For more than 20 years, scientists have characterised the behaviour of cells in different circumstances by analysing the expression of their genes. This is typically done at the level of gene transcripts, and their collective expression (the 'expression profile') is known as the transcriptome. These methods are very powerful, but generate massive amounts of data (mammalian cells typically express some 20,000 gene transcripts). What is needed is a method that provides a simple summary of such data. A team from Manchester, together with colleagues from Sweden, has now come up with one...Read more
Distinct mitotic substages have been identified during cell cycle progression. The different subphases are characterised by variation in protein abundance and degree of phosphorylation...Read more
Researchers from the Human Protein Atlas are planning a clinical trial of a new treatment for nonalcoholic fatty liver disease and type 2 diabetes which harnesses liver cells own ability to burn accumulated fats...Read more
The term precision medicine describes the idea of providing effective treatment based on a patient´s molecular make up.
Eculizumab is used to treat patients with paroxysmal nocturnal hemoglobinuria (PNH) and atypical haemolytic uremic syndrome (aHUS). However, eculizumab is a very expensive drug, and the treatment is not efficient for all patients...Read more
In a recent publication in Journal of Proteome Research, researchers from the Cell Profiling group of the Human Protein Atlas team present a new approach for validation of antibodies for bioimaging applications.
Antibodies are indispensible research tools, yet the scientific community has not adopted standardized procedures to validate their specificity. Here the researchers present a strategy to systematically validate antibodies for immunofluorescence applications using gene tagging.
Marie Skogs is the first author of the study.
– After a M. Sc...Read more
February 28, 2018 - March 2, 2018
The Wellcome Genome Campus organizes the conference Proteomics in Cell Biology and Disease Mechanisms where Dr. Emma Lundberg will present "Dissecting the spatiotemporal subcellular distribution of the human proteome". Her talk is scheduled on March 2. Draft programme