Protein interactions - RALBP1 - The Human Protein Atlas

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	RALBP1
Synonyms	RIP, RIP1, RLIP76
Gene descriptionⁱ Full gene name according to HGNC.	RalA binding protein 1
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s). Read more	Enzymes Metabolic proteins RAS pathway related proteins Transporters
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.	Intracellular
Protein evidence	Evidence at protein level (all genes)

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression analysis and annotation data generated within the Human Protein Atlas project.
Single cell type expression clusterⁱ The RNA data was used to cluster genes according to their expression across single cell types. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity.	Renal epithelial cells - Ion transport & homeostasis (mainly)
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected.	Cell type enhanced (Esophageal apical cells, Esophageal suprabasal cells, Extravillous trophoblasts, Renal collecting duct principal cells, Urothelial cells)
Tissue expression cluster (RNA)ⁱ The RNA data was used to cluster genes according to their expression across tissues. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity.	Skin - Keratinization (mainly)
Tissue specificity (RNA)ⁱ The RNA specificity category is based on mRNA expression levels in the consensus dataset which is calculated from the RNA expression levels in samples from HPA and GTEX. The categories include: tissue enriched, group enriched, tissue enhanced, low tissue specificity and not detected.	Low tissue specificity
Subcellular locationⁱ Main subcellular location based on data generated in the subcellular section of the Human Protein Atlas.	Localized to the Nucleoplasm, Plasma membrane In addition localized to the Nuclear bodies
Secretome annotationⁱ All genes with at least one predicted secreted isoform have been annotated and classified with the aim to determine if the corresponding protein(s) are: secreted into blood locally secreted or actually being attached to membrane or retained in intracellular locations like mitochondria, endoplasmatic reticulum (ER), Golgi apparatus or lysosomes.	Not available

GENE INFORMATIONⁱ Gene information from Ensembl and Entrez, as well as links to available gene identifiers are displayed here. Information was retrieved from Ensembl if not indicated otherwise.
Chromosome	18
Cytoband	p11.22
Chromosome location (bp)	9475009 - 9538114
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	6
Ensembl	ENSG00000017797 (version 109)
Entrez gene	10928
HGNC	HGNC:9841
UniProt	Q15311
GeneCards	RALBP1

ASSAYSⁱ

Interaction

Metabolic

INTERACTIONⁱ

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e.g. Brain enriched, Localized to mitochondria, Skin - Keratinization

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Number of interactions:

Interaction	# Consensus	# IntAct	# BioGrid	# OpenCell	# BioPlex
AAK1	5	2	16	5	0
AP2M1	16	40	65	11	0
AP2S1	12	1	23	17	0
BMP2K	5	19	12	4	2
CBY1	4	27	8	1	2
CCDC6	8	22	27	2	12
CREBZF	3	12	4	0	0
DYRK1A	30	30	142	4	0
GPS2	7	33	20	1	9
GSE1	10	15	25	2	0
HOOK2	5	11	10	1	0
MSANTD4	1	8	1	0	0
PPL	3	31	8	0	23
RALA	4	3	16	4	0
RALB	3	6	6	0	5
REPS1	1	2	8	0	0
REPS2	3	6	4	1	0
SAPCD2	1	11	1	0	1
TFPT	14	14	20	0	37
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View all protein interaction data in IntAct

Interaction	# Consensus	# IntAct	# BioGrid	# OpenCell	# BioPlex
AMOTL2	3	38	18	2	0
AP2M1	16	40	65	11	0
C1orf216	1	69	1	0	0
CBY1	4	27	8	1	2
CCDC13	0	37	0	0	0
CCDC6	8	22	27	2	12
CCDC88B	0	32	0	0	0
CCL20	0	4	0	0	0
CEP57	1	12	3	0	0
CREBZF	3	12	4	0	0
DLG1	8	21	46	0	0
DLG4	11	13	54	0	0
DYRK1A	30	30	142	4	0
FGFR3	4	191	23	0	0
GAS8	1	97	1	0	0
GPS2	7	33	20	1	9
GSE1	10	15	25	2	0
GSN	5	125	21	4	0
HOOK2	5	11	10	1	0
HRAS	14	91	135	0	10
KANK2	5	153	7	3	0
LDOC1	5	83	9	0	2
MSANTD4	1	8	1	0	0
PPL	3	31	8	0	23
PPP1R13B	4	54	17	0	2
RALA	4	3	16	4	0
RALB	3	6	6	0	5
REPS1	1	2	8	0	0
SAPCD2	1	11	1	0	1
SCRIB	8	30	34	0	0
SMARCE1	23	57	58	28	0
SYCE1	3	40	5	0	0
TAX1BP1	12	58	33	0	0
TCP10L	2	28	2	0	3
TNIP1	22	68	77	0	0
TSFM	3	8	20	1	6
ZNF707	3	7	3	0	14
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Interaction	# Consensus	# IntAct	# BioGrid	# OpenCell	# BioPlex
AAK1	5	2	16	5	0
AP1M2	4	1	9	0	9
AP2A1	1	4	46	0	0
AP2B1	17	15	70	9	0
AP2M1	16	40	65	11	0
AP2S1	12	1	23	17	0
BIRC6	0	5	21	1	18
BMP2K	5	19	12	4	2
CBY1	4	27	8	1	2
CCDC6	8	22	27	2	12
CCNB1	10	8	69	7	6
CREBZF	3	12	4	0	0
DYRK1A	30	30	142	4	0
EPN1	3	6	17	7	0
GOPC	6	29	25	0	0
GPS2	7	33	20	1	9
GPSM1	1	1	8	0	0
GSE1	10	15	25	2	0
HOOK2	5	11	10	1	0
HSF1	10	25	79	3	0
JUN	27	50	108	13	4
MSANTD4	1	8	1	0	0
PHLDB3	0	0	3	0	3
PPL	3	31	8	0	23
PPP4R1	2	2	9	1	0
PSMC5	39	31	121	19	25
RAC1	33	61	111	15	0
RALA	4	3	16	4	0
RALB	3	6	6	0	5
REPS1	1	2	8	0	0
REPS2	3	6	4	1	0
SAPCD2	1	11	1	0	1
SEPTIN10	5	2	13	4	0
SEPTIN7	8	9	18	11	0
TFPT	14	14	20	0	37
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Predicted location

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Number of interactions:

Interaction	# Consensus	# IntAct	# BioGrid	# OpenCell	# BioPlex
AAK1	5	2	16	5	0
AP2M1	16	40	65	11	0
AP2S1	12	1	23	17	0
CCDC82	0	0	0	6	0
REPS2	3	6	4	1	0

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Interaction	# Consensus	# IntAct	# BioGrid	# OpenCell	# BioPlex
BMP2K	5	19	12	4	2
C10orf88	4	9	4	1	46
CCDC6	8	22	27	2	12
CRYBG2	0	0	0	0	5
GPS2	7	33	20	1	9
IFT43	6	8	6	0	7
TFPT	14	14	20	0	37
ZNF784	0	6	0	0	5

METABOLIC SUMMARYⁱ In this summary the pathway/subsystems to which the gene belongs is shown together with the associated cellular compartment for the reactions based on metabolite information. The number of proteins and metabolites in the pathway is shown as well as the number of reactions for the selected gene. By clicking on a pathway in the summary table the associated metabolic network map is shown, together with a gene-tissue heatmap that shows the expression of genes in that pathway in different tissues.
Gene RALBP1 is associated with 2 reactions in 1 different subsystems, and present in the compartments: Cytosol, Extracellular. Provided by metabolicatlas.org
Pathway / Subsystem	Subsystem-associated compartments	# proteins	# metabolites	# reactions for this protein
Transport reactions	Cytosol, Extracellular, Lysosome, Peroxisome, Mitochondria, Golgi apparatus, Endoplasmic reticulum, Nucleus, Inner mitochondria	563	1599	2

PROTEIN INFORMATIONⁱ The protein information section displays alternative protein-coding transcripts (splice variants) encoded by this gene according to the Ensembl database. The Splice variant identifier links to the Ensembl website protein summary for the selected splice variant. The data in the Swissprot and TrEMBL columns links to corresponding pages in the UniProt database. The protein classes assigned to this protein are shown if expanding the data in the protein class column. Parent protein classes are in bold font and subclasses are listed under the parent class. The length of the protein (amino acid residues according to Ensembl), molecular mass (kDalton), predicted signal peptide and number of predicted transmembrane region(s) according to in-house majority decision methods based on sets of predictors are also reported.
Splice variant	SwissProt	TrEMBL	Protein class	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
RALBP1-201	Q15311		Enzymes Metabolic proteins Transporters Predicted intracellular proteins RAS pathway related proteins Mapped to neXtProt Protein evidence (Ezkurdia et al 2014) Show all	655 aa 76.1 kDa	No	0
RALBP1-202	Q15311		Enzymes Metabolic proteins Transporters Predicted intracellular proteins RAS pathway related proteins Mapped to neXtProt Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	655 aa 76.1 kDa	No	0
RALBP1-203		E7ENF8	Metabolic proteins Predicted intracellular proteins RAS pathway related proteins Protein evidence (Ezkurdia et al 2014)	207 aa 23.7 kDa	No	0
RALBP1-204			Metabolic proteins Predicted intracellular proteins RAS pathway related proteins Protein evidence (Ezkurdia et al 2014)	3 aa 0.4 kDa	No	0
RALBP1-205		J3QLT3	Metabolic proteins Predicted intracellular proteins RAS pathway related proteins Protein evidence (Ezkurdia et al 2014)	186 aa 21.4 kDa	No	0
RALBP1-206		A0A1W2PRI7	Metabolic proteins Predicted intracellular proteins RAS pathway related proteins Protein evidence (Ezkurdia et al 2014)	242 aa 27.7 kDa	No	0
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