The primary data page shows the detailed antibody staining in 76 different cell types for each analyzed antibody. In addition, for each cell type, a knowledge-based annotated protein expression score based on all analyzed antibodies is displayed furthest to the right. The images and annotations can be accessed by clicking on the tissue name or score bar. More information can be found in Assays & Annotation.
The tissues and cell types can be ordered by organ, cell type or alphabetically. If ordered by organ, the tissues are presented in groups according to functional features. If ordered by cell type, the cells are presented in groups related to origin.
This score describes the level of antibody staining observed in the annotated cell types as not detected (n), low (l), medium (m) or high (h). It is based on the staining intensity and fraction of stained cells. The images and annotations can be accessed by clicking on the tissue name or score bar. More information can be found in Assays & Annotation.
This score describes a knowledge-based best estimate of the protein expression in the annotated cell types as not detected (n), low (l), medium (m) or high (h). It is a result of stringent evaluation of immunohistochemical staining pattern, RNA data from internal and external sources and available protein/gene characterization data. More information can be found in Assays & Annotation.
Summarizing texts describe the staining pattern for each antibody based on staining intensity, fraction of stained cells and subcellular localization. More information can be found in Assays & Annotation.
Most normal tissues displayed moderate to strong nuclear positivity with additional cytoplasmic and membranous staining in glandular cells and hepatocytes. Bile ducat cells, smooth muscle cells and neuropil were weakly stained or negative.
Most normal tissue displayed moderate to strong nuclear immunoreactivity. Additional luminal membranous staining in gastrointestinal tract, gall bladder, epididymis, kidney tubule cells, seminal vesicles, salivary and uterine glands. Liver cells, neuropil and glial cells were weakly stained or negative.
Moderate nuclear positivity was observed in most normal tissues. Cytoplasmic staining was observed in a few cases. Cilia in respiratory epithelia and fallopian tube showed additional staining. Gastrointestinal glands, esophagus, adrenal gland, neuronal cells, germinal center cells, hematopoietic cells and heart myocytes were strongly stained.