Since the release of HPA v24, we are providing a unique highly-multiplexed data set showing the distribution of a large set of reference markers across all major tissues and organs in the human body. The images have been generated using CODEX technology for simultaneous immunostaining of 47 marker proteins across the panel of normal HPA tissue microarrays. The markers have been selected to help distinguish different tissue structures and cell types, and thus histological features, in the TMAs...Read more

In an article in Nature, spatial proteomics was highlighted as a powerful and fast-evolving field - and the Human Protein Atlas was prominently featured as a pioneering initiative in this space. The article explores how researchers are using methods like high-resolution imaging, mass spectrometry, and machine learning in different ways to reveal the dynamic locations of proteins inside human cells...Read more

Knowing where proteins are localized in the cell can help map out cellular processes and signaling pathways to better understand the flow of information within and between cells. The subcellular location of a protein is thought to be tightly linked to its function so that a protein in the nucleus may be involved in gene regulation, while one in the mitochondria might play a role in energy production. However, after having studied the subcellular location of the majority of all human proteins it seems that more than half are in fact multilocalizing proteins (MLPs)...Read more

KTH professor Mathias Uhlén, founder of the Human Protein Atlas and co-founder of numerous biotech companies, discusses science and entrepreneurship with Philip Hemme in a Flot.bio podcast episode...Read more

Among the about 20,000 genes giving rise to the human proteome there are still many rather unknown but potentially interesting genes that deserve some extra attention. Here we will focus on SMIM17, a gene with little evidence and specific expression in the brain...Read more