[{"Gene":"MARCHF5","Gene synonym":["FLJ20445","MARCH-V","MARCH5","MITOL","RNF153"],"Ensembl":"ENSG00000198060","Gene description":"Membrane associated ring-CH-type finger 5","Uniprot":["Q9NX47"],"Chromosome":"10","Position":"92291167-92353964","Protein class":["Enzymes","Metabolic proteins","Predicted membrane proteins"],"Biological process":["Ubl conjugation pathway"],"Molecular function":["Transferase"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in all","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Esophageal apical cells":"684.5"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Apical squamous epithelial cells":"684.5"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Adrenal gland - Adrenal cortex cells"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Low cell type specificity","Protein cell type distribution":"Detected in many","Protein cell type specificity score":null,"Protein cell type specific Intensity":null,"Protein tissue specificity":"Tissue enriched","Protein tissue distribution":"Detected in some","Protein tissue specificity score":null,"Protein tissue specific Intensity":{"lung":"1881757.6"},"Antibody":["HPA056596"],"Reliability (IH)":null,"Reliability (Mouse Brain)":null,"Reliability (IF)":"Supported","Subcellular location":["Mitochondria"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 21: Neutrophils - Unknown function","Tissue expression cluster":"Cluster 76: Non-specific - Metabolism","Brain expression cluster":"Cluster 14: Neurons - Synaptic function","Cell line expression cluster":"Cluster 52: Non-specific - Mitochondria","Single cell expression cluster":"Cluster 84: Apical squamous epithelium - Cornification","Interactions":61,"Subcellular main location":["Mitochondria"],"Subcellular additional location":null,"Antibody RRID":{"HPA056596":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.57e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.25e-3"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":null,"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.60e-1"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.01e-2"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.21e-2"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.06e-3"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"7.41e-4"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.06e-2"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.55e-1"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"5.52e-5"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.99e-2"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.60e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.07e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":null,"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"9.96e-3"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.79e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.41e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.44e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.16e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.38e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.62e-3"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"5.68e-3"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.41e-2"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.02e-2"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.43e-2"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.72e-2"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.05e-1"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.81e-1"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.25e-1"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.15e-1"}},{"Gene":"MFN2","Gene synonym":["CMT2A2","CPRP1","KIAA0214","MARF"],"Ensembl":"ENSG00000116688","Gene description":"Mitofusin 2","Uniprot":["O95140"],"Chromosome":"1","Position":"11980181-12015211","Protein class":["Disease related genes","Essential proteins","Human disease related genes","Potential drug targets","Predicted intracellular proteins","Predicted membrane proteins","Transporters"],"Biological process":["Apoptosis","Autophagy","Unfolded protein response"],"Molecular function":["Hydrolase"],"Disease involvement":["Charcot-Marie-Tooth disease","Disease variant","Neurodegeneration","Neuropathy"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"heart muscle":"253.1","skeletal muscle":"290.9","tongue":"315.0"},"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nCPM":{"Cardiomyocytes":"144.9","Neutrophils":"256.3","Platelets":"260.5"},"RNA single cell type group specificity":"Cell type enhanced","RNA single cell type group distribution":"Detected in all","RNA single cell type group specificity score":null,"RNA single cell type group specific nCPM":{"Neutrophils":"256.3","Platelets":"260.5"},"RNA single nuclei brain specificity":"Low cell type specificity","RNA single nuclei brain distribution":"Detected in all","RNA single nuclei brain specificity score":null,"RNA single nuclei brain specific nCPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific pTPM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cancer specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA tissue cell type enrichment":["Heart muscle - Cardiomyocytes","Prostate - Smooth muscle cells"],"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Protein cell type specificity":"Low cell type specificity","Protein cell type distribution":"Detected in all","Protein cell type specificity score":null,"Protein cell type specific Intensity":null,"Protein tissue specificity":"Tissue enhanced","Protein tissue distribution":"Detected in all","Protein tissue specificity score":null,"Protein tissue specific Intensity":{"cerebral cortex":"23519971.1"},"Antibody":["HPA030554","CAB079902"],"Reliability (IH)":"Uncertain","Reliability (Mouse Brain)":null,"Reliability (IF)":"Supported","Subcellular location":["Mitochondria"],"Secretome location":null,"Secretome function":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 37: Monocytes & Neutrophils - Innate immune response","Tissue expression cluster":"Cluster 41: Striated muscle - Muscle contraction","Brain expression cluster":"Cluster 19: Astrocytes - Mixed function","Cell line expression cluster":"Cluster 37: Non-specific - mRNA processing","Single cell expression cluster":"Cluster 48: Neutrophils - Phagocytosis & degranulation","Interactions":25,"Subcellular main location":["Mitochondria"],"Subcellular additional location":null,"Antibody RRID":{"CAB079902":null,"HPA030554":null},"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.03e-1"},"Cancer prognostics - Breast Invasive Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.68e-2"},"Cancer prognostics - Breast Invasive Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.91e-2"},"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.74e-3"},"Cancer prognostics - Colon Adenocarcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"potential prognostic","is_prognostic":true,"p_val":"8.00e-4"},"Cancer prognostics - Colon Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.71e-1"},"Cancer prognostics - Glioblastoma Multiforme (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.75e-1"},"Cancer prognostics - Glioblastoma Multiforme (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.93e-1"},"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.64e-1"},"Cancer prognostics - Kidney Chromophobe (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.47e-2"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)":{"prognostic type":"favorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"2.58e-8"},"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)":{"prognostic type":"favorable","prognostic":"validated prognostic","is_prognostic":true,"p_val":"2.81e-4"},"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.22e-3"},"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.10e-1"},"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.05e-2"},"Cancer prognostics - Lung Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.31e-1"},"Cancer prognostics - Lung Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.96e-1"},"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.22e-2"},"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.08e-1"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"2.60e-2"},"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.44e-1"},"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.43e-2"},"Cancer prognostics - Pancreatic Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.99e-2"},"Cancer prognostics - Prostate Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"7.49e-2"},"Cancer prognostics - Rectum Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.10e-1"},"Cancer prognostics - Rectum Adenocarcinoma (validation)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"3.58e-1"},"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"4.88e-1"},"Cancer prognostics - Stomach Adenocarcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.91e-2"},"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"8.16e-2"},"Cancer prognostics - Thyroid Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"6.10e-2"},"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)":{"prognostic type":"","prognostic":"unprognostic","is_prognostic":false,"p_val":"1.45e-1"}}]