Gene	"Gene synonym"	Ensembl	"Gene description"	Uniprot	Chromosome	Position	"Protein class"	"Biological process"	"Molecular function"	"Disease involvement"	Evidence	"HPA evidence"	"UniProt evidence"	"NeXtProt evidence"	"RNA tissue specificity"	"RNA tissue distribution"	"RNA tissue specificity score"	"RNA tissue specific nTPM"	"RNA single cell type specificity"	"RNA single cell type distribution"	"RNA single cell type specificity score"	"RNA single cell type specific nCPM"	"RNA single nuclei brain specificity"	"RNA single nuclei brain distribution"	"RNA single nuclei brain specificity score"	"RNA single nuclei brain specific nCPM"	"RNA cancer specificity"	"RNA cancer distribution"	"RNA cancer specificity score"	"RNA cancer specific pTPM"	"RNA brain regional specificity"	"RNA brain regional distribution"	"RNA brain regional specificity score"	"RNA brain regional specific nTPM"	"RNA blood cell specificity"	"RNA blood cell distribution"	"RNA blood cell specificity score"	"RNA blood cell specific nTPM"	"RNA blood lineage specificity"	"RNA blood lineage distribution"	"RNA blood lineage specificity score"	"RNA blood lineage specific nTPM"	"RNA cell line specificity"	"RNA cell line distribution"	"RNA cell line specificity score"	"RNA cell line specific nTPM"	"RNA tissue cell type enrichment"	"RNA mouse brain regional specificity"	"RNA mouse brain regional distribution"	"RNA mouse brain regional specificity score"	"RNA mouse brain regional specific nTPM"	"RNA pig brain regional specificity"	"RNA pig brain regional distribution"	"RNA pig brain regional specificity score"	"RNA pig brain regional specific nTPM"	Antibody	"Reliability (IH)"	"Reliability (Mouse Brain)"	"Reliability (IF)"	"Subcellular location"	"Secretome location"	"Secretome function"	"CCD Protein"	"CCD Transcript"	"Blood concentration - Conc. blood IM [pg/L]"	"Blood concentration - Conc. blood MS [pg/L]"	"Blood expression cluster"	"Tissue expression cluster"	"Brain expression cluster"	"Cell line expression cluster"	"Single cell expression cluster"	Interactions	"Subcellular main location"	"Subcellular additional location"	"Antibody RRID"	"Cancer prognostics - Bladder Urothelial Carcinoma (TCGA)"	"Cancer prognostics - Breast Invasive Carcinoma (TCGA)"	"Cancer prognostics - Breast Invasive Carcinoma (validation)"	"Cancer prognostics - Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA)"	"Cancer prognostics - Colon Adenocarcinoma (TCGA)"	"Cancer prognostics - Colon Adenocarcinoma (validation)"	"Cancer prognostics - Glioblastoma Multiforme (TCGA)"	"Cancer prognostics - Glioblastoma Multiforme (validation)"	"Cancer prognostics - Head and Neck Squamous Cell Carcinoma (TCGA)"	"Cancer prognostics - Kidney Chromophobe (TCGA)"	"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (TCGA)"	"Cancer prognostics - Kidney Renal Clear Cell Carcinoma (validation)"	"Cancer prognostics - Kidney Renal Papillary Cell Carcinoma (TCGA)"	"Cancer prognostics - Liver Hepatocellular Carcinoma (TCGA)"	"Cancer prognostics - Liver Hepatocellular Carcinoma (validation)"	"Cancer prognostics - Lung Adenocarcinoma (TCGA)"	"Cancer prognostics - Lung Adenocarcinoma (validation)"	"Cancer prognostics - Lung Squamous Cell Carcinoma (TCGA)"	"Cancer prognostics - Lung Squamous Cell Carcinoma (validation)"	"Cancer prognostics - Ovary Serous Cystadenocarcinoma (TCGA)"	"Cancer prognostics - Ovary Serous Cystadenocarcinoma (validation)"	"Cancer prognostics - Pancreatic Adenocarcinoma (TCGA)"	"Cancer prognostics - Pancreatic Adenocarcinoma (validation)"	"Cancer prognostics - Prostate Adenocarcinoma (TCGA)"	"Cancer prognostics - Rectum Adenocarcinoma (TCGA)"	"Cancer prognostics - Rectum Adenocarcinoma (validation)"	"Cancer prognostics - Skin Cutaneous Melanoma (TCGA)"	"Cancer prognostics - Stomach Adenocarcinoma (TCGA)"	"Cancer prognostics - Testicular Germ Cell Tumor (TCGA)"	"Cancer prognostics - Thyroid Carcinoma (TCGA)"	"Cancer prognostics - Uterine Corpus Endometrial Carcinoma (TCGA)"
SCO2	"MYP6, SCO1L"	ENSG00000284194	"Synthesis of cytochrome C oxidase 2"	O43819	22	50523568-50526461	"Disease related genes, Human disease related genes, Predicted membrane proteins"		Chaperone	"Cardiomyopathy, Disease variant, Leigh syndrome, Primary mitochondrial disease"	"Evidence at protein level"	"Evidence at protein level"	"Evidence at protein level"	"Evidence at protein level"	"Low tissue specificity"	"Detected in many"			"Cell type enhanced"	"Detected in many"		"Colonocytes: 114.1;Esophageal suprabasal cells: 134.4"	"Cell type enhanced"	"Detected in all"		"ependymal cell: 60.4"	"Low cancer specificity"	"Detected in all"			"Low region specificity"	"Detected in all"			"Low immune cell specificity"	"Detected in all"			"Low lineage specificity"	"Detected in all"			"Low cancer specificity"	"Detected in all"				"Low region specificity"	"Detected in all"			"Low region specificity"	"Detected in all"			"HPA046943, HPA056254"	Uncertain		Supported	Mitochondria			NA	NA			"Cluster 12: Non-specific - Mitochondrial translation"	"Cluster 28: Liver & Adrenal gland - Secretion"	"Cluster 20: Macrophages & Microglia - Immune response"	"Cluster 66: Non-specific - Mitochondria"	"Cluster 97: Non-specific - Cellular respiration"	12	Mitochondria		"HPA046943: , HPA056254: "	"unprognostic (1.03e-1)"	"unprognostic (8.74e-3)"	"unprognostic (3.84e-2)"	"unprognostic (2.75e-1)"	"unprognostic (1.72e-2)"	"unprognostic (9.39e-2)"	"unprognostic (3.74e-1)"		"unprognostic (6.02e-3)"	"unprognostic (7.83e-2)"	"potential prognostic unfavorable (9.11e-4)"	"unprognostic (1.09e-1)"	"unprognostic (1.09e-1)"	"unprognostic (1.52e-3)"	"unprognostic (2.45e-1)"	"unprognostic (1.45e-1)"	"unprognostic (6.72e-2)"	"unprognostic (2.28e-1)"	"unprognostic (2.51e-1)"	"unprognostic (2.96e-1)"		"unprognostic (1.06e-1)"		"unprognostic (1.84e-1)"	"unprognostic (1.44e-1)"	"unprognostic (2.31e-1)"	"unprognostic (2.77e-2)"	"unprognostic (3.55e-2)"	"unprognostic (1.05e-1)"	"unprognostic (1.06e-1)"	"unprognostic (1.58e-2)"
ESCO2	"EFO2, RBS"	ENSG00000171320	"Establishment of sister chromatid cohesion N-acetyltransferase 2"	Q56NI9	8	27771949-27812640	"Disease related genes, Human disease related genes, Metabolic proteins, Predicted intracellular proteins"	"Cell cycle"	"Acyltransferase, Transferase"	"Disease variant, Dwarfism, Intellectual disability"	"Evidence at protein level"	"Evidence at protein level"	"Evidence at protein level"	"Evidence at protein level"	"Tissue enhanced"	"Detected in some"		"bone marrow: 5.6;intestine: 10.3;lymphoid tissue: 7.9;testis: 5.4"	"Cell type enhanced"	"Detected in many"		"Cardiomyocytes: 42.1;Differentiating spermatogonia: 77.7;Early primary spermatocytes: 127.1;Erythrocyte progenitors: 80.4;Megakaryocyte progenitors: 38.1;Monocyte progenitors: 49.1;Oocytes: 336.2"	"Cell type enhanced"	"Detected in some"		"hippocampal CA4: 5.0"	"Low cancer specificity"	"Detected in many"			"Low region specificity"	"Detected in all"			"Immune cell enhanced"	"Detected in single"		"T-reg: 1.4"	"Low lineage specificity"	"Detected in single"			"Low cancer specificity"	"Detected in all"			"Adrenal gland - Mitotic cells (Adrenal gland), Colon - Mitotic cells (Colon), Lung - Mitotic cells (Lung), Minor Salivary Gland - Mitotic cells (Minor salivary gland), Skin - Mitotic cells (Skin), Spleen - Mitotic cells (Spleen), Stomach - Mitotic cells (Stomach), Testis - Spermatocytes, Thyroid gland - Mitotic cells (Thyroid)"	"Low region specificity"	"Detected in single"			"Not detected"	"Not detected"			"HPA027243, HPA053679"			Supported	"Nucleoplasm,Golgi apparatus,Cell Junctions"			Yes	Yes			"Cluster 9: T-regs - Cell cycle regulation"	"Cluster 59: Lymphoid tissue & Bone marrow - Cell proliferation"	"Cluster 9: Non-specific - Receptor signaling"	"Cluster 40: Non-specific - Unknown function"	"Cluster 41: Oocytes - Oogenesis"	11	Nucleoplasm	"Golgi apparatus, Cell Junctions"	"HPA027243: , HPA053679: "	"unprognostic (4.54e-2)"	"unprognostic (1.97e-1)"	"unprognostic (5.63e-2)"	"unprognostic (5.73e-2)"	"potential prognostic favorable (9.95e-5)"	"unprognostic (2.74e-1)"	"unprognostic (1.21e-1)"	"unprognostic (4.53e-3)"	"unprognostic (3.10e-2)"			"unprognostic (9.42e-3)"			"unprognostic (3.12e-3)"	"potential prognostic unfavorable (6.31e-4)"	"unprognostic (1.42e-2)"	"unprognostic (1.28e-3)"	"unprognostic (8.08e-2)"	"unprognostic (5.81e-2)"	"unprognostic (5.31e-2)"	"potential prognostic unfavorable (8.43e-4)"	"unprognostic (2.22e-2)"		"potential prognostic favorable (2.79e-5)"	"unprognostic (3.33e-2)"	"unprognostic (2.11e-2)"	"unprognostic (5.19e-2)"	"unprognostic (2.92e-1)"		"unprognostic (2.55e-1)"
SCO1	SCOD1	ENSG00000133028	"Synthesis of cytochrome C oxidase 1"	O75880	17	10672474-10698375	"Disease related genes, Human disease related genes, Predicted membrane proteins"		Chaperone	"Disease variant, Primary mitochondrial disease"	"Evidence at protein level"	"Evidence at protein level"	"Evidence at protein level"	"Evidence at protein level"	"Low tissue specificity"	"Detected in all"			"Cell type enhanced"	"Detected in many"		"Extravillous trophoblasts: 157.9"	"Low cell type specificity"	"Detected in all"			"Low cancer specificity"	"Detected in all"			"Low region specificity"	"Detected in all"			"Low immune cell specificity"	"Detected in all"			"Low lineage specificity"	"Detected in all"			"Low cancer specificity"	"Detected in all"			"Adrenal gland - Adrenal cortex cells"	"Low region specificity"	"Detected in all"			"Low region specificity"	"Detected in all"			"HPA021565, HPA021579"	Enhanced						NA	NA			"Cluster 29: Non-specific - Unknown function"	"Cluster 76: Non-specific - Metabolism"	"Cluster 21: Non-specific - Metabolism"	"Cluster 42: Non-specific - Unknown function"	"Cluster 21: Extravillous trophoblasts - Placental invasion & endocrine regulatio"	12			"HPA021565: , HPA021579: "	"unprognostic (8.74e-2)"	"unprognostic (5.26e-3)"	"unprognostic (7.22e-2)"	"unprognostic (2.67e-2)"	"unprognostic (3.11e-2)"	"unprognostic (3.11e-3)"	"unprognostic (8.67e-3)"	"unprognostic (7.38e-2)"	"unprognostic (6.44e-2)"	"unprognostic (9.98e-3)"	"potential prognostic favorable (8.56e-6)"	"unprognostic (3.56e-2)"	"unprognostic (4.52e-3)"	"unprognostic (3.80e-2)"	"unprognostic (4.36e-2)"	"unprognostic (1.91e-3)"	"unprognostic (3.88e-1)"	"unprognostic (1.88e-1)"	"unprognostic (1.08e-1)"	"unprognostic (2.28e-1)"	"unprognostic (1.23e-1)"	"unprognostic (4.57e-2)"	"unprognostic (2.08e-1)"	"unprognostic (2.04e-2)"	"unprognostic (1.16e-1)"	"unprognostic (1.97e-1)"	"unprognostic (2.43e-2)"	"unprognostic (4.88e-2)"	"unprognostic (1.02e-1)"	"unprognostic (1.72e-3)"	"unprognostic (1.31e-1)"