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Human secretome resource

A new program was launched to generate a resource comprising most of the secreted proteins in humans. The genes coding for the proteins predicted to be secreted were constructed with synthetic biology and used for mammalian bioproduction using Chinese hamster ovary (CHO) cells. The program was initiated by a collaboration involving the Wallenberg Foundation, the Novo Nordisk Foundation, and the pharmaceutical company AstraZeneca.

Key publication

Other selected publications

Figure legend: Outline of the CHO mammalian cell factory for generation of a resource of the human secretome.

Key facts

  • More than 3,000 full-length genes have been generated with synthetic biology
  • More than 1,500 proteins have been produced and recovered from the CHO culture medium
  • The human secretome resource has been used for phenotypic assays in various screening platforms