The core T-cell enriched transcriptome
A T-cell, or T lymphocyte, is a type of white blood cell that plays a central role in cell-mediated immunity. They mature in the thymus and can be distinguished from other lymphocytes, by the presence of a T-cell receptor on the cell surface. There are several subsets of T-cells, such as cytotoxic T-cells, regulatory T-cells, helper T-cells and natural killer T-cells, with functions related to both innate and adaptive immunity.
In this section we detail the predicted core T-cell transcriptome, highlighting genes classified as having predicted specificity in T-cells in multiple tissue types. Such genes could be useful general markers for T-cells across tissue beds, and are likely critical for T-cell specific functions. These genes are sub-divided into 3 categories, based on the number of tissues in which they were independently classified as T-cell enriched.
Protein expression of genes enriched in T-cells across tissue types
An example of a protein with enriched expression in T-cells across multiple tissue types is RAS Protein Activator Like 3 (RASAL3), which is implicated as a negative regulator of the Ras signaling pathway, which is linked to the control of cellular proliferation, differentiation and survival.
Another example of a protein with enriched expression in T-cells across multiple tissue types is TBC1 Domain Family Member 10C (TBC1D10C), which is also thought to be a negative regulator of the Ras signaling pathway.
T-cell surface antigen (CD2) is a characteristic marker of T-cells that mediates interactions with antigen presenting cells, and has enriched expression in T-cells in almost all tissues.
Genes with predicted specificity in T-cells in individual tissues
A summary table of all genes with predicted high enrichment in t-cells in profiled tissues is provided below. Identified genes are subdivided into 3 categories in each tissue, based on the difference between the enrichment score in t-cells, compared to the other cell types profiled (see Methods Summary page for details):