Transcription factor landscape - Single cell type - Endocrine cells

The human body has a slow and a fast type of systemic signaling system: the endocrine and the nervous system, respectively. The endocrine system communicates through the production and secretion of messenger biomolecules, called hormones, using the cardiovascular system. The cells in charge of the production and secretion of hormones are called endocrine cells and are distributed in many parts of the body in the form of major endocrine organs, such as the adrenal gland and thyroid gland, or organ-associated cells distributed throughout the human body, in for example the brain and the digestive system. Hormones regulate numerous functions of the body, including digestion, reproduction, and fight-and-flight response.

Transcriptome analysis shows that 75% (n=15118) of all human proteins (n=20162) are detected in endocrine cells and 778 of these genes show an elevated expression in any endocrine cells compared to other cell type groups. Learn more about genes wih elevated expression here. In-depth analysis of transcription factor genes expressed in endocrine cells highlights 88 transcription factors with elevated expression in endocrine cells compared to other cell types. In total, 16 transcription factors are classified as enriched in endocrine cells.

Here we provide the expression overview of all transcription factors that show enriched expression levels in endocrine cells compared to other cell types. The gene expression overview, across different cell types is accopanied by the top 3 nearest neighbours based on single cell RNA expression and correlation in the clustering analysis.

Enriched transcription factors

Gene

Expression

Expression clustering

NEUROG3

Cell type enriched (Enteroendocrine cells)

3 nearest neighbours based on single cell RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
SLC18A1	Solute carrier family 18 member A1	0.9533	20
LCN15	Lipocalin 15	0.9525	20
CHGA	Chromogranin A	0.9517	20

FEV

Cell type enriched (Enteroendocrine cells)

3 nearest neighbours based on single cell RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
TPH1	Tryptophan hydroxylase 1	0.9993	20
SLC18A1	Solute carrier family 18 member A1	0.9978	20
UCN3	Urocortin 3	0.9975	20

INSM1

Cell type enriched (Enteroendocrine cells)

3 nearest neighbours based on single cell RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
FEV	FEV transcription factor, ETS family member	0.9954	20
TPH1	Tryptophan hydroxylase 1	0.9946	20
SLC18A1	Solute carrier family 18 member A1	0.9941	20

Enriched transcription factors

Gene

Expression

Expression clustering

ISX

Group enriched (Distal enterocytes, Enteroendocrine cells, Intestinal goblet cells, Paneth cells, Proximal enterocytes, Undifferentiated cells)

3 nearest neighbours based on single cell RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
CDH17	Cadherin 17	0.9448	5
CDX2	Caudal type homeobox 2	0.8984	16
EPCAM	Epithelial cell adhesion molecule	0.8312	5

CDX1

Group enriched (Distal enterocytes, Enteroendocrine cells, Intestinal goblet cells, Paneth cells, Proximal enterocytes, Undifferentiated cells)

3 nearest neighbours based on single cell RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
CDX2	Caudal type homeobox 2	0.8785	16
FOXD2	Forkhead box D2	0.8756	16
NOX1	NADPH oxidase 1	0.8616	16

CDX2

Group enriched (Distal enterocytes, Enteroendocrine cells, Intestinal goblet cells, Paneth cells, Proximal enterocytes, Undifferentiated cells)

3 nearest neighbours based on single cell RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
ISX	Intestine specific homeobox	0.8984	16
CDX1	Caudal type homeobox 1	0.8785	16
FOXD2	Forkhead box D2	0.8776	16

LMX1A

Group enriched (Early spermatids, Enteroendocrine cells, Late spermatids)

3 nearest neighbours based on single cell RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
BARHL1	BarH like homeobox 1	0.7392	11
KRTAP3-3	Keratin associated protein 3-3	0.7202	20
TPH1	Tryptophan hydroxylase 1	0.7071	20

ZNF80

Group enriched (NK-cells, Pancreatic endocrine cells, T-cells)

3 nearest neighbours based on single cell RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
CD7	CD7 molecule	0.9131	19
GZMA	Granzyme A	0.8653	19
KLRB1	Killer cell lectin like receptor B1	0.8641	19

NR5A1

Group enriched (Granulosa cells, Leydig cells, Ovarian stromal cells, Peritubular cells, Sertoli cells)

3 nearest neighbours based on single cell RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
STAR	Steroidogenic acute regulatory protein	0.9662	6
SIGLEC11	Sialic acid binding Ig like lectin 11	0.9504	6
PROK1	Prokineticin 1	0.9498	6

TCF23

Group enriched (Leydig cells, Ovarian stromal cells, Peritubular cells, Sertoli cells)

3 nearest neighbours based on single cell RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
NR5A1	Nuclear receptor subfamily 5 group A member 1	0.9472	6
STAR	Steroidogenic acute regulatory protein	0.9298	6
PROK1	Prokineticin 1	0.9292	6

RFX6

Group enriched (Enteroendocrine cells, Pancreatic endocrine cells)

3 nearest neighbours based on single cell RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
CRYBA2	Crystallin beta A2	0.9723	20
UCN3	Urocortin 3	0.9682	20
SLC18A1	Solute carrier family 18 member A1	0.9677	20

ASCL1

Group enriched (Astrocytes, Enteroendocrine cells, Oligodendrocyte precursor cells, Pancreatic endocrine cells)

3 nearest neighbours based on single cell RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
PTPRZ1	Protein tyrosine phosphatase receptor type Z1	0.7132	76
TNR	Tenascin R	0.6995	76
BCAN	Brevican	0.6897	76

FOXD2

Group enriched (Distal enterocytes, Enteroendocrine cells, Intestinal goblet cells, Paneth cells, Undifferentiated cells)

3 nearest neighbours based on single cell RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
NOX1	NADPH oxidase 1	0.9075	16
CDX2	Caudal type homeobox 2	0.8776	16
CDX1	Caudal type homeobox 1	0.8756	16

GLI1

Group enriched (Leydig cells, Peritubular cells, Sertoli cells)

3 nearest neighbours based on single cell RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
FOXL2	Forkhead box L2	0.7754	6
EMILIN3	Elastin microfibril interfacer 3	0.7702	9
WT1	WT1 transcription factor	0.7526	9

NKX2-6

Group enriched (Oocytes, Pancreatic endocrine cells)

3 nearest neighbours based on single cell RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
SSU72P3	SSU72 pseudogene 3	0.6760	36
PRY2	PTPN13 like Y-linked 2	0.6745	36
SSU72P8	SSU72 pseudogene 8	0.6575	36

PAX4

Group enriched (Enteroendocrine cells, Late spermatids)

3 nearest neighbours based on single cell RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
INSL5	Insulin like 5	0.7524	20
PYY	Peptide YY	0.7516	20
INSM1	INSM transcriptional repressor 1	0.7454	20

Enriched transcription factors

Gene

Expression

Expression clustering

NEUROD2

Cell type enhanced (Bipolar cells, Enteroendocrine cells, Erythroid cells, Excitatory neurons, Horizontal cells, Mucus glandular cells)

3 nearest neighbours based on single cell RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
NEUROD6	Neuronal differentiation 6	0.9752	10
STMN2	Stathmin 2	0.8879	10
SOX11	SRY-box transcription factor 11	0.8518	10

NEUROD1

Cell type enhanced (Bipolar cells, Cone photoreceptor cells, Enteroendocrine cells, Pancreatic endocrine cells, Rod photoreceptor cells)

3 nearest neighbours based on single cell RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
TPH1	Tryptophan hydroxylase 1	0.8924	20
CHGA	Chromogranin A	0.8901	20
SLC18A1	Solute carrier family 18 member A1	0.8887	20

HOXB13

Cell type enhanced (Distal enterocytes, Enteroendocrine cells, Intestinal goblet cells, Paneth cells, Prostatic glandular cells, Undifferentiated cells)

3 nearest neighbours based on single cell RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
HOXA13	Homeobox A13	0.8503	40
IHH	Indian hedgehog signaling molecule	0.7452	16
PRAC1	PRAC1 small nuclear protein	0.7428	16

GBX2

Cell type enhanced (Early spermatids, Late spermatids, Oocytes, Pancreatic endocrine cells)

3 nearest neighbours based on single cell RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
HSFY1	Heat shock transcription factor Y-linked 1	0.6726	13
PTK7	Protein tyrosine kinase 7 (inactive)	0.6697	21
NPIPB7	Nuclear pore complex interacting protein family member B7	0.6696	13

HOXD13

Cell type enhanced (Club cells, Distal enterocytes, Enteroendocrine cells, Intestinal goblet cells, Paneth cells, Undifferentiated cells)

3 nearest neighbours based on single cell RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
PRAC1	PRAC1 small nuclear protein	0.9562	16
HOXD12	Homeobox D12	0.8583	20
B3GNT7	UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 7	0.8390	16

HNF4G

Cell type enhanced (Astrocytes, Distal enterocytes, Enteroendocrine cells, Intestinal goblet cells, Oligodendrocyte precursor cells, Paneth cells, Proximal enterocytes, Undifferentiated cells)

3 nearest neighbours based on single cell RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
MS4A10	Membrane spanning 4-domains A10	0.8920	22
MEP1A	Meprin A subunit alpha	0.8846	22
SLC10A2	Solute carrier family 10 member 2	0.8827	22

MLXIPL

Cell type enhanced (Cholangiocytes, Enteroendocrine cells, Hepatocytes, Kupffer cells, Proximal enterocytes, Skeletal myocytes)

3 nearest neighbours based on single cell RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
MT1B	Metallothionein 1B	0.7354	62
APOB	Apolipoprotein B	0.7178	62
TM4SF5	Transmembrane 4 L six family member 5	0.7061	22

NR0B1

Cell type enhanced (Oligodendrocyte precursor cells, Ovarian stromal cells, Pancreatic endocrine cells, Sertoli cells)

3 nearest neighbours based on single cell RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
DIRAS3	DIRAS family GTPase 3	0.7302	6
NR5A1	Nuclear receptor subfamily 5 group A member 1	0.6973	6
PROK1	Prokineticin 1	0.6934	6

NKX2-2

Cell type enhanced (Astrocytes, Enteroendocrine cells, Oligodendrocyte precursor cells, Oligodendrocytes, Pancreatic endocrine cells)

3 nearest neighbours based on single cell RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
INSM1	INSM transcriptional repressor 1	0.8988	20
CRYBA2	Crystallin beta A2	0.8944	20
TPH1	Tryptophan hydroxylase 1	0.8924	20

ARX

Cell type enhanced (Enteroendocrine cells, Inhibitory neurons, Leydig cells, Ovarian stromal cells, Peritubular cells)

3 nearest neighbours based on single cell RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
IRS4	Insulin receptor substrate 4	0.7975	6
GREB1	Growth regulating estrogen receptor binding 1	0.7974	6
MCHR1	Melanin concentrating hormone receptor 1	0.7814	6

EGR4

Cell type enhanced (Enteroendocrine cells, Glandular and luminal cells, Granulosa cells, Spermatogonia)

3 nearest neighbours based on single cell RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
ARL5B	ADP ribosylation factor like GTPase 5B	0.6720	29
IER3	Immediate early response 3	0.6613	37
AVPR1B	Arginine vasopressin receptor 1B	0.6355	20

HOXD3

Cell type enhanced (Adipocytes, Basal prostatic cells, Collecting duct cells, Distal tubular cells, Early spermatids, Late spermatids, Leydig cells)

3 nearest neighbours based on single cell RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
HOXD4	Homeobox D4	0.8580	3
HOXD8	Homeobox D8	0.7342	54
HOXD9	Homeobox D9	0.7169	54

LHX9

Cell type enhanced (Horizontal cells, Leydig cells, Ovarian stromal cells, Peritubular cells)

3 nearest neighbours based on single cell RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
PROK1	Prokineticin 1	0.9436	6
NR5A1	Nuclear receptor subfamily 5 group A member 1	0.9117	6
TCF23	Transcription factor 23	0.8974	6

PDX1

Cell type enhanced (Cholangiocytes, Ductal cells, Enteroendocrine cells, Exocrine glandular cells, Gastric mucus-secreting cells, Pancreatic endocrine cells)

3 nearest neighbours based on single cell RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
CTRB2	Chymotrypsinogen B2	0.8397	45
REG1A	Regenerating family member 1 alpha	0.8353	45
CUZD1	CUB and zona pellucida like domains 1	0.8230	45

SATB2

Cell type enhanced (Distal enterocytes, Enteroendocrine cells, Excitatory neurons, Intestinal goblet cells, Paneth cells, Undifferentiated cells)

3 nearest neighbours based on single cell RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
SLC6A7	Solute carrier family 6 member 7	0.7455	34
KCNV1	Potassium voltage-gated channel modifier subfamily V member 1	0.7022	34
POU6F2	POU class 6 homeobox 2	0.6895	34

ZFP57

Cell type enhanced (Cardiomyocytes, Erythroid cells, Extravillous trophoblasts, Late spermatids, Pancreatic endocrine cells, Schwann cells, Spermatogonia)

3 nearest neighbours based on single cell RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
CLCN1	Chloride voltage-gated channel 1	0.5578	63
C4orf36	Chromosome 4 open reading frame 36	0.5211	63
P3R3URF	PIK3R3 upstream open reading frame	0.5198	63

HNF4A

Cell type enhanced (Distal enterocytes, Enteroendocrine cells, Hepatocytes, Intestinal goblet cells, Paneth cells, Proximal enterocytes, Proximal tubular cells, Undifferentiated cells)

3 nearest neighbours based on single cell RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
DECR2	2,4-dienoyl-CoA reductase 2	0.7162	56
GIPC2	GIPC PDZ domain containing family member 2	0.7085	56
AGMAT	Agmatinase	0.6818	56

LBX2

Cell type enhanced (granulocytes, Hepatocytes, Pancreatic endocrine cells, Proximal tubular cells, Sertoli cells)

3 nearest neighbours based on single cell RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
ABCC6	ATP binding cassette subfamily C member 6	0.6668	38
PRODH2	Proline dehydrogenase 2	0.6388	38
KL	Klotho	0.6377	38

MNX1

Cell type enhanced (Distal enterocytes, Ductal cells, Enteroendocrine cells, Intestinal goblet cells, Oocytes, Pancreatic endocrine cells, Proximal enterocytes, Undifferentiated cells)

3 nearest neighbours based on single cell RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
KLK1	Kallikrein 1	0.8563	60
REG3G	Regenerating family member 3 gamma	0.7348	60
OLFM4	Olfactomedin 4	0.7326	16

MYB

Cell type enhanced (Breast glandular cells, Ciliated cells, dendritic cells, Distal enterocytes, Enteroendocrine cells, Erythroid cells, granulocytes, Intestinal goblet cells, Undifferentiated cells)

3 nearest neighbours based on single cell RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
B3GNT7	UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 7	0.5741	16
LXN	Latexin	0.5679	1
PRAC1	PRAC1 small nuclear protein	0.5508	16

ALX4

Cell type enhanced (Breast myoepithelial cells, Fibroblasts, Late spermatids, Leydig cells, Microglial cells)

3 nearest neighbours based on single cell RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
TNN	Tenascin N	0.8505	48
INTS6	Integrator complex subunit 6	0.6195	80
OLFML2A	Olfactomedin like 2A	0.6053	53

BATF2

Cell type enhanced (Distal enterocytes, Enteroendocrine cells, Intestinal goblet cells, Paneth cells, Proximal enterocytes)

3 nearest neighbours based on single cell RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
BNIP5	BCL2 interacting protein 5	0.6075	5
MUC12	Mucin 12, cell surface associated	0.5820	5
TMEM171	Transmembrane protein 171	0.5818	5

BNC2

Cell type enhanced (Leydig cells, Mesothelial cells, Microglial cells, Ovarian stromal cells, Peritubular cells)

3 nearest neighbours based on single cell RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
LHCGR	Luteinizing hormone/choriogonadotropin receptor	0.6815	6
GLI2	GLI family zinc finger 2	0.6685	6
MMP23B	Matrix metallopeptidase 23B	0.6265	50

EBF1

Cell type enhanced (Adipocytes, B-cells, Fibroblasts, Leydig cells, Microglial cells, Peritubular cells, Smooth muscle cells)

3 nearest neighbours based on single cell RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
CYGB	Cytoglobin	0.8620	53
GSC	Goosecoid homeobox	0.8357	53
CXCL12	C-X-C motif chemokine ligand 12	0.7991	53

EGR2

Cell type enhanced (Breast myoepithelial cells, Enteroendocrine cells, Macrophages)

3 nearest neighbours based on single cell RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
C1QC	Complement C1q C chain	0.7712	58
GAL3ST4	Galactose-3-O-sulfotransferase 4	0.7473	58
OR4B1	Olfactory receptor family 4 subfamily B member 1	0.7290	58

ETV1

Cell type enhanced (Alveolar cells type 2, Astrocytes, Cardiomyocytes, Enteroendocrine cells, Excitatory neurons, Oligodendrocyte precursor cells, Serous glandular cells)

3 nearest neighbours based on single cell RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
FNBP1L	Formin binding protein 1 like	0.6404	75
RNASE8	Ribonuclease A family member 8	0.6346	75
NXPE2	Neurexophilin and PC-esterase domain family member 2	0.6340	75

ETV4

Cell type enhanced (Basal squamous epithelial cells, Cholangiocytes, Distal tubular cells, Enteroendocrine cells, Extravillous trophoblasts, Melanocytes, Syncytiotrophoblasts)

3 nearest neighbours based on single cell RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
KRTAP17-1	Keratin associated protein 17-1	0.6540	20
PAPPA2	Pappalysin 2	0.6253	4
ASCL2	Achaete-scute family bHLH transcription factor 2	0.5675	4

EVX2

Cell type enhanced (Distal enterocytes, Early spermatids, Enteroendocrine cells, Late spermatids, Paneth cells, Skeletal myocytes)

3 nearest neighbours based on single cell RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
ENSG00000261832	Novel protein	0.7757	13
NPIPB7	Nuclear pore complex interacting protein family member B7	0.6960	13
NPIPB6	Nuclear pore complex interacting protein family member B6	0.6957	13

FOXA1

Cell type enhanced (Basal squamous epithelial cells, Breast glandular cells, Club cells, Enteroendocrine cells, Prostatic glandular cells)

3 nearest neighbours based on single cell RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
MSMB	Microseminoprotein beta	0.7691	40
CREB3L4	CAMP responsive element binding protein 3 like 4	0.7337	40
MESP1	Mesoderm posterior bHLH transcription factor 1	0.7265	40

FOXA2

Cell type enhanced (Alveolar cells type 1, Alveolar cells type 2, Cholangiocytes, Enteroendocrine cells, Exocrine glandular cells, Gastric mucus-secreting cells, Glandular and luminal cells, Hepatocytes, Intestinal goblet cells)

3 nearest neighbours based on single cell RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
MARVELD2	MARVEL domain containing 2	0.6771	37
ARSD	Arylsulfatase D	0.6769	37
LEFTY1	Left-right determination factor 1	0.6202	16

FOXL1

Cell type enhanced (Oocytes, Pancreatic endocrine cells, Peritubular cells, Sertoli cells, Smooth muscle cells)

3 nearest neighbours based on single cell RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
ITGB1	Integrin subunit beta 1	0.7270	45
BGN	Biglycan	0.7120	32
HTR1B	5-hydroxytryptamine receptor 1B	0.6963	32

GATA4

Cell type enhanced (Cardiomyocytes, Gastric mucus-secreting cells, Granulosa cells, Late spermatids, Leydig cells, Ovarian stromal cells, Peritubular cells, Sertoli cells)

3 nearest neighbours based on single cell RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
AMHR2	Anti-Mullerian hormone receptor type 2	0.7277	6
SIGLEC11	Sialic acid binding Ig like lectin 11	0.6554	6
NUDT10	Nudix hydrolase 10	0.6441	6

GLI2

Cell type enhanced (Astrocytes, Leydig cells, Ovarian stromal cells, Peritubular cells)

3 nearest neighbours based on single cell RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
SMO	Smoothened, frizzled class receptor	0.6740	6
BNC2	Basonuclin 2	0.6685	6
GLI3	GLI family zinc finger 3	0.6294	47

GLIS2

Cell type enhanced (Alveolar cells type 1, Leydig cells, Peritubular cells)

3 nearest neighbours based on single cell RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
TNC	Tenascin C	0.6587	32
CCN3	Cellular communication network factor 3	0.6275	32
AEBP1	AE binding protein 1	0.6085	32

HEYL

Cell type enhanced (Granulosa cells, Late spermatids, Leydig cells, Peritubular cells, Sertoli cells, Smooth muscle cells)

3 nearest neighbours based on single cell RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
C11orf96	Chromosome 11 open reading frame 96	0.8047	48
REM1	RRAD and GEM like GTPase 1	0.7853	48
CRISPLD2	Cysteine rich secretory protein LCCL domain containing 2	0.7818	48

HIC1

Cell type enhanced (Endometrial stromal cells, Fibroblasts, Leydig cells, Lymphatic endothelial cells, Peritubular cells, Smooth muscle cells)

3 nearest neighbours based on single cell RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
SFRP4	Secreted frizzled related protein 4	0.7669	9
CCN4	Cellular communication network factor 4	0.7113	9
PCDHB4	Protocadherin beta 4	0.6980	53

HIF3A

Cell type enhanced (Adipocytes, Astrocytes, Endothelial cells, Leydig cells, Muller glia cells, Oligodendrocyte precursor cells, Peritubular cells)

3 nearest neighbours based on single cell RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
RAPGEF3	Rap guanine nucleotide exchange factor 3	0.6388	41
SLC14A1	Solute carrier family 14 member 1 (Kidd blood group)	0.6316	41
PREX2	Phosphatidylinositol-3,4,5-trisphosphate dependent Rac exchange factor 2	0.5954	47

HOXA10

Cell type enhanced (Endometrial stromal cells, Enteroendocrine cells, Paneth cells, Prostatic glandular cells)

3 nearest neighbours based on single cell RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
HOXD11	Homeobox D11	0.8907	9
HOXA11	Homeobox A11	0.8827	9
APCDD1	APC down-regulated 1	0.8427	9

HOXA13

Cell type enhanced (Club cells, Distal enterocytes, Enteroendocrine cells, Intestinal goblet cells, Paneth cells, Prostatic glandular cells, Undifferentiated cells)

3 nearest neighbours based on single cell RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
HOXB13	Homeobox B13	0.8503	40
TMPRSS2	Transmembrane serine protease 2	0.7486	5
NPY	Neuropeptide Y	0.6450	40

HOXA6

Cell type enhanced (Breast myoepithelial cells, Endometrial stromal cells, Enteroendocrine cells, Paneth cells, Prostatic glandular cells, Skeletal myocytes, Undifferentiated cells)

3 nearest neighbours based on single cell RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
HOXA10	Homeobox A10	0.7121	9
HOXD11	Homeobox D11	0.6815	9
IGF1	Insulin like growth factor 1	0.6324	9

HOXA9

Cell type enhanced (Distal tubular cells, Endometrial stromal cells, Enteroendocrine cells, Intestinal goblet cells, Proximal tubular cells, Undifferentiated cells)

3 nearest neighbours based on single cell RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
KL	Klotho	0.6525	38
FXYD2	FXYD domain containing ion transport regulator 2	0.6358	38
PRDX3	Peroxiredoxin 3	0.6329	39

HOXB8

Cell type enhanced (Basal prostatic cells, Collecting duct cells, Distal tubular cells, Enteroendocrine cells, Glandular and luminal cells)

3 nearest neighbours based on single cell RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
HOXB6	Homeobox B6	0.9157	3
EDDM3A	Epididymal protein 3A	0.8013	3
ENPP3	Ectonucleotide pyrophosphatase/phosphodiesterase 3	0.7931	37

HOXB9

Cell type enhanced (Basal prostatic cells, Collecting duct cells, Distal enterocytes, Distal tubular cells, Enteroendocrine cells, Intestinal goblet cells, Undifferentiated cells)

3 nearest neighbours based on single cell RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
PPP1R1B	Protein phosphatase 1 regulatory inhibitor subunit 1B	0.7783	16
HOXB7	Homeobox B7	0.7354	16
ANXA13	Annexin A13	0.7129	16

HOXC6

Cell type enhanced (Distal tubular cells, Fibroblasts, Leydig cells, Melanocytes, Ovarian stromal cells, Peritubular cells, Smooth muscle cells, Spermatocytes)

3 nearest neighbours based on single cell RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
HOXC8	Homeobox C8	0.8300	53
HOXC11	Homeobox C11	0.6242	53
NDN	Necdin, MAGE family member	0.6123	6

HOXC8

Cell type enhanced (Fibroblasts, Leydig cells, Melanocytes, Ovarian stromal cells, Peritubular cells, Proximal tubular cells, Sertoli cells, Smooth muscle cells, Spermatocytes)

3 nearest neighbours based on single cell RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
HOXC6	Homeobox C6	0.8300	6
C1QTNF2	C1q and TNF related 2	0.8129	53
HOXC11	Homeobox C11	0.7533	53

HOXD10

Cell type enhanced (Adipocytes, Collecting duct cells, Distal enterocytes, Endometrial stromal cells, Endothelial cells, Enteroendocrine cells, Lymphatic endothelial cells, Oocytes)

3 nearest neighbours based on single cell RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
HOXD11	Homeobox D11	0.7675	9
HOXD9	Homeobox D9	0.7208	54
HOXA10	Homeobox A10	0.7045	9

HOXD11

Cell type enhanced (Collecting duct cells, Distal enterocytes, Endometrial stromal cells, Enteroendocrine cells, Intestinal goblet cells, Paneth cells, Undifferentiated cells)

3 nearest neighbours based on single cell RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
HOXA10	Homeobox A10	0.8907	9
HOXA11	Homeobox A11	0.8037	9
HOXD10	Homeobox D10	0.7675	9

HOXD12

Cell type enhanced (Enteroendocrine cells, Intestinal goblet cells, Paneth cells, Undifferentiated cells)

3 nearest neighbours based on single cell RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
RXFP4	Relaxin family peptide/INSL5 receptor 4	0.9496	20
PYY	Peptide YY	0.9235	20
INSL5	Insulin like 5	0.9185	20

HOXD4

Cell type enhanced (Adipocytes, Basal prostatic cells, Collecting duct cells, Leydig cells, Proximal tubular cells, Secretory cells)

3 nearest neighbours based on single cell RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
HOXD3	Homeobox D3	0.8580	3
HOXD8	Homeobox D8	0.7169	54
AQP2	Aquaporin 2	0.6918	3

HOXD8

Cell type enhanced (Basal prostatic cells, Distal tubular cells, Early spermatids, Leydig cells, Lymphatic endothelial cells, Spermatocytes)

3 nearest neighbours based on single cell RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
HOXD3	Homeobox D3	0.7342	3
HOXD9	Homeobox D9	0.7233	54
HOXD4	Homeobox D4	0.7169	3

HOXD9

Cell type enhanced (Adipocytes, Basal prostatic cells, Collecting duct cells, Distal tubular cells, Endothelial cells, Leydig cells, Lymphatic endothelial cells, Oocytes, Peritubular cells)

3 nearest neighbours based on single cell RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
GJD3	Gap junction protein delta 3	0.7955	54
ECSCR	Endothelial cell surface expressed chemotaxis and apoptosis regulator	0.7333	54
HOXD8	Homeobox D8	0.7233	54

HSF4

Cell type enhanced (Astrocytes, Excitatory neurons, Horizontal cells, Inhibitory neurons, Leydig cells)

3 nearest neighbours based on single cell RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
LRP3	LDL receptor related protein 3	0.6889	71
NAT8L	N-acetyltransferase 8 like	0.5657	47
NTRK2	Neurotrophic receptor tyrosine kinase 2	0.5340	8

ISL1

Cell type enhanced (Bipolar cells, Cytotrophoblasts, Enteroendocrine cells, Pancreatic endocrine cells, Syncytiotrophoblasts)

3 nearest neighbours based on single cell RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
GNG13	G protein subunit gamma 13	0.9633	25
CRHR1	Corticotropin releasing hormone receptor 1	0.9589	25
AANAT	Aralkylamine N-acetyltransferase	0.9580	25

KLF8

Cell type enhanced (Leydig cells, Peritubular cells, Squamous epithelial cells)

3 nearest neighbours based on single cell RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
TENT5B	Terminal nucleotidyltransferase 5B	0.5667	12
ZBTB5	Zinc finger and BTB domain containing 5	0.5165	12
LDAF1	Lipid droplet assembly factor 1	0.5046	12

MEOX2

Cell type enhanced (Adipocytes, Endothelial cells, Fibroblasts, Leydig cells, Mesothelial cells, Peritubular cells, Smooth muscle cells)

3 nearest neighbours based on single cell RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
TNMD	Tenomodulin	0.7408	41
CAV1	Caveolin 1	0.7119	41
EBF3	EBF transcription factor 3	0.7117	53

MSC

Cell type enhanced (Exocrine glandular cells, Fibroblasts, Leydig cells, Melanocytes, Pancreatic endocrine cells, Peritubular cells, Skeletal myocytes)

3 nearest neighbours based on single cell RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
ESM1	Endothelial cell specific molecule 1	0.6014	45
CCL2	C-C motif chemokine ligand 2	0.5917	48
CD70	CD70 molecule	0.5674	14

NKX6-1

Cell type enhanced (Ductal cells, Early spermatids, Pancreatic endocrine cells, Spermatocytes)

3 nearest neighbours based on single cell RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
ZC3H11B	Zinc finger CCCH-type containing 11B	0.7552	70
GOLGA8S	Golgin A8 family member S	0.7172	70
SULT6B1	Sulfotransferase family 6B member 1	0.7063	70

NR2F2

Cell type enhanced (Endometrial stromal cells, Leydig cells, Ovarian stromal cells, Peritubular cells, Smooth muscle cells)

3 nearest neighbours based on single cell RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
IGFBP7	Insulin like growth factor binding protein 7	0.7225	48
EDNRA	Endothelin receptor type A	0.7203	48
TMEM200B	Transmembrane protein 200B	0.6697	48

OSR1

Cell type enhanced (Fibroblasts, Leydig cells, Mesothelial cells, Peritubular cells)

3 nearest neighbours based on single cell RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
EFEMP2	EGF containing fibulin extracellular matrix protein 2	0.8339	50
FIBIN	Fin bud initiation factor homolog	0.7619	50
PCOLCE	Procollagen C-endopeptidase enhancer	0.7033	50

OSR2

Cell type enhanced (Endometrial stromal cells, Extravillous trophoblasts, Leydig cells, Ovarian stromal cells, Peritubular cells)

3 nearest neighbours based on single cell RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
RPRM	Reprimo, TP53 dependent G2 arrest mediator homolog	0.8244	9
CPXM1	Carboxypeptidase X, M14 family member 1	0.7997	9
FOXL2NB	FOXL2 neighbor	0.7796	6

PLAGL1

Cell type enhanced (Fibroblasts, Leydig cells, Peritubular cells)

3 nearest neighbours based on single cell RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
GPC3	Glypican 3	0.8128	50
LUM	Lumican	0.8115	50
COL3A1	Collagen type III alpha 1 chain	0.7936	50

PRRX1

Cell type enhanced (Early spermatids, Endometrial stromal cells, Fibroblasts, Late spermatids, Leydig cells, Oligodendrocyte precursor cells, Smooth muscle cells)

3 nearest neighbours based on single cell RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
EBF1	EBF transcription factor 1	0.6779	53
FAM76A	Family with sequence similarity 76 member A	0.6712	53
COL6A3	Collagen type VI alpha 3 chain	0.6614	53

SMARCA1

Cell type enhanced (Leydig cells)

3 nearest neighbours based on single cell RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
PWWP3B	PWWP domain containing 3B	0.6008	6
GREB1	Growth regulating estrogen receptor binding 1	0.5783	6
LRRC17	Leucine rich repeat containing 17	0.5693	6

SNAI2

Cell type enhanced (Basal keratinocytes, Basal respiratory cells, Endometrial stromal cells, Fibroblasts, Leydig cells, Melanocytes, Peritubular cells, Suprabasal keratinocytes)

3 nearest neighbours based on single cell RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
LAMC3	Laminin subunit gamma 3	0.7924	9
LUM	Lumican	0.7084	50
COL3A1	Collagen type III alpha 1 chain	0.7075	50

SOX11

Cell type enhanced (Breast glandular cells, Breast myoepithelial cells, Cardiomyocytes, Fibroblasts, Inhibitory neurons, Oligodendrocyte precursor cells, Pancreatic endocrine cells)

3 nearest neighbours based on single cell RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
NEUROD6	Neuronal differentiation 6	0.9241	10
PHOX2B	Paired like homeobox 2B	0.9172	10
NEUROD2	Neuronal differentiation 2	0.8518	10

TCF21

Cell type enhanced (Fibroblasts, Leydig cells, Ovarian stromal cells, Peritubular cells, Sertoli cells, Smooth muscle cells)

3 nearest neighbours based on single cell RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
ADRB3	Adrenoceptor beta 3	0.9259	50
SERPINE2	Serpin family E member 2	0.7797	50
MMP23B	Matrix metallopeptidase 23B	0.7772	50

TCF7L1

Cell type enhanced (Adipocytes, Alveolar cells type 2, Astrocytes, Leydig cells)

3 nearest neighbours based on single cell RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
TRIL	TLR4 interactor with leucine rich repeats	0.5501	53
ADGRF5	Adhesion G protein-coupled receptor F5	0.5127	41
TNS2	Tensin 2	0.5075	48

TSHZ2

Cell type enhanced (Leydig cells, Lymphatic endothelial cells, Mucus glandular cells, Ovarian stromal cells, Peritubular cells)

3 nearest neighbours based on single cell RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
ENSG00000285218	Novel protein	0.6053	6
DIRAS3	DIRAS family GTPase 3	0.6029	6
PWWP3B	PWWP domain containing 3B	0.5973	6

TWIST2

Cell type enhanced (Endometrial stromal cells, Fibroblasts, Langerhans cells, Leydig cells, Mesothelial cells, Ovarian stromal cells, Peritubular cells)

3 nearest neighbours based on single cell RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
GLI1	GLI family zinc finger 1	0.6990	9
CLEC11A	C-type lectin domain containing 11A	0.6951	50
CPXM1	Carboxypeptidase X, M14 family member 1	0.6941	9

ZNF423

Cell type enhanced (Astrocytes, Late spermatids, Leydig cells, Microglial cells, Oligodendrocyte precursor cells, Peritubular cells)

3 nearest neighbours based on single cell RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
FUT10	Fucosyltransferase 10	0.6722	63
NOTO	Notochord homeobox	0.6448	63
CLCN1	Chloride voltage-gated channel 1	0.6008	63

ZNF469

Cell type enhanced (Excitatory neurons, Inhibitory neurons, monocytes, Oligodendrocyte precursor cells, Pancreatic endocrine cells)

3 nearest neighbours based on single cell RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
DACH2	Dachshund family transcription factor 2	0.6254	69
ADAMTS3	ADAM metallopeptidase with thrombospondin type 1 motif 3	0.6215	34
PROP1	PROP paired-like homeobox 1	0.6163	69

ZNF765

Cell type enhanced (Extravillous trophoblasts, Leydig cells)

3 nearest neighbours based on single cell RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
ZNF813	Zinc finger protein 813	0.6462	40
ZNF66	Zinc finger protein 66	0.6172	6
DHRS2	Dehydrogenase/reductase 2	0.6145	6