAP1	Endoplasmic reticulum aminopeptidase 1	0.4965	83
CFAP298-TCP10L	CFAP298-TCP10L readthrough	0.4667	83
ZNF76	Zinc finger protein 76	0.4524	83

ETV1

Cell type enhanced (Adrenal cortex cells, Alveolar cells type 2, Bergmann glia, Brain excitatory neurons, Corticotrophs, Neuroendocrine cells, Oligodendrocyte progenitor cells, Salivary acinar cells)

3 nearest neighbours based on single cell RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
GRM4	Glutamate metabotropic receptor 4	0.6374	2
CBLN3	Cerebellin 3 precursor	0.6152	2
FGF3	Fibroblast growth factor 3	0.6083	2

FIZ1

Cell type enhanced (Adrenal medulla cells)

3 nearest neighbours based on single cell RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
RBM7	RNA binding motif protein 7	0.5670	60
LRRC10	Leucine rich repeat containing 10	0.5196	60
DLAT	Dihydrolipoamide S-acetyltransferase	0.5079	89

FOSL2

Cell type enhanced (Adrenal cortex cells, Esophageal apical cells, monocytes, Neutrophils)

3 nearest neighbours based on single cell RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
MAP3K8	Mitogen-activated protein kinase kinase kinase 8	0.6258	40
RBKS	Ribokinase	0.5617	103
ARL5B	ADP ribosylation factor like GTPase 5B	0.5483	31

FOXA1

Cell type enhanced (Breast hormone-responsive cells, Gastric chief cells, Mucous neck cells, Neuroendocrine cells, Parietal cells, Prostatic club cells, Prostatic glandular cells, Prostatic hillock cells, Respiratory basal cells, Respiratory ciliated cells, Respiratory deuterosomal cells, Respiratory secretory cells, Urothelial cells)

3 nearest neighbours based on single cell RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
TTC6	Tetratricopeptide repeat domain 6	0.6758	16
GRHL2	Grainyhead like transcription factor 2	0.6208	16
SORD	Sorbitol dehydrogenase	0.6159	16

FOXA2

Cell type enhanced (Alveolar cells type 1, Alveolar cells type 2, Cholangiocytes, Endometrial glandular cells, Fallopian tube ciliated cells, Foveolar cells, Gastric chief cells, Goblet cells, Hepatocytes, Mucous neck cells, Neuroendocrine cells, Pancreatic acinar cells, Pancreatic duct cells, Pancreatic islet cells, Paneth cells, Parietal cells, Transitional alveolar cells)

3 nearest neighbours based on single cell RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
TM4SF4	Transmembrane 4 L six family member 4	0.5614	76
LRRC31	Leucine rich repeat containing 31	0.5490	70
NR0B2	Nuclear receptor subfamily 0 group B member 2	0.5453	93

FOXD2

Cell type enhanced (Colonocytes, Enteric stem cells, Enteric transient amplifying cells, Goblet cells, Neuroendocrine cells, Podocytes, Respiratory deuterosomal cells, Tuft cells)

3 nearest neighbours based on single cell RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
ISX	Intestine specific homeobox	0.6817	54
CDX1	Caudal type homeobox 1	0.6529	54
HNF4A	Hepatocyte nuclear factor 4 alpha	0.6207	54

FOXK1

Cell type enhanced (Lactotrophs, Somatotrophs)

3 nearest neighbours based on single cell RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
FAM163A	Family with sequence similarity 163 member A	0.6009	59
CHST8	Carbohydrate sulfotransferase 8	0.5833	59
POU1F1	POU class 1 homeobox 1	0.5800	59

FOXL2

Cell type enhanced (Decidual stromal cells, Endometrial stromal cells, Gonadotrophs, Granulosa cells, Ovarian stromal cells, Smooth muscle cells, Thyrotrophs)

3 nearest neighbours based on single cell RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
FOXL2NB	FOXL2 neighbor	0.9540	94
RBP1	Retinol binding protein 1	0.8196	94
PWWP3B	PWWP domain containing 3B	0.7816	94

FOXO1

Cell type enhanced (Adipocytes, Decidual stromal cells, Endometrial stromal cells, Renal collecting duct intercalated cells, Somatotrophs, Thymic myoid cells)

3 nearest neighbours based on single cell RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
CALCRL	Calcitonin receptor like receptor	0.4911	12
WWTR1	WW domain containing transcription regulator 1	0.4693	12
TGFBR2	Transforming growth factor beta receptor 2	0.4663	12

GATA4

Cell type enhanced (Cardiomyocytes, Foveolar cells, Gastric chief cells, Gastric progenitor cells, Granulosa cells, Hepatic stellate cells, Late spermatids, Leydig cells, Mucous neck cells, Ovarian stromal cells, Pancreatic acinar cells, Paneth cells, Parietal cells, Peritubular myoid cells, Sertoli cells)

3 nearest neighbours based on single cell RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
ACSM3	Acyl-CoA synthetase medium chain family member 3	0.6721	94
NUDT10	Nudix hydrolase 10	0.6132	94
CLEC4M	C-type lectin domain family 4 member M	0.6033	32

GATA6

Cell type enhanced (Adrenal cortex cells, Alveolar cells type 2, Cardiomyocytes, Foveolar cells, Gastric chief cells, Hepatic stellate cells, Mesothelial cells, Mucous neck cells, Ovarian stromal cells, Pancreatic duct cells, Parietal cells)

3 nearest neighbours based on single cell RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
STAR	Steroidogenic acute regulatory protein	0.6218	18
AMHR2	Anti-Mullerian hormone receptor type 2	0.5801	18
CYP17A1	Cytochrome P450 family 17 subfamily A member 1	0.5302	18

GLI2

Cell type enhanced (Astrocytes, Bergmann glia, Early spermatids, Ependymal cells, Epicardial cells, Fibro-adipogenic progenitors, Hepatic stellate cells, Lactotrophs, Late spermatids, Leydig cells, Mesothelial cells, Myosatellite cells, Ovarian stromal cells, Peritubular myoid cells, Somatotrophs, Thyrotrophs)

3 nearest neighbours based on single cell RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
PTCH1	Patched 1	0.6155	94
GPR173	G protein-coupled receptor 173	0.5995	59
SYTL4	Synaptotagmin like 4	0.5746	59

HAND2

Cell type enhanced (Adrenal medulla cells, Decidual stromal cells, Endometrial stromal cells, Epicardial cells, Hepatic stellate cells, Ovarian stromal cells, Schwann cells, Smooth muscle cells)

3 nearest neighbours based on single cell RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
CPXM1	Carboxypeptidase X, M14 family member 1	0.8269	108
HOXA11	Homeobox A11	0.7749	108
FOXL2	Forkhead box L2	0.7524	94

HES6

Cell type enhanced (Fallopian tube ciliated cells, Goblet cells, Late primary spermatocytes, Oocytes, Paneth cells, Respiratory deuterosomal cells, Respiratory ionocytes, Somatotrophs)

3 nearest neighbours based on single cell RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
AGR2	Anterior gradient 2, protein disulphide isomerase family member	0.5467	70
RETNLB	Resistin like beta	0.5444	70
HEPACAM2	HEPACAM family member 2	0.5279	70

HEYL

Cell type enhanced (Adrenal medulla cells, Granulosa cells, Hepatic stellate cells, Leydig cells, Myosatellite cells, Pancreatic acinar cells, Pericytes, Peritubular myoid cells, Rod photoreceptor cells, Sertoli cells, Vascular smooth muscle cells)

3 nearest neighbours based on single cell RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
FOXS1	Forkhead box S1	0.8213	110
NOTCH3	Notch receptor 3	0.7584	110
RGS5	Regulator of G protein signaling 5	0.7396	110

HIC1

Cell type enhanced (Decidual stromal cells, Endometrial stromal cells, Epicardial cells, Fibro-adipogenic progenitors, Fibroblasts, Hepatic stellate cells, Innate lymphoid cells, Leydig cells, Lymphatic endothelial cells, Ovarian stromal cells, Pericytes, Peritubular myoid cells, Vascular endothelial cells)

3 nearest neighbours based on single cell RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
GGT5	Gamma-glutamyltransferase 5	0.7414	110
NID1	Nidogen 1	0.6681	108
CYGB	Cytoglobin	0.6203	110

HIF3A

Cell type enhanced (Astrocytes, Bergmann glia, Cardiomyocytes, Hematopoietic stem cells, Leydig cells, Lymphatic endothelial cells, Medullary thymic epithelial cells, Müller glia, Oligodendrocyte progenitor cells, Peritubular myoid cells, Vascular endothelial cells)

3 nearest neighbours based on single cell RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
THSD1	Thrombospondin type 1 domain containing 1	0.5957	32
SPTBN1	Spectrin beta, non-erythrocytic 1	0.5644	32
SEMA3D	Semaphorin 3D	0.5344	32

HIVEP3

Cell type enhanced (Corticotrophs, Lactotrophs, Microglia, Retinal amacrine cells, Retinal horizontal cells, Thymocytes, Thyrotrophs)

3 nearest neighbours based on single cell RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
NCK1	NCK adaptor protein 1	0.4250	7
RNF165	Ring finger protein 165	0.4157	109
JAKMIP2	Janus kinase and microtubule interacting protein 2	0.4133	59

HLF

Cell type enhanced (Distal convoluted tubule cells, Hematopoietic stem cells, Hepatocytes, Müller glia, Renal connecting tubule cells, Retinal amacrine cells, Retinal bipolar cells, Retinal horizontal cells, Thyrotrophs)

3 nearest neighbours based on single cell RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
GPR85	G protein-coupled receptor 85	0.5799	104
CT45A9	Cancer/testis antigen family 45 member A9	0.5580	104
ABCG2	ATP binding cassette subfamily G member 2 (Junior blood group)	0.5412	104

HMBOX1

Cell type enhanced (Adrenal cortex cells, Pituicytes/FSCs, Renal collecting duct intercalated cells)

3 nearest neighbours based on single cell RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
CALCRL	Calcitonin receptor like receptor	0.8915	12
TEK	TEK receptor tyrosine kinase	0.8504	12
WWTR1	WW domain containing transcription regulator 1	0.7994	12

HOXA5

Cell type enhanced (Adrenal cortex cells, Basal prostatic cells, Breast lactating cells, Breast myoepithelial cells, Epididymal efferent duct absorptive cells, Epididymal principal cells, Fibroblasts, Hematopoietic stem cells, Innate lymphoid cells, Prostatic club cells, Smooth muscle cells, Thymic myoid cells)

3 nearest neighbours based on single cell RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
HOXA6	Homeobox A6	0.5834	108
HOXA4	Homeobox A4	0.5386	108
HIC1	HIC ZBTB transcriptional repressor 1	0.4707	110

HOXA9

Cell type enhanced (Basal prostatic cells, Enteric stem cells, Epididymal principal cells, Goblet cells, Hematopoietic stem cells, Innate lymphoid cells, Megakaryocyte-Erythroid progenitors, Neuroendocrine cells, Podocytes, Prostatic club cells, Prostatic hillock cells, Renal connecting tubule cells, Thymocytes)

3 nearest neighbours based on single cell RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
HOXA6	Homeobox A6	0.6619	108
HOXA10	Homeobox A10	0.5650	108
HOXA7	Homeobox A7	0.4997	15

HOXC8

Cell type enhanced (Breast myoepithelial cells, Differentiating spermatogonia, Epididymal efferent duct absorptive cells, Epididymal efferent duct ciliated cells, Fibroblasts, Leydig cells, pDCs, Pericytes, Smooth muscle cells, Thymic myoid cells)

3 nearest neighbours based on single cell RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
HOXC6	Homeobox C6	0.8718	62
HOXC10	Homeobox C10	0.6696	108
MRGPRF	MAS related GPR family member F	0.6501	62

HOXD10

Cell type enhanced (Basal prostatic cells, Colonocytes, Decidual stromal cells, Distal convoluted tubule cells, Endometrial stromal cells, Loop of henle epithelial cells, Lymphatic endothelial cells, Neuroendocrine cells, Papillary tip epithelial cells, Prostatic club cells, Prostatic hillock cells, Renal collecting duct principal cells, Renal connecting tubule cells)

3 nearest neighbours based on single cell RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
HOXD11	Homeobox D11	0.6974	108
HOXD9	Homeobox D9	0.5974	32
ARMCX5	Armadillo repeat containing X-linked 5	0.5448	105

HOXD11

Cell type enhanced (Basal prostatic cells, Decidual stromal cells, Endometrial stromal cells, Neuroendocrine cells, Papillary tip epithelial cells, Prostatic club cells, Prostatic glandular cells, Prostatic hillock cells, Renal collecting duct principal cells, Renal connecting tubule cells)

3 nearest neighbours based on single cell RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
HOXA11	Homeobox A11	0.9039	108
GDF7	Growth differentiation factor 7	0.8150	108
HOXA10	Homeobox A10	0.7946	108

HOXD12

Cell type enhanced (Colonocytes, Goblet cells, Neuroendocrine cells)

3 nearest neighbours based on single cell RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
INSL5	Insulin like 5	0.9116	96
RXFP4	Relaxin family peptide/INSL5 receptor 4	0.8858	96
PYY	Peptide YY	0.8816	96

HOXD3

Cell type enhanced (Adrenal medulla cells, Distal convoluted tubule cells, Epididymal efferent duct absorptive cells, Epididymal principal cells, Leydig cells, Loop of henle epithelial cells, Lymphatic endothelial cells, Papillary tip epithelial cells, Peritubular myoid cells, Renal collecting duct intercalated cells, Renal collecting duct principal cells, Renal connecting tubule cells, Vascular endothelial cells)

3 nearest neighbours based on single cell RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
HOXD9	Homeobox D9	0.7559	32
HOXD4	Homeobox D4	0.6860	32
HOXD8	Homeobox D8	0.6391	32

HOXD8

Cell type enhanced (Distal convoluted tubule cells, Early primary spermatocytes, Early spermatids, Epididymal efferent duct absorptive cells, Epididymal efferent duct ciliated cells, Epididymal principal cells, Fallopian tube ciliated cells, Late primary spermatocytes, Leydig cells, Lymphatic endothelial cells, Peritubular myoid cells, Renal connecting tubule cells, Vascular endothelial cells)

3 nearest neighbours based on single cell RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
HOXD9	Homeobox D9	0.8115	32
HOXD3	Homeobox D3	0.6391	32
CCL21	C-C motif chemokine ligand 21	0.5602	32

HOXD9

Cell type enhanced (Distal convoluted tubule cells, Epididymal principal cells, Leydig cells, Loop of henle epithelial cells, Lymphatic endothelial cells, Oocytes, Papillary tip epithelial cells, Peritubular myoid cells, Renal collecting duct principal cells, Renal connecting tubule cells, Vascular endothelial cells)

3 nearest neighbours based on single cell RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
HOXD8	Homeobox D8	0.8115	32
HOXD3	Homeobox D3	0.7559	32
AVPR2	Arginine vasopressin receptor 2	0.7087	32

HSF4

Cell type enhanced (Adrenal medulla cells, Astrocytes, Hofbauer cells, Leydig cells, Melanocytes, Myonuclei, Peritubular myoid cells, Retinal ganglion cells)

3 nearest neighbours based on single cell RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
PTCH2	Patched 2	0.5285	94
INSL3	Insulin like 3	0.5012	94
FBXO44	F-box protein 44	0.4807	109

INSM1

Cell type enhanced (Adrenal medulla cells, Corticotrophs, Lactotrophs, Neuroendocrine cells, Pancreatic islet cells, Thyrotrophs)

3 nearest neighbours based on single cell RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
UCN3	Urocortin 3	0.9759	96
FEV	FEV transcription factor, ETS family member	0.9759	96
TPH1	Tryptophan hydroxylase 1	0.9690	96

IRX2

Cell type enhanced (Alveolar cells type 1, Alveolar cells type 2, Basal keratinocytes, Breast hormone-responsive cells, Breast lactating cells, Breast myoepithelial cells, Gastric chief cells, Pancreatic islet cells, Parietal cells, Salivary basal cells, Transitional alveolar cells)

3 nearest neighbours based on single cell RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
IRX1	Iroquois homeobox 1	0.8083	4
PTHLH	Parathyroid hormone like hormone	0.7369	4
FASN	Fatty acid synthase	0.7100	4

ISL1

Cell type enhanced (Cytotrophoblasts, Medullary thymic epithelial cells, Neuroendocrine cells, Other brain neurons, Pancreatic islet cells, Retinal bipolar cells, Retinal ganglion cells, Retinal horizontal cells, Syncytiotrophoblasts, Thymic myoid cells)

3 nearest neighbours based on single cell RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
GRM6	Glutamate metabotropic receptor 6	0.8362	86
TRNP1	TMF1 regulated nuclear protein 1	0.8218	86
B4GALT6	Beta-1,4-galactosyltransferase 6	0.8201	86

ISL2

Cell type enhanced (Basal keratinocytes, Basal prostatic cells, Cone photoreceptor cells, Oocytes, Pituitary stem cells, Plasma cells, Prostatic club cells, Prostatic hillock cells, Salivary basal cells, Salivary myoepithelial cells, Thyrotrophs)

3 nearest neighbours based on single cell RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
IGHV4-28	Immunoglobulin heavy variable 4-28	0.5546	67
IGHV2-26	Immunoglobulin heavy variable 2-26	0.5507	67
IGLC7	Immunoglobulin lambda constant 7	0.5437	67

KDM5D

Cell type enhanced (Leydig cells, Myonuclei, Oligodendrocytes, Retinal bipolar cells)

3 nearest neighbours based on single cell RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
UTY	Ubiquitously transcribed tetratricopeptide repeat containing, Y-linked	0.5746	48
USP9Y	Ubiquitin specific peptidase 9 Y-linked	0.4139	101
PER3	Period circadian regulator 3	0.4052	86

KLF8

Cell type enhanced (Adipocytes, Esophageal apical cells, Esophageal suprabasal cells, Leydig cells, Peritubular myoid cells, Sertoli cells)

3 nearest neighbours based on single cell RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
MEOX2	Mesenchyme homeobox 2	0.6409	32
EBF3	EBF transcription factor 3	0.5722	32
EBF1	EBF transcription factor 1	0.5197	89

MAFB

Cell type enhanced (Breast lactating cells, Breast myoepithelial cells, Hofbauer cells, Kupffer cells, Macrophages, monocytes, Pancreatic islet cells)

3 nearest neighbours based on single cell RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
IL10	Interleukin 10	0.6893	40
CCR1	C-C motif chemokine receptor 1	0.6472	72
CD163	CD163 molecule	0.5882	72

MEIS1

Cell type enhanced (Adrenal cortex cells, Endometrial stromal cells, Hematopoietic stem cells, Lacrimal acinar cells, Megakaryocyte progenitors, Mesothelial cells, Rod photoreceptor cells, Salivary acinar cells)

3 nearest neighbours based on single cell RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
HOXD11	Homeobox D11	0.5426	108
DENND2B	DENN domain containing 2B	0.5350	79
CCN4	Cellular communication network factor 4	0.5002	105

MEIS2

Cell type enhanced (Adrenal cortex cells, Basal prostatic cells, Ependymal cells, Lacrimal acinar cells, Medullary thymic epithelial cells, Mesothelial cells, Pituitary stem cells, Prostatic club cells, Retinal amacrine cells, Salivary acinar cells, Salivary ionocytes, Somatotrophs)

3 nearest neighbours based on single cell RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
RARB	Retinoic acid receptor beta	0.6167	105
CHRM3	Cholinergic receptor muscarinic 3	0.5383	38
PBX1	PBX homeobox 1	0.4903	105

MEIS3

Cell type enhanced (Brain excitatory neurons, Early spermatids, Endometrial stromal cells, Late spermatids, Other brain neurons, Pancreatic islet cells, Retinal amacrine cells, Retinal horizontal cells, Smooth muscle cells)

3 nearest neighbours based on single cell RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
TRPC4	Transient receptor potential cation channel subfamily C member 4	0.5691	35
CLSTN2	Calsyntenin 2	0.5154	35
ENC1	Ectodermal-neural cortex 1	0.5109	35

MEOX2

Cell type enhanced (Fibro-adipogenic progenitors, Fibroblasts, Leydig cells, Mesothelial cells, Pericytes, Peritubular myoid cells, Vascular endothelial cells, Vascular smooth muscle cells)

3 nearest neighbours based on single cell RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
EBF3	EBF transcription factor 3	0.7884	32
STARD9	StAR related lipid transfer domain containing 9	0.7144	32
HMCN2	Hemicentin 2	0.6528	108

MSC

Cell type enhanced (Adipocytes, Fibroblasts, Hepatic stellate cells, Leydig cells, Melanocytes, Myosatellite cells, Pericytes, Peritubular myoid cells, Vascular smooth muscle cells)

3 nearest neighbours based on single cell RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
THPO	Thrombopoietin	0.6659	71
SMIM12	Small integral membrane protein 12	0.6607	71
DEFB124	Defensin beta 124	0.6469	71

MTA3

Cell type enhanced (Adrenal cortex cells)

3 nearest neighbours based on single cell RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
NBPF3	NBPF member 3	0.4301	18
COG1	Component of oligomeric golgi complex 1	0.4206	35
MOCOS	Molybdenum cofactor sulfurase	0.4109	18

MYT1L

Cell type enhanced (Adrenal medulla cells, Brain excitatory neurons, Brain inhibitory neurons, Early primary spermatocytes, Lactotrophs, Oligodendrocyte progenitor cells, Other brain neurons, Retinal amacrine cells, Retinal ganglion cells, Retinal horizontal cells, Somatotrophs, Thyrotrophs)

3 nearest neighbours based on single cell RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
GPR158	G protein-coupled receptor 158	0.8011	59
KSR2	Kinase suppressor of ras 2	0.7170	59
NRG1	Neuregulin 1	0.7132	59

NOBOX

Cell type enhanced (Loop of henle epithelial cells, Neuroendocrine cells)