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General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene namei
Official gene symbol, which is typically a short form of the gene name, according to HGNC.
All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions.
Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached.
Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s).
The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.
Gene information from Ensembl and Entrez, as well as links to available gene identifiers are displayed here. Information was retrieved from Ensembl if not indicated otherwise.
Chromosome
X
Cytoband
p11.23
Chromosome location (bp)
48973720 - 49002265
Number of transcriptsi
Number of protein-coding transcripts from the gene as defined by Ensembl.
Useful information about the protein provided by UniProt.
Regulates the endosomal recycling back to the neuronal plasma membrane, possibly by connecting early and late recycling endosomal domains and promoting segregation of recycling endosomes from early endosomal membranes. Involved in the localization of recycling endosomes to dendritic spines, thereby playing a role in the maintenance of dendritic spine morphology. Required for the activity-induced AMPA receptor recycling to dendrite membranes and for long-term potentiation and synaptic plasticity (By similarity)....show less
Biological process (UniProt)i
Keywords assigned by UniProt to proteins because they are involved in a particular biological process.
Protein transport, Transport
Gene summary (Entrez)i
Useful information about the gene from Entrez
This gene encodes a guanine nucleotide exchange factor for the Ras family of small G proteins (RasGEF). The encoded protein interacts in a complex with glutamate receptor interacting protein 1 (GRIP1) and plays a role in the regulation of AMPA receptor function. [provided by RefSeq, Aug 2013]...show less
PROTEIN INFORMATIONi
The protein information section displays alternative protein-coding transcripts (splice variants) encoded by this gene according to the Ensembl database.
The Splice variant identifier links to the Ensembl website protein summary for the selected splice variant. The data in the Swissprot and TrEMBL columns links to corresponding pages in the UniProt database.
The protein classes assigned to this protein are shown if expanding the data in the protein class column. Parent protein classes are in bold font and subclasses are listed under the parent class.
The length of the protein (amino acid residues according to Ensembl), molecular mass (kDalton), predicted signal peptide and number of predicted transmembrane region(s) according to in-house majority decision methods based on sets of predictors are also reported.
Q4V328 [Direct mapping] GRIP1-associated protein 1 GRASP-1 C-terminal chain
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003674[molecular_function] GO:0005085[guanyl-nucleotide exchange factor activity] GO:0005515[protein binding] GO:0005654[nucleoplasm] GO:0005768[endosome] GO:0005829[cytosol] GO:0008150[biological_process] GO:0014069[postsynaptic density] GO:0015031[protein transport] GO:0016020[membrane] GO:0030424[axon] GO:0030425[dendrite] GO:0031901[early endosome membrane] GO:0035255[ionotropic glutamate receptor binding] GO:0042734[presynaptic membrane] GO:0042802[identical protein binding] GO:0042995[cell projection] GO:0043025[neuronal cell body] GO:0043231[intracellular membrane-bounded organelle] GO:0045202[synapse] GO:0055038[recycling endosome membrane] GO:0072562[blood microparticle] GO:0098837[postsynaptic recycling endosome] GO:0098887[neurotransmitter receptor transport, endosome to postsynaptic membrane] GO:0098978[glutamatergic synapse] GO:0098998[extrinsic component of postsynaptic early endosome membrane] GO:0099152[regulation of neurotransmitter receptor transport, endosome to postsynaptic membrane] GO:0099158[regulation of recycling endosome localization within postsynapse] GO:1903828[negative regulation of protein localization] GO:1903910[negative regulation of receptor clustering] GO:1905244[regulation of modification of synaptic structure]
Q4V328 [Direct mapping] GRIP1-associated protein 1 GRASP-1 C-terminal chain
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Ezkurdia et al 2014)
The Human Protein Atlas project is funded
