[{"Gene":"IL11RA","Gene synonym":[],"Ensembl":"ENSG00000137070","Gene description":"Interleukin 11 receptor subunit alpha","Uniprot":["Q14626"],"Chromosome":"9","Position":"34652162-34661902","Protein class":["Disease related genes","FDA approved drug targets","Human disease related genes","Predicted membrane proteins","Predicted secreted proteins"],"Biological process":null,"Molecular function":["Receptor"],"Disease involvement":["Craniosynostosis","Disease variant","FDA approved drug targets"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in many","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"heart muscle":"36.3"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in some","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Astrocytes":"24.6","Bergmann glia":"22.8","Brain excitatory neurons":"7.6","Brain inhibitory neurons":"13.9","Late spermatids":"7.9","Microglia":"8.2","Oligodendrocyte progenitor cells":"8.0","Oligodendrocytes":"9.3","Other brain neurons":"8.4","Podocytes":"15.2","Proximal tubule cells":"17.2","Renal connecting tubule cells":"11.4"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in many","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Ductal cells":"11.4","Glial cells":"24.6","Neuronal cells":"13.9","Renal nephron cells":"17.2"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in many","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in many","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Cancer enhanced","RNA cell line distribution":"Detected in many","RNA cell line specificity score":null,"RNA cell line specific nTPM":{"Neuroblastoma":"14.6"},"RNA tissue cell type enrichment":["Adipose subcutaneous - Adipose progenitor cells","Heart muscle - Cardiomyocytes","Thyroid gland - Fibroblasts"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Not detected","Protein cell type distribution":"Not detected","Protein cell type specificity score":null,"Protein cell type specific Intensity":null,"Protein tissue specificity":"Not detected","Protein tissue distribution":"Not detected","Protein tissue specificity score":null,"Protein tissue specific Intensity":null,"Antibody":["HPA013162","CAB032830","HPA036652","HPA036653"],"Reliability (IH)":"Supported","Reliability (Mouse Brain)":null,"Reliability (IF)":"Approved","Subcellular location":["Vesicles","Plasma membrane"],"Secretome location":"Secreted to blood","Secretome function":"Receptor","CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 5: Non-specific - Cell proliferation","Tissue expression cluster":"Cluster 41: Striated muscle - Muscle contraction","Brain expression cluster":"Cluster 13: Oligodendrocytes - Mixed function","Cell line expression cluster":"Cluster 1: Neuronal - Visual perception","Single cell expression cluster":"Cluster 102: Non-specific - Mixed function","Interactions":1,"Subcellular main location":["Vesicles","Plasma membrane"],"Subcellular additional location":null,"Antibody RRID":{"CAB032830":null,"HPA013162":null,"HPA036652":null,"HPA036653":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.71e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.91e-1"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.88e-2"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.81e-2"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.32e-2"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.49e-2"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.19e-2"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.27e-2"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.77e-2"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"unfavorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"5.81e-5"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.87e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.65e-1"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.57e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.82e-2"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.17e-3"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.38e-3"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.81e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.22e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.02e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.19e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.69e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"9.36e-4"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.85e-2"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.18e-1"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.96e-1"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.22e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.00e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.32e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.58e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.95e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.60e-2"}}]