We are very happy to see that the HPA primary cilia research by Hansen et al., published in Cell in November, has been recognized as 'setting a new standard for understanding ciliary function and its role in health and disease'. The recent research highlight published in Nature Signal Transduction and Targeted Therapy praises the HPA work as fundamentally transformative for ciliary biology...Read more

The ability to balance the amount of cellular components, remove damaged entities and recycle molecules by controlled degradation is crucial for cellular function and homeostasis. Lysosomes play a central role by acting as a major hub for degrading proteins, polysaccharides and lipids delivered by autophagy and endocytosis. This is mediated by various hydrolases, specifically acting in the acidic environment maintained in the lysosomal lumen. The lysosomal degradation chamber is isolated from the rest of the cell by a lipid bilayer containing numerous membrane proteins, which are coordinating the functions of lysosomes in processes such as cell homeostasis, metabolism, signalling and stress responses. The membrane proteins themselves are protected on the luminal side by glycosylation, which is key to lysosomal integrity...Read more

2025 was a year of intensified global conflicts, political instability and climate extremes, but also the year when renewable energy became a larger energy source than coal, the first gene therapy for Huntington's disease showed remarkable results, the first malaria treatment for infants was approved by WHO and the green sea turtle bounced back from near extinction. From the HPA perspective it was an interesting and fruitful year from which we will share some of the highlights...Read more

The Human Pan Disease Atlas article is now available in the latest issue of Science released December 18. The article describes how a next-generation targeted proteomics assay was used to analyze the blood profiles of thousands of patients representing most major disease classes, and to assess the stability and variability of protein profiles in healthy adults as well as for the child to adult development...Read more

In an article in PNAS HPA related researchers have used a combinatorial protein library to select binders against the overexpressed cancer receptor EGFR. The design of the scaffold protein allows for selection of both calcium -and pH dependency, an approach that can generate fine-tuned binders and possibly enable new treatment regimes...Read more