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Protein 3D structures

The structure of a protein gives valuable clues of its interaction with other molecules and thereby important information of its functions. For the majority of the proteins in the Human Protein Atlas a predicted 3D structure from the AlphaFold Protein Structure Database project is shown. The structures can be explored and antigens corresponding to many of the antibodies in the Atlas, as well as other features and clinical -and population variants, can be displayed on the structures.

Key publications

- Jumper J et al., Highly accurate protein structure prediction with AlphaFold. Nature. (2021)
PubMed: 34265844 DOI: 10.1038/s41586-021-03819-2

- Varadi M et al., AlphaFold Protein Structure Database: massively expanding the structural coverage of protein-sequence space with high-accuracy models. Nucleic Acids Res. (2022)
PubMed: 34791371 DOI: 10.1093/nar/gkab1061

Figure legend: The predicted structure of the receptor tyrosine kinase ERBB2 with variants classified as pathogenic or likely pathogenic in the clinical variants data set marked in red and variants present both in the clinical and the population variants sets marked in purple.

Key facts

  • 93% of the genes have a predicted 3D structure