Tissue expression cluster

e.g. Metabolic proteins, Localized to mitochondria, Genes tissue enriched in brain (RNA)

Field

Cluster

Cell type

Category

Cluster

Pathway

IDⁱ The ID of each cluster.	Main specificityⁱ The annotated specificity of the cluster. This annotation aims to reflect which type of tissues or cell types the genes of the cluster show elevated expression in.	Main functionⁱ The annotated function of the cluster, based on an overrepresentation of genes associated with the annotated function.	# Genesⁱ Number of genes in the cluster.	Annotation reliabilityⁱ The annotation reliability is manually set for all clusters and indicates the level of reliability of the annotated specificity and function.
1	Choroid plexus	Transmembrane transport	267	Medium
3	Oligodendrocytes	Myelination	518	High
4	Adrenal gland	Steroid metabolism	206	Medium
5	Spleen	Immune response	173	Medium
6	Testis	Spermatogenesis	155	High
7	Small intestine	Absorption and Digestion	104	High
8	Pancreas	Proteolysis	168	High
9	Skin	Hair follicle development	122	High
10	Brain	Synaptic signal transduction	208	High
11	Esophagus	Basic cellular processes	352	Medium
12	Smooth muscle tissue	ECM organization	384	Medium
13	Lung	Secretion	57	Medium
14	Adipose tissue	Angiogenesis	418	Medium
15	Bone marrow	Innate immune response	259	High
16	Liver & Kidney	Metabolism	129	High
17	Intestine	Digestion	98	High
18	Lymphoid tissue	Immune response	170	High
19	Skeletal muscle	Striated muscle contraction	214	High
20	Pituitary gland	Hormone signaling	48	High
21	Testis	Mixed function	161	Medium
22	Epididymis	Mixed function	321	Low
23	Testis	Spermatogenesis	142	High
24	Non-specific	Transcription	405	Medium
25	Non-specific	Basic cellular processes	592	High
26	Kidney & Intestine	Metabolism	114	Medium
27	Cerebellum	Synaptic function	321	High
28	Liver & Adrenal gland	Secretion	29	Medium
29	Lymphoid tissue & Bone marrow	Innate immune response	127	High
30	Skeletal muscle	Striated muscle contraction	149	High
31	Liver	Metabolism & Coagulation	182	Medium
32	Retina & Lymphoid tissues	Signaling	139	Medium
33	Thyroid gland	Tissue development	51	Low
34	Lymphoid tissue	Adaptive immune response	209	High
35	Non-specific	Mixed function	212	Low
36	Brain & Liver	Signaling	153	Low
37	Skin	Keratinization	109	High
38	Non-specific	Basic cellular processes	121	Low
39	Testis	Nuclear processes	296	Low
40	Non-specific	Mixed function	132	Medium
41	Striated muscle	Muscle contraction	146	High
42	Retina	Visual perception	234	High
43	Placenta	Pregnancy hormone signaling	179	Medium
44	Bone marrow	Nuclear processes	361	Medium
45	Liver	Metabolism & Coagulation	288	High
46	Brain & retina	Neuronal signaling	317	High
47	Testis	Mixed function	173	Low
48	Ciliated tissues	Cilium organization	359	Medium
49	Non-specific	Transcription	129	High
50	Epididymis	Male reproductive secretion	86	High
51	Lymphoid tissue	Adaptive immune response	181	High
52	Non-specific	Cellular respiration	297	High
53	Liver	Plasma proteins	51	High
54	Non-specific	Ribosome	181	High
55	Breast	Lactation	53	Medium
56	Ciliated tissues	Cilium organization	224	High
57	Testis	Spermatogenesis	322	High
58	Skin	Keratinization	193	High
59	Lymphoid tissue & Bone marrow	Cell proliferation	211	High
60	Stomach	Digestion	188	High
61	Non-specific	Transcription	686	High
62	Skeletal muscle	Muscle contraction	74	High
63	Non-specific	Basic cellular processes	635	Medium
64	Non-specific	Transcription	490	Medium
65	Brain	Transcription	190	Low
66	Lymphoid tissue	Immune response	435	High
67	Testis	Mixed function	290	Medium
68	Non-specific	Basic cellular processes	425	Medium
69	Parathyroid gland	Mixed function	186	Medium
70	Non-specific	Protein processing	417	Medium
71	Cerebellum	Nervous system development	78	High
72	Kidney	Transmembrane transport	256	High
73	Brain	Neuronal signaling	314	High
74	Non-specific	Signal transduction	222	Low
75	Ovary	Mixed function	370	Medium
76	Non-specific	Metabolism	465	Medium
77	Intestine	Digestion	327	High
78	Brain	Neuronal signaling	296	High
79	Testis	Spermatogenesis	237	High
80	Thymus	Adaptive immune response	126	High
81	Squamous epithelium	Keratinization	260	High
82	Salivary gland	Secretion	73	High

The interactive UMAP plot displays the 82 gene clusters resulting from Louvain clustering of gene expression across all tissue types. General information about the different clusters regarding annotation and number of included genes is shown upon mouse-over, while clicking on a specific cluster in the table will highlight the selected cluster in the plot and display the general information together with a heatmap of the RNA expression across all tissue types for corresponding genes and a Gene Ontology treemap showing the enrichment of GO-terms in the cluster, where applicable.

Brain
Male reproductive system
Breast & female reproductive system
Muscle & Vascular tissue
Connective & Soft tissue
Skin
Bone marrow & Lymphoid tissues
Endocrine tissues
Respiratory system
Proximal digestive tract
Gastrointestinal tract
Liver & Gallbladder
Pancreas
Kidney & Urinary bladder
Other
Non-Specific