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On the top, protein expression in current human tissue, based on all annotated cell types, is reported with the units not detected (n), low (l), medium (m) and high (h). Underneath, protein expression in each annotated cell type are reported using the same units.
Protein expression data is based on knowledge-based annotation. For genes where more than one antibody has been used, a collective score is set.
If knowledge-based annotation could not be performed for a gene, no data is displayed here. View antibody staining data further down this page.
h
m
l
n
Bowman's capsule:
Medium
Cells in glomeruli:
Not detected
Collecting ducts:
High
Distal tubules:
Medium
Proximal tubules (cell body):
Not detected
Proximal tubules (microvilli):
Not detected
Protein profiling Multiplex tissuei
A summary of the protein localization in the current human tissue based on multiplex immunohistochemistry profiling in selected tissues is shown for genes where this analysis has been performed.
Cytoplasmic staining in collecting ducts.
RNA expressioni
A summary of mRNA expression data available for current tissue based on several datasets. The mRNA expression levels in human tissues are based on RNA-seq data generated by the Human Protein Atlas (HPA), Genotype-Tissue Expression (GTEx) portal and CAGE data generated by the FANTOM5 consortium. Consensus normalized expression levels for human tissues was created by combining the data from HPA and GTEx datasets.
The mRNA expression levels in pig are based on RNA-seq data generated by the Human Protein Atlas (HPA), and for mouse, HPA data and in situ hybridization generated by the Allen brain atlas are reported.
Scroll down to view mRNA expression data in more detail.
Consensus:
45.4
nTPM
HPA:
45.4
nTPM
GTEx:
42.1
nTPM
FANTOM5:
93.3
Scaled Tags Per Million
KIDNEY - Multiplex stainingi
Antibody localization in the annotated cell types/states/structures of the current human tissue is reported as main/additional locations, percent overlap between the antibody and cell type/state/structure-specific markers, and, when applicable also subcellular localization. The scores are based on multiplex immunohistochemistry profiling in selected tissues.
Main locations are characterized by a high overlap between the antibody and the cell type/state-specific marker combined with strong antibody signal intensity,
while additional locations are characterized by lower overlap and weaker antibody signal intensity.
The antibody of interest is reported in green, while cell types/states/structures are reported in various other colors, and DAPI (marks nucleus) is reported in blue. Colors can be toggled on and off by clicking on the name of the cell type/state of interest, “Antibody” or “DAPI”. To toggle between the different tissue samples, click on the miniature images at the right bottom corner of the main image. The miniature images appear upon hovering the mouse over that area.
- Antibody HPA024264
Main location
Collecting ducts
Antibody overlap
>75%
Location
Cytoplasm
No antibody overlap
No antibody overlap
No antibody overlap
No antibody overlap
KIDNEY - Antibody stainingi
Antibody staining in the annotated cell types in the current human tissue is reported as not detected, low, medium, or high, based on conventional immunohistochemistry profiling in selected tissues. This score is based on the combination of the staining intensity and fraction of stained cells.
Each image is clickable and will lead to virtual microscopy that enables deeper exploration of all samples and also displays staining intensity scores, fraction scores and subcellular localization as well as patient and tissue information for each sample.
Antibody HPA020518
Antibody HPA024264
Bowman's capsule
-
Medium
Cells in glomeruli
Not detected
Not detected
Cells in tubules
High
-
Collecting ducts
-
High
Distal tubules
-
Medium
Proximal tubules (cell body)
-
Not detected
Proximal tubules (microvilli)
-
Not detected
KIDNEY - HPA RNA-seqi
The RNA-seq details section shows detailed information about the individual samples used for the transcript profiling and results of the RNA-seq analysis.
Information about each individual sample is listed below, including gender, age, a tissue section image and estimated fractions of cell types. nTPM (normalized transcripts per million) values give a quantification of the gene abundance which is comparable between different genes and samples.
Average nTPMi
Max subtype nTPM is the value for the subtype with the largest average nTPM across the subtype samples.
45.4
Female, age 58
Kidney sample 55 nTPM: 38.5
Cell types%
Cells in tubules:
60
Cells in glomeruli:
20
Fibroblasts:
5
Other cell types:
15
Female, age 67
Kidney sample 56 nTPM: 25.6
Cell types%
Cells in tubules:
70
Cells in glomeruli:
15
Fibroblasts:
10
Other cell types:
5
Female, age 55
Kidney sample 57 nTPM: 62
Cell types%
Cells in tubules:
80
Cells in glomeruli:
10
Fibroblasts:
5
Other cell types:
5
Male, age 46
Kidney sample 58 nTPM: 27.5
Cell types%
Cells in tubules:
60
Cells in glomeruli:
25
Fibroblasts:
5
Other cell types:
10
Female, age 57
Kidney sample 358 nTPM: 68.2
Cell types%
Cells in tubules:
60
Cells in glomeruli:
10
Fibroblasts:
10
Other cell types:
20
Male, age 78
Kidney sample 377 nTPM: 56.3
Cell types%
Cells in tubules:
65
Cells in glomeruli:
10
Fibroblasts:
5
Other cell types:
20
Male, age 73
Kidney sample 380 nTPM: 29.1
Cell types%
Cells in tubules:
60
Cells in glomeruli:
10
Fibroblasts:
10
Other cell types:
20
Female, age 59
Kidney sample 394 nTPM: 58.7
Cell types%
Cells in tubules:
65
Cells in glomeruli:
10
Fibroblasts:
10
Other cell types:
15
Female, age 48
Kidney sample 414 nTPM: 43.1
Cell types%
Cells in tubules:
60
Cells in glomeruli:
5
Fibroblasts:
10
Other cell types:
25
KIDNEY - GTEx RNA-seqi
RNA-Seq data generated by the Genotype-Tissue Expression (GTEx) project from human tissues is reported as mean nTPM. More information can be found on the GTEx portal.
Distribution across the dataset is visualized with box plots, shown as median and 25th and 75th percentiles. Points are displayed as outliers if they are above or below 1.5 times the interquartile range. nTPM values of the individual samples are presented next to the box plot.
Max subtype nTPMi
Max subtype nTPM is the value for the subtype with the largest average nTPM across the subtype samples.
42.1
GTEx sample id
Sample description
nTPM
Kidney - Cortex Average nTPM: 33.9
Samples: 85
Max nTPM: 71.4
Min nTPM: 10.7
Std nTPM: 12.1
Median nTPM: 32.6
GTEX-1EKGG-2226-SM-7IGOA
60-69 years, male
71.4
GTEX-1GF9V-1926-SM-9JGHE
60-69 years, male
66.6
GTEX-ZYT6-2226-SM-5GIC9
30-39 years, male
55.2
GTEX-11GS4-2326-SM-5A5KS
60-69 years, male
53.7
GTEX-1CB4J-1926-SM-7MGX8
60-69 years, male
51.5
GTEX-14C39-2126-SM-664OH
40-49 years, male
50.8
GTEX-1F48J-2226-SM-7MXTN
50-59 years, female
50.2
GTEX-1LG7Y-2726-SM-D5OVW
50-59 years, male
49.7
GTEX-1A8FM-2026-SM-7P8RN
50-59 years, female
49.4
GTEX-1NV8Z-2226-SM-EXOJ2
60-69 years, male
48.7
GTEX-ZE9C-1426-SM-4WKGM
60-69 years, male
47.9
GTEX-1GN1U-2126-SM-AHZ4J
50-59 years, female
47.8
GTEX-1IKK5-0926-SM-A9G2U
60-69 years, male
47.6
GTEX-ZYFG-1626-SM-5GZYY
60-69 years, female
47.2
GTEX-RN64-1626-SM-48FD7
50-59 years, male
46.9
GTEX-1QP6S-1526-SM-EXUSG
40-49 years, male
46.5
GTEX-11OF3-1326-SM-5N9FJ
60-69 years, male
46.0
GTEX-ZDXO-0226-SM-4WKH7
60-69 years, male
45.9
GTEX-1JMLX-1526-SM-AHZ3N
50-59 years, male
45.6
GTEX-1N2DW-1826-SM-EAZ54
50-59 years, male
43.5
GTEX-1GTWX-1826-SM-9QEHG
60-69 years, male
43.3
GTEX-1PWST-2226-SM-EVR3G
70-79 years, male
43.2
GTEX-1HBPI-2026-SM-CE6RZ
50-59 years, male
42.7
GTEX-1A3MW-2226-SM-73KUX
60-69 years, female
42.2
GTEX-13112-2126-SM-5GCO4
50-59 years, male
40.8
GTEX-1JMPZ-1226-SM-ARU8Y
30-39 years, male
39.9
GTEX-13RTJ-2226-SM-5S2Q1
60-69 years, male
39.6
GTEX-P4QS-1126-SM-3NMD5
60-69 years, male
39.4
GTEX-15DYW-2026-SM-6AJBD
60-69 years, female
38.4
GTEX-1KWVE-0826-SM-CXZKO
30-39 years, male
38.4
GTEX-1K9T9-1826-SM-CXZK2
50-59 years, female
38.3
GTEX-ZVZP-0926-SM-5GIDB
50-59 years, male
37.7
GTEX-17F97-1926-SM-7IGM4
50-59 years, male
37.4
GTEX-17F96-1926-SM-7MGWY
70-79 years, male
35.9
GTEX-1BAJH-1826-SM-731DA
70-79 years, male
35.6
GTEX-O5YV-1226-SM-EV795
60-69 years, female
35.3
GTEX-Y5V5-1226-SM-EYYVP
60-69 years, female
35.2
GTEX-ZC5H-1726-SM-5HL7X
40-49 years, female
34.8
GTEX-13OW6-1826-SM-5N9F9
50-59 years, male
33.6
GTEX-1IL2V-1826-SM-ARU7R
70-79 years, male
33.3
GTEX-147F4-2626-SM-5Q5CS
50-59 years, male
33.2
GTEX-13OVL-1826-SM-5KLZR
50-59 years, male
32.6
GTEX-145MN-0326-SM-5QGQI
30-39 years, male
32.6
GTEX-17HHY-2326-SM-7KFSR
50-59 years, male
32.6
GTEX-12696-0926-SM-5FQTV
60-69 years, male
31.6
GTEX-14E6D-2526-SM-5YYA9
50-59 years, male
31.2
GTEX-1JMQJ-1726-SM-E9U4V
50-59 years, male
31.2
GTEX-S33H-1426-SM-EZ6L7
30-39 years, male
30.9
GTEX-1GMR3-2426-SM-7MXV2
40-49 years, male
30.8
GTEX-1AX8Z-2326-SM-731CR
60-69 years, male
30.7
GTEX-Y5V6-2026-SM-5IFHO
60-69 years, male
29.8
GTEX-1JJ6O-2526-SM-AHZ3J
60-69 years, male
29.7
GTEX-11TTK-1926-SM-5PNW8
60-69 years, female
29.3
GTEX-12WSG-0826-SM-5EQ5A
50-59 years, female
29.3
GTEX-ZLFU-0926-SM-5P9F8
40-49 years, male
28.8
GTEX-1GF9W-1326-SM-7P8PX
60-69 years, male
28.5
GTEX-1MUQO-2526-SM-E9TJN
60-69 years, male
28.3
GTEX-1R9PO-1626-SM-E6CPT
60-69 years, female
28.1
GTEX-XPVG-0526-SM-4B65N
50-59 years, male
28.0
GTEX-T6MN-1826-SM-EXOHN
50-59 years, male
27.4
GTEX-13OVI-1126-SM-5KLZF
60-69 years, female
26.9
GTEX-1I1GP-1926-SM-CNNQU
50-59 years, male
26.6
GTEX-1OJC4-2326-SM-DTXA5
50-59 years, female
25.9
GTEX-16MT8-1926-SM-7EPGL
60-69 years, female
24.2
GTEX-QDT8-1726-SM-EYYV6
30-39 years, female
23.6
GTEX-1C6VQ-2326-SM-7IGN1
50-59 years, male
23.5
GTEX-QLQW-1626-SM-CMKFE
30-39 years, male
23.5
GTEX-15CHQ-2126-SM-6871M
60-69 years, male
23.2
GTEX-13NYB-1726-SM-5N9G2
40-49 years, male
23.1
GTEX-1399S-0526-SM-5IJG8
30-39 years, female
22.9
GTEX-1JMQK-1926-SM-CJI3B
60-69 years, male
22.3
GTEX-1HCU7-1826-SM-A9G2A
50-59 years, male
21.8
GTEX-1497J-0826-SM-5NQAJ
60-69 years, male
20.6
GTEX-REY6-1826-SM-EAZAT
60-69 years, male
19.1
GTEX-1H3VY-1926-SM-9JGHJ
50-59 years, male
18.4
GTEX-T5JC-1526-SM-4DM68
20-29 years, male
18.3
GTEX-QDVN-1626-SM-48TZC
50-59 years, male
17.7
GTEX-1E2YA-1626-SM-7MGXS
50-59 years, male
17.2
GTEX-1J1OQ-1426-SM-AHZ3P
40-49 years, female
16.7
GTEX-1N2EF-1426-SM-EXUSH
60-69 years, male
16.5
GTEX-NPJ8-2226-SM-3TW8D
40-49 years, male
16.2
GTEX-1HB9E-1826-SM-D4P33
50-59 years, male
16.1
GTEX-1H3NZ-2126-SM-9WPQ6
60-69 years, male
13.8
GTEX-14C5O-2026-SM-5YYB1
60-69 years, male
12.6
GTEX-13O1R-2526-SM-5N9FW
60-69 years, male
10.7
Show allShow less
Kidney - Medulla Average nTPM: 42.1
Samples: 4
Max nTPM: 68.1
Min nTPM: 24.6
Std nTPM: 17.9
Median nTPM: 37.9
GTEX-TKQ2-0626-SM-EZ6LB
50-59 years, male
68.1
GTEX-R55E-2026-SM-EZ6L1
20-29 years, male
49.5
GTEX-T5JC-1626-SM-EZ6KW
20-29 years, male
26.3
GTEX-RU72-1926-SM-EAZ3F
50-59 years, female
24.6
KIDNEY - FANTOM5 CAGEi
RNA expression in human tissues obtained through Cap Analysis of Gene Expression (CAGE) generated by the FANTOM5 project are reported as Scaled Tags Per Million.
Max subtype Scaled Tags Per Millioni
Max subtype Scaled Tags Per Million is the value for the subtype with the largest average Scaled Tags Per Million across the subtype samples.
The Human Protein Atlas project is funded
