The Human Protein Atlas background and history
The Human Protein Atlas (HPA) journey started in 2000, the same year as the announcement of the completion of the Human Genome Project. In 2003, the program received generous support from the Knut and Alice Wallenberg Foundation (KAW), and the program was changed to an exclusively academic endeavor. The aim of the program has been to map the human proteins in cells, tissues, organs and blood, using integration of various 'omics technologies, including antibody-based imaging, mass spectrometry-based proteomics, transcriptomics, proximity extension assay (PEA)-based protein profiling and systems biology.
Primarily based in Sweden, the Human Protein Atlas project involves the joint efforts of the Royal Institute of Technology in Stockholm, Uppsala University, Uppsala Akademiska University Hospital, and more recently also Science for Life Laboratory based in both Uppsala and Stockholm. Formal collaborations are with groups in India, South Korea, Japan, China, Germany, France, Switzerland, USA, Canada, Denmark, Finland, The Netherlands, Spain, and Italy.
The first version of the Human Protein Atlas website was launched in 2005 and consisted of protein expression data based on approximately 700 antibodies. Since then, each new release has included more data and new functionalities and features to the website.
Important additions include:
A 20-year journey into the body
In an expansive supplement published by Science, a journey is taken through the 20 years since the establishment of the Human Protein Atlas (HPA) consortium, to underscore milestones reached and to celebrate releases of updates and additions to the atlas. For the reader’s convenience, reprints of the relevant journal articles associated with the most important of these milestones are provided. You can download the pdf version here.