Tissue expression cluster

e.g. Metabolic proteins, Localized to mitochondria, Genes tissue enriched in brain (RNA)

Field

Cluster

Pathway

IDⁱ The ID of each cluster.	Main specificityⁱ The annotated specificity of the cluster. This annotation aims to reflect which type of tissues or cell types the genes of the cluster show elevated expression in.	Main functionⁱ The annotated function of the cluster, based on an overrepresentation of genes associated with the annotated function.	# Genesⁱ Number of genes in the cluster.	Annotation reliabilityⁱ The annotation reliability is manually set for all clusters and indicates the level of reliability of the annotated specificity and function.
1	Liver & Kidney	Metabolism	234	High
2	Skeletal muscle	Striated muscle contraction	177	High
3	Non-specific	Unknown function	218	Medium
4	Testis	Basic cellular processes	313	Medium
5	Brain & Testis	Signal transduction	119	Medium
6	Bone marrow	Innate immune response	154	High
7	Adipose tissue	Mixed function	320	Medium
8	Ciliated cells	Cilium organization	384	High
9	Oligodendrocytes	Myelination	457	High
10	Testis	Spermatid development	245	High
11	Liver	Plasma proteins	103	Low
12	Heart muscle	Cardiac muscle contraction	142	Medium
13	Skin	Cornification	288	High
14	Skeletal muscle	Muscle contraction	231	Medium
15	Pancreas	Proteolysis	135	High
16	Non-specific	Transcription	690	High
17	Neuronal	Synaptic function	188	High
18	Non-specific	Ribosome	169	High
19	Non-specific	Basic cellular processes	569	Low
20	Testis	Spermatogenesis	78	High
21	Testis	Unknown function	144	Medium
22	Brain	Synaptic signal transduction	245	High
23	Non-specific	Cellular respiration	279	High
24	Parathyroid gland	Vesicular transport	195	Medium
25	Small intestine	Absorption	151	High
26	Adrenal gland	Steroid metabolism	87	Medium
27	Squamous epithelium	Keratinization	226	Medium
28	Neuronal	Transcription	217	Medium
29	Squamous epithelium	Innate immune response	159	High
30	Heart muscle	Heart development	158	High
31	Liver	Plasma proteins	126	High
32	Endocrine & Neural	Unknown function	76	Low
33	Brain	Neuronal signaling	354	High
34	Non-specific	Mixed function	202	Low
35	Non-specific	Mitochondria	391	High
36	Lymphoid tissue	Cytokine signaling	167	High
37	Liver & Intestine	Lipid metabolism	184	Medium
38	Salivary gland	Salivary secretion	74	High
39	Retina & Testis	Cilium	257	Low
40	Non-specific	Transcription	474	High
41	Smooth muscle tissue	ECM organization	262	Medium
42	Testis	Spermatogenesis	209	High
43	Non-specific	Mitochondrial translation	243	Medium
44	Testis	Spermatogenesis	384	Medium
45	Intestine	Digestion	300	Medium
46	Testis	Spermatogenesis	120	Medium
47	Spleen	Immune response	210	Medium
48	Stomach	Proteolysis	160	Medium
49	Pituitary gland	Hormone signaling	60	High
50	Epididymis	Male reproductive secretion	185	High
51	Thyroid gland	Unknown function	170	Low
52	Kidney	Transmembrane transport	206	High
53	Non-specific	Glycosylation	194	Medium
54	Non-specific	Basic cellular processes	258	Medium
55	Kidney & Intestine	Metabolism	179	Low
56	Non-specific	Unknown function	137	Medium
57	Lung	Lung function	58	Medium
58	Placenta	Pregnancy	142	High
59	Fallopian tube	Tissue development	51	Medium
60	Choroid plexus	Transmembrane transport	207	Medium
61	Brain	Neuronal signaling	238	High
62	Connective tissue	ECM organization	389	Medium
63	Testis	Spermatid development	85	High
64	Neuronal	Transcription	381	Low
65	Cerebellum	Nervous system development	373	High
66	Non-specific	Transcription	492	High
67	Lymphoid tissue & Bone marrow	Cell proliferation	184	Medium
68	Non-specific	Protein processing	342	Medium
69	Liver	Oxidoreductase activity	84	Low
70	Lymphoid tissue	Immune response	420	High
71	Thymus	Adaptive immune response	106	High
72	Testis & Skeletal muscle	Protein ubiquitination	29	Medium
73	Breast	Lactation	26	High
74	Spermatids	Flagellum assembly	196	Medium
75	Epithelium	Extracellular exosomes	176	Low
76	Retina	Visual perception	175	High
77	Bone marrow	Cell proliferation	370	Medium
78	Testis	Transcription	332	Low
79	Non-specific	Transcription	215	Medium
80	Non-specific	Endocytosis	113	Low
81	Lymphoid tissue & Bone marrow	Innate immune response	233	Medium
82	Skin	Keratinization	81	High
83	Liver	Metabolism	337	High

The interactive UMAP plot displays the 83 gene clusters resulting from Louvain clustering of gene expression across all tissue types. General information about the different clusters regarding annotation and number of included genes is shown upon mouse-over, while clicking on a specific cluster in the table will highlight the selected cluster in the plot and display the general information together with a heatmap of the RNA expression across all tissue types for corresponding genes and a Gene Ontology treemap showing the enrichment of GO-terms in the cluster, where applicable.

Brain
Male reproductive system
Breast and female reproductive system
Muscle tissues
Connective & Soft tissue
Skin
Bone marrow & Lymphoid tissues
Eye
Endocrine tissues
Respiratory system
Proximal digestive tract
Gastrointestinal tract
Liver & Gallbladder
Pancreas
Kidney & Urinary bladder
Other
Non-Specific