The tissue cell type resource - Explore the cell type specificity of genes in human tissues

Tissue cell type methods

The Tissue Cell Type section contains cell type expression specificity predictions for all human protein coding genes, generated using integrated network analysis of publicly available bulk RNAseq data. A specificity classification is used to predict which genes are enriched in each constituent cell type within an individual tissue. The data can be explored on a tissue-by-tissue basis, together with in-house generated immunohistochemically stained tissue sections. In addition, a core cell type analysis focuses on the cell types found in all, or the majority, of the profiled tissues, e.g., endothelial cells or macrophages. Here, genes with predicted specificity in these core cell types in multiple tissues are detailed. More information about the specific content and data analysis in the section can be found in the Methods Summary.

Key Publications:
Norreen-Thorsen M et al. (2022), "A human adipose tissue cell-type transcriptome atlas." Cell Rep 40
Öling S et al. (2024), "A human stomach cell type transcriptome atlas" BMC Biol 22
Dusart P et al. (2023), "A tissue centric atlas of cell type transcriptome enrichment signatures." bioRXiv, pre-print

Learn about:

• if a gene is predicted to have cell type specificity within a given tissue
• which genes have a common cell type specificity prediction within each tissue
• the catalogue of genes with predicted specificity in core cell types across tissues