2025 was a year of intensified global conflicts, political instability and climate extremes, but also the year when renewable energy became a larger energy source than coal, the first gene therapy for Huntington's disease showed remarkable results, the first malaria treatment for infants was approved by WHO and the green sea turtle bounced back from near extinction. From the HPA perspective it was an interesting and fruitful year from which we will share some of the highlights...Read more

Endocrine pancreas is the new addition to the exploration of protein expression with multiplex immunohistochemistry (mIHC/IF). Cell-specific markers, including insulin (gene: INS), are utilized to map the various endocrine cell types...Read more

The Human Pan Disease Atlas article is now available in the latest issue of Science released December 18. The article describes how a next-generation targeted proteomics assay was used to analyze the blood profiles of thousands of patients representing most major disease classes, and to assess the stability and variability of protein profiles in healthy adults as well as for the child to adult development...Read more

In an article in PNAS HPA related researchers have used a combinatorial protein library to select binders against the overexpressed cancer receptor EGFR. The design of the scaffold protein allows for selection of both calcium -and pH dependency, an approach that can generate fine-tuned binders and possibly enable new treatment regimes...Read more

This year's Nobel Prize in Physiology and Medicine was awarded to Mary E. Brunkow, Fred Ramsdell and Shimon Sakaguchi for their discoveries concerning peripheral immune tolerance and regulatory T cells. These immune cells play an important role in protecting us from autoimmune diseases, and key to their development and function is the transcription factor FOXP3...Read more