News Articles


Over a thousand genes associated with prognostic outcome in bladder cancer

EHBP1 uro.jpg

Urothelial cancer, also called bladder cancer, typically presents in patients over 50 years and is approximately three times as common in males compared to females. Tobacco is considered an important risk factor for developing bladder cancer. By using a systems level approach to analyze the urothelial cancer proteome based on clinical metadata and genome-wide transcriptomics data, 1093 genes were found to be associated with prognostic outcome...Read more


Cell Image of the Month - CCNB1

793_A6_1_blue_red_green_medium.jpg

Some proteins are expressed periodically during a specific stage of the cell cycle or as a response to various stimuli. As a result, at any given time some cells express the protein of interest and some do not. In the Cell Atlas we denote these images as single-cell variation (SCV). An example of a protein with such variations is CCNB1.

CCNB1, shown here in U-251 MG cells, is essential for cellular proliferation. The abundance of CCNB1 oscillates across the cell cycle, and peaks during G2/M phase. CCNB1 is expressed in the cytoplasm during interphase and translocate to the nucleus during G2/M transition...Read more


263 genes associated with prognostic outcome in glioma

Glioma HPA031813_gene REEP2.jpg

Gliomas are a group of brain tumors that originate from different types of glial cells in the central nervous system. The prognosis for glioma is generally poor due to limited possibilities for curative treatment. By using a systems level approach to analyze the glioma proteome with respect to clinical outcome based on genome-wide transcriptomics, 263 genes were found to be associated with prognostic outcome...Read more


Cell Image of the Month - Let there be SUN

21_H8_1_red_green.jpg

SUN2 (Sad1 and UNC84 domain containing 2), found in the nuclear membrane of cells, is an essential protein for many cellular processes. SUN plays a large role in the organization of multi-nucleated muscle cells, and dysregulation of SUN can cause muscular dystrophy among other diseases...Read more


205 genes associated with prognosis in melanoma

MCM6 melanoma unfav_2.jpg

Malignant melanoma originates from the pigment-producing melanocytes in the epidermal basal layer, and is considered to develop in a multi-step process. By using a systems level approach to analyze the melanoma proteome with respect to clinical outcome based on genome-wide transcriptomics, 205 genes were found to be associated with prognostic outcome...Read more


Upcoming Events


Proteomics in Cell Biology and Disease Mechanisms

February 28, 2018 - March 2, 2018

The Wellcome Genome Campus organizes the conference Proteomics in Cell Biology and Disease Mechanisms where Dr. Emma Lundberg will present "Dissecting the spatiotemporal subcellular distribution of the human proteome". Her talk is scheduled on March 2. Draft programme

US HUPO

March 11, 2018 - March 14, 2018

The title of 2018 year's US HUPO conference is "Technology accelerating discovery". Dr. Emma Lundberg will hold the closing plenary session on March 14. Programme