Transcription factor landscape - Single cell type - Glial cells

The function of the nervous system is to receive, process and execute the coordinated higher functions of perception, motion and cognition that signify human life. The nervous system is divided into a central nervous system (CNS), including the brain and the spinal cord, and a peripheral nervous system (PNS), including nerves branching out from the spinal cord to all parts of the body. Retina is an extension of the CNS responsible specifically for vision. The cellular components of this highly complex signal network include neurons and supportive glial cells.

Transcriptome analysis shows that 67% (n=13603) of all human proteins (n=20162) are detected in glial cells and 3533 of these genes show an elevated expression in any glial cells compared to other cell type groups. Learn more about genes wih elevated expression here. In-depth analysis of transcription factor genes expressed in glial cells highlights 148 transcription factors with elevated expression in glial cells compared to other cell types. In total, 20 transcription factors are classified as enriched in glial cells.

Here we provide the expression overview of all transcription factors that show enriched expression levels in glial cells compared to other cell types. The gene expression overview, across different cell types is accopanied by the top 3 nearest neighbours based on single cell RNA expression and correlation in the clustering analysis.

Enriched transcription factors

Gene

Expression

Expression clustering

NR2E1

Cell type enriched (Müller glia)

3 nearest neighbours based on single cell RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
PRSS35	Serine protease 35	0.8701	11
STAC2	SH3 and cysteine rich domain 2	0.8652	11
SEC14L3	SEC14 like lipid binding 3	0.8566	11

ST18

Cell type enriched (Oligodendrocytes)

3 nearest neighbours based on single cell RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
SLC5A11	Solute carrier family 5 member 11	0.8896	80
MOBP	Myelin associated oligodendrocyte basic protein	0.8530	80
OR9A2	Olfactory receptor family 9 subfamily A member 2	0.8070	80

MYT1

Cell type enriched (Oligodendrocyte progenitor cells)

3 nearest neighbours based on single cell RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
MEGF11	Multiple EGF like domains 11	0.8117	14
NEU4	Neuraminidase 4	0.7105	14
PCDHA4	Protocadherin alpha 4	0.7055	14

Enriched transcription factors

Gene

Expression

Expression clustering

VSX2

Group enriched (Müller glia, Retinal bipolar cells)

3 nearest neighbours based on single cell RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
GRM6	Glutamate metabotropic receptor 6	0.8962	86
GABRR1	Gamma-aminobutyric acid type A receptor subunit rho1	0.8935	86
VSX1	Visual system homeobox 1	0.8679	86

OLIG1

Group enriched (Oligodendrocyte progenitor cells, Oligodendrocytes)

3 nearest neighbours based on single cell RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
OLIG2	Oligodendrocyte transcription factor 2	0.9799	14
NEU4	Neuraminidase 4	0.9174	14
ENSG00000285837	Novel protein	0.8828	14

OLIG2

Group enriched (Oligodendrocyte progenitor cells, Oligodendrocytes)

3 nearest neighbours based on single cell RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
OLIG1	Oligodendrocyte transcription factor 1	0.9799	14
NEU4	Neuraminidase 4	0.9614	14
TNR	Tenascin R	0.9101	14

DLX1

Group enriched (Adrenal medulla cells, Brain inhibitory neurons, Conjunctival goblet cells, Megakaryocytes, Other brain neurons, Schwann cells, Tuft cells)

3 nearest neighbours based on single cell RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
CORT	Cortistatin	0.8302	109
GPR83	G protein-coupled receptor 83	0.8177	109
SP9	Sp9 transcription factor	0.7977	109

NKX6-2

Group enriched (Foveolar cells, Oligodendrocytes)

3 nearest neighbours based on single cell RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
OPALIN	Oligodendrocytic myelin paranodal and inner loop protein	0.8596	80
DBNDD2	Dysbindin domain containing 2	0.8334	80
CARNS1	Carnosine synthase 1	0.8225	80

SOX8

Group enriched (Müller glia, Oligodendrocyte progenitor cells, Oligodendrocytes)

3 nearest neighbours based on single cell RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
HMX1	H6 family homeobox 1	0.9143	14
SLITRK2	SLIT and NTRK like family member 2	0.7700	11
OLIG2	Oligodendrocyte transcription factor 2	0.7373	14

DBX2

Group enriched (Adipocytes, Astrocytes, Bergmann glia, Fibro-adipogenic progenitors, Oligodendrocyte progenitor cells, Undifferentiated spermatogonia)

3 nearest neighbours based on single cell RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
HES5	Hes family bHLH transcription factor 5	0.6426	28
GPR37L1	G protein-coupled receptor 37 like 1	0.5992	14
PTPRZ1	Protein tyrosine phosphatase receptor type Z1	0.5901	14

NKX2-2

Group enriched (Bergmann glia, Neuroendocrine cells, Oligodendrocyte progenitor cells, Oligodendrocytes, Pancreatic islet cells, Somatotrophs)

3 nearest neighbours based on single cell RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
RFX6	Regulatory factor X6	0.8103	96
CRYBA2	Crystallin beta A2	0.8100	96
PCSK1N	Proprotein convertase subtilisin/kexin type 1 inhibitor	0.8080	96

ZFP57

Group enriched (Oligodendrocytes, Renal collecting duct intercalated cells)

3 nearest neighbours based on single cell RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
PLCG2	Phospholipase C gamma 2	0.7002	50
SLC4A9	Solute carrier family 4 member 9	0.6168	50
SLC26A4	Solute carrier family 26 member 4	0.6083	50

SOX10

Group enriched (Breast lactating cells, Breast myoepithelial cells, Breast secretory cells, Lacrimal acinar cells, Melanocytes, Oligodendrocyte progenitor cells, Oligodendrocytes, Salivary acinar cells, Salivary myoepithelial cells, Schwann cells)

3 nearest neighbours based on single cell RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
CHADL	Chondroadherin like	0.7010	61
CDH19	Cadherin 19	0.6890	61
FOXD3	Forkhead box D3	0.6603	61

ZIC5

Group enriched (Astrocytes, Bergmann glia, Brain excitatory neurons, Choroid plexus epithelial cells, Ependymal cells)

3 nearest neighbours based on single cell RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
ZIC2	Zic family member 2	0.9182	2
ZIC3	Zic family member 3	0.7171	104
ZIC4	Zic family member 4	0.6915	2

GLI1

Group enriched (Bergmann glia, Leydig cells, Peritubular myoid cells)

3 nearest neighbours based on single cell RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
INSL3	Insulin like 3	0.8184	94
PTGDS	Prostaglandin D2 synthase	0.7884	94
PRPS2	Phosphoribosyl pyrophosphate synthetase 2	0.7714	94

HES5

Group enriched (Astrocytes, Bergmann glia, Oligodendrocyte progenitor cells)

3 nearest neighbours based on single cell RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
TTYH1	Tweety family member 1	0.8105	28
ETNPPL	Ethanolamine-phosphate phospho-lyase	0.7892	28
NCAN	Neurocan	0.7810	28

NFATC4

Group enriched (Astrocytes, Bergmann glia)

3 nearest neighbours based on single cell RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
SLC2A4	Solute carrier family 2 member 4	0.7300	22
PTEN	Phosphatase and tensin homolog	0.6696	22
ISLR	Immunoglobulin superfamily containing leucine rich repeat	0.6663	22

PAX3

Group enriched (Bergmann glia, Melanocytes)

3 nearest neighbours based on single cell RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
TYR	Tyrosinase	0.7418	61
DCT	Dopachrome tautomerase	0.7406	61
MLANA	Melan-A	0.7283	61

RBAK

Group enriched (Astrocytes, Bergmann glia, Brain excitatory neurons, Brain inhibitory neurons, Choroid plexus epithelial cells, Ependymal cells, Microglia, Oligodendrocyte progenitor cells, Oligodendrocytes, Other brain neurons)

3 nearest neighbours based on single cell RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
ST3GAL3	ST3 beta-galactoside alpha-2,3-sialyltransferase 3	0.8259	22
RABGEF1	RAB guanine nucleotide exchange factor 1	0.7698	22
SLC25A51	Solute carrier family 25 member 51	0.7698	22

SIX3

Group enriched (Müller glia, Pituicytes/FSCs, Retinal amacrine cells, Retinal bipolar cells, Retinal horizontal cells, Retinal pigment epithelial cells)

3 nearest neighbours based on single cell RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
LHX2	LIM homeobox 2	0.7252	11
WIF1	WNT inhibitory factor 1	0.6859	11
RLBP1	Retinaldehyde binding protein 1	0.6388	11

TGIF2

Group enriched (Choroid plexus epithelial cells, Microglia)

3 nearest neighbours based on single cell RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
HSPA6	Heat shock protein family A (Hsp70) member 6	0.8101	102
LILRB1	Leukocyte immunoglobulin like receptor B1	0.7759	102
LY75	Lymphocyte antigen 75	0.7617	74

VENTX

Group enriched (cDC, Macrophages, Microglia, monocytes)

3 nearest neighbours based on single cell RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
MS4A4E	Membrane spanning 4-domains A4E	0.7388	72
ADAP2	ArfGAP with dual PH domains 2	0.7202	72
CD209	CD209 molecule	0.6625	72

ZNF223

3 nearest neighbours based on single cell RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
SCG5	Secretogranin V	0.7658	98
NME2	NME/NM23 nucleoside diphosphate kinase 2	0.7493	98
RNASEK	Ribonuclease K	0.7481	98

ZNF23

3 nearest neighbours based on single cell RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
BBS1	Bardet-Biedl syndrome 1	0.7105	22
C2orf81	Chromosome 2 open reading frame 81	0.7083	34
PIK3R2	Phosphoinositide-3-kinase regulatory subunit 2	0.6918	22

ZNF285

Group enriched (Astrocytes, Bergmann glia, Brain excitatory neurons, Brain inhibitory neurons, Choroid plexus epithelial cells, Ependymal cells, Oligodendrocyte progenitor cells, Oligodendrocytes, Oocytes, Other brain neurons)

3 nearest neighbours based on single cell RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
C7orf25	Chromosome 7 open reading frame 25	0.6404	98
ZNF223	Zinc finger protein 223	0.6104	98
BTNL2	Butyrophilin like 2	0.5939	109

ZNF559

3 nearest neighbours based on single cell RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
GNG10	G protein subunit gamma 10	0.7192	98
ZNF10	Zinc finger protein 10	0.7174	22
STX16	Syntaxin 16	0.7133	22

ZNF625

3 nearest neighbours based on single cell RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
RBAK	RB associated KRAB zinc finger	0.7563	22
ZNF8	Zinc finger protein 8	0.7450	22
ZNF222	Zinc finger protein 222	0.7049	109

ZNF8

3 nearest neighbours based on single cell RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
RAD50	RAD50 double strand break repair protein	0.7919	22
ZNF625	Zinc finger protein 625	0.7450	22
DEPDC5	DEP domain containing 5, GATOR1 subcomplex subunit	0.7387	22

Enriched transcription factors

Gene

Expression

Expression clustering

NRL

Cell type enhanced (Astrocytes, Bergmann glia, Brain inhibitory neurons, Choroid plexus epithelial cells, Distal convoluted tubule cells, Ependymal cells, Loop of henle epithelial cells, Microglia, Oligodendrocyte progenitor cells, Oligodendrocytes, Other brain neurons, Papillary tip epithelial cells, Podocytes, Proximal tubule cells, Renal collecting duct intercalated cells, Renal collecting duct principal cells, Renal connecting tubule cells)

3 nearest neighbours based on single cell RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
OTUD1	OTU deubiquitinase 1	0.6025	74
DDTL	D-dopachrome tautomerase like	0.5987	74
ENSG00000251357	Novel protein	0.5783	88

EN2

Cell type enhanced (Bergmann glia, Brain excitatory neurons, Endometrial glandular cells, Endometrial luminal cells, Epididymal efferent duct absorptive cells, Epididymal efferent duct ciliated cells, Melanocytes, Oocytes)

3 nearest neighbours based on single cell RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
FGF3	Fibroblast growth factor 3	0.7258	2
BARHL1	BarH like homeobox 1	0.7234	2
GABRA6	Gamma-aminobutyric acid type A receptor subunit alpha6	0.7136	2

RAX

Cell type enhanced (Cone photoreceptor cells, Müller glia, Pituicytes/FSCs)

3 nearest neighbours based on single cell RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
SIX6	SIX homeobox 6	0.9285	11
CRABP1	Cellular retinoic acid binding protein 1	0.9192	11
PRSS35	Serine protease 35	0.9095	11

LEF1

Cell type enhanced (Adrenal cortex cells, Choroid plexus epithelial cells, Endometrial stromal cells, Ependymal cells, Melanocytes, Pituicytes/FSCs, Renal collecting duct intercalated cells, T-cells, Thymocytes, Vascular endothelial cells)

3 nearest neighbours based on single cell RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
TNFSF8	TNF superfamily member 8	0.6846	9
TCF7	Transcription factor 7	0.6687	9
ERFL	ETS repressor factor like	0.6619	9

ZIC1

Cell type enhanced (Astrocytes, Bergmann glia, Brain excitatory neurons, Choroid plexus epithelial cells, Ependymal cells, Myonuclei, Myosatellite cells, Oligodendrocytes)

3 nearest neighbours based on single cell RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
ZIC4	Zic family member 4	0.8567	2
ZIC2	Zic family member 2	0.7104	2
PDLIM2	PDZ and LIM domain 2	0.6656	22

POU3F2

Cell type enhanced (Astrocytes, Bergmann glia, Ependymal cells, Müller glia, Oligodendrocyte progenitor cells, Oligodendrocytes, Other brain neurons)

3 nearest neighbours based on single cell RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
PRSS50	Serine protease 50	0.8268	28
PIRT	Phosphoinositide interacting regulator of transient receptor potential channels	0.7300	28
GFAP	Glial fibrillary acidic protein	0.7035	28

ZIC4

Cell type enhanced (Astrocytes, Bergmann glia, Brain excitatory neurons, Choroid plexus epithelial cells, Ependymal cells, Late spermatids, Myonuclei, Myosatellite cells, Oligodendrocytes, Other brain neurons)

3 nearest neighbours based on single cell RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
ZIC1	Zic family member 1	0.8567	22
ZIC2	Zic family member 2	0.7269	2
FGF3	Fibroblast growth factor 3	0.7073	2

GBX2

Cell type enhanced (Bergmann glia, Early spermatids, Ependymal cells, Other brain neurons, Undifferentiated spermatogonia)

3 nearest neighbours based on single cell RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
HAPLN1	Hyaluronan and proteoglycan link protein 1	0.6673	108
PLAC1	Placenta enriched 1	0.6487	108
EGFL6	EGF like domain multiple 6	0.6467	108

VAX1

Cell type enhanced (Astrocytes, Brain inhibitory neurons, Choroid plexus epithelial cells, Ependymal cells, Late spermatids, Oligodendrocytes, Other brain neurons, Pituitary stem cells)

3 nearest neighbours based on single cell RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
DLX1	Distal-less homeobox 1	0.6276	109
CHRNA7	Cholinergic receptor nicotinic alpha 7 subunit	0.6192	109
CORT	Cortistatin	0.5811	109

HMX1

Cell type enhanced (Astrocytes, Müller glia, Oligodendrocyte progenitor cells, Oligodendrocytes, Retinal horizontal cells)

3 nearest neighbours based on single cell RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
SOX8	SRY-box transcription factor 8	0.9143	14
NEU4	Neuraminidase 4	0.8334	14
OLIG2	Oligodendrocyte transcription factor 2	0.8271	14

TSC22D4

Cell type enhanced (Astrocytes, Bergmann glia, Esophageal apical cells, Müller glia, Neutrophils, Oligodendrocytes, Retinal pigment epithelial cells, Schwann cells)

3 nearest neighbours based on single cell RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
SLITRK2	SLIT and NTRK like family member 2	0.5489	11
NR2E1	Nuclear receptor subfamily 2 group E member 1	0.5268	11
MT3	Metallothionein 3	0.5240	11

FOXI3

Cell type enhanced (Breast myoepithelial cells, Cytotrophoblasts, Migrating cytotrophoblasts, Müller glia, Syncytiotrophoblasts)

3 nearest neighbours based on single cell RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
GATB	Glutamyl-tRNA amidotransferase subunit B	0.7180	11
PRSS35	Serine protease 35	0.7148	11
NR2E1	Nuclear receptor subfamily 2 group E member 1	0.6961	11

IKZF1

Cell type enhanced (B-cells, Erythrocyte progenitors, Hematopoietic stem cells, Innate lymphoid cells, Mast cells, Megakaryocyte-Erythroid progenitors, Microglia, Monocyte progenitors, monocytes, Neutrophil progenitors, Neutrophils, NK-cells, pDCs, Plasma cells, T-cells, Thymocytes)

3 nearest neighbours based on single cell RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
OR6K3	Olfactory receptor family 6 subfamily K member 3	0.6499	37
CEACAM8	CEA cell adhesion molecule 8	0.6488	37
OR6N2	Olfactory receptor family 6 subfamily N member 2	0.6382	37

NR0B1

Cell type enhanced (Adrenal cortex cells, Adrenal medulla cells, Corticotrophs, Epididymal efferent duct ciliated cells, Gonadotrophs, Oligodendrocyte progenitor cells, Pancreatic islet cells, Sertoli cells)

3 nearest neighbours based on single cell RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
CYP11B1	Cytochrome P450 family 11 subfamily B member 1	0.7690	18
MC2R	Melanocortin 2 receptor	0.7635	18
CYP17A1	Cytochrome P450 family 17 subfamily A member 1	0.7599	18

PAX6

Cell type enhanced (Astrocytes, Bergmann glia, Lacrimal acinar cells, Müller glia, Ocular epithelial cells, Pancreatic islet cells, Retinal amacrine cells, Retinal ganglion cells, Retinal horizontal cells)

3 nearest neighbours based on single cell RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
KRTAP4-5	Keratin associated protein 4-5	0.6784	100
MGARP	Mitochondria localized glutamic acid rich protein	0.6521	100
CLU	Clusterin	0.6505	100

ZIC2

Cell type enhanced (Astrocytes, Bergmann glia, Brain excitatory neurons, Brain inhibitory neurons, Choroid plexus epithelial cells, Ependymal cells, Müller glia, Other brain neurons)

3 nearest neighbours based on single cell RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
ZIC5	Zic family member 5	0.9182	2
ZIC3	Zic family member 3	0.8023	104
PPT2	Palmitoyl-protein thioesterase 2	0.7284	104

MLXIPL

Cell type enhanced (Adipocytes, Adrenal cortex cells, Cholangiocytes, Enterocytes, Epididymal principal cells, Hepatocytes, Microglia, Myonuclei, Neuroendocrine cells, Paneth cells, Proximal tubule cells, Sertoli cells)

3 nearest neighbours based on single cell RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
PC	Pyruvate carboxylase	0.6878	89
GPAM	Glycerol-3-phosphate acyltransferase, mitochondrial	0.6641	89
AQP7B	Aquaporin 7B	0.6489	89

SOX1

Cell type enhanced (Bergmann glia)

3 nearest neighbours based on single cell RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
SLC6A11	Solute carrier family 6 member 11	0.5507	28
VIP	Vasoactive intestinal peptide	0.5440	109
MAGED4B	MAGE family member D4B	0.5110	98

ZIC3

Cell type enhanced (Bergmann glia, Brain excitatory neurons, Choroid plexus epithelial cells, Ependymal cells, Müller glia, Other brain neurons, Undifferentiated spermatogonia)

3 nearest neighbours based on single cell RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
ZIC2	Zic family member 2	0.8023	2
PPT2	Palmitoyl-protein thioesterase 2	0.7380	104
EGFL8	EGF like domain multiple 8	0.7245	104

ZNF99

Cell type enhanced (Differentiating spermatogonia, Distal convoluted tubule cells, Early primary spermatocytes, Epididymal clear cells, Late primary spermatocytes, Oligodendrocyte progenitor cells, Renal collecting duct intercalated cells, Renal collecting duct principal cells, Renal connecting tubule cells, Retinal bipolar cells, Undifferentiated spermatogonia)

3 nearest neighbours based on single cell RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
MAGEA9B	MAGE family member A9B	0.6283	3
MAGEA9	MAGE family member A9	0.6184	3
TERB1	Telomere repeat binding bouquet formation protein 1	0.6155	3

ARNT2

Cell type enhanced (Astrocytes, Bergmann glia, Brain excitatory neurons, Brain inhibitory neurons, Choroid plexus epithelial cells, Distal convoluted tubule cells, Ependymal cells, Oligodendrocyte progenitor cells, Pituicytes/FSCs, Renal collecting duct intercalated cells, Sertoli cells)

3 nearest neighbours based on single cell RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
PRICKLE4	Prickle planar cell polarity protein 4	0.6661	104
HILPDA	Hypoxia inducible lipid droplet associated	0.6441	104
ARHGEF10	Rho guanine nucleotide exchange factor 10	0.6059	104

FOXB1

Cell type enhanced (Astrocytes, Early spermatids, Endometrial ciliated cells, Endometrial glandular cells, Ependymal cells, Fallopian tube ciliated cells, Late primary spermatocytes, Late spermatids)

3 nearest neighbours based on single cell RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
TMEM170A	Transmembrane protein 170A	0.5290	77
ENSG00000251012	Novel chromosome 3 open reading frame 30 (C3orf30) and uroplakin 1B (UPK1B)	0.5192	77
EBLN1	Endogenous Bornavirus like nucleoprotein 1	0.5155	77

LHX2

Cell type enhanced (Astrocytes, Early spermatids, Hepatic stellate cells, Late spermatids, Müller glia, Pituicytes/FSCs, Retinal pigment epithelial cells)

3 nearest neighbours based on single cell RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
WIF1	WNT inhibitory factor 1	0.8038	11
RAX	Retina and anterior neural fold homeobox	0.7293	11
SIX3	SIX homeobox 3	0.7252	11

MEF2B

Cell type enhanced (Astrocytes, Bergmann glia, Choroid plexus epithelial cells, Ependymal cells, Microglia, Oligodendrocyte progenitor cells, Oligodendrocytes)

3 nearest neighbours based on single cell RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
SMARCB1	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily b, member 1	0.5791	67
PMF1	Polyamine modulated factor 1	0.5559	22
TXNDC5	Thioredoxin domain containing 5	0.5364	67

SOX21

Cell type enhanced (Astrocytes, Conjunctival goblet cells, Ependymal cells, Esophageal apical cells, Esophageal suprabasal cells, Foveolar cells, Gastric chief cells, Mucous neck cells, Oligodendrocyte progenitor cells, Respiratory basal cells, Respiratory deuterosomal cells, Respiratory secretory cells)

3 nearest neighbours based on single cell RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
MUC5AC	Mucin 5AC, oligomeric mucus/gel-forming	0.8408	68
MUCL3	Mucin like 3	0.8337	68
TFF2	Trefoil factor 2	0.8292	68

ZGPAT

Cell type enhanced (Astrocytes, Bergmann glia, Brain excitatory neurons, Brain inhibitory neurons, Cardiomyocytes, Choroid plexus epithelial cells, Ependymal cells, Epicardial cells, Microglia, Oligodendrocyte progenitor cells, Oligodendrocytes, Other brain neurons, Tuft cells)

3 nearest neighbours based on single cell RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
VPS33A	VPS33A core subunit of CORVET and HOPS complexes	0.6330	22
SRCAP	Snf2 related CREBBP activator protein	0.6115	22
PRORP	Protein only RNase P catalytic subunit	0.6084	22

AIRE

Cell type enhanced (Astrocytes, Brain excitatory neurons, Brain inhibitory neurons, Epididymal efferent duct absorptive cells, Fibroblasts, Other brain neurons, Peritubular myoid cells)

3 nearest neighbours based on single cell RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
OTP	Orthopedia homeobox	0.7470	109
AVP	Arginine vasopressin	0.6947	109
OXT	Oxytocin/neurophysin I prepropeptide	0.6867	109

CEBPA

Cell type enhanced (Alveolar cells type 2, Cholangiocytes, Colonocytes, Hepatocytes, Hofbauer cells, Microglia, Monocyte progenitors, Suprabasal keratinocytes, Syncytiotrophoblasts)

3 nearest neighbours based on single cell RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
GDE1	Glycerophosphodiester phosphodiesterase 1	0.5461	39
TINCR	TINCR ubiquitin domain containing	0.5447	13
ZNF703	Zinc finger protein 703	0.5311	39

FEZF2

Cell type enhanced (Astrocytes, Brain excitatory neurons, Oocytes, Retinal bipolar cells)

3 nearest neighbours based on single cell RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
BLACAT1	BLACAT1 overlapping LEMD1 locus	0.8112	86
GABRA5	Gamma-aminobutyric acid type A receptor subunit alpha5	0.7987	86
OR52E1	Olfactory receptor family 52 subfamily E member 1 (gene/pseudogene)	0.7921	86

FOXG1

Cell type enhanced (Astrocytes, Brain excitatory neurons, Brain inhibitory neurons, Ependymal cells, Medullary thymic epithelial cells, Oligodendrocyte progenitor cells, Other brain neurons)

3 nearest neighbours based on single cell RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
DLGAP2	DLG associated protein 2	0.7938	35
GRIN2B	Glutamate ionotropic receptor NMDA type subunit 2B	0.7040	35
MCHR2	Melanin concentrating hormone receptor 2	0.7035	35

NHLH2

Cell type enhanced (Basal keratinocytes, Brain excitatory neurons, Breast myoepithelial cells, Early primary spermatocytes, Ependymal cells, Epididymal basal cells, Esophageal basal cells, Esophageal suprabasal cells, Oligodendrocytes, Other brain neurons, Retinal amacrine cells, Retinal ganglion cells, Suprabasal keratinocytes, Thymic myoid cells, Undifferentiated spermatogonia)

3 nearest neighbours based on single cell RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
KLHL1	Kelch like family member 1	0.6535	109
SLC17A6	Solute carrier family 17 member 6	0.6410	98
STMN2	Stathmin 2	0.6179	98

OTX1

Cell type enhanced (Astrocytes, Conjunctival goblet cells, Ependymal cells, Lacrimal acinar cells, Neutrophils, Ocular epithelial cells, Respiratory basal cells, Respiratory deuterosomal cells, Respiratory ionocytes, Respiratory secretory cells, Salivary basal cells, Salivary duct cells, Salivary ionocytes)

3 nearest neighbours based on single cell RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
SCGB3A1	Secretoglobin family 3A member 1	0.7078	38
BPIFB1	BPI fold containing family B member 1	0.7043	38
CYP2F1	Cytochrome P450 family 2 subfamily F member 1	0.7006	38

POU2F2

Cell type enhanced (B-cells, cDC, Early primary spermatocytes, Kupffer cells, Macrophages, Microglia, Monocyte progenitors, monocytes, Neutrophils, Plasma cells, Retinal bipolar cells)

3 nearest neighbours based on single cell RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
SCIMP	SLP adaptor and CSK interacting membrane protein	0.7433	87
CD1D	CD1d molecule	0.6737	40
FGD2	FYVE, RhoGEF and PH domain containing 2	0.6346	40

POU3F1

Cell type enhanced (Basal keratinocytes, Bergmann glia, Breast lactating cells, Breast myoepithelial cells, Epididymal basal cells, Schwann cells, Suprabasal keratinocytes, Urothelial cells)

3 nearest neighbours based on single cell RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
THSD8	Thrombospondin type 1 domain containing 8	0.6877	65
H2AX	H2A.X variant histone	0.6696	20
UBE2S	Ubiquitin conjugating enzyme E2 S	0.6592	20

RFX4

Cell type enhanced (Astrocytes, Bergmann glia, Early primary spermatocytes, Ependymal cells, Late primary spermatocytes, Pituitary stem cells, Somatotrophs)

3 nearest neighbours based on single cell RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
SERPINA3	Serpin family A member 3	0.8352	28
GFAP	Glial fibrillary acidic protein	0.8241	28
GTF2A1L	General transcription factor IIA subunit 1 like	0.8105	28

RORB

Cell type enhanced (Astrocytes, Cone photoreceptor cells, Corticotrophs, Decidual stromal cells, Endometrial stromal cells, Müller glia, Retinal amacrine cells, Retinal horizontal cells, Retinal pigment epithelial cells, Rod photoreceptor cells)

3 nearest neighbours based on single cell RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
HOXA11	Homeobox A11	0.7047	108
HOXD11	Homeobox D11	0.6595	108
GDF7	Growth differentiation factor 7	0.6170	108

SIX6

Cell type enhanced (Cone photoreceptor cells, Lactotrophs, Müller glia, Pituicytes/FSCs, Pituitary stem cells, Retinal horizontal cells, Thyrotrophs)

3 nearest neighbours based on single cell RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
RAX	Retina and anterior neural fold homeobox	0.9285	11
CRABP1	Cellular retinoic acid binding protein 1	0.9086	11
NPVF	Neuropeptide VF precursor	0.8959	11

SP140

Cell type enhanced (B-cells, Innate lymphoid cells, Microglia, NK-cells, Plasma cells, T-cells)

3 nearest neighbours based on single cell RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
MS4A1	Membrane spanning 4-domains A1	0.7686	87
CD70	CD70 molecule	0.7649	87
TMEM156	Transmembrane protein 156	0.7421	87

TOX

Cell type enhanced (Alveolar cells type 2, Bergmann glia, Gonadotrophs, Innate lymphoid cells, Neuroendocrine cells, NK-cells, Oligodendrocyte progenitor cells, Renal collecting duct principal cells, Renal connecting tubule cells, Sertoli cells, T-cells, Thymocytes)

3 nearest neighbours based on single cell RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
TMSB15B	Thymosin beta 15B	0.5508	76
TOX2	TOX high mobility group box family member 2	0.4968	92
CCR9	C-C motif chemokine receptor 9	0.4909	9

DMRTC1

Cell type enhanced (Brain excitatory neurons, Brain inhibitory neurons, Cone photoreceptor cells, Early primary spermatocytes, Gonadotrophs, Lactotrophs, Oligodendrocyte progenitor cells, Other brain neurons, Rod photoreceptor cells, Sertoli cells, Somatotrophs, Thyrotrophs)

3 nearest neighbours based on single cell RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
DZIP3	DAZ interacting zinc finger protein 3	0.5695	34
GAGE10	G antigen 10	0.5580	59
PRDM7	PR/SET domain 7	0.5563	3

NKX2-8

Cell type enhanced (Esophageal apical cells, Esophageal basal cells, Esophageal suprabasal cells, Late spermatids, Oocytes, Pituicytes/FSCs, Respiratory ciliated cells, Respiratory ionocytes, Sertoli cells, Transitional alveolar cells)

3 nearest neighbours based on single cell RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
GJB5	Gap junction protein beta 5	0.5765	85
HSPB1	Heat shock protein family B (small) member 1	0.5663	85
S100A2	S100 calcium binding protein A2	0.5610	85

OVOL3

Cell type enhanced (Cone photoreceptor cells, Early primary spermatocytes, Müller glia, Myonuclei, Plasma cells, Respiratory ionocytes, Rod photoreceptor cells, Tuft cells)

3 nearest neighbours based on single cell RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
OR14A16	Olfactory receptor family 14 subfamily A member 16	0.5240	95
IGHV1-69-2	Immunoglobulin heavy variable 1-69-2	0.4849	44
IGKV1D-39	Immunoglobulin kappa variable 1D-39	0.4815	44

SALL3

Cell type enhanced (Astrocytes, Distal convoluted tubule cells, Ependymal cells, Oligodendrocyte progenitor cells, Renal connecting tubule cells)

3 nearest neighbours based on single cell RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
PTPRZ1	Protein tyrosine phosphatase receptor type Z1	0.6579	14
ENSG00000276256		0.6551	14
ASAP3	ArfGAP with SH3 domain, ankyrin repeat and PH domain 3	0.6454	28

TAL2

Cell type enhanced (B-cells, Differentiating spermatogonia, Distal convoluted tubule cells, Müller glia, Myonuclei, Other brain neurons, Somatotrophs)

3 nearest neighbours based on single cell RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
TNFRSF13C	TNF receptor superfamily member 13C	0.5154	87
QRSL1	Glutaminyl-tRNA amidotransferase subunit QRSL1	0.5068	87
BEND4	BEN domain containing 4	0.5063	87

TRPS1

Cell type enhanced (Adipocytes, Astrocytes, Bergmann glia, Breast hormone-responsive cells, Breast secretory cells, Ependymal cells)

3 nearest neighbours based on single cell RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
VENTX	VENT homeobox	0.4701	72
NOD2	Nucleotide binding oligomerization domain containing 2	0.4456	40
SRGAP1	SLIT-ROBO Rho GTPase activating protein 1	0.4403	74

ZNF534

Cell type enhanced (Bergmann glia, Brain excitatory neurons, Brain inhibitory neurons, Differentiating spermatogonia, Early primary spermatocytes, Oocytes, Retinal amacrine cells, Retinal horizontal cells, Undifferentiated spermatogonia)

3 nearest neighbours based on single cell RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
CAMKV	CaM kinase like vesicle associated	0.5939	35
KCNJ4	Potassium inwardly rectifying channel subfamily J member 4	0.5819	35
MGAT5B	Alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase B	0.5680	35

ARID5A

Cell type enhanced (Breast secretory cells, Hofbauer cells, Neutrophils, Schwann cells, Smooth muscle cells, Vascular endothelial cells, Vascular smooth muscle cells)

3 nearest neighbours based on single cell RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
ADAMTS9	ADAM metallopeptidase with thrombospondin type 1 motif 9	0.5767	32
CCL2	C-C motif chemokine ligand 2	0.5521	103
IL6	Interleukin 6	0.5421	103

ASCL1

Cell type enhanced (Bergmann glia, Corticotrophs, Medullary thymic epithelial cells, Neuroendocrine cells, Oligodendrocyte progenitor cells, Pancreatic islet cells)

3 nearest neighbours based on single cell RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
CHGB	Chromogranin B	0.7201	76
NKX2-2	NK2 homeobox 2	0.7050	96
RAB3B	RAB3B, member RAS oncogene family	0.6665	76

ASCL4

Cell type enhanced (cDC, Epicardial cells, Microglia, Respiratory ionocytes, Retinal ganglion cells)

3 nearest neighbours based on single cell RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
CX3CR1	C-X3-C motif chemokine receptor 1	0.7547	74
LILRB4	Leukocyte immunoglobulin like receptor B4	0.7542	74
FGF20	Fibroblast growth factor 20	0.7260	74

ATF6B

Cell type enhanced (Astrocytes, Bergmann glia, Brain excitatory neurons, Brain inhibitory neurons, Choroid plexus epithelial cells, Distal convoluted tubule cells, Loop of henle epithelial cells, Microglia, Oligodendrocyte progenitor cells, Oligodendrocytes, Papillary tip epithelial cells, Podocytes, Proximal tubule cells, Renal collecting duct intercalated cells, Renal collecting duct principal cells, Renal connecting tubule cells)

3 nearest neighbours based on single cell RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
DDX51	DEAD-box helicase 51	0.7224	102
TNK1	Tyrosine kinase non receptor 1	0.6604	102
PANK4	Pantothenate kinase 4 (inactive)	0.6513	98

ATF7

Cell type enhanced (Astrocytes, Bergmann glia, Brain excitatory neurons, Brain inhibitory neurons, Choroid plexus epithelial cells, Ependymal cells, Microglia, Oligodendrocyte progenitor cells, Oligodendrocytes, Other brain neurons)

3 nearest neighbours based on single cell RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
ZC3H11A	Zinc finger CCCH-type containing 11A	0.7377	22
ANKHD1	Ankyrin repeat and KH domain containing 1	0.7254	22
SPECC1L	Sperm antigen with calponin homology and coiled-coil domains 1 like	0.7077	22

ATOH8

Cell type enhanced (Alveolar cells type 1, Endometrial glandular cells, Hepatocytes, Late spermatids, Myosatellite cells, Pituicytes/FSCs, Podocytes, Prostatic club cells, Schwann cells, Thymic myoid cells, Vascular endothelial cells)

3 nearest neighbours based on single cell RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
FZD8	Frizzled class receptor 8	0.5762	91
CD300LG	CD300 molecule like family member g	0.5429	32
GPIHBP1	Glycosylphosphatidylinositol anchored high density lipoprotein binding protein 1	0.4953	32

BATF3

Cell type enhanced (Breast lactating cells, cDC, Choroid plexus epithelial cells, Extravillous trophoblasts, Hepatic stellate cells, Kupffer cells, Macrophages, Microglia, Migrating cytotrophoblasts, Pericytes, Vascular smooth muscle cells)

3 nearest neighbours based on single cell RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
CLEC9A	C-type lectin domain containing 9A	0.8370	82
GPR31	G protein-coupled receptor 31	0.8358	82
C1orf54	Chromosome 1 open reading frame 54	0.8335	82

BHLHE41

Cell type enhanced (Epididymal efferent duct absorptive cells, Epididymal efferent duct ciliated cells, Fallopian secretory cells, Hofbauer cells, Microglia, Müller glia, Retinal bipolar cells, Retinal horizontal cells, Rod photoreceptor cells)

3 nearest neighbours based on single cell RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
FAM149A	Family with sequence similarity 149 member A	0.6043	74
P2RY12	Purinergic receptor P2Y12	0.5734	74
HS3ST4	Heparan sulfate-glucosamine 3-sulfotransferase 4	0.5697	74

BNC2

Cell type enhanced (Adipocytes, Epicardial cells, Fibro-adipogenic progenitors, Leydig cells, Mast cells, Melanocytes, Mesothelial cells, Microglia, Myonuclei, Ovarian stromal cells, Peritubular myoid cells, Pituitary stem cells, Proximal tubule cells)

3 nearest neighbours based on single cell RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
EVC2	EvC ciliary complex subunit 2	0.5419	108
PWWP3B	PWWP domain containing 3B	0.5232	94
MMP23B	Matrix metallopeptidase 23B	0.5165	94

CREB5

Cell type enhanced (Fibro-adipogenic progenitors, Neutrophils, Oligodendrocytes, Pancreatic duct cells, Schwann cells)

3 nearest neighbours based on single cell RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
PHF21A	PHD finger protein 21A	0.7876	24
VMP1	Vacuole membrane protein 1	0.7604	24
PROK2	Prokineticin 2	0.7574	24

CSRNP3

Cell type enhanced (Brain excitatory neurons, Brain inhibitory neurons, Choroid plexus epithelial cells, Cone photoreceptor cells, Corticotrophs, Lacrimal acinar cells, Lactotrophs, Oligodendrocyte progenitor cells, Other brain neurons, Retinal pigment epithelial cells, Somatotrophs, Thyrotrophs)

3 nearest neighbours based on single cell RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
NBEA	Neurobeachin	0.5359	35
PLPPR5	Phospholipid phosphatase related 5	0.5316	35
SLC4A10	Solute carrier family 4 member 10	0.5291	101

DBP

Cell type enhanced (Müller glia, Retinal amacrine cells, Retinal bipolar cells, Retinal horizontal cells, Retinal pigment epithelial cells)

3 nearest neighbours based on single cell RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
VSX2	Visual system homeobox 2	0.6345	86
ZNF593OS	ZNF593 opposite strand	0.6327	100
CABP2	Calcium binding protein 2	0.5838	86

DLX2

Cell type enhanced (Adrenal medulla cells, Brain inhibitory neurons, Breast hormone-responsive cells, Breast secretory cells, Conjunctival goblet cells, Early spermatids, Innate lymphoid cells, Melanocytes, Other brain neurons, Schwann cells, Tuft cells)

3 nearest neighbours based on single cell RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
DLX1	Distal-less homeobox 1	0.5987	109
UBE2S	Ubiquitin conjugating enzyme E2 S	0.5809	20
CER1	Cerberus 1, DAN family BMP antagonist	0.5638	109

EBF4

Cell type enhanced (Basal prostatic cells, Endometrial stromal cells, Oligodendrocyte progenitor cells, Somatotrophs)

3 nearest neighbours based on single cell RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
TSHZ3	Teashirt zinc finger homeobox 3	0.4996	108
GPR173	G protein-coupled receptor 173	0.4509	59
FOXL2	Forkhead box L2	0.4501	94

ERF

Cell type enhanced (Epicardial cells, Epididymal clear cells, Fallopian secretory cells, Fallopian tube ciliated cells, Ocular epithelial cells, Schwann cells)

3 nearest neighbours based on single cell RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
PPRC1	PPARG related coactivator 1	0.4679	103
CCL2	C-C motif chemokine ligand 2	0.4591	103
SERTAD1	SERTA domain containing 1	0.4384	20

ESRRG

Cell type enhanced (Bergmann glia, Distal convoluted tubule cells, Loop of henle epithelial cells, Parietal cells, Renal collecting duct intercalated cells, Renal connecting tubule cells)

3 nearest neighbours based on single cell RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
GCGR	Glucagon receptor	0.8251	50
SLC12A3	Solute carrier family 12 member 3	0.8214	50
TMEM207	Transmembrane protein 207	0.7997	50

ETV1

Cell type enhanced (Adrenal cortex cells, Alveolar cells type 2, Bergmann glia, Brain excitatory neurons, Corticotrophs, Neuroendocrine cells, Oligodendrocyte progenitor cells, Salivary acinar cells)

3 nearest neighbours based on single cell RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
GRM4	Glutamate metabotropic receptor 4	0.6374	2
CBLN3	Cerebellin 3 precursor	0.6152	2
FGF3	Fibroblast growth factor 3	0.6083	2

ETV5

Cell type enhanced (Alveolar cells type 2, Bergmann glia, Hofbauer cells, Kupffer cells, Microglia, Mucous neck cells, Oligodendrocyte progenitor cells, Pituitary stem cells, Syncytiotrophoblasts)

3 nearest neighbours based on single cell RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
C1QA	Complement C1q A chain	0.5869	74
SPRED1	Sprouty related EVH1 domain containing 1	0.5444	72
CSF1R	Colony stimulating factor 1 receptor	0.5366	72

FEZF1

Cell type enhanced (Gastric progenitor cells, Late primary spermatocytes, Oocytes, Other brain neurons, Pituicytes/FSCs, Retinal bipolar cells)

3 nearest neighbours based on single cell RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
CARTPT	CART prepropeptide	0.6369	98
PNMA6F	PNMA family member 6F	0.6056	98
FNDC9	Fibronectin type III domain containing 9	0.5694	98

FLI1

Cell type enhanced (B-cells, Hematopoietic stem cells, Kupffer cells, Lymphatic endothelial cells, Macrophages, Megakaryocyte progenitors, Microglia, Monocyte progenitors, monocytes, Neutrophil progenitors, Neutrophils, NK-cells, Platelets, T-cells, Thymocytes, Vascular endothelial cells)

3 nearest neighbours based on single cell RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
CARD8	Caspase recruitment domain family member 8	0.6741	12
IKBKB	Inhibitor of nuclear factor kappa B kinase subunit beta	0.5735	12
CLEC1A	C-type lectin domain family 1 member A	0.5371	12

FOXD1

Cell type enhanced (Enterocytes, Fibroblasts, Late primary spermatocytes, Müller glia, Oocytes, Pericytes, Podocytes, Respiratory basal cells, Respiratory deuterosomal cells, Respiratory ionocytes, Retinal bipolar cells, Retinal ganglion cells, Retinal pigment epithelial cells, Smooth muscle cells, Thymic myoid cells)

3 nearest neighbours based on single cell RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
ENSG00000284779	Novel protein	0.6579	22
MUSTN1	Musculoskeletal, embryonic nuclear protein 1	0.6516	22
ISLR	Immunoglobulin superfamily containing leucine rich repeat	0.6246	22

FOXD3

Cell type enhanced (Melanocytes, Schwann cells, Thymic myoid cells)

3 nearest neighbours based on single cell RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
MPZ	Myelin protein zero	0.9625	61
CDH19	Cadherin 19	0.9534	61
SCN7A	Sodium voltage-gated channel alpha subunit 7	0.7592	61

FOXN2

Cell type enhanced (cDC, Monocyte progenitors, Neutrophil progenitors, Neutrophils, Oligodendrocyte progenitor cells, Oligodendrocytes)

3 nearest neighbours based on single cell RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
KDM1B	Lysine demethylase 1B	0.4607	37
CPNE3	Copine 3	0.4323	37
APAF1	Apoptotic peptidase activating factor 1	0.4224	37

FOXP2

Cell type enhanced (Loop of henle epithelial cells, Microglia, Müller glia, Myonuclei, Myosatellite cells, Respiratory basal cells, Respiratory ciliated cells, Salivary acinar cells)

3 nearest neighbours based on single cell RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
SIX1	SIX homeobox 1	0.4342	38
ABI3BP	ABI family member 3 binding protein	0.4160	108
CPED1	Cadherin like and PC-esterase domain containing 1	0.4047	36

GATAD1

Cell type enhanced (Oligodendrocytes)

3 nearest neighbours based on single cell RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
KLHDC1	Kelch domain containing 1	0.5606	7
ZNF322	Zinc finger protein 322	0.5469	7
ZSCAN30	Zinc finger and SCAN domain containing 30	0.4766	55

GLI2

Cell type enhanced (Astrocytes, Bergmann glia, Early spermatids, Ependymal cells, Epicardial cells, Fibro-adipogenic progenitors, Hepatic stellate cells, Lactotrophs, Late spermatids, Leydig cells, Mesothelial cells, Myosatellite cells, Ovarian stromal cells, Peritubular myoid cells, Somatotrophs, Thyrotrophs)

3 nearest neighbours based on single cell RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
PTCH1	Patched 1	0.6155	94
GPR173	G protein-coupled receptor 173	0.5995	59
SYTL4	Synaptotagmin like 4	0.5746	59

GLI3

Cell type enhanced (Astrocytes, Cytotrophoblasts, Fibro-adipogenic progenitors, Medullary thymic epithelial cells, Mesothelial cells, Pituicytes/FSCs, Syncytiotrophoblasts)

3 nearest neighbours based on single cell RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
BOC	BOC cell adhesion associated, oncogene regulated	0.6533	91
GFRA1	GDNF family receptor alpha 1	0.5511	91
SVEP1	Sushi, von Willebrand factor type A, EGF and pentraxin domain containing 1	0.5418	108

GLIS2

Cell type enhanced (Astrocytes, Choroid plexus epithelial cells, Distal convoluted tubule cells, Loop of henle epithelial cells, Oligodendrocyte progenitor cells, Papillary tip epithelial cells, Podocytes, Proximal tubule cells, Renal collecting duct intercalated cells, Renal collecting duct principal cells, Renal connecting tubule cells)

3 nearest neighbours based on single cell RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
PALM3	Paralemmin 3	0.8408	64
POU5F1	POU class 5 homeobox 1	0.7382	88
ENSG00000250349	Novel proline rich Gla (G-carboxyglutamic acid) 1 (PRRG1) and tetraspanin 7 (TSPAN7) protein	0.7260	64

GLIS3

Cell type enhanced (Astrocytes, Choroid plexus epithelial cells, Endometrial glandular cells, Ependymal cells, Pancreatic duct cells, Pituicytes/FSCs, Renal collecting duct intercalated cells, Renal collecting duct principal cells, Renal connecting tubule cells)

3 nearest neighbours based on single cell RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
DCDC2	Doublecortin domain containing 2	0.5553	51
GRAMD2B	GRAM domain containing 2B	0.5152	51
ITGB8	Integrin subunit beta 8	0.5077	51

HAND2

Cell type enhanced (Adrenal medulla cells, Decidual stromal cells, Endometrial stromal cells, Epicardial cells, Hepatic stellate cells, Ovarian stromal cells, Schwann cells, Smooth muscle cells)

3 nearest neighbours based on single cell RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
CPXM1	Carboxypeptidase X, M14 family member 1	0.8269	108
HOXA11	Homeobox A11	0.7749	108
FOXL2	Forkhead box L2	0.7524	94

HES1

Cell type enhanced (Colonocytes, Enteric stem cells, Enteric transient amplifying cells, Epididymal basal cells, Epididymal efferent duct absorptive cells, Epididymal principal cells, Esophageal apical cells, Granulosa cells, Müller glia, Prostatic club cells, Prostatic hillock cells)

3 nearest neighbours based on single cell RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
ENSG00000262660	Novel protein	0.6372	54
SQSTM1	Sequestosome 1	0.5698	65
HOXD1	Homeobox D1	0.5578	54

HEY2

Cell type enhanced (Bergmann glia, Cardiomyocytes, Endometrial luminal cells, Epididymal principal cells, Fallopian tube ciliated cells, Granulosa cells, Late primary spermatocytes, Late spermatids, Müller glia, Oocytes, Pituitary stem cells, Vascular smooth muscle cells)

3 nearest neighbours based on single cell RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
RGS6	Regulator of G protein signaling 6	0.5448	103
RERGL	RERG like	0.5099	62
JAG1	Jagged canonical Notch ligand 1	0.5024	32

HIF3A

Cell type enhanced (Astrocytes, Bergmann glia, Cardiomyocytes, Hematopoietic stem cells, Leydig cells, Lymphatic endothelial cells, Medullary thymic epithelial cells, Müller glia, Oligodendrocyte progenitor cells, Peritubular myoid cells, Vascular endothelial cells)

3 nearest neighbours based on single cell RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
THSD1	Thrombospondin type 1 domain containing 1	0.5957	32
SPTBN1	Spectrin beta, non-erythrocytic 1	0.5644	32
SEMA3D	Semaphorin 3D	0.5344	32

HIVEP3

Cell type enhanced (Corticotrophs, Lactotrophs, Microglia, Retinal amacrine cells, Retinal horizontal cells, Thymocytes, Thyrotrophs)

3 nearest neighbours based on single cell RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
NCK1	NCK adaptor protein 1	0.4250	7
RNF165	Ring finger protein 165	0.4157	109
JAKMIP2	Janus kinase and microtubule interacting protein 2	0.4133	59

HLF

Cell type enhanced (Distal convoluted tubule cells, Hematopoietic stem cells, Hepatocytes, Müller glia, Renal connecting tubule cells, Retinal amacrine cells, Retinal bipolar cells, Retinal horizontal cells, Thyrotrophs)

3 nearest neighbours based on single cell RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
GPR85	G protein-coupled receptor 85	0.5799	104
CT45A9	Cancer/testis antigen family 45 member A9	0.5580	104
ABCG2	ATP binding cassette subfamily G member 2 (Junior blood group)	0.5412	104

HMBOX1

Cell type enhanced (Adrenal cortex cells, Pituicytes/FSCs, Renal collecting duct intercalated cells)

3 nearest neighbours based on single cell RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
CALCRL	Calcitonin receptor like receptor	0.8915	12
TEK	TEK receptor tyrosine kinase	0.8504	12
WWTR1	WW domain containing transcription regulator 1	0.7994	12

HMGA2

Cell type enhanced (Endometrial secretory cells, Erythrocyte progenitors, Granulosa cells, Hematopoietic stem cells, Megakaryocyte progenitors, Megakaryocyte-Erythroid progenitors, Pituicytes/FSCs)

3 nearest neighbours based on single cell RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
LGR6	Leucine rich repeat containing G protein-coupled receptor 6	0.6482	91
SLCO1C1	Solute carrier organic anion transporter family member 1C1	0.6345	91
COL25A1	Collagen type XXV alpha 1 chain	0.6192	91

HOXC11

Cell type enhanced (Basal keratinocytes, Early primary spermatocytes, Enterocytes, Gastric progenitor cells, Myosatellite cells, Schwann cells, Smooth muscle cells, Suprabasal keratinocytes)

3 nearest neighbours based on single cell RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
OR11H2	Olfactory receptor family 11 subfamily H member 2	0.7534	103
HOXC10	Homeobox C10	0.7403	108
HOXC9	Homeobox C9	0.7325	108

HOXD1

Cell type enhanced (Colonocytes, Enteric stem cells, Enteric transient amplifying cells, Enterocytes, Epididymal basal cells, Epididymal clear cells, Epididymal efferent duct absorptive cells, Epididymal efferent duct ciliated cells, Epididymal principal cells, Fallopian tube ciliated cells, Goblet cells, Oligodendrocytes, Oocytes, Paneth cells, Tuft cells)

3 nearest neighbours based on single cell RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
RNF186	Ring finger protein 186	0.6512	54
HOXB9	Homeobox B9	0.6226	95
HES1	Hes family bHLH transcription factor 1	0.5578	54

HSF1

Cell type enhanced (Astrocytes, Bergmann glia, Brain excitatory neurons, Choroid plexus epithelial cells, Distal convoluted tubule cells, Ependymal cells, Loop of henle epithelial cells, Microglia, Oligodendrocytes, Other brain neurons, Papillary tip epithelial cells, Podocytes, Proximal tubule cells, Renal collecting duct intercalated cells, Renal collecting duct principal cells, Renal connecting tubule cells)

3 nearest neighbours based on single cell RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
NUP160	Nucleoporin 160	0.7616	102
TRIM27	Tripartite motif containing 27	0.7532	102
POLR2A	RNA polymerase II subunit A	0.7378	102

HSF4

Cell type enhanced (Adrenal medulla cells, Astrocytes, Hofbauer cells, Leydig cells, Melanocytes, Myonuclei, Peritubular myoid cells, Retinal ganglion cells)