Tissue-based map of the human proteome

This section of the Human Protein Atlas focus on the expression profiles in human tissues of genes both on the mRNA and protein level. The protein expression data from 44 normal human tissue types is derived from antibody-based protein profiling using immunohistochemistry. All underlying images of immunohistochemistry stained normal tissues are available together with knowledge-based annotation of protein expression levels. The protein data covers 15323 genes (76%) for which there are available antibodies. The mRNA expression data is derived from deep sequencing of RNA (RNA-seq) from 256 different normal tissue types.

More information about the specific content and the generation and analysis of the data in the section can be found on the Methods Summary.

Learn about:

  • protein localization in tissues at a single-cell level
  • if a gene is enriched in a particular tissue (specificity)
  • which genes have a similar expression profile across tissues (expression cluster)


THE TISSUE AND ORGAN PROTEOMESi
Explore the proteomes of specific tissues and organs

The expression for all protein-coding genes in all major tissues and organs in the human body can be explored in this interactive database, including numerous catalogs of proteins expressed in a tissue-restricted manner.

Based on transcriptomics analysis across all major organs and tissue types in the human body, all putative 20090 protein coding genes have been classified with regard to abundance and distribution of transcribed mRNA molecules, including 10992 proteins showing a significantly elevated level of expression in a particular tissue or a group of related tissues and 8839 proteins detected in all organs and tissues. Read more about the different categories of elevated expression here.

Specificity
Distribution

TISSUE EXPRESSIONi

The RNA data was used to cluster genes according to their expression across tissues. The clustering of 19019 genes expressed in tissues resulted in 87 expression clusters, which have been manually annotated to describe common features in terms of function and specificity. The result of the cluster analysis is presented as a UMAP based on gene expression, where each cluster has been summarized as colored areas containing most of the cluster genes.

Go to interactive expression cluster page


THE ENRICHED GENES i

An interactive network plot of the numbers of enriched and group enriched genes in all major organs and tissue types in the human body, connected to their respective enriched tissues. Click to obtain the corresponding list of genes.


HUMAN SUBPROTEOMES
Explore the various proteomes

The various subproteomes can be explored in this interactive database including numerous catalogs of protein-coding genes with detailed information regarding expression and localization of the corresponding proteins.


The Tissue-
specific Proteome

The Housekeeping
Proteome

The Regulatory
Proteome

The Secretome and
Membrane Proteome

The Isoform Proteome

The Cancer Proteome

The Druggable Proteome