Protein interactions - USP2 - The Human Protein Atlas

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	USP2
Synonyms	UBP41
Gene descriptionⁱ Full gene name according to HGNC.	Ubiquitin specific peptidase 2
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s). Read more	Enzymes Metabolic proteins
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.	Intracellular
Protein evidence	Evidence at protein level (all genes)

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression analysis and annotation data generated within the Human Protein Atlas project.
Single cell type expression clusterⁱ The RNA data was used to cluster genes according to their expression across single cell types. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity.	Late spermatids - Spermiogenesis: Maturation (mainly)
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected.	Group enriched (Early spermatids, Late spermatids)
Tissue expression cluster (RNA)ⁱ The RNA data was used to cluster genes according to their expression across tissues. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity.	Non-specific - Basic cellular processes (mainly)
Tissue specificity (RNA)ⁱ The RNA specificity category is based on mRNA expression levels in the consensus dataset which is calculated from the RNA expression levels in samples from HPA and GTEX. The categories include: tissue enriched, group enriched, tissue enhanced, low tissue specificity and not detected.	Tissue enhanced (Skeletal muscle)
Subcellular locationⁱ Main subcellular location based on data generated in the subcellular section of the Human Protein Atlas.	Localized to the Cytosol In addition localized to the Plasma membrane
Secretome annotationⁱ All genes with at least one predicted secreted isoform have been annotated and classified with the aim to determine if the corresponding protein(s) are: secreted into blood locally secreted or actually being attached to membrane or retained in intracellular locations like mitochondria, endoplasmatic reticulum (ER), Golgi apparatus or lysosomes.	Not available

GENE INFORMATIONⁱ Gene information from Ensembl and Entrez, as well as links to available gene identifiers are displayed here. Information was retrieved from Ensembl if not indicated otherwise.
Chromosome	11
Cytoband	q23.3
Chromosome location (bp)	119355215 - 119381711
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	5
Ensembl	ENSG00000036672 (version 109)
Entrez gene	9099
HGNC	HGNC:12618
UniProt	O75604
GeneCards	USP2

ASSAYSⁱ

Interaction

Metabolic

INTERACTIONⁱ

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e.g. Brain enriched, Localized to mitochondria, Non-specific - Basic cellular processes

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Interaction:

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Number of interactions:

Interaction	# Consensus	# IntAct	# BioGrid	# OpenCell	# BioPlex
DTX3	7	20	13	0	0
KRT15	22	101	30	0	0
TRAF2	53	240	125	2	0
TRAF6	31	60	155	0	3
TRIM23	9	142	23	0	0
TRIM27	20	235	63	0	0

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View all protein interaction data in IntAct

Interaction	# Consensus	# IntAct	# BioGrid	# OpenCell	# BioPlex
ACTN1	8	26	56	7	0
ACTN2	10	66	19	9	1
ACTN3	2	38	5	0	8
ASPG	0	11	1	0	0
BCAR1	19	21	44	12	2
BIRC7	6	25	8	0	6
CALCOCO2	21	118	59	0	5
CCDC57	1	32	2	0	0
CCDC88B	0	32	0	0	0
CEP70	17	197	18	0	0
CRACR2A	0	33	1	0	0
DDI1	1	17	3	0	2
DTX3	7	20	13	0	0
DUSP21	0	15	1	0	1
DYDC1	1	24	1	0	0
EFHC2	3	79	3	0	0
EIF4ENIF1	5	23	13	5	0
EXOC5	9	46	12	2	9
EXOSC8	11	46	29	2	8
GEMIN4	11	29	31	12	20
GOLGA2	21	350	58	11	0
GOLGA6A	1	37	1	0	0
GOLGA6L9	0	177	0	0	0
GPRASP3	0	50	1	0	0
GRIPAP1	4	48	6	0	4
HOMER3	6	65	13	1	0
HOOK1	5	24	20	1	8
IHO1	2	62	2	0	0
IKZF3	4	131	22	0	0
INTS11	3	28	6	9	0
JAKMIP1	0	14	1	0	0
KIFC3	1	70	4	0	0
KRT15	22	101	30	0	0
KRT27	5	113	6	0	0
KRT31	19	284	21	0	0
KRT33B	8	65	8	0	0
KRT34	5	201	5	0	0
KRT35	0	69	0	0	0
KRT40	11	289	12	0	0
LHX4	5	37	11	0	4
LMNB2	2	22	16	6	4
LZTS2	21	178	46	4	7
MORN5	0	8	0	0	0
MRPL28	17	21	26	0	54
MTUS2	3	130	6	0	0
NAB2	1	62	2	0	18
NDEL1	17	63	28	3	0
NEFL	7	71	13	1	1
OIP5	3	113	9	3	6
OPTN	23	128	71	2	14
PICK1	10	276	36	0	9
PLEKHG4	0	50	1	0	15
PNMA1	5	115	6	0	3
POU2AF1	1	35	3	0	0
PRDM14	4	42	6	0	2
PRR5L	0	13	4	0	0
RABEP1	11	40	23	5	0
RFX6	1	24	1	0	0
S100A10	3	9	13	2	2
SORBS3	4	88	7	0	0
SPDYE4	3	12	9	0	0
STAT5B	2	15	8	0	3
TAX1BP1	12	58	33	0	0
TEKT4	1	81	2	0	1
TFIP11	22	180	39	10	11
TNFAIP2	0	1	1	0	18
TRAF1	17	168	46	0	9
TRAF2	53	240	125	2	0
TRAF6	31	60	155	0	3
TRIM23	9	142	23	0	0
TRIM27	20	235	63	0	0
TRIM50	5	31	10	0	0
TRIP6	9	90	24	2	9
USHBP1	8	162	12	0	0
VPS52	6	83	11	0	7
ZBED1	4	35	8	0	0
ZIM2	0	26	0	0	6
ZRANB1	35	112	197	0	1
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Cell type specificity

Protein class

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Number of interactions:

Interaction	# Consensus	# IntAct	# BioGrid	# OpenCell	# BioPlex
ARID2	5	5	23	1	0
AURKA	11	18	116	0	2
BRCA1	36	39	311	3	0
CCND1	14	17	56	0	11
CD274	2	5	49	0	4
CRY1	6	3	17	1	6
CTNNB1	47	85	285	13	13
DCAF1	4	6	58	7	0
DNAJA1	12	3	69	19	9
DTX3	7	20	13	0	0
E2F4	7	9	26	0	5
FASN	2	6	39	9	4
HSPA1A	1	7	318	0	0
KCNQ1	1	1	7	0	0
KRT15	22	101	30	0	0
MALT1	6	8	15	0	0
MDM2	47	61	261	0	0
MDM4	11	23	28	1	2
PCNA	34	37	150	10	14
RAB1A	15	6	43	40	3
RIPK1	13	18	57	0	9
RUVBL1	52	16	129	29	39
SCNN1A	2	3	5	0	0
SCNN1G	0	1	5	0	0
SMAD7	5	7	46	0	0
SNAI1	9	29	57	0	0
TARDBP	16	141	74	7	0
TCP1	23	11	85	19	57
TGFBR1	2	3	43	1	0
TGFBR2	3	54	24	0	13
TRAF2	53	240	125	2	0
TRAF6	31	60	155	0	3
TRIM23	9	142	23	0	0
TRIM27	20	235	63	0	0
UBC	35	59	463	4	0
VDAC2	8	21	62	8	0
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METABOLIC SUMMARYⁱ In this summary the pathway/subsystems to which the gene belongs is shown together with the associated cellular compartment for the reactions based on metabolite information. The number of proteins and metabolites in the pathway is shown as well as the number of reactions for the selected gene. By clicking on a pathway in the summary table the associated metabolic network map is shown, together with a gene-tissue heatmap that shows the expression of genes in that pathway in different tissues.
Gene USP2 is associated with 1 reactions in 1 different subsystems, and present in the compartments: Cytosol. Provided by metabolicatlas.org
Pathway / Subsystem	Subsystem-associated compartments	# proteins	# metabolites	# reactions for this protein
Isolated	Cytosol, Mitochondria, Peroxisome, Endoplasmic reticulum, Extracellular, Nucleus, Golgi apparatus	524	320	1

PROTEIN INFORMATIONⁱ The protein information section displays alternative protein-coding transcripts (splice variants) encoded by this gene according to the Ensembl database. The Splice variant identifier links to the Ensembl website protein summary for the selected splice variant. The data in the Swissprot and TrEMBL columns links to corresponding pages in the UniProt database. The protein classes assigned to this protein are shown if expanding the data in the protein class column. Parent protein classes are in bold font and subclasses are listed under the parent class. The length of the protein (amino acid residues according to Ensembl), molecular mass (kDalton), predicted signal peptide and number of predicted transmembrane region(s) according to in-house majority decision methods based on sets of predictors are also reported.
Splice variant	SwissProt	TrEMBL	Protein class	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
USP2-201	O75604		Enzymes Metabolic proteins Predicted intracellular proteins Mapped to neXtProt	605 aa 68.1 kDa	No	0
USP2-202	O75604		Enzymes Metabolic proteins Predicted intracellular proteins Mapped to neXtProt	362 aa 41.7 kDa	No	0
USP2-204	O75604		Enzymes Metabolic proteins Predicted intracellular proteins Mapped to neXtProt	396 aa 45.2 kDa	No	0
USP2-205		E9PJ34	Metabolic proteins Predicted intracellular proteins	137 aa 14.7 kDa	No	0
USP2-206		E9PSH6	Metabolic proteins Predicted intracellular proteins	167 aa 18.2 kDa	No	0
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