[{"Gene":"CASP1","Gene synonym":["ICE","IL1BC"],"Ensembl":"ENSG00000137752","Gene description":"Caspase 1","Uniprot":["P29466"],"Chromosome":"11","Position":"105025397-105035250","Protein class":["Cancer-related genes","Enzymes","Predicted intracellular proteins"],"Biological process":["Apoptosis"],"Molecular function":["Hydrolase","Protease","Thiol protease"],"Disease involvement":["Cancer-related genes"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in many","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"intestine":"122.0","lymphoid tissue":"87.0"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"cDC":"113.2","Enteric transient amplifying cells":"83.5","Enterocytes":"94.8","Esophageal basal cells":"56.1","Hofbauer cells":"134.6","Kupffer cells":"117.9","Macrophages":"76.0","Monocyte progenitors":"67.1","monocytes":"165.4","Neutrophils":"134.4"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"dendritic cells":"113.2","Enterocytes":"94.8","Mononuclear phagocytes":"165.4","Neutrophils":"134.4"},"RNA single nuclei brain specificity":"Group enriched","RNA single nuclei brain distribution":"Detected in some","RNA single nuclei brain specificity score":"5","RNA single nuclei brain specific nCPM":{"central nervous system macrophage":"38.9","endothelial cell":"12.0","leukocyte":"43.0"},"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in many","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Thyroid gland - T-cells"],"RNA mouse brain regional specificity":"Region enhanced","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":{"olfactory bulb":"18.4"},"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Cell type enhanced","Protein cell type distribution":"Detected in many","Protein cell type specificity score":null,"Protein cell type specific Intensity":{"Macrophages":"20199769.8","T-cells":"10963816.8"},"Protein tissue specificity":"Tissue enhanced","Protein tissue distribution":"Detected in many","Protein tissue specificity score":null,"Protein tissue specific Intensity":{"intestine":"80962624.3"},"Antibody":["CAB002685","HPA003056"],"Reliability (IH)":"Approved","Reliability (Mouse Brain)":null,"Reliability (IF)":"Supported","Subcellular location":["Nucleoplasm","Cytosol"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 37: Monocytes & Neutrophils - Innate immune response","Tissue expression cluster":"Cluster 5: Spleen - Immune response","Brain expression cluster":"Cluster 12: Non-specific - Vasculature","Cell line expression cluster":"Cluster 31: Non-specific - Antiviral immune response","Single cell expression cluster":"Cluster 40: Monocytes & Neutrophils - Inflammatory signaling","Interactions":25,"Subcellular main location":["Cytosol"],"Subcellular additional location":["Nucleoplasm"],"Antibody RRID":{"CAB002685":null,"HPA003056":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.29e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.38e-3"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.10e-1"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.51e-1"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.37e-1"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.03e-2"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.66e-2"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.35e-1"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.01e-2"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.03e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.01e-1"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.00e-1"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.36e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.67e-3"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.01e-1"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.16e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.54e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.38e-3"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.91e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.48e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.87e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.16e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.29e-2"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.33e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.04e-2"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.47e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.46e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.25e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.25e-3"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.59e-1"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.75e-2"}},{"Gene":"CASP14","Gene synonym":["MGC119078","MGC119079","MICE"],"Ensembl":"ENSG00000105141","Gene description":"Caspase 14","Uniprot":["P31944"],"Chromosome":"19","Position":"15049480-15058293","Protein class":["Disease related genes","Enzymes","Human disease related genes","Plasma proteins","Potential drug targets","Predicted intracellular proteins"],"Biological process":["Differentiation"],"Molecular function":["Hydrolase","Protease","Thiol protease"],"Disease involvement":["Ichthyosis"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enriched","RNA tissue distribution":"Detected in some","RNA tissue specificity score":"13","RNA tissue specific nTPM":{"skin 1":"458.8"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in some","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Basal keratinocytes":"11.2","Extravillous trophoblasts":"5.6","Late spermatids":"6.2","Ocular epithelial cells":"23.8","Suprabasal keratinocytes":"64.8"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in some","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Barrier epithelial cells":"23.8","Basal cells":"11.2","Suprabasal cells":"64.8"},"RNA single nuclei brain specificity":"Not detected","RNA single nuclei brain distribution":"Not detected","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Group enriched","RNA cancer distribution":"Detected in many","RNA cancer specificity score":"5","RNA cancer specific pTPM":{"Bladder Urothelial Carcinoma (TCGA)":"104.3","Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":"122.4","Head and Neck Squamous Cell Carcinoma (TCGA)":"37.6","Skin Cutaneous Melanoma (TCGA)":"82.3"},"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Cancer enriched","RNA cell line distribution":"Detected in some","RNA cell line specificity score":"7","RNA cell line specific nTPM":{"breast cancer":"18.2"},"RNA tissue cell type enrichment":["Skin - Keratinocyte (other)","Testis - Late spermatids"],"RNA mouse brain regional specificity":"Not detected","RNA mouse brain regional distribution":"Not detected","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Not detected","RNA pig brain regional distribution":"Not detected","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Cell type enriched","Protein cell type distribution":"Detected in many","Protein cell type specificity score":null,"Protein cell type specific Intensity":{"Keratinocytes":"235440556.4"},"Protein tissue specificity":"Tissue enhanced","Protein tissue distribution":"Detected in all","Protein tissue specificity score":null,"Protein tissue specific Intensity":{"skin":"1867282549.4"},"Antibody":["CAB010059","HPA027062"],"Reliability (IH)":"Enhanced","Reliability (Mouse Brain)":null,"Reliability (IF)":"Supported","Subcellular location":["Nucleoplasm","Mitochondria","Cytosol"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":"18000000","Blood expression cluster":null,"Tissue expression cluster":"Cluster 37: Skin - Keratinization","Brain expression cluster":"Cluster 11: White matter - Signal transduction","Cell line expression cluster":"Cluster 53: Squamous epithelial cells - Keratinization","Single cell expression cluster":"Cluster 26: Keratinocytes - Keratinization","Interactions":25,"Subcellular main location":["Nucleoplasm","Cytosol"],"Subcellular additional location":["Mitochondria"],"Antibody RRID":{"CAB010059":null,"HPA027062":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.62e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.40e-3"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.19e-1"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.15e-2"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":null,"Cancer prognostics - Glioblastoma Multiforme (TCGA)":null,"Cancer prognostics - Glioblastoma Multiforme (validation)":null,"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.34e-1"},"Cancer prognostics - Kidney Chromophobe (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"2.55e-4"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":null,"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.51e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.42e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.50e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.79e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"6.14e-4"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"unfavorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"6.41e-4"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.98e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.09e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":null,"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.00e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.76e-2"}},{"Gene":"CASP10","Gene synonym":["FLICE-2","MCH4"],"Ensembl":"ENSG00000003400","Gene description":"Caspase 10","Uniprot":["Q92851"],"Chromosome":"2","Position":"201182872-201229428","Protein class":["Cancer-related genes","Disease related genes","Enzymes","Human disease related genes","Potential drug targets","Predicted intracellular proteins"],"Biological process":["Apoptosis"],"Molecular function":["Hydrolase","Protease","Thiol protease"],"Disease involvement":["Cancer-related genes","Disease variant"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Colonocytes":"66.8","Esophageal apical cells":"73.8","Neutrophil progenitors":"125.5","Neutrophils":"65.4","Ocular epithelial cells":"63.0","Plasma cells":"137.8","Urothelial cells":"63.4"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Neutrophils":"125.5","Plasma cells":"137.8"},"RNA single nuclei brain specificity":"Group enriched","RNA single nuclei brain distribution":"Detected in many","RNA single nuclei brain specificity score":"10","RNA single nuclei brain specific nCPM":{"central nervous system macrophage":"77.3","endothelial cell":"170.8","leukocyte":"55.1"},"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in many","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Cancer enhanced","RNA cell line distribution":"Detected in many","RNA cell line specificity score":null,"RNA cell line specific nTPM":{"Myeloma":"31.0"},"RNA tissue cell type enrichment":["Breast - Endothelial cells","Skeletal muscle - Endothelial cells","Thyroid gland - T-cells"],"RNA mouse brain regional specificity":null,"RNA mouse brain regional distribution":null,"RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Cell type enhanced","Protein cell type distribution":"Detected in many","Protein cell type specificity score":null,"Protein cell type specific Intensity":{"Macrophages":"2179632.8","Neutrophils":"2514554.2"},"Protein tissue specificity":"Tissue enhanced","Protein tissue distribution":"Detected in many","Protein tissue specificity score":null,"Protein tissue specific Intensity":{"Stomach":"5389807.8"},"Antibody":["CAB003780","HPA017059"],"Reliability (IH)":"Approved","Reliability (Mouse Brain)":null,"Reliability (IF)":"Approved","Subcellular location":["Golgi apparatus","Vesicles"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 2: Dendritic cells - Unknown function","Tissue expression cluster":"Cluster 5: Spleen - Immune response","Brain expression cluster":"Cluster 47: Endothelial cells - Vasculature","Cell line expression cluster":"Cluster 51: Myeloma - Immunoglobulins","Single cell expression cluster":"Cluster 37: Neutrophil progenitors - Granulopoiesis","Interactions":21,"Subcellular main location":["Golgi apparatus"],"Subcellular additional location":["Vesicles"],"Antibody RRID":{"CAB003780":null,"HPA017059":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.76e-3"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.90e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.52e-3"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.36e-1"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.63e-2"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.68e-2"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.82e-1"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.41e-1"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.29e-1"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.60e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.56e-3"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.08e-3"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.65e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"2.75e-4"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.01e-2"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.00e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.11e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.63e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.38e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.69e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.91e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.02e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.06e-1"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.75e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.22e-3"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.09e-1"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.03e-3"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.67e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.12e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.38e-1"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.43e-2"}},{"Gene":"CARD18","Gene synonym":["ICEBERG","pseudo-ICE","UNQ5804"],"Ensembl":"ENSG00000255501","Gene description":"Caspase recruitment domain family member 18","Uniprot":["P57730"],"Chromosome":"11","Position":"105137714-105531697","Protein class":["Predicted intracellular proteins"],"Biological process":null,"Molecular function":["Protease inhibitor","Thiol protease inhibitor"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enriched","RNA tissue distribution":"Detected in some","RNA tissue specificity score":"6","RNA tissue specific nTPM":{"skin 1":"40.1"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Bergmann glia":"96.0","Cytotrophoblasts":"141.8","Differentiating spermatogonia":"63.6","Early primary spermatocytes":"114.9","Early spermatids":"63.3","Extravillous trophoblasts":"86.3","Gastric progenitor cells":"107.7","Hofbauer cells":"78.9","Late primary spermatocytes":"66.5","Migrating cytotrophoblasts":"73.4","M\u00fcller glia":"113.5","Syncytiotrophoblasts":"72.6"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Glial cells":"113.5","Mononuclear phagocytes":"78.9","Proliferating cells":"107.7","Spermatogenic cell types":"114.9","Trophoblast cells":"141.8"},"RNA single nuclei brain specificity":"Cell type enhanced","RNA single nuclei brain distribution":"Detected in many","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":{"Bergmann glia":"97.7","cerebellar inhibitory":"45.6"},"RNA cancer specificity":"Cancer enhanced","RNA cancer distribution":"Detected in some","RNA cancer specificity score":null,"RNA cancer specific pTPM":{"Head and Neck Squamous Cell Carcinoma (TCGA)":"8.2"},"RNA brain regional specificity":"Not detected","RNA brain regional distribution":"Not detected","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Cancer enhanced","RNA cell line distribution":"Detected in some","RNA cell line specificity score":null,"RNA cell line specific nTPM":{"Gallbladder cancer":"4.7"},"RNA tissue cell type enrichment":["Skin - Sebaceous gland cells","Testis - Early spermatids","Testis - Late spermatids"],"RNA mouse brain regional specificity":null,"RNA mouse brain regional distribution":null,"RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":null,"RNA pig brain regional distribution":null,"RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Cell type enriched","Protein cell type distribution":"Detected in single","Protein cell type specificity score":"11788","Protein cell type specific Intensity":{"Keratinocytes":"1178789.0"},"Protein tissue specificity":"Tissue enriched","Protein tissue distribution":"Detected in some","Protein tissue specificity score":null,"Protein tissue specific Intensity":{"skin":"14553618.6"},"Antibody":["HPA038582"],"Reliability (IH)":"Approved","Reliability (Mouse Brain)":null,"Reliability (IF)":null,"Subcellular location":null,"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 37: Skin - Keratinization","Brain expression cluster":null,"Cell line expression cluster":"Cluster 51: Myeloma - Immunoglobulins","Single cell expression cluster":"Cluster 63: Cytotrophoblasts - Basic cellular functions","Interactions":1,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":{"HPA038582":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.04e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.93e-2"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":null,"Cancer prognostics - Glioblastoma Multiforme (TCGA)":null,"Cancer prognostics - Glioblastoma Multiforme (validation)":null,"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.86e-1"},"Cancer prognostics - Kidney Chromophobe (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":null,"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":null,"Cancer prognostics - Lung Adenocarcinoma (validation)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.11e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.71e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":null,"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":null,"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.81e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":null,"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.82e-2"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":null},{"Gene":"IL18","Gene synonym":["IGIF","IL-18","IL-1g","IL1F4"],"Ensembl":"ENSG00000150782","Gene description":"Interleukin 18","Uniprot":["Q14116"],"Chromosome":"11","Position":"112143253-112164096","Protein class":["Cancer-related genes","Candidate cardiovascular disease genes","Human disease related genes","Plasma proteins","Predicted intracellular proteins","Predicted secreted proteins"],"Biological process":["Inflammatory response"],"Molecular function":["Cytokine"],"Disease involvement":["Cancer-related genes"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"esophagus":"117.0","skin 1":"140.9"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Endometrial ciliated cells":"318.3","Esophageal apical cells":"2424.9","Kupffer cells":"460.2","Ocular epithelial cells":"815.7","Renal collecting duct intercalated cells":"638.3"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Apical squamous epithelial cells":"2424.9","Barrier epithelial cells":"815.7","Ductal cells":"638.3"},"RNA single nuclei brain specificity":"Cell type enriched","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":"8","RNA single nuclei brain specific nCPM":{"central nervous system macrophage":"338.5"},"RNA cancer specificity":"Cancer enhanced","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":{"Kidney Chromophobe (TCGA)":"141.4"},"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Immune cell enhanced","RNA blood cell distribution":"Detected in many","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":{"myeloid DC":"25.8"},"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in many","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in many","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Adipose subcutaneous - Macrophages","Adipose visceral - Mesothelial cells","Adrenal gland - Macrophages","Liver - Kupffer cells","Spleen - Macrophages"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Cell type enhanced","Protein cell type distribution":"Detected in many","Protein cell type specificity score":null,"Protein cell type specific Intensity":{"Keratinocytes":"6230368.3","Macrophages":"5084763.5"},"Protein tissue specificity":"Tissue enhanced","Protein tissue distribution":"Detected in many","Protein tissue specificity score":null,"Protein tissue specific Intensity":{"skin":"29074064.8"},"Antibody":["HPA003980","CAB007772"],"Reliability (IH)":"Enhanced","Reliability (Mouse Brain)":null,"Reliability (IF)":"Approved","Subcellular location":["Nucleoplasm","Golgi apparatus","Cytosol"],"Secretome location":"Secreted to blood","Secretome function":"Interleukin","CCD Protein":"NA","CCD Transcript":"Yes","Blood concentration - Conc. blood IM [pg\/L]":196000,"Blood concentration - Conc. blood MS [pg\/L]":"21000","Blood expression cluster":"Cluster 29: Non-specific - Unknown function","Tissue expression cluster":"Cluster 81: Squamous epithelium - Keratinization","Brain expression cluster":"Cluster 20: Macrophages & Microglia - Immune response","Cell line expression cluster":"Cluster 30: Non-specific - Gene expression regulation","Single cell expression cluster":"Cluster 84: Apical squamous epithelium - Cornification","Interactions":3,"Subcellular main location":["Nucleoplasm","Golgi apparatus"],"Subcellular additional location":["Cytosol"],"Antibody RRID":{"CAB007772":null,"HPA003980":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.17e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.04e-3"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.37e-2"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.22e-1"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.40e-3"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.32e-2"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.29e-2"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.14e-2"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.34e-2"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.19e-1"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.91e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.01e-2"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.25e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.12e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.77e-2"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.46e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.78e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.80e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.28e-3"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.71e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.60e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"4.43e-4"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"unfavorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"1.19e-4"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.40e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.56e-1"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.18e-1"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.34e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.94e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.75e-2"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.42e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.82e-1"}},{"Gene":"LRRFIP2","Gene synonym":["HUFI-2"],"Ensembl":"ENSG00000093167","Gene description":"LRR binding FLII interacting protein 2","Uniprot":["Q9Y608"],"Chromosome":"3","Position":"37052626-37183689","Protein class":["Predicted intracellular proteins","Transcription factors"],"Biological process":["Wnt signaling pathway"],"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in all","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Esophageal apical cells":"1232.3"},"RNA single cell type group specificity":"Low cell type specificity","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":null,"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Spleen - Endothelial cells","Testis - Early spermatids"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Cell type enhanced","Protein cell type distribution":"Detected in many","Protein cell type specificity score":null,"Protein cell type specific Intensity":{"Smooth muscle cells":"11154527.5"},"Protein tissue specificity":"Low tissue specificity","Protein tissue distribution":"Detected in all","Protein tissue specificity score":null,"Protein tissue specific Intensity":null,"Antibody":["HPA035956","HPA042023"],"Reliability (IH)":"Uncertain","Reliability (Mouse Brain)":null,"Reliability (IF)":"Approved","Subcellular location":["Plasma membrane","Actin filaments"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":"250000","Blood expression cluster":"Cluster 45: Eosinophils - Unknown function","Tissue expression cluster":"Cluster 52: Non-specific - Cellular respiration","Brain expression cluster":"Cluster 28: Oligodendrocytes - Mixed function","Cell line expression cluster":"Cluster 8: Non-specific - Basic cellular processes","Single cell expression cluster":"Cluster 51: Secretory epithelial cells - Mixed function","Interactions":13,"Subcellular main location":["Plasma membrane","Actin filaments"],"Subcellular additional location":null,"Antibody RRID":{"HPA035956":null,"HPA042023":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.39e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.88e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.62e-2"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.43e-1"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.02e-2"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.92e-1"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.69e-1"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.73e-2"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.04e-1"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"5.04e-6"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.42e-3"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.87e-2"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"5.75e-4"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.02e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.69e-1"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.88e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.70e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.02e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.82e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.89e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.65e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.41e-3"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.19e-2"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.50e-3"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.85e-1"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.47e-1"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.95e-2"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.56e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.17e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"8.11e-4"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.58e-2"}},{"Gene":"NLRP10","Gene synonym":["CLR11.1","NALP10","NOD8","PAN5","Pynod"],"Ensembl":"ENSG00000182261","Gene description":"NLR family pyrin domain containing 10","Uniprot":["Q86W26"],"Chromosome":"11","Position":"7957537-7965447","Protein class":["Plasma proteins","Predicted intracellular proteins"],"Biological process":["Adaptive immunity","Immunity","Inflammatory response","Innate immunity"],"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Group enriched","RNA tissue distribution":"Detected in some","RNA tissue specificity score":"11","RNA tissue specific nTPM":{"breast":"1.3","skin 1":"4.6"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in single","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Papillary tip epithelial cells":"1.3"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in single","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Renal nephron cells":"1.3"},"RNA single nuclei brain specificity":"Not detected","RNA single nuclei brain distribution":"Not detected","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Not detected","RNA cancer distribution":"Not detected","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in single","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Skin - Keratinocyte (granular)"],"RNA mouse brain regional specificity":"Region enhanced","RNA mouse brain regional distribution":"Detected in some","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":{"olfactory bulb":"2.1"},"RNA pig brain regional specificity":null,"RNA pig brain regional distribution":null,"RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Cell type enriched","Protein cell type distribution":"Detected in single","Protein cell type specificity score":"25272","Protein cell type specific Intensity":{"Keratinocytes":"2527164.2"},"Protein tissue specificity":"Not detected","Protein tissue distribution":"Not detected","Protein tissue specificity score":null,"Protein tissue specific Intensity":null,"Antibody":["HPA039498","HPA040101"],"Reliability (IH)":"Uncertain","Reliability (Mouse Brain)":null,"Reliability (IF)":"Approved","Subcellular location":["Nucleoplasm","Cytosol"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 37: Skin - Keratinization","Brain expression cluster":"Cluster 9: Non-specific - Receptor signaling","Cell line expression cluster":"Cluster 64: Connective tissue cells - ECM organization","Single cell expression cluster":"Cluster 64: Renal epithelial cells - Ion transport & homeostasis","Interactions":1,"Subcellular main location":["Nucleoplasm"],"Subcellular additional location":["Cytosol"],"Antibody RRID":{"HPA039498":null,"HPA040101":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":null,"Cancer prognostics - Glioblastoma Multiforme (TCGA)":null,"Cancer prognostics - Glioblastoma Multiforme (validation)":null,"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Chromophobe (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":null,"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":null,"Cancer prognostics - Lung Adenocarcinoma (validation)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":null,"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":null,"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":null,"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":null,"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":null,"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":null},{"Gene":"NLRP14","Gene synonym":["CLR11.2","GC-LRR","Nalp-iota","NALP14","NOD5","PAN8"],"Ensembl":"ENSG00000158077","Gene description":"NLR family pyrin domain containing 14","Uniprot":["Q86W24"],"Chromosome":"11","Position":"7020479-7071526","Protein class":["Plasma proteins","Predicted intracellular proteins"],"Biological process":["Differentiation","Spermatogenesis"],"Molecular function":["Developmental protein"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Not detected","RNA tissue distribution":"Not detected","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in some","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Early primary spermatocytes":"5.6","Ependymal cells":"6.8","Late primary spermatocytes":"4.0","Loop of henle epithelial cells":"4.0","Oocytes":"9.2","Paneth cells":"3.9","Plasma cells":"5.8","Podocytes":"4.6","Proximal tubule cells":"7.0","Renal collecting duct intercalated cells":"5.8","Renal connecting tubule cells":"3.9","Retinal bipolar cells":"4.7","Rod photoreceptor cells":"5.2"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in some","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Ciliated cells":"6.8","Ductal cells":"5.8","Neuronal cells":"5.2","Oocytes":"9.2","Plasma cells":"5.8","Renal nephron cells":"7.0","Spermatogenic cell types":"5.6"},"RNA single nuclei brain specificity":"Cell type enriched","RNA single nuclei brain distribution":"Detected in many","RNA single nuclei brain specificity score":"4","RNA single nuclei brain specific nCPM":{"ependymal cell":"8.3"},"RNA cancer specificity":"Not detected","RNA cancer distribution":"Not detected","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in single","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Not detected","RNA cell line distribution":"Not detected","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Liver - Hepatocytes","Minor Salivary Gland - Plasma cells","Spleen - Plasma cells","Stomach - Plasma cells","Testis - Early spermatids","Testis - Spermatocytes"],"RNA mouse brain regional specificity":"Not detected","RNA mouse brain regional distribution":"Not detected","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":null,"RNA pig brain regional distribution":null,"RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Cell type enriched","Protein cell type distribution":"Detected in single","Protein cell type specificity score":"7159","Protein cell type specific Intensity":{"Oocytes":"715907.5"},"Protein tissue specificity":"Not detected","Protein tissue distribution":"Not detected","Protein tissue specificity score":null,"Protein tissue specific Intensity":null,"Antibody":["HPA039477"],"Reliability (IH)":"Approved","Reliability (Mouse Brain)":null,"Reliability (IF)":"Uncertain","Subcellular location":["Cytosol"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":null,"Brain expression cluster":"Cluster 13: Oligodendrocytes - Mixed function","Cell line expression cluster":"Cluster 16: Thyroid cancer - Neuronal signaling","Single cell expression cluster":"Cluster 78: Plasma cells - Antibody production & ER-stress response","Interactions":null,"Subcellular main location":["Cytosol"],"Subcellular additional location":null,"Antibody RRID":{"HPA039477":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":null,"Cancer prognostics - Glioblastoma Multiforme (TCGA)":null,"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.78e-2"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Chromophobe (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":null,"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":null,"Cancer prognostics - Lung Adenocarcinoma (validation)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":null,"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":null,"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":null,"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":null,"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":null,"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":null},{"Gene":"NLRP2","Gene synonym":["CLR19.9","FLJ20510","NALP2","NBS1","PAN1","PYPAF2"],"Ensembl":"ENSG00000022556","Gene description":"NLR family pyrin domain containing 2","Uniprot":["Q9NX02"],"Chromosome":"19","Position":"54953130-55001142","Protein class":["Predicted intracellular proteins"],"Biological process":["Apoptosis","Immunity","Inflammatory response","Innate immunity"],"Molecular function":null,"Disease involvement":["Disease variant"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in many","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Early spermatids":"8.7","Endometrial secretory cells":"10.7","Extravillous trophoblasts":"35.5","Late primary spermatocytes":"12.2","Migrating cytotrophoblasts":"26.3","Oocytes":"32.2","Papillary tip epithelial cells":"8.8","Syncytiotrophoblasts":"16.5"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Oocytes":"32.2","Trophoblast cells":"35.5"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in many","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Cancer enhanced","RNA cancer distribution":"Detected in many","RNA cancer specificity score":null,"RNA cancer specific pTPM":{"Testicular Germ Cell Tumor (TCGA)":"48.7"},"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in some","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in many","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Cancer enhanced","RNA cell line distribution":"Detected in many","RNA cell line specificity score":null,"RNA cell line specific nTPM":{"Gallbladder cancer":"54.6","testis cancer":"73.5"},"RNA tissue cell type enrichment":null,"RNA mouse brain regional specificity":"Not detected","RNA mouse brain regional distribution":"Not detected","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in single","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Cell type enriched","Protein cell type distribution":"Detected in many","Protein cell type specificity score":null,"Protein cell type specific Intensity":{"Oocytes":"104233295.5"},"Protein tissue specificity":"Tissue enriched","Protein tissue distribution":"Detected in some","Protein tissue specificity score":null,"Protein tissue specific Intensity":{"salivary gland":"615840.9"},"Antibody":["HPA021183"],"Reliability (IH)":null,"Reliability (Mouse Brain)":null,"Reliability (IF)":"Supported","Subcellular location":["Golgi apparatus","Vesicles","Cytosol"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 5: Non-specific - Cell proliferation","Tissue expression cluster":"Cluster 39: Testis - Nuclear processes","Brain expression cluster":"Cluster 40: Astrocytes - Astrocyte-neuron interactions","Cell line expression cluster":"Cluster 15: Kidney cancer - Membrane components","Single cell expression cluster":"Cluster 21: Extravillous trophoblasts - Placental invasion & endocrine regulatio","Interactions":5,"Subcellular main location":["Golgi apparatus","Vesicles","Cytosol"],"Subcellular additional location":null,"Antibody RRID":{"HPA021183":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.00e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.20e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.96e-2"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.73e-1"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.87e-1"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.07e-1"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":null,"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.70e-3"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.08e-3"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.11e-1"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":null,"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.21e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.12e-1"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.61e-3"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.33e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.41e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.81e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.72e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.04e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.98e-3"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.03e-1"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.78e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.38e-2"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.21e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.45e-2"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.93e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.60e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.89e-1"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.34e-2"}},{"Gene":"NLRP9","Gene synonym":["CLR19.1","NALP9","NOD6","PAN12"],"Ensembl":"ENSG00000185792","Gene description":"NLR family pyrin domain containing 9","Uniprot":["Q7RTR0"],"Chromosome":"19","Position":"55708438-55738402","Protein class":["Predicted intracellular proteins"],"Biological process":["Immunity","Inflammatory response","Innate immunity"],"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in single","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"ovary":"1.9"},"RNA single cell type specificity":"Group enriched","RNA single cell type distribution":"Detected in some","RNA single cell type specificity score":"11","RNA single cell type specific nCPM":{"Extravillous trophoblasts":"90.5","Oocytes":"128.9"},"RNA single cell type group specificity":"Group enriched","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":"11","RNA single cell type group specific nCPM":{"Oocytes":"128.9","Trophoblast cells":"90.5"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in some","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Cancer enriched","RNA cancer distribution":"Detected in single","RNA cancer specificity score":"40","RNA cancer specific pTPM":{"Testicular Germ Cell Tumor (TCGA)":"26.3"},"RNA brain regional specificity":"Not detected","RNA brain regional distribution":"Not detected","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Not detected","RNA cell line distribution":"Not detected","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Prostate - Prostate glandular cells"],"RNA mouse brain regional specificity":null,"RNA mouse brain regional distribution":null,"RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Not detected","RNA pig brain regional distribution":"Not detected","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Cell type enriched","Protein cell type distribution":"Detected in single","Protein cell type specificity score":"1054723","Protein cell type specific Intensity":{"Oocytes":"105472334.9"},"Protein tissue specificity":"Tissue enriched","Protein tissue distribution":"Detected in single","Protein tissue specificity score":"494","Protein tissue specific Intensity":{"kidney":"49434.5"},"Antibody":["HPA042623"],"Reliability (IH)":"Approved","Reliability (Mouse Brain)":null,"Reliability (IF)":null,"Subcellular location":null,"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 75: Ovary - Mixed function","Brain expression cluster":null,"Cell line expression cluster":"Cluster 16: Thyroid cancer - Neuronal signaling","Single cell expression cluster":"Cluster 21: Extravillous trophoblasts - Placental invasion & endocrine regulatio","Interactions":null,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":{"HPA042623":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":null,"Cancer prognostics - Glioblastoma Multiforme (TCGA)":null,"Cancer prognostics - Glioblastoma Multiforme (validation)":null,"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Chromophobe (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":null,"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.49e-2"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":null,"Cancer prognostics - Lung Adenocarcinoma (validation)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":null,"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":null,"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":null,"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":null,"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.60e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":null},{"Gene":"NLRP7","Gene synonym":["CLR19.4","NALP7","NOD12","PAN7","PYPAF3"],"Ensembl":"ENSG00000167634","Gene description":"NLR family pyrin domain containing 7","Uniprot":["Q8WX94"],"Chromosome":"19","Position":"54923509-54966312","Protein class":["Disease related genes","Human disease related genes","Predicted intracellular proteins"],"Biological process":null,"Molecular function":null,"Disease involvement":["Disease variant"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enriched","RNA tissue distribution":"Detected in single","RNA tissue specificity score":"6","RNA tissue specific nTPM":{"testis":"3.7"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in some","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Early spermatids":"3.1","Late primary spermatocytes":"4.2","Late spermatids":"7.9","Loop of henle epithelial cells":"1.3","Oocytes":"4.6","Papillary tip epithelial cells":"1.6","pDCs":"3.5","Plasma cells":"2.2","Podocytes":"1.3","Renal collecting duct principal cells":"1.3","Undifferentiated spermatogonia":"4.4"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in some","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"dendritic cells":"3.5","Oocytes":"4.6","Plasma cells":"2.2","Spermatogenic cell types":"7.9"},"RNA single nuclei brain specificity":"Cell type enhanced","RNA single nuclei brain distribution":"Detected in some","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":{"leukocyte":"2.6"},"RNA cancer specificity":"Cancer enriched","RNA cancer distribution":"Detected in some","RNA cancer specificity score":"9","RNA cancer specific pTPM":{"Testicular Germ Cell Tumor (TCGA)":"13.2"},"RNA brain regional specificity":"Not detected","RNA brain regional distribution":"Not detected","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Immune cell enriched","RNA blood cell distribution":"Detected in single","RNA blood cell specificity score":"6","RNA blood cell specific nTPM":{"plasmacytoid DC":"3.9"},"RNA blood lineage specificity":"Lineage enriched","RNA blood lineage distribution":"Detected in single","RNA blood lineage specificity score":"6","RNA blood lineage specific nTPM":{"dendritic cells":"3.9"},"RNA cell line specificity":"Cancer enhanced","RNA cell line distribution":"Detected in some","RNA cell line specificity score":null,"RNA cell line specific nTPM":{"lymphoma":"1.7","testis cancer":"1.3"},"RNA tissue cell type enrichment":null,"RNA mouse brain regional specificity":null,"RNA mouse brain regional distribution":null,"RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":null,"RNA pig brain regional distribution":null,"RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Cell type enriched","Protein cell type distribution":"Detected in single","Protein cell type specificity score":"1432520","Protein cell type specific Intensity":{"Oocytes":"143252002.7"},"Protein tissue specificity":"Not detected","Protein tissue distribution":"Not detected","Protein tissue specificity score":null,"Protein tissue specific Intensity":null,"Antibody":["HPA051382"],"Reliability (IH)":"Uncertain","Reliability (Mouse Brain)":null,"Reliability (IF)":"Uncertain","Subcellular location":["Golgi apparatus"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 8: Plasmacytoid DCs - Unknown function","Tissue expression cluster":"Cluster 79: Testis - Spermatogenesis","Brain expression cluster":null,"Cell line expression cluster":"Cluster 55: Lymphoma - Immune response","Single cell expression cluster":"Cluster 23: Elongating spermatids - Sperm cell metabolism & fertilization","Interactions":3,"Subcellular main location":["Golgi apparatus"],"Subcellular additional location":null,"Antibody RRID":{"HPA051382":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":null,"Cancer prognostics - Glioblastoma Multiforme (TCGA)":null,"Cancer prognostics - Glioblastoma Multiforme (validation)":null,"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Chromophobe (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":null,"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":null,"Cancer prognostics - Lung Adenocarcinoma (validation)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.01e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":null,"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":null,"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.37e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":null,"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.51e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":null}]