News Articles


The role of trypsin in bottom-up proteomics moving towards clinical application

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The impact of different trypsins on commonly used bottom-up proteomics workflows were investigated across a range of sample types in a publication in Analytical Chemistry. Besides the type of trypsin, different protease concentrations, sample matrices, instrument acquisition techniques, and protease storage times were investigated...Read more


A proteomics strategy to assess the reliability of biomarkers for Duchenne muscular dystrophy

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In a publication in Clinical Proteomics a novel orthogonal strategy based on affinity proteomics and mass spectrometry was used for analytical validation of biomarkers in longitudinally collected serum samples from Duchenne muscular dystrophy (DMD) patients...Read more


The plasma proteome signature of multiple myeloma

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In a publication in Cancers a comprehensive mass spectrometry strategy was used to profile blood plasma samples from a large pan-cancer cohort including 15 different cancer types. Differential expression analysis and machine learning was then used to identify a potential biomarker panel able to correctly diagnose multiple myeloma...Read more


Advances and Utility of the Human Plasma Proteome

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Human blood provides an easily obtainable, extensive, and sensitive diagnostic material for the assessment of wellness and disease in individuals and populations. The abundance of proteins and their primary isoforms, alternative splice isoforms, post-translational modifications (PTMs), and protein sequence variants provide a distinct snapshot into the current function of the circulatory system and all organs with which blood comes in contact...Read more


Important link between genomics and proteomics

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Several previous reports have concluded that RNA levels cannot be used to predict protein levels. However, in a new study from KTH Royal Institute of Technology, published in the journal Molecular Systems Biology scientists from the Human Protein Atlas show that protein levels can be predicted from RNA levels if a gene-specific RNA-to-protein factor is used.

The human genome consists of DNA, a molecule that contains the instructions needed to build and maintain cells. For the instructions to be carried out, DNA must be read and transcribed into RNA transcripts that can be used to produce protein. The transcriptome is a collection of all the transcripts present in a cell...Read more