Gene "Gene synonym" Ensembl "Gene description" Uniprot Chromosome Position "Protein class" "Biological process" "Molecular function" "Disease involvement" Evidence "HPA evidence" "UniProt evidence" "NeXtProt evidence" "RNA tissue specificity" "RNA tissue distribution" "RNA tissue specificity score" "RNA tissue specific nTPM" "RNA single cell type specificity" "RNA single cell type distribution" "RNA single cell type specificity score" "RNA single cell type specific nTPM" "RNA cancer specificity" "RNA cancer distribution" "RNA cancer specificity score" "RNA cancer specific FPKM" "RNA brain regional specificity" "RNA brain regional distribution" "RNA brain regional specificity score" "RNA brain regional specific nTPM" "RNA blood cell specificity" "RNA blood cell distribution" "RNA blood cell specificity score" "RNA blood cell specific nTPM" "RNA blood lineage specificity" "RNA blood lineage distribution" "RNA blood lineage specificity score" "RNA blood lineage specific nTPM" "RNA cell line specificity" "RNA cell line distribution" "RNA cell line specificity score" "RNA cell line specific nTPM" "RNA tissue cell type enrichment" "RNA mouse brain regional specificity" "RNA mouse brain regional distribution" "RNA mouse brain regional specificity score" "RNA mouse brain regional specific nTPM" "RNA pig brain regional specificity" "RNA pig brain regional distribution" "RNA pig brain regional specificity score" "RNA pig brain regional specific nTPM" Antibody "Reliability (IH)" "Reliability (Mouse Brain)" "Reliability (IF)" "Subcellular location" "Secretome location" "Secretome function" "CCD Protein" "CCD Transcript" "Blood concentration - Conc. blood IM [pg/L]" "Blood concentration - Conc. blood MS [pg/L]" "Blood expression cluster" "Tissue expression cluster" "Brain expression cluster" "Cell line expression cluster" "Single cell expression cluster" Interactions "Subcellular main location" "Subcellular additional location" "Antibody RRID" "Pathology prognostics - Breast cancer" "Pathology prognostics - Cervical cancer" "Pathology prognostics - Colorectal cancer" "Pathology prognostics - Endometrial cancer" "Pathology prognostics - Glioma" "Pathology prognostics - Head and neck cancer" "Pathology prognostics - Liver cancer" "Pathology prognostics - Lung cancer" "Pathology prognostics - Melanoma" "Pathology prognostics - Ovarian cancer" "Pathology prognostics - Pancreatic cancer" "Pathology prognostics - Prostate cancer" "Pathology prognostics - Renal cancer" "Pathology prognostics - Stomach cancer" "Pathology prognostics - Testis cancer" "Pathology prognostics - Thyroid cancer" "Pathology prognostics - Urothelial cancer" ABCB1 "ABC20, CD243, CLCS, GP170, MDR1, p-170, P-gp, PGY1" ENSG00000085563 "ATP binding cassette subfamily B member 1" P08183 7 87503017-87713323 "Cancer-related genes, CD markers, Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Plasma proteins, Predicted intracellular proteins, Predicted membrane proteins, Transporters" "Lipid transport, Transport" Translocase "Cancer-related genes" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "adrenal gland: 98.7;intestine: 68.8" "Cell type enhanced" "Detected in many" "Cholangiocytes: 101.1;Microglial cells: 544.8;Proximal enterocytes: 247.2" "Cancer enhanced" "Detected in many" "renal cancer: 14.2" "Low region specificity" "Detected in all" "Immune cell enhanced" "Detected in many" "MAIT T-cell: 27.2;NK-cell: 17.9" "Group enriched" "Detected in many" 9 "NK-cells: 17.9;T-cells: 27.2" "Cancer enhanced" "Detected in many" "colorectal cancer: 26.0;liver cancer: 17.4" "Prostate - Endothelial cells" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "CAB001716, HPA002199, HPA074614" Enhanced Supported "Plasma membrane" NA NA "Cluster 24: Non-specific - Transcription" "Cluster 55: Kidney & Intestine - Metabolism" "Cluster 47: Endothelial cells - Vasculature" "Cluster 70: DU4475 - Unknown function" "Cluster 22: Proximal enterocytes - Digestion" 1 "Plasma membrane" "CAB001716: , HPA002199: AB_1844428, HPA074614: " "unprognostic (5.38e-3)" "unprognostic (2.45e-2)" "unprognostic (1.42e-1)" "unprognostic (1.06e-1)" "unprognostic (2.25e-2)" "unprognostic (9.99e-5)" "unprognostic (2.23e-3)" "unprognostic (5.65e-3)" "unprognostic (1.14e-1)" "unprognostic (5.17e-2)" "prognostic favorable (3.33e-4)" "unprognostic (5.19e-1)" "prognostic favorable (2.95e-4)" "unprognostic (2.06e-1)" "unprognostic (1.50e-1)" "unprognostic (3.83e-1)" "unprognostic (6.12e-2)" ACAN "AGC1, CSPG1, CSPGCP, MSK16" ENSG00000157766 Aggrecan P16112 15 88803436-88875353 "Disease related genes, Human disease related genes, Predicted intracellular proteins, Predicted secreted proteins" "Disease variant, Dwarfism" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in some" "seminal vesicle: 3.0" "Cell type enriched" "Detected in some" 16 "Extravillous trophoblasts: 152.8" "Low cancer specificity" "Detected in many" "Low region specificity" "Detected in many" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Group enriched" "Detected in some" 4 "Bone cancer: 7.5;skin cancer: 8.0" "Adipose visceral - Smooth muscle cells, Heart muscle - Smooth muscle cells, Testis - Spermatocytes, Testis - Spermatogonia, Thyroid - Smooth muscle cells" "Low region specificity" "Detected in many" "Low region specificity" "Detected in many" "CAB016377, HPA038241, HPA038242" Enhanced "Secreted to extracellular matrix" "No annotated function" NA NA 17000000 "Cluster 64: Neuronal - Transcription" "Cluster 1: Neurons - Mixed function" "Cluster 64: Connective tissue cells - ECM organization" "Cluster 4: Extravillous trophoblasts - Unknown function" 1 "CAB016377: AB_626650, HPA038241: AB_2675909, HPA038242: AB_2675910" "unprognostic (2.69e-3)" "unprognostic (4.09e-2)" "unprognostic (2.52e-1)" "unprognostic (1.82e-1)" "unprognostic (4.43e-2)" "unprognostic (2.13e-2)" "unprognostic (1.40e-2)" "unprognostic (1.15e-1)" "unprognostic (7.12e-2)" "unprognostic (8.57e-2)" "unprognostic (2.34e-1)" "unprognostic (2.38e-2)" "prognostic unfavorable (1.47e-6)" "unprognostic (7.79e-2)" "unprognostic (1.53e-1)" "unprognostic (7.71e-2)" "unprognostic (7.27e-2)" ACVR1 "ACVR1A, ACVRLK2, ALK2, SKR1" ENSG00000115170 "Activin A receptor type 1" Q04771 2 157736251-157876330 "Cancer-related genes, Disease related genes, Enzymes, Human disease related genes, Potential drug targets, Predicted intracellular proteins, Predicted membrane proteins" "Kinase, Receptor, Serine/threonine-protein kinase, Transferase" "Cancer-related genes, Disease variant" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in many" "Microglial cells: 102.0" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Immune cell enhanced" "Detected in many" "T-reg: 5.6" "Low lineage specificity" "Detected in many" "Low cancer specificity" "Detected in all" "Thyroid - Thyroid glandular cells" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA007505, HPA046514" Approved Uncertain Nucleoli,Cytosol NA NA "Cluster 9: T-regs - Cell cycle regulation" "Cluster 62: Connective tissue - ECM organization" "Cluster 42: Choroid plexus - Mitochondria" "Cluster 26: Non-specific - Mitochondria & RNA binding" "Cluster 53: Fibroblasts - ECM organization" Nucleoli Cytosol "HPA007505: AB_1844752, HPA046514: AB_2732526" "unprognostic (6.99e-2)" "unprognostic (3.32e-2)" "unprognostic (3.02e-1)" "unprognostic (1.19e-2)" "unprognostic (2.73e-1)" "unprognostic (6.09e-2)" "unprognostic (3.66e-3)" "unprognostic (1.08e-1)" "unprognostic (3.99e-1)" "unprognostic (3.20e-1)" "unprognostic (2.65e-2)" "unprognostic (4.29e-2)" "unprognostic (2.42e-1)" "unprognostic (3.43e-3)" "unprognostic (3.17e-1)" "unprognostic (1.76e-2)" "prognostic unfavorable (5.17e-4)" ANO5 "GDD1, LGMD2L, TMEM16E" ENSG00000171714 "Anoctamin 5" Q75V66 11 21782659-22283567 "Disease related genes, Human disease related genes, Potential drug targets, Predicted membrane proteins, Transporters" "Disease variant, Limb-girdle muscular dystrophy, Osteogenesis imperfecta" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Group enriched" "Detected in many" 7 "heart muscle: 23.4;parathyroid gland: 16.6;skeletal muscle: 63.3;tongue: 47.8" "Group enriched" "Detected in many" 6 "Astrocytes: 64.4;Cardiomyocytes: 97.8;Excitatory neurons: 161.2;Inhibitory neurons: 130.7;Oligodendrocyte precursor cells: 76.4;Skeletal myocytes: 80.0" "Low cancer specificity" "Detected in many" "Low region specificity" "Detected in all" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cancer enhanced" "Detected in some" "Myeloma: 4.4" "Heart muscle - Cardiomyocytes, Skeletal muscle - Skeletal myocytes, Skin - Eccrine sweat gland cells, Testis - Early spermatids, Thyroid - Thyroid glandular cells" "Low region specificity" "Detected in some" "Low region specificity" "Detected in all" HPA058857 Uncertain NA NA "Cluster 14: Skeletal muscle - Muscle contraction" "Cluster 52: Neurons & Synapses - Synaptic function" "Cluster 11: Neuronal - Sensory perception" "Cluster 34: Neurons - Neuronal signaling" "HPA058857: AB_2683835" "unprognostic (5.25e-3)" "unprognostic (1.36e-3)" "unprognostic (2.43e-1)" "unprognostic (7.67e-3)" "unprognostic (3.50e-2)" "unprognostic (5.85e-2)" "unprognostic (8.17e-3)" "unprognostic (2.30e-2)" "unprognostic (1.68e-1)" "unprognostic (3.89e-2)" "unprognostic (2.54e-4)" "unprognostic (8.55e-2)" "prognostic favorable (2.50e-7)" "unprognostic (3.65e-3)" "unprognostic (2.84e-1)" "unprognostic (2.77e-4)" "unprognostic (7.94e-2)" ASPN "FLJ20129, PLAP-1, SLRR1C" ENSG00000106819 Asporin Q9BXN1 9 92456205-92482506 "Disease related genes, Human disease related genes, Plasma proteins, Predicted intracellular proteins, Predicted secreted proteins" Biomineralization "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "heart muscle: 92.0;smooth muscle: 106.5" "Cell type enhanced" "Detected in some" "Basal keratinocytes: 40.4;Fibroblasts: 71.3;Microglial cells: 23.3;Ovarian stromal cells: 17.3;Sertoli cells: 21.8;Smooth muscle cells: 62.8" "Cancer enhanced" "Detected in all" "breast cancer: 51.0" "Low region specificity" "Detected in all" "Immune cell enriched" "Detected in single" 5 "basophil: 1.8" "Lineage enriched" "Detected in single" 5 "granulocytes: 1.8" "Cancer enhanced" "Detected in single" "Brain cancer: 1.0" "Adipose subcutaneous - Adipose progenitor cells, Heart muscle - Fibroblasts, Kidney - Fibroblasts, Liver - Hepatic stellate cells, Skin - Fibroblast_1, Thyroid - Fibroblasts" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA007894, HPA008435, HPA024230" Approved Uncertain Nucleoplasm,Cytosol "Secreted to extracellular matrix" Other NA NA 2100000 "Cluster 41: Smooth muscle tissue - ECM organization" "Cluster 25: Non-specific - Transcription" "Cluster 64: Connective tissue cells - ECM organization" "Cluster 53: Fibroblasts - ECM organization" Nucleoplasm Cytosol "HPA007894: , HPA008435: AB_1845112, HPA024230: AB_1845113" "unprognostic (2.40e-1)" "unprognostic (1.02e-2)" "unprognostic (8.13e-3)" "unprognostic (3.51e-2)" "unprognostic (1.22e-1)" "unprognostic (1.01e-2)" "unprognostic (9.50e-3)" "unprognostic (1.17e-1)" "unprognostic (2.74e-3)" "unprognostic (6.38e-2)" "unprognostic (3.70e-2)" "unprognostic (4.70e-2)" "prognostic unfavorable (1.64e-7)" "unprognostic (1.42e-3)" "unprognostic (3.04e-2)" "unprognostic (6.27e-3)" "unprognostic (2.48e-2)" CALCR "CT-R, CTR" ENSG00000004948 "Calcitonin receptor" 7 93424486-93574730 "Human disease related genes, Predicted membrane proteins" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in some" "brain: 4.0;kidney: 1.4" "Group enriched" "Detected in some" 5 "Early spermatids: 17.8;Late spermatids: 9.2;Microglial cells: 15.2" "Cancer enriched" "Detected in single" 5 "renal cancer: 1.1" "Low region specificity" "Detected in many" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cancer enhanced" "Detected in some" "testis cancer: 2.6;Uterine cancer: 2.9" "Testis - Early spermatids, Testis - Late spermatids" "Group enriched" "Detected in many" 5 "basal ganglia: 6.3;hypothalamus: 24.6" "Low region specificity" "Detected in all" "HPA028962, HPA061428" Enhanced Supported Approved "Vesicles,Cell Junctions,Centriolar satellite" NA NA "Cluster 54: Non-specific - Basic cellular processes" "Cluster 56: Hypothalamus - Neuropeptide signaling" "Cluster 15: Kidney cancer - Membrane components" "Cluster 2: Skeletal myocytes - Muscle contraction" "Cell Junctions" "Vesicles, Centriolar satellite" "HPA028962: AB_10602339, HPA061428: AB_2732661" "unprognostic (1.95e-1)" "unprognostic (2.43e-1)" "unprognostic (3.88e-2)" "unprognostic (1.88e-1)" "unprognostic (1.55e-2)" "unprognostic (3.43e-1)" "unprognostic (7.73e-5)" "unprognostic (1.64e-1)" "unprognostic (9.24e-3)" "unprognostic (8.70e-2)" "unprognostic (1.86e-2)" "unprognostic (6.68e-2)" "unprognostic (2.71e-3)" "unprognostic (1.46e-3)" "unprognostic (1.69e-1)" "unprognostic (2.49e-4)" "unprognostic (1.05e-2)" CILP HsT18872 ENSG00000138615 "Cartilage intermediate layer protein" O75339 15 65194760-65211473 "Disease related genes, Human disease related genes, Predicted secreted proteins" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in many" "Cell type enhanced" "Detected in many" "Endometrial stromal cells: 40.5;Fibroblasts: 160.9;Leydig cells: 222.4;Peritubular cells: 55.4;Skeletal myocytes: 73.2" "Cancer enhanced" "Detected in many" "breast cancer: 30.3" "Not detected" "Not detected" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Group enriched" "Detected in some" 12 "ovarian cancer: 2.8;Uterine cancer: 3.7" "Breast - Fibroblasts, Colon - Fibroblasts, Heart muscle - Fibroblasts, Kidney - Fibroblasts, Liver - Hepatic stellate cells, Lung - Fibroblast_2, Skeletal muscle - Fibroblasts, Skin - Fibroblast_2" "Not detected" "Not detected" "Low region specificity" "Detected in some" HPA003195 Uncertain "Secreted to extracellular matrix" "No annotated function" NA NA 13000000 "Cluster 41: Smooth muscle tissue - ECM organization" "Cluster 15: Kidney cancer - Membrane components" "Cluster 53: Fibroblasts - ECM organization" "HPA003195: AB_1078524" "unprognostic (2.21e-2)" "unprognostic (3.43e-2)" "unprognostic (4.22e-2)" "unprognostic (7.18e-2)" "unprognostic (2.94e-1)" "unprognostic (2.28e-1)" "unprognostic (2.60e-1)" "unprognostic (1.14e-1)" "unprognostic (1.88e-2)" "unprognostic (3.00e-2)" "unprognostic (1.84e-1)" "unprognostic (1.27e-1)" "unprognostic (2.31e-13)" "unprognostic (5.10e-2)" "unprognostic (2.50e-1)" "prognostic unfavorable (2.24e-5)" "unprognostic (4.68e-3)" COL11A1 "CO11A1, COLL6, DFNA37, STL2" ENSG00000060718 "Collagen type XI alpha 1 chain" P12107 1 102876467-103108872 "Cancer-related genes, Disease related genes, Human disease related genes, Plasma proteins, Predicted intracellular proteins, Predicted secreted proteins" "Cancer-related genes, Cataract, Deafness, Disease variant, Dwarfism, Ectodermal dysplasia, Non-syndromic deafness, Stickler syndrome" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in some" "placenta: 19.5;retina: 9.3" "Cell type enriched" "Detected in some" 5 "Oligodendrocyte precursor cells: 523.1" "Cancer enhanced" "Detected in many" "breast cancer: 27.4" "Low region specificity" "Detected in all" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cancer enhanced" "Detected in many" "Rhabdoid: 252.9" "Skeletal muscle - Fibroblasts, Testis - Early spermatids, Testis - Late spermatids" "Low region specificity" "Detected in many" "Low region specificity" "Detected in all" HPA058335 Supported "Endoplasmic reticulum" "Secreted to extracellular matrix" "No annotated function" No No 640000 "Cluster 34: Non-specific - Mixed function" "Cluster 53: Neurons - Mixed function" "Cluster 69: Skin cancer - ECM organization" "Cluster 76: Oligodendrocyte precursor - Unknown function" "Endoplasmic reticulum" "HPA058335: AB_2683682" "unprognostic (2.60e-3)" "unprognostic (6.61e-4)" "unprognostic (9.58e-2)" "unprognostic (5.06e-5)" "unprognostic (2.83e-1)" "unprognostic (2.85e-2)" "unprognostic (6.03e-3)" "unprognostic (2.23e-3)" "unprognostic (9.08e-2)" "unprognostic (1.21e-1)" "unprognostic (1.12e-2)" "unprognostic (1.94e-2)" "unprognostic (3.01e-12)" "unprognostic (1.27e-2)" "unprognostic (3.53e-1)" "unprognostic (3.54e-2)" "unprognostic (2.32e-2)" COL11A2 "DFNA13, DFNB53, HKE5" ENSG00000204248 "Collagen type XI alpha 2 chain" P13942 6 33162681-33192499 "Disease related genes, Human disease related genes, Plasma proteins, Predicted intracellular proteins, Predicted secreted proteins" "Deafness, Disease variant, Dwarfism, Non-syndromic deafness, Stickler syndrome" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Group enriched" "Detected in many" 4 "brain: 14.9;pituitary gland: 22.8;testis: 7.8" "Cell type enhanced" "Detected in some" "Astrocytes: 8.1;Early spermatids: 7.1;Horizontal cells: 5.7;Late spermatids: 5.7;Muller glia cells: 5.0;Oligodendrocytes: 6.2" "Cancer enriched" "Detected in many" 8 "melanoma: 13.3" "Low region specificity" "Detected in many" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Group enriched" "Detected in some" 4 "Bone cancer: 2.7;skin cancer: 1.7" "Testis - Late spermatids" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "Secreted to extracellular matrix" "No annotated function" NA NA 2100000 "Cluster 65: Cerebellum - Nervous system development" "Cluster 6: Non-specific - Immune response" "Cluster 12: Bone cancer - Neuronal signaling" "Cluster 21: Early spermatids - Spermatogenesis" 1 "unprognostic (4.62e-1)" "unprognostic (8.69e-2)" "unprognostic (1.65e-4)" "unprognostic (5.15e-3)" "unprognostic (1.14e-1)" "unprognostic (1.69e-1)" "unprognostic (1.04e-2)" "unprognostic (9.67e-2)" "unprognostic (2.05e-2)" "unprognostic (4.47e-2)" "unprognostic (1.22e-1)" "unprognostic (3.41e-3)" "unprognostic (2.26e-6)" "unprognostic (8.27e-2)" "unprognostic (2.17e-1)" "unprognostic (1.88e-1)" "unprognostic (5.96e-2)" COL1A1 OI4 ENSG00000108821 "Collagen type I alpha 1 chain" P02452 17 50184101-50201632 "Cancer-related genes, Disease related genes, FDA approved drug targets, Human disease related genes, Plasma proteins, Predicted intracellular proteins, Predicted secreted proteins" "Cancer-related genes, Disease variant, Dwarfism, Ehlers-Danlos syndrome, FDA approved drug targets, Osteogenesis imperfecta" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "cervix: 1284.0;gallbladder: 1170.7;ovary: 1172.9" "Cell type enhanced" "Detected in many" "Endometrial stromal cells: 1832.0;Fibroblasts: 1713.3;Leydig cells: 547.1;Ovarian stromal cells: 435.9;Pancreatic endocrine cells: 1558.7;Smooth muscle cells: 617.8" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cancer enhanced" "Detected in all" "Brain cancer: 1387.0" "Adipose subcutaneous - Adipose progenitor cells, Adipose visceral - Adipose progenitor cells, Breast - Fibroblasts, Heart muscle - Fibroblasts, Kidney - Fibroblasts, Lung - Fibroblast_2, Skeletal muscle - Fibroblasts, Skin - Fibroblast_1, Stomach - Fibroblasts, Thyroid - Fibroblasts" "Low region specificity" "Detected in all" "Region enhanced" "Detected in all" "spinal cord: 170.5" "HPA011795, HPA012111" Approved Approved "Endoplasmic reticulum,Vesicles" "Secreted to extracellular matrix" "No annotated function" NA NA 80000000 "Cluster 62: Connective tissue - ECM organization" "Cluster 12: Non-specific - Vasculature" "Cluster 64: Connective tissue cells - ECM organization" "Cluster 50: Connective tissue cells - ECM organization" 22 "Endoplasmic reticulum" Vesicles "HPA011795: AB_1847088, HPA012111: " "unprognostic (1.61e-1)" "unprognostic (3.60e-3)" "unprognostic (8.29e-2)" "unprognostic (5.52e-2)" "unprognostic (7.74e-2)" "unprognostic (2.22e-1)" "unprognostic (6.01e-2)" "prognostic unfavorable (4.43e-4)" "unprognostic (1.23e-2)" "unprognostic (2.55e-2)" "unprognostic (8.53e-2)" "unprognostic (9.90e-2)" "prognostic unfavorable (7.19e-12)" "unprognostic (2.74e-2)" "unprognostic (4.73e-2)" "unprognostic (7.26e-2)" "unprognostic (3.87e-3)" COL1A2 OI4 ENSG00000164692 "Collagen type I alpha 2 chain" P08123 7 94394895-94431227 "Cancer-related genes, Disease related genes, Human disease related genes, Plasma proteins, Predicted secreted proteins" "Cancer-related genes, Disease variant, Dwarfism, Ehlers-Danlos syndrome, Osteogenesis imperfecta" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in all" "cervix: 1678.8;gallbladder: 1290.4;ovary: 1367.1;smooth muscle: 1307.1" "Cell type enhanced" "Detected in many" "Endometrial stromal cells: 699.6;Fibroblasts: 1831.0;Glandular and luminal cells: 445.8;Leydig cells: 980.2;Pancreatic endocrine cells: 492.4;Peritubular cells: 486.3;Smooth muscle cells: 570.4" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cancer enhanced" "Detected in many" "Brain cancer: 1425.0;Sarcoma: 742.4" "Adipose subcutaneous - Adipose progenitor cells, Adipose visceral - Adipose progenitor cells, Breast - Fibroblasts, Heart muscle - Fibroblasts, Kidney - Fibroblasts, Lung - Fibroblast_2, Skeletal muscle - Fibroblasts, Skin - Fibroblast_1, Stomach - Fibroblasts" "Low region specificity" "Detected in all" "Region enhanced" "Detected in all" "spinal cord: 172.6" "CAB032650, HPA068464, HPA068494" Approved Supported "Endoplasmic reticulum" "Secreted to extracellular matrix" "No annotated function" NA NA 27000000 "Cluster 62: Connective tissue - ECM organization" "Cluster 12: Non-specific - Vasculature" "Cluster 64: Connective tissue cells - ECM organization" "Cluster 50: Connective tissue cells - ECM organization" 9 "Endoplasmic reticulum" "CAB032650: AB_2082039, HPA068464: , HPA068494: " "unprognostic (1.20e-1)" "unprognostic (6.34e-2)" "unprognostic (1.32e-1)" "unprognostic (3.40e-2)" "unprognostic (2.86e-2)" "unprognostic (2.81e-1)" "unprognostic (5.15e-2)" "unprognostic (7.38e-3)" "unprognostic (2.01e-2)" "unprognostic (1.40e-2)" "unprognostic (5.83e-2)" "unprognostic (2.15e-1)" "prognostic unfavorable (1.51e-9)" "unprognostic (1.35e-2)" "unprognostic (5.25e-2)" "unprognostic (1.15e-1)" "unprognostic (3.31e-3)" COL2A1 "AOM, SEDC, STL1" ENSG00000139219 "Collagen type II alpha 1 chain" P02458 12 47972967-48004554 "Cancer-related genes, Disease related genes, FDA approved drug targets, Human disease related genes, Predicted secreted proteins" "Cancer-related genes, Cataract, Deafness, Disease variant, Dwarfism, FDA approved drug targets, Stickler syndrome" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Group enriched" "Detected in some" 4 "epididymis: 18.6;pituitary gland: 8.9;retina: 5.4;stomach 1: 12.2" "Cell type enhanced" "Detected in some" "Breast myoepithelial cells: 6.6;Early spermatids: 11.0;Enteroendocrine cells: 27.4;Granulosa cells: 9.7;Horizontal cells: 24.5;Late spermatids: 11.5;Muller glia cells: 21.3" "Low cancer specificity" "Detected in many" "Not detected" "Not detected" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cancer enriched" "Detected in many" 7 "liver cancer: 78.5" "Testis - Late spermatids" "Not detected" "Not detected" "Low region specificity" "Detected in many" "CAB002214, HPA055753" Approved Approved Nucleoplasm "Secreted to extracellular matrix" "No annotated function" No NA 1400000 "Cluster 50: Epididymis - Male reproductive secretion" "Cluster 34: Testis cancer - Unknown function" "Cluster 20: Enteroendocrine cells - Hormone signaling" Nucleoplasm "CAB002214: AB_563666, HPA055753: AB_2682908" "unprognostic (7.25e-2)" "unprognostic (1.20e-1)" "unprognostic (2.58e-1)" "unprognostic (3.44e-1)" "unprognostic (2.88e-2)" "unprognostic (3.08e-2)" "unprognostic (8.63e-2)" "unprognostic (2.77e-1)" "unprognostic (1.22e-1)" "unprognostic (3.12e-2)" "unprognostic (1.31e-4)" "unprognostic (2.64e-1)" "unprognostic (3.44e-3)" "unprognostic (1.89e-1)" "unprognostic (2.93e-1)" "unprognostic (2.07e-1)" "unprognostic (1.02e-1)" COL6A1 ENSG00000142156 "Collagen type VI alpha 1 chain" P12109 21 45981770-46005050 "Cancer-related genes, Disease related genes, Human disease related genes, Plasma proteins, Predicted intracellular proteins, Predicted secreted proteins" "Cell adhesion" "Cancer-related genes, Congenital muscular dystrophy, Disease variant, Limb-girdle muscular dystrophy" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "intestine: 770.1" "Cell type enhanced" "Detected in many" "Endometrial stromal cells: 529.6;Fibroblasts: 726.0;Leydig cells: 341.2;Ovarian stromal cells: 267.7;Peritubular cells: 233.8;Smooth muscle cells: 352.4" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cancer enhanced" "Detected in all" "Brain cancer: 520.5" "Adipose subcutaneous - Adipose progenitor cells, Adipose visceral - Adipose progenitor cells, Breast - Fibroblasts, Heart muscle - Fibroblasts, Liver - Hepatic stellate cells, Lung - Fibroblast_2, Skeletal muscle - Fibroblasts, Skin - Fibroblast_1, Thyroid - Fibroblasts" "Low region specificity" "Detected in all" "Region enhanced" "Detected in all" "spinal cord: 81.4" "HPA019142, HPA029401" Enhanced Approved Cytosol "Secreted to extracellular matrix" "Cell adhesion" NA NA 250000000 "Cluster 41: Smooth muscle tissue - ECM organization" "Cluster 50: Non-specific - Nucleic acid binding" "Cluster 64: Connective tissue cells - ECM organization" "Cluster 53: Fibroblasts - ECM organization" Cytosol "HPA019142: AB_1847093, HPA029401: AB_10601361" "unprognostic (3.45e-1)" "unprognostic (4.09e-2)" "unprognostic (8.71e-2)" "unprognostic (1.72e-1)" "unprognostic (5.79e-3)" "unprognostic (2.12e-1)" "unprognostic (6.27e-2)" "unprognostic (1.09e-2)" "unprognostic (4.47e-2)" "unprognostic (3.69e-2)" "unprognostic (6.06e-3)" "unprognostic (3.86e-1)" "prognostic unfavorable (1.07e-8)" "unprognostic (5.16e-2)" "unprognostic (7.39e-2)" "unprognostic (3.53e-3)" "prognostic unfavorable (4.54e-4)" COL9A3 "DJ885L7.4.1, EDM3, FLJ90759, IDD, MED" ENSG00000092758 "Collagen type IX alpha 3 chain" Q14050 20 62816244-62841159 "Disease related genes, Human disease related genes, Predicted intracellular proteins, Predicted secreted proteins" "Deafness, Disease variant, Dwarfism, Stickler syndrome" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "brain: 69.3" "Cell type enriched" "Detected in many" 4 "Late spermatids: 419.8" "Cancer enhanced" "Detected in many" "thyroid cancer: 30.0" "Low region specificity" "Detected in all" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cancer enhanced" "Detected in many" "skin cancer: 154.3" "Adipose subcutaneous - Smooth muscle cells, Colon - Enteric glia cells, Liver - Hepatocytes, Skin - Outer root sheath cells, Testis - Late spermatids" "Low region specificity" "Detected in all" "HPA040125, HPA058323" Supported Approved "Nucleoplasm,Intermediate filaments" "Secreted to extracellular matrix" "No annotated function" NA NA "Cluster 9: Oligodendrocytes - Myelination" "Cluster 11: White matter - Signal transduction" "Cluster 69: Skin cancer - ECM organization" "Cluster 50: Connective tissue cells - ECM organization" 1 Nucleoplasm "Intermediate filaments" "HPA040125: AB_10805604, HPA058323: AB_2683679" "unprognostic (1.14e-3)" "unprognostic (2.14e-2)" "unprognostic (3.93e-1)" "unprognostic (1.21e-3)" "unprognostic (4.25e-2)" "unprognostic (2.39e-2)" "unprognostic (2.33e-1)" "unprognostic (1.24e-2)" "unprognostic (1.27e-1)" "unprognostic (1.25e-1)" "unprognostic (2.39e-1)" "unprognostic (2.13e-1)" "unprognostic (1.64e-2)" "unprognostic (2.94e-1)" "unprognostic (1.51e-1)" "unprognostic (4.79e-2)" "unprognostic (2.67e-1)" ENPP1 "M6S1, NPPS, PC-1, PCA1, PDNP1" ENSG00000197594 "Ectonucleotide pyrophosphatase/phosphodiesterase 1" P22413 6 131808016-131895155 "CD markers, Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Potential drug targets, Predicted membrane proteins, Predicted secreted proteins" Biomineralization Hydrolase "Diabetes mellitus, Disease variant, Obesity" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "placenta: 42.0" "Cell type enhanced" "Detected in many" "Basal prostatic cells: 102.2;Endometrial stromal cells: 78.6;Hepatocytes: 95.2;Peritubular cells: 70.1" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Immune cell enhanced" "Detected in single" "NK-cell: 1.5" "Low lineage specificity" "Detected in single" "Low cancer specificity" "Detected in many" "Adipose subcutaneous - Adipocytes (Subcutaneous), Adipose visceral - Adipocytes (Visceral), Liver - Hepatocytes" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "CAB032904, HPA062066" Enhanced "Secreted - unknown location" Enzyme NA NA 4400000 "Cluster 35: Neutrophils - Protein binding" "Cluster 11: Liver - Plasma proteins" "Cluster 41: Monoamines - Neurotransmitter signalling" "Cluster 64: Connective tissue cells - ECM organization" "Cluster 50: Connective tissue cells - ECM organization" 2 "CAB032904: AB_2099635, HPA062066: AB_2684674" "unprognostic (1.47e-1)" "unprognostic (1.23e-1)" "unprognostic (2.15e-1)" "unprognostic (1.60e-3)" "unprognostic (2.40e-1)" "unprognostic (1.11e-1)" "unprognostic (2.00e-1)" "unprognostic (1.60e-2)" "unprognostic (7.22e-3)" "unprognostic (8.96e-2)" "unprognostic (1.95e-1)" "unprognostic (3.00e-1)" "unprognostic (2.61e-2)" "unprognostic (1.41e-1)" "unprognostic (1.96e-1)" "unprognostic (1.84e-1)" "unprognostic (3.28e-3)" GNAS "GNAS1, GNASXL, GPSA, NESP, NESP55, SCG6, SgVI" ENSG00000087460 "GNAS complex locus" "O95467, P63092, Q5JWF2" 20 58839718-58911192 "Cancer-related genes, Disease related genes, Human disease related genes, Potential drug targets, Predicted intracellular proteins, Predicted membrane proteins, Transporters" Transducer "Cancer-related genes, Cushing syndrome, Disease variant, Dwarfism, Obesity, Proto-oncogene" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell type specificity" "Detected in all" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "CAB010337, HPA018122, HPA027478, HPA028386" Uncertain Approved "Nucleoplasm,Plasma membrane,Cytosol" "Intracellular and membrane" Other NA NA "Cluster 10: Non-specific - Membrane trafficking" "Cluster 68: Non-specific - Protein processing" "Cluster 1: Neurons - Mixed function" "Cluster 62: Non-specific - Plasma proteins" "Cluster 33: Non-specific - DNA binding" 3 Nucleoplasm "Plasma membrane, Cytosol" "CAB010337: AB_631538, HPA018122: AB_1849236, HPA027478: AB_10599284, HPA028386: AB_10601983" "unprognostic (7.48e-2)" "unprognostic (1.41e-1)" "unprognostic (3.90e-2)" "unprognostic (4.77e-2)" "unprognostic (8.37e-3)" "unprognostic (2.82e-2)" "unprognostic (4.53e-3)" "unprognostic (8.01e-2)" "unprognostic (4.29e-2)" "prognostic favorable (8.76e-4)" "unprognostic (2.07e-2)" "unprognostic (1.58e-1)" "prognostic unfavorable (3.49e-4)" "unprognostic (5.24e-3)" "unprognostic (1.61e-1)" "unprognostic (8.25e-2)" "unprognostic (1.36e-1)" H3-3A "H3.3A, H3F3, H3F3A" ENSG00000163041 "H3.3 histone A" P84243 1 226061851-226072019 "Cancer-related genes, Disease related genes, Human disease related genes, Predicted intracellular proteins" DNA-binding "Cancer-related genes, Disease variant, Intellectual disability" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell type specificity" "Detected in all" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Immune cell enhanced" "Detected in all" "neutrophil: 4496.2" "Lineage enriched" "Detected in all" 4 "granulocytes: 4496.2" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "CAB011481, CAB037178, HPA042570, HPA050968, HPA064058" Supported Supported Nucleoplasm NA NA "Cluster 21: Neutrophils - Unknown function" "Cluster 77: Bone marrow - Cell proliferation" "Cluster 55: Non-specific - Transcription" "Cluster 45: Non-specific - Nuclear processes" "Cluster 57: Platelets - Hemostasis" 24 Nucleoplasm "CAB011481: AB_880446, CAB037178: AB_532248, HPA042570: AB_2678056, HPA050968: , HPA064058: " "unprognostic (1.82e-1)" "unprognostic (1.95e-2)" "unprognostic (1.00e-1)" "unprognostic (2.19e-3)" "unprognostic (2.83e-2)" "unprognostic (3.74e-1)" "unprognostic (9.83e-3)" "unprognostic (4.71e-2)" "unprognostic (1.77e-3)" "unprognostic (3.69e-2)" "unprognostic (1.29e-1)" "unprognostic (1.29e-1)" "prognostic unfavorable (1.21e-6)" "unprognostic (3.66e-2)" "unprognostic (8.03e-3)" "unprognostic (2.21e-3)" "unprognostic (6.03e-2)" HLA-B AS ENSG00000234745 "Major histocompatibility complex, class I, B" P01889 6 31353872-31367067 "Cancer-related genes, Disease related genes, Human disease related genes, Predicted intracellular proteins, Predicted membrane proteins" "Adaptive immunity, Host-virus interaction, Immunity, Innate immunity" "Cancer-related genes" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "lymphoid tissue: 2389.7" "Cell type enhanced" "Detected in all" "monocytes: 4080.4;NK-cells: 5111.3;Proximal enterocytes: 4325.5" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cancer specificity" "Detected in many" "Skin - Keratinocyte (other), Thyroid - T-cells" CAB015418 Enhanced NA NA 190000000 "Cluster 7: Non-specific - Innate immune response" "Cluster 47: Spleen - Immune response" "Cluster 43: Hindbrain - Mixed function" "Cluster 55: Lymphoma - Immune response" "Cluster 14: Langerhans cells - Innate immune response" 5 "CAB015418: AB_831547" "unprognostic (2.87e-2)" "unprognostic (1.49e-1)" "unprognostic (4.90e-2)" "unprognostic (2.65e-2)" "unprognostic (1.86e-1)" "unprognostic (1.81e-1)" "unprognostic (5.16e-3)" "unprognostic (8.51e-2)" "prognostic favorable (2.90e-4)" "unprognostic (2.69e-3)" "unprognostic (3.05e-2)" "unprognostic (1.59e-1)" "unprognostic (9.28e-3)" "unprognostic (3.27e-1)" "unprognostic (7.83e-2)" "unprognostic (8.24e-3)" "unprognostic (3.67e-2)" HPGD SDR36C1 ENSG00000164120 "15-hydroxyprostaglandin dehydrogenase" P15428 4 174490175-174523154 "Cancer-related genes, Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Potential drug targets, Predicted intracellular proteins" "Fatty acid metabolism, Lipid metabolism, Prostaglandin metabolism" Oxidoreductase "Cancer-related genes, Disease variant, Tumor suppressor" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "stomach 1: 229.1;urinary bladder: 363.3" "Cell type enhanced" "Detected in many" "Club cells: 296.3;Distal enterocytes: 340.0;Extravillous trophoblasts: 883.5;granulocytes: 945.1;Hepatocytes: 277.8;Proximal enterocytes: 470.9" "Cancer enhanced" "Detected in many" "urothelial cancer: 52.4" "Region enhanced" "Detected in many" "choroid plexus: 17.4" "Group enriched" "Detected in many" 5 "basophil: 123.8;T-reg: 45.1" "Group enriched" "Detected in many" 73 "granulocytes: 123.8;T-cells: 45.1" "Cancer enhanced" "Detected in many" "testis cancer: 111.7" "Kidney - Proximal tubular cells, Liver - Hepatocytes, Skin - Keratinocyte (granular)" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA004919, HPA005679" Enhanced Supported Nucleoplasm,Cytosol No NA 20000 "Cluster 42: Non-specific - Vesicular transport" "Cluster 37: Liver & Intestine - Lipid metabolism" "Cluster 36: Choroid plexus - Mixed function" "Cluster 47: Leukemia - Hemostasis" "Cluster 30: Granulocytes - Unknown function" Cytosol Nucleoplasm "HPA004919: AB_1079081, HPA005679: AB_1079080" "unprognostic (1.23e-3)" "unprognostic (1.61e-1)" "unprognostic (5.96e-2)" "unprognostic (1.25e-1)" "unprognostic (1.09e-2)" "unprognostic (2.53e-2)" "unprognostic (1.27e-1)" "unprognostic (2.23e-1)" "unprognostic (1.08e-1)" "unprognostic (4.28e-2)" "unprognostic (3.54e-3)" "unprognostic (2.34e-2)" "prognostic favorable (3.20e-4)" "unprognostic (2.44e-1)" "unprognostic (2.59e-1)" "unprognostic (1.37e-4)" "unprognostic (2.33e-2)" HRAS HRAS1 ENSG00000174775 "HRas proto-oncogene, GTPase" P01112 11 532242-537321 "Cancer-related genes, Disease related genes, Enzymes, Human disease related genes, Plasma proteins, Potential drug targets, Predicted intracellular proteins, RAS pathway related proteins" Hydrolase "Cancer-related genes, Disease variant, Proto-oncogene" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in many" "Suprabasal keratinocytes: 201.1" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Immune cell enhanced" "Detected in some" "non-classical monocyte: 4.0" "Low lineage specificity" "Detected in many" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "CAB002015, HPA049830, HPA070222, HPA072761, CAB080330, CAB080331, CAB080332" Supported Supported Nucleoplasm,Cytosol NA NA "Cluster 13: Non-specific - Mitochondria" "Cluster 34: Non-specific - Mixed function" "Cluster 45: Non-specific - Mixed function" "Cluster 53: Squamous epithelial cells - Keratinization" "Cluster 12: Squamous epithelial cells - Keratinization" 87 "Nucleoplasm, Cytosol" "CAB002015: , CAB080330: , CAB080331: , CAB080332: , HPA049830: AB_2680903, HPA070222: , HPA072761: " "unprognostic (3.06e-2)" "unprognostic (2.98e-2)" "unprognostic (7.01e-2)" "unprognostic (3.08e-3)" "unprognostic (3.49e-3)" "unprognostic (3.87e-1)" "prognostic unfavorable (2.32e-4)" "unprognostic (1.07e-1)" "unprognostic (2.25e-1)" "unprognostic (1.50e-1)" "unprognostic (2.88e-3)" "unprognostic (9.85e-2)" "unprognostic (2.81e-1)" "unprognostic (1.85e-1)" "unprognostic (1.80e-1)" "unprognostic (1.58e-2)" "unprognostic (1.38e-1)" HSD11B2 SDR9C3 ENSG00000176387 "Hydroxysteroid 11-beta dehydrogenase 2" P80365 16 67430652-67437553 "Disease related genes, Human disease related genes, Metabolic proteins, Predicted membrane proteins" "Lipid metabolism, Steroid metabolism" Oxidoreductase "Disease variant" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Group enriched" "Detected in many" 4 "intestine: 243.0;kidney: 326.2;salivary gland: 252.7" "Cell type enhanced" "Detected in many" "Collecting duct cells: 140.0;Distal enterocytes: 701.0;Enteroendocrine cells: 133.5;Intestinal goblet cells: 254.5;Paneth cells: 272.9;Proximal enterocytes: 247.9;Syncytiotrophoblasts: 165.6" "Cancer enhanced" "Detected in all" "renal cancer: 62.6" "Low region specificity" "Detected in many" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cancer enhanced" "Detected in many" "colorectal cancer: 16.0;prostate cancer: 15.6" "Colon - Colon enterocytes, Kidney - Intercalated cells, Liver - Hepatocytes" "Not detected" "Not detected" "Low region specificity" "Detected in some" "CAB032443, HPA042186, HPA056385" Enhanced Supported Vesicles NA NA "Cluster 52: Kidney - Transmembrane transport" "Cluster 37: Neurons - Mixed function" "Cluster 57: Stomach & Colon cancer - Digestion" "Cluster 5: Enterocytes - Absorption" Vesicles "CAB032443: AB_2233199, HPA042186: AB_2677888, HPA056385: AB_2683110" "unprognostic (2.87e-3)" "unprognostic (5.24e-2)" "unprognostic (7.10e-2)" "unprognostic (6.55e-2)" "unprognostic (9.29e-3)" "unprognostic (3.14e-1)" "unprognostic (2.68e-2)" "unprognostic (2.07e-1)" "unprognostic (2.21e-3)" "unprognostic (2.25e-3)" "unprognostic (3.27e-2)" "unprognostic (2.34e-1)" "prognostic favorable (9.51e-5)" "unprognostic (7.20e-2)" "unprognostic (3.19e-1)" "unprognostic (1.55e-2)" "unprognostic (1.84e-1)" LGR4 GPR48 ENSG00000205213 "Leucine rich repeat containing G protein-coupled receptor 4" Q9BXB1 11 27365961-27472790 "Disease related genes, G-protein coupled receptors, Human disease related genes, Potential drug targets, Predicted intracellular proteins, Predicted membrane proteins" "Biological rhythms, Differentiation, Immunity, Innate immunity, Spermatogenesis, Wnt signaling pathway" "Developmental protein, G-protein coupled receptor, Receptor, Transducer" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in many" "Astrocytes: 193.8;Glandular and luminal cells: 134.5;Syncytiotrophoblasts: 120.5" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Low cancer specificity" "Detected in all" "Adipose visceral - Adipocytes (Visceral), Skin - Outer root sheath cells, Testis - Sertoli cells, Thyroid - Thyroid glandular cells" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA030267, HPA054350" Uncertain Approved "Centriolar satellite" NA NA "Cluster 48: Stomach - Proteolysis" "Cluster 44: Non-specific - Mixed function" "Cluster 57: Stomach & Colon cancer - Digestion" "Cluster 37: Glandular & Luminal cells - Unknown function" 1 "Centriolar satellite" "HPA030267: AB_10610004, HPA054350: " "unprognostic (5.27e-3)" "unprognostic (5.18e-2)" "unprognostic (4.64e-3)" "unprognostic (1.59e-1)" "unprognostic (4.92e-2)" "unprognostic (2.31e-1)" "unprognostic (1.98e-1)" "unprognostic (2.02e-2)" "unprognostic (2.00e-2)" "unprognostic (4.63e-2)" "unprognostic (5.84e-3)" "unprognostic (2.10e-1)" "prognostic favorable (2.00e-7)" "unprognostic (5.01e-1)" "unprognostic (3.59e-1)" "unprognostic (3.54e-2)" "unprognostic (1.76e-1)" LRP5 "BMND1, EVR1, EVR4, HBM, LR3, LRP7, OPPG, OPS, OPTA1, VBCH2" ENSG00000162337 "LDL receptor related protein 5" O75197 11 68312591-68449275 "Disease related genes, Human disease related genes, Predicted intracellular proteins, Predicted membrane proteins" "Endocytosis, Wnt signaling pathway" "Developmental protein, Receptor" "Disease variant, Osteogenesis imperfecta, Osteopetrosis" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in all" "liver: 126.5" "Low cell type specificity" "Detected in many" "Low cancer specificity" "Detected in all" "Region enriched" "Detected in all" 5 "choroid plexus: 91.2" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "CAB013001, HPA030505" Enhanced NA NA 1500000 "Cluster 83: Liver - Metabolism" "Cluster 36: Choroid plexus - Mixed function" "Cluster 2: Mucus-secreting cells - Unknown function" "Cluster 75: Serous glandular cells - Salivary secretion" 3 "CAB013001: AB_2533267, HPA030505: AB_2673505" "unprognostic (3.67e-1)" "unprognostic (2.98e-2)" "unprognostic (1.11e-1)" "unprognostic (3.13e-2)" "unprognostic (3.33e-1)" "unprognostic (1.97e-2)" "unprognostic (1.05e-1)" "unprognostic (2.94e-2)" "unprognostic (9.63e-2)" "unprognostic (2.54e-1)" "unprognostic (2.78e-1)" "unprognostic (6.82e-2)" "prognostic favorable (3.55e-10)" "unprognostic (2.28e-2)" "unprognostic (1.62e-2)" "unprognostic (1.58e-1)" "unprognostic (7.42e-2)" MAFB KRML ENSG00000204103 "MAF bZIP transcription factor B" Q9Y5Q3 20 40685848-40689236 "Cancer-related genes, Disease related genes, Human disease related genes, Predicted intracellular proteins, Transcription factors" "Transcription, Transcription regulation" "Activator, DNA-binding, Repressor" "Cancer-related genes, Disease variant, Proto-oncogene, Tumor suppressor" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "parathyroid gland: 264.2" "Cell type enhanced" "Detected in many" "Hofbauer cells: 399.9;Kupffer cells: 528.6;Macrophages: 538.4;monocytes: 1168.6;Squamous epithelial cells: 370.2" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Group enriched" "Detected in some" 4 "intermediate monocyte: 88.3;non-classical monocyte: 121.9" "Lineage enriched" "Detected in many" 15 "monocytes: 121.9" "Cancer enhanced" "Detected in many" "Bone cancer: 29.3" "Adipose subcutaneous - Macrophages, Adipose visceral - Macrophages, Breast - Fibroblasts, Colon - Macrophages, Heart muscle - Macrophages, Kidney - Podocytes, Lung - Macrophages, Prostate - Macrophages" "Low region specificity" "Detected in many" "Low region specificity" "Detected in all" HPA005653 Approved Approved "Nucleoplasm,Nucleoli,Golgi apparatus,Cytosol" Yes NA "Cluster 40: Monocytes - Innate immune response" "Cluster 24: Parathyroid gland - Vesicular transport" "Cluster 20: Macrophages & Microglia - Immune response" "Cluster 12: Bone cancer - Neuronal signaling" "Cluster 58: Macrophages - Innate immune response" 5 Nucleoplasm "Nucleoli, Golgi apparatus, Cytosol" "HPA005653: AB_1079293" "unprognostic (1.55e-1)" "unprognostic (1.17e-2)" "unprognostic (1.16e-3)" "prognostic unfavorable (5.64e-4)" "unprognostic (9.16e-2)" "unprognostic (3.92e-2)" "unprognostic (1.10e-1)" "unprognostic (2.10e-1)" "unprognostic (2.57e-2)" "unprognostic (6.09e-2)" "unprognostic (5.45e-3)" "unprognostic (9.92e-2)" "unprognostic (3.95e-2)" "unprognostic (1.05e-1)" "unprognostic (3.21e-3)" "unprognostic (3.49e-2)" "unprognostic (2.30e-2)" MAP2K1 "MAPKK1, MEK1, PRKMK1" ENSG00000169032 "Mitogen-activated protein kinase kinase 1" Q02750 15 66386837-66491656 "Cancer-related genes, Disease related genes, Enzymes, FDA approved drug targets, Human disease related genes, Predicted intracellular proteins, RAS pathway related proteins" "Kinase, Serine/threonine-protein kinase, Transferase, Tyrosine-protein kinase" "Cancer-related genes, Cardiomyopathy, Disease variant, Ectodermal dysplasia, FDA approved drug targets, Intellectual disability" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in all" "Hepatocytes: 182.8;Langerhans cells: 316.8;monocytes: 356.2" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cancer specificity" "Detected in all" "Breast - Adipocytes (Breast), Testis - Spermatogonia" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "CAB003834, HPA026430, CAB080093" Approved Supported "Plasma membrane,Cytosol" NA NA 120000 "Cluster 44: Plasmacytoid DCs - Plasma membrane proteins" "Cluster 61: Brain - Neuronal signaling" "Cluster 51: Neurons - Mixed function" "Cluster 46: Lymphoma - Humoral immune response" "Cluster 29: Monocytes - Innate immune response" 10 "Plasma membrane, Cytosol" "CAB003834: AB_562310, CAB080093: , HPA026430: AB_1853742" "unprognostic (4.05e-2)" "unprognostic (1.23e-2)" "unprognostic (2.07e-1)" "unprognostic (4.92e-2)" "prognostic unfavorable (1.95e-4)" "unprognostic (1.81e-3)" "unprognostic (5.78e-2)" "unprognostic (9.91e-3)" "unprognostic (1.11e-1)" "unprognostic (1.77e-1)" "unprognostic (1.45e-1)" "unprognostic (7.62e-3)" "unprognostic (1.20e-1)" "unprognostic (2.71e-1)" "unprognostic (1.96e-1)" "unprognostic (1.15e-1)" "unprognostic (9.40e-3)" MMP2 "CLG4, CLG4A, TBE-1" ENSG00000087245 "Matrix metallopeptidase 2" P08253 16 55389700-55506691 "Cancer-related genes, Candidate cardiovascular disease genes, Disease related genes, Enzymes, Human disease related genes, Plasma proteins, Potential drug targets, Predicted intracellular proteins, Predicted secreted proteins" "Angiogenesis, Collagen degradation" "Hydrolase, Metalloprotease, Protease" "Cancer-related genes, Disease variant" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in all" "gallbladder: 1025.9" "Cell type enhanced" "Detected in many" "Endometrial stromal cells: 219.7;Extravillous trophoblasts: 528.1;Fibroblasts: 757.2;Leydig cells: 332.5;Peritubular cells: 398.7" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cancer enhanced" "Detected in many" "testis cancer: 781.9" "Heart muscle - Fibroblasts, Kidney - Fibroblasts, Liver - Hepatic stellate cells, Lung - Fibroblast_2, Prostate - Fibroblasts, Skin - Fibroblast_2, Stomach - Fibroblasts" "Low region specificity" "Detected in many" "Low region specificity" "Detected in all" "HPA001939, CAB002788" Approved Approved Vesicles "Secreted to extracellular matrix" Enzyme NA NA 1600000000 220000000 "Cluster 62: Connective tissue - ECM organization" "Cluster 20: Macrophages & Microglia - Immune response" "Cluster 44: Connective tissue cells - ECM organization" "Cluster 53: Fibroblasts - ECM organization" 5 Vesicles "CAB002788: , HPA001939: AB_1079395" "unprognostic (7.26e-2)" "unprognostic (1.36e-3)" "unprognostic (1.66e-1)" "unprognostic (2.14e-3)" "unprognostic (5.03e-2)" "unprognostic (1.20e-1)" "unprognostic (1.74e-1)" "unprognostic (9.36e-3)" "unprognostic (4.81e-3)" "unprognostic (3.79e-2)" "unprognostic (4.59e-3)" "unprognostic (6.12e-2)" "unprognostic (1.28e-3)" "unprognostic (1.59e-2)" "unprognostic (8.00e-2)" "unprognostic (8.98e-2)" "unprognostic (4.63e-2)" NOS3 "ECNOS, eNOS" ENSG00000164867 "Nitric oxide synthase 3" P29474 7 150991017-151014588 "Cancer-related genes, Disease related genes, Enzymes, FDA approved drug targets, Human disease related genes, Metabolic proteins, Plasma proteins, Predicted intracellular proteins" "Calmodulin-binding, Oxidoreductase" "Cancer-related genes, FDA approved drug targets" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "lymphoid tissue: 60.9" "Cell type enhanced" "Detected in some" "Adipocytes: 18.8;Early spermatids: 94.6;Endothelial cells: 26.3;Late spermatids: 33.8" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in some" "Lineage enriched" "Detected in single" 4 "T-cells: 2.3" "Low cancer specificity" "Detected in many" "Breast - Endothelial cells, Colon - Endothelial cells, Heart muscle - Endothelial cells, Kidney - Endothelial cells, Liver - Vascular Endothelial cells, Prostate - Endothelial cells, Testis - Late spermatids" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" CAB002168 Enhanced NA NA "Cluster 31: T-cells - T-cell receptor" "Cluster 47: Spleen - Immune response" "Cluster 47: Endothelial cells - Vasculature" "Cluster 48: Adipocytes & Endothelial cells - Angiogenesis" "Cluster 41: Adipocytes & Endothelial cells - Mixed function" 40 "CAB002168: AB_564072" "unprognostic (6.53e-2)" "unprognostic (3.36e-1)" "unprognostic (1.63e-2)" "unprognostic (8.46e-2)" "unprognostic (2.96e-2)" "unprognostic (1.47e-1)" "unprognostic (1.35e-1)" "unprognostic (1.36e-1)" "unprognostic (6.97e-2)" "unprognostic (2.56e-1)" "unprognostic (9.40e-2)" "unprognostic (2.36e-1)" "prognostic unfavorable (3.63e-4)" "unprognostic (1.25e-2)" "unprognostic (6.63e-2)" "unprognostic (1.05e-1)" "unprognostic (1.01e-1)" NOTCH2 ENSG00000134250 "Notch receptor 2" Q04721 1 119911553-120100779 "Cancer-related genes, Disease related genes, Human disease related genes, Plasma proteins, Predicted intracellular proteins, Predicted membrane proteins" "Differentiation, Notch signaling pathway, Transcription, Transcription regulation" "Activator, Developmental protein, Receptor" "Cancer-related genes, Disease variant" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in many" "monocytes: 175.0" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in many" "Low lineage specificity" "Detected in all" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA048743 Approved Supported "Nucleoplasm,Plasma membrane" NA NA 160000000 "Cluster 2: Dendritic cells - Unknown function" "Cluster 62: Connective tissue - ECM organization" "Cluster 39: Astrocytes - Mixed function" "Cluster 45: Non-specific - Nuclear processes" "Cluster 29: Monocytes - Innate immune response" 1 "Nucleoplasm, Plasma membrane" "HPA048743: AB_2680508" "unprognostic (1.33e-1)" "unprognostic (1.43e-2)" "unprognostic (2.66e-1)" "unprognostic (1.40e-3)" "unprognostic (7.98e-2)" "unprognostic (4.01e-2)" "unprognostic (1.22e-1)" "unprognostic (7.32e-2)" "unprognostic (1.18e-2)" "prognostic unfavorable (5.24e-4)" "prognostic unfavorable (9.48e-4)" "unprognostic (3.86e-2)" "unprognostic (6.12e-3)" "unprognostic (1.55e-2)" "unprognostic (2.65e-2)" "unprognostic (1.12e-2)" "unprognostic (7.35e-3)" NR3C1 "GR, GRL" ENSG00000113580 "Nuclear receptor subfamily 3 group C member 1" P04150 5 143277931-143435512 "Disease related genes, FDA approved drug targets, Human disease related genes, Nuclear receptors, Plasma proteins, Predicted intracellular proteins, Transcription factors" "Apoptosis, Cell cycle, Cell division, Chromosome partition, Mitosis, Transcription, Transcription regulation" "Chromatin regulator, DNA-binding, Receptor, RNA-binding" "Disease variant, FDA approved drug targets, Pseudohermaphroditism" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in all" "dendritic cells: 942.3;Excitatory neurons: 397.7" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cancer specificity" "Detected in all" "Testis - Peritubular cells, Thyroid - Fibroblasts" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA004248, CAB010435" Supported Supported Nucleoplasm,Mitochondria,Cytosol NA NA "Cluster 35: Neutrophils - Protein binding" "Cluster 19: Non-specific - Basic cellular processes" "Cluster 31: Non-specific - Transcription" "Cluster 15: Kidney cancer - Membrane components" "Cluster 28: Dendritic cells - Antigen presentation" 10 "Nucleoplasm, Cytosol" Mitochondria "CAB010435: AB_2155784, HPA004248: AB_1078976" "unprognostic (1.38e-1)" "unprognostic (1.93e-1)" "unprognostic (1.17e-1)" "prognostic unfavorable (3.64e-5)" "unprognostic (1.43e-2)" "unprognostic (2.74e-1)" "unprognostic (4.19e-1)" "unprognostic (1.39e-1)" "unprognostic (2.46e-2)" "unprognostic (3.87e-2)" "unprognostic (2.15e-1)" "unprognostic (6.85e-2)" "prognostic unfavorable (1.72e-6)" "unprognostic (9.06e-3)" "unprognostic (1.02e-1)" "unprognostic (2.43e-3)" "unprognostic (2.45e-2)" PDLIM4 RIL ENSG00000131435 "PDZ and LIM domain 4" P50479 5 132257696-132273454 "Human disease related genes, Predicted intracellular proteins" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in many" "Cell type enhanced" "Detected in many" "Basal respiratory cells: 168.2;Breast myoepithelial cells: 184.9;Melanocytes: 249.1;Paneth cells: 168.2;Sertoli cells: 193.1" "Low cancer specificity" "Detected in many" "Low region specificity" "Detected in all" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Low cancer specificity" "Detected in many" "Skeletal muscle - Fibroblasts" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA011912 Uncertain Approved "Actin filaments,Cytosol" NA NA "Cluster 41: Smooth muscle tissue - ECM organization" "Cluster 39: Astrocytes - Mixed function" "Cluster 53: Squamous epithelial cells - Keratinization" "Cluster 35: Respiratory epithelial cells - Unknown function" 3 "Actin filaments, Cytosol" "HPA011912: AB_1856277" "unprognostic (1.36e-3)" "unprognostic (1.93e-1)" "unprognostic (1.62e-2)" "unprognostic (8.08e-3)" "unprognostic (4.70e-3)" "unprognostic (2.01e-2)" "unprognostic (1.89e-1)" "unprognostic (2.39e-1)" "unprognostic (1.34e-1)" "unprognostic (3.38e-2)" "unprognostic (3.94e-2)" "unprognostic (4.20e-2)" "unprognostic (5.84e-3)" "unprognostic (1.13e-2)" "unprognostic (2.61e-1)" "unprognostic (3.57e-2)" "unprognostic (3.40e-3)" PLS3 T-plastin ENSG00000102024 "Plastin 3" P13797 X 115561174-115650861 "Disease related genes, Human disease related genes, Plasma proteins, Predicted intracellular proteins" Actin-binding "Disease variant" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in many" "Adipocytes: 182.8;Alveolar cells type 1: 316.7;Suprabasal keratinocytes: 170.0" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Group enriched" "Detected in some" 5 "NK-cell: 3.8;plasmacytoid DC: 12.2" "Group enriched" "Detected in many" 5 "dendritic cells: 12.2;NK-cells: 3.8" "Low cancer specificity" "Detected in all" "Kidney - Fibroblasts, Skin - Keratinocyte (other), Thyroid - Thyroid glandular cells" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA000895, HPA020433, HPA076083" Approved Approved "Plasma membrane,Cytosol" NA NA 120000000 "Cluster 13: Non-specific - Mitochondria" "Cluster 7: Adipose tissue - Mixed function" "Cluster 28: Oligodendrocytes - Mixed function" "Cluster 64: Connective tissue cells - ECM organization" "Cluster 32: Smooth muscle cells - Muscle contraction" 1 "Plasma membrane, Cytosol" "HPA000895: , HPA020433: AB_2670440, HPA076083: AB_2686773" "unprognostic (1.32e-1)" "unprognostic (1.85e-2)" "unprognostic (6.10e-2)" "unprognostic (4.37e-2)" "unprognostic (9.63e-2)" "prognostic unfavorable (6.07e-5)" "unprognostic (2.40e-1)" "unprognostic (1.71e-1)" "unprognostic (1.83e-2)" "unprognostic (1.31e-1)" "prognostic unfavorable (4.59e-4)" "unprognostic (2.23e-1)" "prognostic unfavorable (1.01e-4)" "unprognostic (5.15e-2)" "unprognostic (1.54e-1)" "prognostic favorable (3.72e-4)" "prognostic unfavorable (7.04e-4)" SERPINE1 "PAI, PAI1, PLANH1" ENSG00000106366 "Serpin family E member 1" P05121 7 101127104-101139247 "Cancer-related genes, Candidate cardiovascular disease genes, Disease related genes, FDA approved drug targets, Human disease related genes, Plasma proteins, Predicted secreted proteins" "Protease inhibitor, Serine protease inhibitor" "Cancer-related genes, FDA approved drug targets" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in all" "gallbladder: 348.4;placenta: 403.7" "Cell type enhanced" "Detected in many" "Fibroblasts: 212.1;Ovarian stromal cells: 138.1;Pancreatic endocrine cells: 466.9;Syncytiotrophoblasts: 739.0" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Immune cell enriched" "Detected in single" 25 "NK-cell: 9.5" "Lineage enriched" "Detected in single" 25 "NK-cells: 9.5" "Cancer enhanced" "Detected in all" "Kidney cancer: 1620.4" "Colon - Neutrophils" "Low region specificity" "Detected in many" "Low region specificity" "Detected in many" CAB068501 Uncertain "Secreted to blood" "Enzyme inhibitor" NA No 142000000 13000000 "Cluster 14: Non-specific - Unknown function" "Cluster 11: Liver - Plasma proteins" "Cluster 12: Non-specific - Vasculature" "Cluster 15: Kidney cancer - Membrane components" "Cluster 45: Non-specific - Mixed function" 8 "CAB068501: AB_1642775" "unprognostic (5.02e-2)" "prognostic unfavorable (5.01e-4)" "prognostic unfavorable (2.82e-4)" "unprognostic (2.10e-2)" "unprognostic (9.04e-3)" "prognostic unfavorable (2.84e-5)" "unprognostic (6.80e-3)" "prognostic unfavorable (4.41e-6)" "unprognostic (2.33e-1)" "unprognostic (1.45e-1)" "unprognostic (2.88e-3)" "unprognostic (1.58e-1)" "prognostic unfavorable (5.88e-8)" "prognostic unfavorable (3.27e-6)" "unprognostic (1.05e-1)" "unprognostic (4.33e-2)" "prognostic unfavorable (5.51e-4)" SGMS2 "MGC26963, SMS2" ENSG00000164023 "Sphingomyelin synthase 2" Q8NHU3 4 107824563-107915047 "Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Potential drug targets, Predicted intracellular proteins, Predicted membrane proteins" "Lipid metabolism, Sphingolipid metabolism" "Kinase, Transferase" "Disease variant" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in many" "Cell type enhanced" "Detected in many" "Alveolar cells type 1: 115.3;Alveolar cells type 2: 128.7;Ciliated cells: 104.5;Early spermatids: 94.6;Glandular and luminal cells: 130.3" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Group enriched" "Detected in some" 8 "classical monocyte: 3.7;eosinophil: 2.4;intermediate monocyte: 1.5;myeloid DC: 4.2;non-classical monocyte: 1.4" "Group enriched" "Detected in many" 35 "dendritic cells: 4.2;granulocytes: 2.4;monocytes: 3.7" "Low cancer specificity" "Detected in many" "Lung - Alveolar cells type 2, Pancreas - Ductal cells, Testis - Early spermatids, Testis - Late spermatids" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA015076, HPA015541" Supported Supported "Nucleoplasm,Golgi apparatus" NA NA "Cluster 38: Monocytes & Neutrophils - Degranulation" "Cluster 45: Intestine - Digestion" "Cluster 50: Non-specific - Nucleic acid binding" "Cluster 64: Connective tissue cells - ECM organization" "Cluster 37: Glandular & Luminal cells - Unknown function" 3 "Golgi apparatus" Nucleoplasm "HPA015076: AB_1857298, HPA015541: " "unprognostic (7.44e-2)" "unprognostic (2.32e-2)" "unprognostic (2.36e-2)" "unprognostic (1.87e-2)" "unprognostic (7.88e-3)" "unprognostic (9.53e-2)" "unprognostic (5.01e-2)" "unprognostic (1.32e-1)" "unprognostic (4.15e-1)" "unprognostic (1.10e-1)" "unprognostic (1.82e-3)" "unprognostic (3.26e-1)" "prognostic favorable (1.37e-4)" "unprognostic (6.18e-2)" "unprognostic (5.63e-2)" "unprognostic (8.71e-2)" "unprognostic (5.22e-3)" SLC34A1 "NAPI-3, NPT2, NPTIIa, SLC11, SLC17A2" ENSG00000131183 "Solute carrier family 34 member 1" Q06495 5 177379235-177398848 "Disease related genes, Human disease related genes, Metabolic proteins, Plasma proteins, Potential drug targets, Predicted intracellular proteins, Predicted membrane proteins, Transporters" "Ion transport, Sodium transport, Symport, Transport" "Disease variant" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Tissue enriched" "Detected in some" 54 "kidney: 149.8" "Cell type enriched" "Detected in some" 8 "Proximal tubular cells: 101.4" "Cancer enriched" "Detected in single" 12 "renal cancer: 1.8" "Not detected" "Not detected" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Kidney - Proximal tubular cells, Liver - Hepatocytes" "Not detected" "Not detected" "Not detected" "Not detected" "HPA051255, HPA077175" Approved Approved "Nucleoplasm,Nuclear speckles,Plasma membrane,Mitotic spindle,Cytosol" Yes NA "Cluster 52: Kidney - Transmembrane transport" "Cluster 47: Leukemia - Hemostasis" "Cluster 38: Proximal tubular cells - Transmembrane transport" "Nuclear speckles, Plasma membrane" "Nucleoplasm, Mitotic spindle, Cytosol" "HPA051255: AB_2681409, HPA077175: " "unprognostic (1.17e-1)" "unprognostic (3.33e-3)" "unprognostic (1.49e-1)" "unprognostic (3.49e-2)" "unprognostic (1.56e-3)" "unprognostic (2.28e-1)" "unprognostic (4.50e-2)" "unprognostic (4.43e-3)" "unprognostic (1.91e-1)" "unprognostic (1.14e-1)" "unprognostic (5.95e-2)" "unprognostic (1.23e-3)" "unprognostic (1.38e-1)" "unprognostic (2.01e-1)" "unprognostic (1.28e-2)" "unprognostic (4.66e-2)" SLC9A3R1 "EBP50, NHERF, NHERF1" ENSG00000109062 "SLC9A3 regulator 1" O14745 17 74748628-74769353 "Disease related genes, Human disease related genes, Plasma proteins, Potential drug targets, Predicted intracellular proteins, Transporters" "Wnt signaling pathway" "Disease variant" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in all" "esophagus: 342.9" "Cell type enhanced" "Detected in many" "Proximal enterocytes: 562.4;Proximal tubular cells: 378.0;Squamous epithelial cells: 344.6" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Cancer enhanced" "Detected in all" "breast cancer: 462.6" "Adipose visceral - Mesothelial cells, Breast - Breast glandular cells, Kidney - Proximal tubular cells, Kidney - Proximal tubular cells, Prostate - Prostate glandular cells, Testis - Early spermatids" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "CAB001962, HPA009672, HPA027247" Enhanced Approved "Vesicles,Plasma membrane,Centriolar satellite" NA Yes 940000 "Cluster 42: Non-specific - Vesicular transport" "Cluster 75: Epithelium - Extracellular exosomes" "Cluster 12: Non-specific - Vasculature" "Cluster 27: Breast cancer - Unknown function" "Cluster 59: Suprabasal keratinocytes - Cornification" 16 "Plasma membrane" "Vesicles, Centriolar satellite" "CAB001962: , HPA009672: AB_1857215, HPA027247: AB_10601162" "unprognostic (1.29e-1)" "unprognostic (4.58e-2)" "unprognostic (1.73e-2)" "unprognostic (5.51e-2)" "unprognostic (5.83e-2)" "unprognostic (1.73e-1)" "prognostic unfavorable (9.83e-5)" "unprognostic (7.41e-2)" "unprognostic (5.61e-2)" "unprognostic (5.38e-2)" "unprognostic (7.53e-2)" "unprognostic (4.49e-2)" "unprognostic (1.56e-3)" "unprognostic (7.81e-3)" "unprognostic (5.53e-2)" "unprognostic (3.84e-2)" "unprognostic (2.08e-2)" SLCO2A1 "MATR1, OATP2A1, PGT, SLC21A2" ENSG00000174640 "Solute carrier organic anion transporter family member 2A1" Q92959 3 133932701-134052184 "Disease related genes, Human disease related genes, Metabolic proteins, Potential drug targets, Predicted membrane proteins, Transporters" "Lipid transport, Transport" "Disease variant" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "lung: 119.9" "Group enriched" "Detected in many" 5 "Basal prostatic cells: 108.1;Endothelial cells: 123.2" "Low cancer specificity" "Detected in all" "Region enriched" "Detected in all" 4 "choroid plexus: 18.3" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cancer enhanced" "Detected in many" "thyroid cancer: 14.2" "Colon - Endothelial cells, Liver - Vascular Endothelial cells" "Low region specificity" "Detected in some" "Low region specificity" "Detected in all" HPA013742 Enhanced NA NA "Cluster 7: Adipose tissue - Mixed function" "Cluster 42: Choroid plexus - Mitochondria" "Cluster 30: Non-specific - Gene expression regulation" "Cluster 41: Adipocytes & Endothelial cells - Mixed function" "HPA013742: AB_2668877" "unprognostic (4.39e-3)" "unprognostic (2.84e-1)" "unprognostic (1.33e-1)" "prognostic favorable (9.69e-4)" "unprognostic (8.53e-2)" "unprognostic (2.32e-3)" "prognostic favorable (9.24e-5)" "unprognostic (1.92e-1)" "unprognostic (1.29e-1)" "unprognostic (7.60e-2)" "unprognostic (2.04e-2)" "unprognostic (6.87e-2)" "unprognostic (5.63e-3)" "prognostic unfavorable (3.25e-4)" "unprognostic (2.78e-1)" "unprognostic (1.45e-1)" "unprognostic (3.07e-2)" SOST "DAND6, VBCH" ENSG00000167941 Sclerostin Q9BQB4 17 43753738-43758791 "Disease related genes, FDA approved drug targets, Human disease related genes, Predicted secreted proteins" "Wnt signaling pathway" Heparin-binding "Disease variant, FDA approved drug targets" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Tissue enriched" "Detected in some" 12 "kidney: 13.0" "Group enriched" "Detected in some" 5 "B-cells: 1.6;Cholangiocytes: 1.9;Collecting duct cells: 5.8;Pancreatic endocrine cells: 1.7" "Cancer enhanced" "Detected in some" "lung cancer: 6.2" "Not detected" "Not detected" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cancer enhanced" "Detected in some" "Bladder cancer: 12.3;Rhabdoid: 19.6" "Group enriched" "Detected in some" 11 "basal ganglia: 1.7;cerebellum: 1.0" "Not detected" "Not detected" "Secreted to extracellular matrix" Other NA NA 16000 "Cluster 52: Kidney - Transmembrane transport" "Cluster 7: Liver cancer - Metabolism" "Cluster 73: B-cells - B-cell function" 4 "unprognostic (1.26e-1)" "unprognostic (4.06e-2)" "unprognostic (6.57e-2)" "unprognostic (2.55e-3)" "unprognostic (3.37e-1)" "unprognostic (4.67e-2)" "unprognostic (1.16e-1)" "unprognostic (8.35e-2)" "unprognostic (1.38e-2)" "unprognostic (1.20e-1)" "unprognostic (8.92e-2)" "unprognostic (1.56e-1)" "unprognostic (7.90e-2)" SQSTM1 "A170, OSIL, p60, p62, p62B, PDB3" ENSG00000161011 "Sequestosome 1" Q13501 5 179806398-179838078 "Disease related genes, Human disease related genes, Predicted intracellular proteins" "Apoptosis, Autophagy, Differentiation, Immunity" "Amyotrophic lateral sclerosis, Disease variant, Neurodegeneration" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in all" "skeletal muscle: 1141.6" "Cell type enhanced" "Detected in all" "Syncytiotrophoblasts: 2518.9" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "CAB004587, HPA064165, HPA068843" Supported Supported Vesicles,Cytosol No No 81000 "Cluster 21: Neutrophils - Unknown function" "Cluster 2: Skeletal muscle - Striated muscle contraction" "Cluster 55: Non-specific - Transcription" "Cluster 7: Liver cancer - Metabolism" "Cluster 45: Non-specific - Mixed function" 36 "Vesicles, Cytosol" "CAB004587: AB_628279, HPA064165: AB_2685203, HPA068843: AB_2732120" "unprognostic (1.08e-1)" "unprognostic (1.39e-1)" "unprognostic (3.19e-1)" "unprognostic (9.45e-2)" "unprognostic (1.47e-2)" "unprognostic (1.08e-1)" "prognostic unfavorable (2.31e-5)" "unprognostic (1.34e-1)" "unprognostic (2.34e-1)" "unprognostic (5.65e-2)" "unprognostic (1.66e-1)" "unprognostic (1.70e-1)" "unprognostic (9.52e-2)" "unprognostic (3.21e-1)" "unprognostic (8.68e-3)" "unprognostic (4.41e-2)" "unprognostic (2.01e-1)" TGFB3 "ARVD, ARVD1" ENSG00000119699 "Transforming growth factor beta 3" P10600 14 75958097-75983011 "Cancer-related genes, Disease related genes, Human disease related genes, Predicted secreted proteins" "Growth factor, Mitogen" "Cancer-related genes, Cardiomyopathy, Disease variant" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in many" "Fibroblasts: 20.5;Late spermatids: 53.6;Leydig cells: 27.0;Prostatic glandular cells: 26.2;Smooth muscle cells: 29.3" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cancer enhanced" "Detected in many" "breast cancer: 23.8" "Heart muscle - Fibroblasts, Thyroid - Fibroblasts" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA063582 Approved Vesicles "Secreted to blood" "Growth factor" NA NA 44800 "Cluster 34: Non-specific - Mixed function" "Cluster 11: White matter - Signal transduction" "Cluster 27: Breast cancer - Unknown function" "Cluster 50: Connective tissue cells - ECM organization" 2 Vesicles "HPA063582: AB_2685049" "unprognostic (7.84e-2)" "unprognostic (1.89e-1)" "unprognostic (4.32e-3)" "unprognostic (1.29e-1)" "unprognostic (3.27e-2)" "unprognostic (1.58e-1)" "unprognostic (1.24e-1)" "unprognostic (9.79e-2)" "unprognostic (2.83e-2)" "unprognostic (1.51e-2)" "unprognostic (5.63e-2)" "unprognostic (4.10e-1)" "prognostic unfavorable (4.01e-7)" "unprognostic (6.38e-3)" "unprognostic (1.10e-1)" "unprognostic (1.22e-2)" "unprognostic (3.27e-3)" THBS2 TSP2 ENSG00000186340 "Thrombospondin 2" P35442 6 169215780-169254050 "Cancer-related genes, Disease related genes, Human disease related genes, Plasma proteins, Predicted secreted proteins" "Cell adhesion" Heparin-binding "Cancer-related genes" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in many" "Cell type enhanced" "Detected in many" "Basal keratinocytes: 40.9;Endometrial stromal cells: 67.9;Fibroblasts: 125.1;Langerhans cells: 48.4;Oligodendrocyte precursor cells: 38.2;Oligodendrocytes: 51.9;Pancreatic endocrine cells: 47.5;Smooth muscle cells: 41.6" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cancer enhanced" "Detected in many" "skin cancer: 156.5" "Heart muscle - Fibroblasts, Lung - Fibroblast_2" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "CAB017716, HPA044304" Approved Approved "Nuclear speckles,Plasma membrane,Cytosol" "Secreted to extracellular matrix" "Cell adhesion" NA NA 21000000 "Cluster 41: Smooth muscle tissue - ECM organization" "Cluster 26: Oligodendrocytes - Mixed function" "Cluster 64: Connective tissue cells - ECM organization" "Cluster 32: Smooth muscle cells - Muscle contraction" "Plasma membrane" "Nuclear speckles, Cytosol" "CAB017716: , HPA044304: AB_2678891" "unprognostic (2.85e-2)" "unprognostic (1.41e-1)" "unprognostic (5.87e-2)" "unprognostic (8.90e-2)" "unprognostic (3.64e-2)" "unprognostic (8.73e-2)" "unprognostic (2.93e-1)" "unprognostic (5.10e-3)" "unprognostic (1.39e-1)" "unprognostic (4.71e-2)" "unprognostic (4.00e-2)" "unprognostic (2.56e-1)" "prognostic unfavorable (3.77e-6)" "unprognostic (2.19e-3)" "unprognostic (4.38e-2)" "unprognostic (4.16e-2)" "unprognostic (2.48e-3)" TNFRSF11A "CD265, FEO, LOH18CR1, ODFR, PDB2, RANK, TRANCE-R" ENSG00000141655 "TNF receptor superfamily member 11a" Q9Y6Q6 18 62325287-62391288 "CD markers, Disease related genes, Human disease related genes, Predicted intracellular proteins, Predicted membrane proteins" Receptor "Deafness, Disease variant, Osteopetrosis" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "intestine: 29.4;salivary gland: 24.5" "Cell type enhanced" "Detected in many" "Distal enterocytes: 32.3;Enteroendocrine cells: 21.9;Lymphatic endothelial cells: 27.9;Paneth cells: 39.1;Proximal enterocytes: 23.4;Serous glandular cells: 36.3;Undifferentiated cells: 33.2" "Low cancer specificity" "Detected in many" "Low region specificity" "Detected in all" "Immune cell enriched" "Detected in single" 8 "NK-cell: 2.3" "Lineage enriched" "Detected in single" 8 "NK-cells: 2.3" "Cancer enhanced" "Detected in many" "Gastric cancer: 9.7" "Adipose subcutaneous - Macrophages, Kidney - Macrophages, Skeletal muscle - Macrophages, Stomach - Mitotic cells (Stomach), Testis - Spermatogonia, Thyroid - Fibroblasts" "Low region specificity" "Detected in many" "Low region specificity" "Detected in all" "CAB010391, HPA047976" Approved Supported "Plasma membrane,Cytosol" "Intracellular and membrane" Receptor NA NA 110000 "Cluster 15: NK-cells - Unknown function" "Cluster 45: Intestine - Digestion" "Cluster 40: Astrocytes - Astrocyte-neuron interactions" "Cluster 50: Lymphoma - Unknown function" "Cluster 16: Intestinal goblet cells - Mucin production" 2 "Plasma membrane" Cytosol "CAB010391: AB_2205352, HPA047976: AB_2680227" "unprognostic (4.08e-1)" "unprognostic (2.71e-1)" "unprognostic (3.23e-3)" "unprognostic (1.73e-1)" "unprognostic (6.03e-2)" "unprognostic (1.35e-1)" "unprognostic (9.96e-4)" "unprognostic (4.24e-3)" "unprognostic (7.79e-4)" "unprognostic (1.52e-1)" "unprognostic (4.05e-2)" "unprognostic (2.88e-1)" "unprognostic (4.69e-5)" "unprognostic (1.56e-1)" "unprognostic (1.78e-1)" "unprognostic (4.02e-2)" "unprognostic (7.07e-2)" TNFRSF11B "OCIF, OPG, TR1" ENSG00000164761 "TNF receptor superfamily member 11b" O00300 8 118923557-118951885 "Cancer-related genes, Candidate cardiovascular disease genes, Disease related genes, Human disease related genes, Plasma proteins, Predicted secreted proteins" Apoptosis Receptor "Cancer-related genes, Disease variant" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Group enriched" "Detected in many" 5 "kidney: 28.8;thyroid gland: 98.8" "Cell type enhanced" "Detected in many" "Breast glandular cells: 129.2;Collecting duct cells: 64.2;Mesothelial cells: 80.4;Pancreatic endocrine cells: 32.3;Proximal tubular cells: 106.7" "Cancer enhanced" "Detected in all" "renal cancer: 22.7" "Low region specificity" "Detected in all" "Immune cell enriched" "Detected in single" 40 "plasmacytoid DC: 4.0" "Lineage enriched" "Detected in single" 40 "dendritic cells: 4.0" "Cancer enhanced" "Detected in many" "ovarian cancer: 54.6" "Thyroid - Thyroid glandular cells" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "CAB034939, HPA058613" Approved Approved "Nucleoplasm,Nucleoli,Golgi apparatus" "Secreted in other tissues" Receptor NA NA "Cluster 44: Plasmacytoid DCs - Plasma membrane proteins" "Cluster 51: Thyroid gland - Unknown function" "Cluster 39: Astrocytes - Mixed function" "Cluster 64: Connective tissue cells - ECM organization" "Cluster 17: Breast glandular cells - Lactation" 3 "Golgi apparatus" "Nucleoplasm, Nucleoli" "CAB034939: , HPA058613: " "unprognostic (1.39e-2)" "prognostic unfavorable (6.22e-4)" "unprognostic (5.27e-2)" "unprognostic (2.33e-2)" "unprognostic (4.27e-3)" "unprognostic (1.10e-3)" "unprognostic (1.21e-3)" "unprognostic (5.50e-2)" "unprognostic (9.94e-2)" "unprognostic (6.32e-2)" "unprognostic (3.53e-2)" "unprognostic (2.43e-1)" "prognostic favorable (6.79e-4)" "unprognostic (1.32e-2)" "unprognostic (4.52e-2)" "unprognostic (1.61e-3)" "prognostic unfavorable (3.88e-4)" TNFSF11 "CD254, ODF, OPGL, RANKL, TRANCE" ENSG00000120659 "TNF superfamily member 11" O14788 13 42562736-42608013 "Cancer-related genes, CD markers, Disease related genes, FDA approved drug targets, Human disease related genes, Predicted intracellular proteins, Predicted membrane proteins, Predicted secreted proteins" Differentiation "Cytokine, Developmental protein, Receptor" "Cancer-related genes, Disease variant, FDA approved drug targets, Osteopetrosis" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in some" "liver: 4.0;lymphoid tissue: 12.0" "Cell type enhanced" "Detected in some" "Breast glandular cells: 10.1;Ductal cells: 5.6;Early spermatids: 8.4;Late spermatids: 14.2;NK-cells: 3.9;Pancreatic endocrine cells: 3.4" "Cancer enhanced" "Detected in many" "pancreatic cancer: 2.6" "Low region specificity" "Detected in single" "Immune cell enriched" "Detected in some" 8 "NK-cell: 9.9" "Lineage enriched" "Detected in many" 8 "NK-cells: 9.9" "Cancer enhanced" "Detected in some" "Rhabdoid: 1.5;thyroid cancer: 1.7" "Testis - Late spermatids" "Not detected" "Not detected" "Not detected" "Not detected" "CAB009193, HPA045142" Enhanced "Secreted to blood" Cytokine NA NA 17200 "Cluster 15: NK-cells - Unknown function" "Cluster 36: Lymphoid tissue - Cytokine signaling" "Cluster 44: Non-specific - Mixed function" "Cluster 55: Lymphoma - Immune response" "Cluster 17: Breast glandular cells - Lactation" 4 "CAB009193: , HPA045142: AB_2679231" "unprognostic (3.97e-4)" "unprognostic (1.40e-1)" "unprognostic (9.01e-3)" "unprognostic (3.81e-3)" "unprognostic (1.12e-1)" "unprognostic (1.09e-1)" "unprognostic (7.09e-2)" "unprognostic (7.70e-2)" "unprognostic (2.29e-1)" "unprognostic (1.25e-3)" "unprognostic (1.00e-1)" "unprognostic (1.50e-1)" "unprognostic (3.94e-5)" "unprognostic (1.87e-1)" "unprognostic (9.67e-2)" "unprognostic (5.46e-2)" "unprognostic (7.74e-2)" TP53 "LFS1, p53" ENSG00000141510 "Tumor protein p53" P04637 17 7661779-7687538 "Cancer-related genes, Disease related genes, Human disease related genes, Plasma proteins, Potential drug targets, Predicted intracellular proteins, Transcription factors, Transporters" "Apoptosis, Biological rhythms, Cell cycle, Host-virus interaction, Necrosis, Transcription, Transcription regulation" "Activator, DNA-binding, Repressor" "Cancer-related genes, Disease variant, Li-Fraumeni syndrome, Tumor suppressor" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell type specificity" "Detected in many" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "CAB002973, CAB039238, CAB039239, HPA051244, HPA063532, CAB072876" Enhanced Enhanced Nucleoplasm,Vesicles,Cytosol Yes No "Cluster 13: Non-specific - Mitochondria" "Cluster 36: Lymphoid tissue - Cytokine signaling" "Cluster 44: Non-specific - Mixed function" "Cluster 42: Non-specific - Unknown function" "Cluster 16: Intestinal goblet cells - Mucin production" 157 Nucleoplasm "Vesicles, Cytosol" "CAB002973: AB_2206626, CAB039238: , CAB039239: , CAB072876: AB_2665731, HPA051244: AB_2681403, HPA063532: " "unprognostic (2.29e-2)" "unprognostic (8.83e-3)" "unprognostic (1.26e-2)" "prognostic favorable (1.35e-4)" "unprognostic (9.95e-2)" "unprognostic (4.00e-2)" "unprognostic (2.79e-3)" "unprognostic (4.99e-2)" "unprognostic (2.75e-2)" "unprognostic (2.55e-1)" "unprognostic (1.30e-1)" "prognostic unfavorable (5.01e-4)" "unprognostic (1.86e-3)" "unprognostic (7.89e-3)" "unprognostic (8.05e-2)" "unprognostic (2.74e-1)" "unprognostic (1.08e-1)" TRPV4 "CMT2C, OTRPC4, TRP12, VR-OAC, VRL-2, VROAC" ENSG00000111199 "Transient receptor potential cation channel subfamily V member 4" Q9HBA0 12 109783087-109833406 "Disease related genes, Human disease related genes, Potential drug targets, Predicted membrane proteins, Voltage-gated ion channels" "Calcium transport, Ion transport, Transport" "Calcium channel, Calmodulin-binding, Ion channel" "Charcot-Marie-Tooth disease, Disease variant, Dwarfism, Neurodegeneration, Neuropathy" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "choroid plexus: 71.9" "Cell type enhanced" "Detected in many" "Basal respiratory cells: 15.5;Cholangiocytes: 15.3;Ciliated cells: 18.7;Cytotrophoblasts: 19.4;Ionocytes: 19.1;Kupffer cells: 14.6;Salivary duct cells: 15.0;Serous glandular cells: 15.4;Syncytiotrophoblasts: 19.4" "Low cancer specificity" "Detected in all" "Region enriched" "Detected in some" 12 "choroid plexus: 107.5" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cancer enhanced" "Detected in many" "skin cancer: 10.6" "Adipose subcutaneous - Macrophages, Adipose visceral - Macrophages, Lung - Respiratory ciliated cells, Prostate - Prostate basal glandular cells, Skin - Eccrine sweat gland cells, Testis - Spermatogonia" "Low region specificity" "Detected in many" "Region enhanced" "Detected in single" "medulla oblongata: 1.2" HPA007150 Uncertain NA NA "Cluster 38: Monocytes & Neutrophils - Degranulation" "Cluster 60: Choroid plexus - Transmembrane transport" "Cluster 36: Choroid plexus - Mixed function" "Cluster 69: Skin cancer - ECM organization" "Cluster 35: Respiratory epithelial cells - Unknown function" "HPA007150: AB_1080393" "unprognostic (2.98e-2)" "unprognostic (1.12e-2)" "unprognostic (2.33e-2)" "unprognostic (4.20e-3)" "unprognostic (6.25e-3)" "unprognostic (1.09e-2)" "unprognostic (7.95e-2)" "unprognostic (2.03e-1)" "unprognostic (9.02e-2)" "prognostic unfavorable (8.10e-4)" "unprognostic (1.24e-1)" "unprognostic (1.68e-1)" "prognostic favorable (4.12e-5)" "unprognostic (1.20e-1)" "unprognostic (2.30e-1)" "unprognostic (1.72e-1)" "unprognostic (1.73e-2)" UGT2B17 ENSG00000197888 "UDP glucuronosyltransferase family 2 member B17" O75795 4 68537173-68576413 "Enzymes, Human disease related genes, Metabolic proteins, Predicted intracellular proteins, Predicted membrane proteins" "Lipid metabolism, Steroid metabolism" "Glycosyltransferase, Transferase" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Group enriched" "Detected in some" 8 "intestine: 368.4;liver: 107.8" "Group enriched" "Detected in some" 4 "Distal enterocytes: 173.2;Enteroendocrine cells: 123.6;Undifferentiated cells: 82.6" "Group enriched" "Detected in many" 7 "colorectal cancer: 16.3;liver cancer: 10.1" "Low region specificity" "Detected in all" "Group enriched" "Detected in some" 39 "memory B-cell: 4.0;naive B-cell: 15.2" "Lineage enriched" "Detected in single" 61 "B-cells: 15.2" "Group enriched" "Detected in some" 4 "lymphoma: 5.2;Myeloma: 7.1;prostate cancer: 12.6" "Colon - Colon enterocytes" HPA045108 Supported NA NA "Cluster 34: B-cells - Unknown function" "Cluster 25: Small intestine - Absorption" "Cluster 10: Cerebellum - Nucleic acid binding" "Cluster 55: Lymphoma - Immune response" "Cluster 5: Enterocytes - Absorption" "HPA045108: AB_2679218" "unprognostic (1.66e-1)" "unprognostic (2.97e-2)" "unprognostic (2.96e-2)" "unprognostic (2.41e-1)" "unprognostic (1.88e-1)" "unprognostic (1.19e-2)" "unprognostic (2.36e-1)" "unprognostic (8.44e-3)" "unprognostic (9.67e-2)" "unprognostic (4.80e-3)" "unprognostic (8.52e-2)" "unprognostic (2.45e-1)" "unprognostic (6.44e-2)" "unprognostic (1.75e-1)" "unprognostic (1.76e-1)" VEGFA "VEGF, VEGF-A, VPF" ENSG00000112715 "Vascular endothelial growth factor A" P15692 6 43770184-43786487 "Cancer-related genes, Candidate cardiovascular disease genes, Disease related genes, FDA approved drug targets, Human disease related genes, Plasma proteins, Predicted intracellular proteins, Predicted secreted proteins, RAS pathway related proteins" "Angiogenesis, Differentiation" "Developmental protein, Growth factor, Heparin-binding, Mitogen" "Cancer-related genes, FDA approved drug targets" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in many" "Alveolar cells type 1: 241.3;granulocytes: 274.5;Langerhans cells: 272.3" "Cancer enhanced" "Detected in all" "renal cancer: 79.5" "Low region specificity" "Detected in all" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Low cancer specificity" "Detected in all" "Kidney - Podocytes" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "CAB005429, CAB039240, HPA069116, CAB069907" Supported "Secreted to blood" "Growth factor" NA NA 562000 57000 "Cluster 19: Non-specific - Basic cellular processes" "Cluster 42: Choroid plexus - Mitochondria" "Cluster 15: Kidney cancer - Membrane components" "Cluster 29: Monocytes - Innate immune response" 3 "CAB005429: AB_2212984, CAB039240: , CAB069907: AB_10001947, HPA069116: AB_2686089" "unprognostic (1.12e-1)" "prognostic unfavorable (4.50e-4)" "unprognostic (2.42e-2)" "prognostic unfavorable (2.10e-4)" "unprognostic (4.35e-2)" "unprognostic (1.49e-1)" "prognostic unfavorable (2.34e-5)" "unprognostic (5.10e-2)" "unprognostic (5.27e-3)" "unprognostic (2.30e-2)" "unprognostic (1.40e-1)" "unprognostic (1.00e-2)" "prognostic unfavorable (1.76e-5)" "unprognostic (2.20e-1)" "unprognostic (1.80e-1)" "unprognostic (1.43e-1)" "prognostic favorable (2.73e-4)" WNT1 INT1 ENSG00000125084 "Wnt family member 1" P04628 12 48978322-48982620 "Cancer-related genes, Disease related genes, Human disease related genes, Predicted secreted proteins" "Wnt signaling pathway" "Developmental protein" "Cancer-related genes, Disease variant, Osteogenesis imperfecta, Proto-oncogene" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in single" "brain: 1.8" "Cell type enhanced" "Detected in some" "Extravillous trophoblasts: 4.4;Langerhans cells: 2.3;NK-cells: 2.9;Spermatocytes: 4.9;Spermatogonia: 3.5;T-cells: 4.3" "Not detected" "Not detected" "Low region specificity" "Detected in many" "Group enriched" "Detected in some" 8 "gdT-cell: 3.1;MAIT T-cell: 5.1;memory CD4 T-cell: 2.0;memory CD8 T-cell: 2.9;naive CD8 T-cell: 2.1" "Lineage enriched" "Detected in single" 32 "T-cells: 5.1" "Cancer enriched" "Detected in single" 26 "ovarian cancer: 10.0" "Prostate - T-cells, Thyroid - T-cells" "Not detected" "Not detected" "Low region specificity" "Detected in some" "Secreted to extracellular matrix" "Developmental protein" NA NA "Cluster 1: T-cells - Unknown function" "Cluster 5: Brain & Testis - Signal transduction" "Cluster 33: Neurons - Mixed function" "Cluster 15: Kidney cancer - Membrane components" "Cluster 78: NK-cells & T-cells - Immune system & Transcription" "unprognostic (2.02e-2)" "unprognostic (5.80e-3)" "unprognostic (1.23e-1)" "unprognostic (1.64e-2)" "unprognostic (1.03e-1)" "unprognostic (7.65e-3)" "unprognostic (5.29e-3)" "unprognostic (5.68e-2)" "unprognostic (1.63e-1)" "unprognostic (1.20e-1)" "unprognostic (4.08e-2)" "unprognostic (4.97e-2)" "unprognostic (1.32e-2)" "unprognostic (1.67e-2)" "unprognostic (1.70e-1)" "unprognostic (7.35e-3)" "unprognostic (2.76e-2)" ZNF687 KIAA1441 ENSG00000143373 "Zinc finger protein 687" Q8N1G0 1 151281618-151292176 "Disease related genes, Human disease related genes, Predicted intracellular proteins, Transcription factors" "Transcription, Transcription regulation" DNA-binding "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell type specificity" "Detected in many" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Immune cell enhanced" "Detected in many" "eosinophil: 13.5" "Group enriched" "Detected in many" 8 "granulocytes: 13.5;monocytes: 4.5" "Low cancer specificity" "Detected in all" "Testis - Spermatocytes" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA021193, HPA023948" Approved Enhanced Nucleoplasm NA NA "Cluster 7: Non-specific - Innate immune response" "Cluster 40: Non-specific - Transcription" "Cluster 6: Non-specific - Immune response" "Cluster 45: Non-specific - Nuclear processes" "Cluster 58: Macrophages - Innate immune response" 1 Nucleoplasm "HPA021193: AB_1859415, HPA023948: AB_2671380" "unprognostic (2.23e-1)" "unprognostic (3.25e-1)" "unprognostic (2.93e-2)" "unprognostic (9.64e-3)" "unprognostic (2.44e-2)" "unprognostic (7.82e-2)" "unprognostic (2.62e-2)" "unprognostic (1.56e-1)" "unprognostic (1.39e-1)" "unprognostic (9.91e-2)" "unprognostic (8.69e-3)" "unprognostic (2.10e-1)" "unprognostic (5.82e-3)" "unprognostic (1.36e-1)" "unprognostic (1.41e-1)" "unprognostic (8.54e-2)" "unprognostic (7.99e-2)"