[{"Gene":"DNASE2","Gene synonym":["DNL","DNL2"],"Ensembl":"ENSG00000105612","Gene description":"Deoxyribonuclease 2, lysosomal","Uniprot":["O00115"],"Chromosome":"19","Position":"12875209-12881595","Protein class":["Disease related genes","Enzymes","Human disease related genes","Potential drug targets","Predicted intracellular proteins"],"Biological process":["Apoptosis"],"Molecular function":["Developmental protein","Endonuclease","Hydrolase","Nuclease"],"Disease involvement":["Disease variant"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Extravillous trophoblasts":"131.9","Hofbauer cells":"210.7","Kupffer cells":"109.7"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Mononuclear phagocytes":"210.7","Trophoblast cells":"131.9"},"RNA single nuclei brain specificity":"Cell type enhanced","RNA single nuclei brain distribution":"Detected in many","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":{"central nervous system macrophage":"28.6"},"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Adrenal gland - Adrenal cortex cells","Kidney - Fibroblasts","Lung - Macrophages","Thyroid gland - Thyroid glandular cells"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Cell type enhanced","Protein cell type distribution":"Detected in many","Protein cell type specificity score":null,"Protein cell type specific Intensity":{"Alveolar cell types":"1451502.2"},"Protein tissue specificity":"Low tissue specificity","Protein tissue distribution":"Detected in many","Protein tissue specificity score":null,"Protein tissue specific Intensity":null,"Antibody":["HPA066185"],"Reliability (IH)":"Enhanced","Reliability (Mouse Brain)":null,"Reliability (IF)":null,"Subcellular location":null,"Secretome location":"Intracellular and membrane","Secretome function":"Developmental protein","CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":"130000","Blood expression cluster":"Cluster 37: Monocytes & Neutrophils - Innate immune response","Tissue expression cluster":"Cluster 70: Non-specific - Protein processing","Brain expression cluster":"Cluster 39: Astrocytes - Mixed function","Cell line expression cluster":"Cluster 63: Non-specific - Protein processing","Single cell expression cluster":"Cluster 72: Macrophages - Phagocytosis & lysosomal degradation","Interactions":1,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":{"HPA066185":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.53e-2"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.62e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.30e-2"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.85e-1"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.18e-2"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.07e-2"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.08e-2"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.15e-3"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.33e-1"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.10e-3"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"5.42e-4"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.95e-2"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.26e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.02e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.80e-1"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.25e-2"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.79e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.54e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.48e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.93e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.50e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.03e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.43e-1"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.20e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.06e-2"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.26e-3"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.76e-2"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.03e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.98e-2"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.91e-1"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.01e-2"}},{"Gene":"DNASE2B","Gene synonym":["DLAD"],"Ensembl":"ENSG00000137976","Gene description":"Deoxyribonuclease 2 beta","Uniprot":["Q8WZ79"],"Chromosome":"1","Position":"84398484-84415018","Protein class":["Enzymes","Predicted intracellular proteins"],"Biological process":null,"Molecular function":["Endonuclease","Hydrolase","Nuclease"],"Disease involvement":null,"Evidence":"Evidence at transcript level","HPA evidence":"Evidence at transcript level","UniProt evidence":"Evidence at transcript level","NeXtProt evidence":"Evidence at transcript level","RNA tissue specificity":"Tissue enriched","RNA tissue distribution":"Detected in some","RNA tissue specificity score":"25","RNA tissue specific nTPM":{"salivary gland":"160.3"},"RNA single cell type specificity":"Group enriched","RNA single cell type distribution":"Detected in some","RNA single cell type specificity score":"6","RNA single cell type specific nCPM":{"Lacrimal acinar cells":"33.5","Salivary acinar cells":"98.4","Salivary myoepithelial cells":"52.3"},"RNA single cell type group specificity":"Group enriched","RNA single cell type group distribution":"Detected in some","RNA single cell type group specificity score":"7","RNA single cell type group specific nCPM":{"Acinar cells":"98.4","Secretory gland support":"52.3"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in some","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Group enriched","RNA cancer distribution":"Detected in some","RNA cancer specificity score":"4","RNA cancer specific pTPM":{"Prostate Adenocarcinoma (TCGA)":"19.4","Skin Cutaneous Melanoma (TCGA)":"5.7"},"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in some","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Cancer enhanced","RNA cell line distribution":"Detected in some","RNA cell line specificity score":null,"RNA cell line specific nTPM":{"head and neck cancer":"8.4","prostate cancer":"4.1"},"RNA tissue cell type enrichment":["Lung - Macrophages","Minor Salivary Gland - Minor salivary glandular cells","Prostate - Prostate glandular cells","Testis - Early spermatids"],"RNA mouse brain regional specificity":"Not detected","RNA mouse brain regional distribution":"Not detected","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Not detected","RNA pig brain regional distribution":"Not detected","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Not detected","Protein cell type distribution":"Not detected","Protein cell type specificity score":null,"Protein cell type specific Intensity":null,"Protein tissue specificity":"Not detected","Protein tissue distribution":"Not detected","Protein tissue specificity score":null,"Protein tissue specific Intensity":null,"Antibody":null,"Reliability (IH)":null,"Reliability (Mouse Brain)":null,"Reliability (IF)":null,"Subcellular location":null,"Secretome location":"Intracellular and membrane","Secretome function":"Enzyme","CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":null,"Tissue expression cluster":"Cluster 82: Salivary gland - Secretion","Brain expression cluster":"Cluster 30: White matter - Myelination","Cell line expression cluster":"Cluster 65: Non-specific - Unknown function","Single cell expression cluster":"Cluster 38: Secretory epithelial cells - Exocrine secretion","Interactions":3,"Subcellular main location":null,"Subcellular additional location":null,"Antibody RRID":null,"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":null,"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.13e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.43e-2"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (TCGA)":null,"Cancer prognostics - Colon Adenocarcinoma (validation)":null,"Cancer prognostics - Glioblastoma Multiforme (TCGA)":null,"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.87e-2"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Chromophobe (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":null,"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":null,"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.44e-3"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":null,"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.46e-2"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":null,"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.66e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":null,"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":null,"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":null,"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.28e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":null,"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.96e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":null,"Cancer prognostics - Rectum Adenocarcinoma (validation)":null,"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.16e-2"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":null,"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":null,"Cancer prognostics - Thyroid Carcinoma (TCGA)":null,"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":null}]