NFE2L2 protein expression summary - The Human Protein Atlas

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NFE2L2

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HUMAN PROTEIN ATLAS SUMMARYⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Proteinⁱ Full gene name according to HGNC.	Nuclear factor, erythroid 2 like 2
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	NFE2L2 (NRF2)
Tissue specificityⁱ ??The RNA specificity category is based on mRNA expression levels in the consensus dataset which is calculated from the RNA expression levels in samples from HPA and GTEX. The categories include: tissue enriched, group enriched, tissue enhanced, low tissue specificity and not detected. Read more	Low tissue specificity
Tissue expression clusterⁱ The RNA data was used to cluster genes according to their expression across tissues. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity. Read more	Esophagus - Epithelial junctions (mainly)
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low cell type specificity
Single cell type expression clusterⁱ The RNA data was used to cluster genes according to their expression across single cell types. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity. Read more	Macrophages - Immune response (mainly)
Immune cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed blood cell samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low immune cell specificity
Brain specificityⁱ The regional specificity category is based on mRNA expression levels in the analysed brain samples, grouped into 13 main brain regions and calculated for the three different species. All brain expression profiles are based on data from HPA. The specificity categories include: regionally enriched, group enriched, regionally enhanced, low regional specificity and not detected. The classification rules are the same used for the tissue specificity category Read more	Low human brain regional specificity
Cancer prognostic summary	Prognostic marker in renal cancer (favorable)
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular
Subcellular summaryⁱ Describes the main and potential additional location(s) of the encoded protein according to ICC-IF resukt in the Cell Atlas, as well as potential data regarding cell cycle depency (CCD) for the RNA and/or protein expression.	Located in Nucleoplasm, Plasma membrane, Cytosol
Protein function (UniProt)ⁱ Useful information about the protein provided by UniProt.	Transcription factor that plays a key role in the response to oxidative stress: binds to antioxidant response (ARE) elements present in the promoter region of many cytoprotective genes, such as phase 2 detoxifying enzymes, and promotes their expression, thereby neutralizing reactive electrophiles 1, 2, 3, 4. In normal conditions, ubiquitinated and degraded in the cytoplasm by the BCR(KEAP1) complex 5, 6, 7. In response to oxidative stress, electrophile metabolites inhibit activity of the BCR(KEAP1) complex, promoting nuclear accumulation of NFE2L2/NRF2, heterodimerization with one of the small Maf proteins and binding to ARE elements of cytoprotective target genes 8, 9. The NFE2L2/NRF2 pathway is also activated in response to selective autophagy: autophagy promotes interaction between KEAP1 and SQSTM1/p62 and subsequent inactivation of the BCR(KEAP1) complex, leading to NFE2L2/NRF2 nuclear accumulation and expression of cytoprotective genes 10. May also be involved in the transcriptional activation of genes of the beta-globin cluster by mediating enhancer activity of hypersensitive site 2 of the beta-globin locus control region 11.... show less
Molecular function (UniProt)ⁱ Keywords assigned by UniProt to proteins due to their particular molecular function.	Activator, DNA-binding
Biological process (UniProt)ⁱ Keywords assigned by UniProt to proteins because they are involved in a particular biological process.	Host-virus interaction, Transcription, Transcription regulation
Disease involvementⁱ Disease related keywords assigned by UniProt combined with Cancer-related genes and FDA approved drug targets Read more	Cancer-related genes, Disease variant
Gene summary (Entrez)ⁱ Useful information about the gene from Entrez	This gene encodes a transcription factor which is a member of a small family of basic leucine zipper (bZIP) proteins. The encoded transcription factor regulates genes which contain antioxidant response elements (ARE) in their promoters; many of these genes encode proteins involved in response to injury and inflammation which includes the production of free radicals. Multiple transcript variants encoding different isoforms have been characterized for this gene. [provided by RefSeq, Sep 2015]... show less

TISSUEⁱ Summary of data presented in the Tissue section, with a representative image of protein expression (left) and an interactive chart showing the tissue-specific mRNA expression (right). The image and the chart are clickable and will redirect to more Tissue data. This section contains information regarding the expression profiles of protein-coding genes in normal human tissue, both on the mRNA and protein level. The protein expression data is derived from antibody-based protein profiling using immunohistochemistry. Read more

Tissue expression clusterⁱ The RNA data was used to cluster genes according to their expression across tissues. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity. Read more	Esophagus - Epithelial junctions (mainly)
Tissue specificityⁱ The RNA specificity category is based on mRNA expression levels in the consensus dataset which is calculated from the RNA expression levels in samples from HPA and GTEX. The categories include: tissue enriched, group enriched, tissue enhanced, low tissue specificity and not detected. Read more	Low tissue specificity
Tissue distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on a combination of data from HPA and GTEX. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in all
Protein expressionⁱ A summary of the overall protein expression pattern across the analyzed normal tissues. The summary is based on knowledge-based annotation. "Estimation of protein expression could not be performed. View primary data." is shown for genes analyzed with a knowledge-based approach where available RNA-seq and gene/protein characterization data has been evaluated as not sufficient in combination with immunohistochemistry data to yield a reliable estimation of the protein expression profile. Read more	Ubiquitous nuclear and cytoplasmic expression.

BRAINⁱ Summary of data presented in the Brain Atlas and a representative image of mRNA expression in the human brain. The image is clickable and will redirect to more Brain Atlas data. The Brain Atlas explores the protein expression in the mammalian brain by visualization and integration of data from three mammalian species (human, pig and mouse). Transcriptomics data combined with affinity-based protein in situ localization down to single cell level is available in a brain-centric sub atlas of the Human Protein Atlas. Read more

Human regional specificityⁱ The regional specificity category is based on mRNA expression levels in the analysed brain samples, grouped into 13 main brain regions and calculated for the three different species. All brain expression profiles are based on data from HPA. The specificity categories include: regionally enriched, group enriched, regionally enhanced, low regional specificity and not detected. The classification rules are the same used for the tissue specificity category. Read more	Low region specificity
Pig regional specificityⁱ The regional specificity category is based on mRNA expression levels in the analysed brain samples, grouped into 13 main brain regions and calculated for the three different species. All brain expression profiles are based on data from HPA. The specificity categories include: regionally enriched, group enriched, regionally enhanced, low regional specificity and not detected. The classification rules are the same used for the tissue specificity category. Read more	Low region specificity
Mouse regional specificityⁱ The regional specificity category is based on mRNA expression levels in the analysed brain samples, grouped into 13 main brain regions and calculated for the three different species. All brain expression profiles are based on data from HPA. The specificity categories include: regionally enriched, group enriched, regionally enhanced, low regional specificity and not detected. The classification rules are the same used for the tissue specificity category. Read more	Low region specificity

SINGLE CELL TYPEⁱ Summary of data presented in the Single cell Type section, with an interactive chart showing the cell type-specific mRNA expression. The chart is clickable and will redirect to more Cell Type data. This section contains information about single cell type RNA expression based on scRNAseq of human tissues. The data also covers transcriptomics analysis of human blood and cultured cell lines. Read more

Single cell type expression clusterⁱ The RNA data was used to cluster genes according to their expression across single cell types. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity. Read more	Macrophages - Immune response (mainly)
Cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low cell type specificity

TISSUE CELL TYPEⁱ

Keratinocyte (other)

Classificationⁱ

Cell type enriched in single tissue

PATHOLOGYⁱ Summary of data presented in the Pathology section, with representative images of protein expression in cancer (left) and correlation between mRNA expression and patient survival (right). Images are clickable and redirect to pages with more Pathology data. This section contains mRNA and protein expression data from 17 different forms of human cancer, as well as correlation analysis of mRNA expression and patient survival. The protein expression data is derived from antibody-based protein profiling using immunohistochemistry. Read more
	Renal cancer p<0.001
Prognostic summary	Prognostic marker in renal cancer (favorable)
Cancer specificityⁱ Specificity of RNA expression in 17 cancer types is categorized as either cancer enriched, group enriched, cancer enhanced, low cancer specificity and not detected. Read more	Low cancer specificity
Cancer distributionⁱ Distribution of RNA expression in 17 cancer types is categorized as either detected in single, detected in some, detected in many, detected in all, or not detected. Read more	Detected in all

IMMUNE CELLⁱ Summary of data presented in the Immune Cell section and a representative image of mRNA expression in immune cells in the blood. The image is clickable and will redirect to more immune cell related data. The Immune Cell section contains information regarding single cell type mRNA expression profiles of protein-coding genes in various immune cells in the blood, e.g. B-cells and granulocytes. Read more

Immune cell expression clusterⁱ The RNA data was used to cluster genes according to their expression across single cell types. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity. Read more	Monocytes - Inflammatory response (mainly)
Immune cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low immune cell specificity

BLOOD PROTEINⁱ Summary of data presented in the Blood proteins section and a representative image of the concentration in plasma and related function for the protein in plasma. The image is clickable and will redirect to more data. The Blood proteins section contains plasma levels of proteins detected in human blood and an analysis of the human secretome (including annotation of the genes predicted to be actively secreted to human blood) is also presented. Read more
Detected in blood by immunoassayⁱ The blood-based immunoassay category applies to actively secreted proteins and is based on plasma or serum protein concentrations established with enzyme-linked immunosorbent assays, compiled from a literature search. The categories include: detected and not detected, where detection refers to a concentration found in the literature search. Read more	No (not applicable)
Detected in blood by mass spectrometryⁱ Detection or not of the gene in blood, based on spectral count estimations from a publicly available mass spectrometry-based plasma proteomics data set obtained from the PeptideAtlas.	No
Detected in blood by proximity extension assayⁱ Detection or not of the gene in blood, based on proximity extension assays (Olink) for a longitudinal wellness study covering 76 individuals with three visits during two years. Read more	No

SUBCELLULARⁱ Summary of data presented in the Cell Atlas and a representative image of subcellular localization. The Cell Atlas provides RNA expression data derived from RNA sequencing of a large panel of cell lines and protein localization data derived from antibody-based profiling by immunofluorescence confocal microscopy, using a subset of cell lines selected based on RNA expression. Read more

Main locationⁱ Main subcellular location(s) and reliability score(s) for the encoded protein(s) in human cells. The main location(s) may be characterized by presence in all tested cell lines and/or ihigher staining intensity compared to the potential additional location(s). If available, links to overrepresentation analyses in Reactome, a free, open-source, curated and peer reviewed biological pathway database, are provided. An analysis is done for the corresponding gene set of the proteome localizing to the main and additional locations of the protein on this page, respectively. Read more	Localized to the Nucleoplasm, Plasma membrane
Additional locationⁱ Additonal subcellular location(s) for the encoded protein(s) in human cells. The additional location(s) may not be present i all cell lines and may have lower staining intensity compared to the main location(s). If available, links to overrepresentation analyses in Reactome, a free, open-source, curated and peer reviewed biological pathway database, are provided. An analysis is done for the corresponding gene set of the proteome localizing to the main and additional locations of the protein on this page, respectively. Read more	In addition localized to the Cytosol

CELL LINEⁱ Summary of data presented in the Cell Line section and a representative image of mRNA expression across different human cell lines. The image is clickable and will redirect to more cell line data. This section contains information regarding mRNA expression profiles of human protein-coding genes for a large variety of cell lines. Read more

Cell line expression clusterⁱ The RNA data was used to cluster genes according to their expression across single cell types. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity. Read more	Epithelial cell lines - Translation (mainly)
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines. Read more	Low cell line specificity
Cell type distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in all

METABOLIC

Metabolic info	Not available

GENE INFORMATIONⁱ Gene information from Ensembl and Entrez, as well as links to available gene identifiers are displayed here. Information was retrieved from Ensembl if not indicated otherwise.
Gene name	NFE2L2 (HGNC Symbol)
Synonyms	NRF2
Description	Nuclear factor, erythroid 2 like 2 (HGNC Symbol)
Chromosome	2
Cytoband	q31.2
Chromosome location (bp)	177227595 - 177392697
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	12
Protein evidence	Evidence at protein level (all genes)
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s). Read more	Cancer-related genes Disease related genes Human disease related genes Transcription factors
Ensembl	ENSG00000116044 (version 103.38)
Entrez gene	4780
UniProt	Q16236 (UniProt - Evidence at protein level)
neXtProt	NX_Q16236
Antibodypedia	NFE2L2 antibodies

PROTEIN BROWSERⁱ

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NFE2L2-201

NFE2L2-202

NFE2L2-203

NFE2L2-204

NFE2L2-205

NFE2L2-206

NFE2L2-207

NFE2L2-208

NFE2L2-209

NFE2L2-211

NFE2L2-213

NFE2L2-214

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PROTEIN INFORMATIONⁱ The protein information section displays alternative protein-coding transcripts (splice variants) encoded by this gene according to the Ensembl database. The ENSP identifier links to the Ensembl website protein summary, while the ENST identifier links to the Ensembl website transcript summary for the selected splice variant. The data in the UniProt column can be expanded to show links to all matching UniProt identifiers for this protein. The protein classes assigned to this protein are shown if expanding the data in the protein class column. Parent protein classes are in bold font and subclasses are listed under the parent class. The Gene Ontology terms assigned to this protein are listed if expanding the Gene ontology column. The length of the protein (amino acid residues according to Ensembl), molecular mass (kDalton), predicted signal peptide (according to a majority of the signal peptide predictors SPOCTOPUS, SignalP 4.0, and Phobius) and the number of predicted transmembrane region(s) (according to MDM) are also reported.
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
NFE2L2-201 ENSP00000380252 ENST00000397062	Q16236 [Direct mapping] Nuclear factor erythroid 2-related factor 2 Show all	Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Transcription factors Basic domains Cancer-related genes Mutated cancer genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Missense Mutations Disease related genes Human disease related genes Cancers Cancers of the digestive system Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Ezkurdia et al 2014) Show all	GO:0000785 [chromatin] GO:0000976 [transcription regulatory region sequence-specific DNA binding] GO:0000978 [RNA polymerase II cis-regulatory region sequence-specific DNA binding] GO:0000981 [DNA-binding transcription factor activity, RNA polymerase II-specific] GO:0001102 [RNA polymerase II activating transcription factor binding] GO:0001221 [transcription cofactor binding] GO:0001228 [DNA-binding transcription activator activity, RNA polymerase II-specific] GO:0003677 [DNA binding] GO:0003700 [DNA-binding transcription factor activity] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] GO:0005794 [Golgi apparatus] GO:0005813 [centrosome] GO:0005829 [cytosol] GO:0005886 [plasma membrane] GO:0006355 [regulation of transcription, DNA-templated] GO:0006357 [regulation of transcription by RNA polymerase II] GO:0006954 [inflammatory response] GO:0007568 [aging] GO:0008134 [transcription factor binding] GO:0010226 [response to lithium ion] GO:0010499 [proteasomal ubiquitin-independent protein catabolic process] GO:0010628 [positive regulation of gene expression] GO:0010667 [negative regulation of cardiac muscle cell apoptotic process] GO:0010976 [positive regulation of neuron projection development] GO:0016032 [viral process] GO:0016567 [protein ubiquitination] GO:0019904 [protein domain specific binding] GO:0030194 [positive regulation of blood coagulation] GO:0030968 [endoplasmic reticulum unfolded protein response] GO:0032993 [protein-DNA complex] GO:0034599 [cellular response to oxidative stress] GO:0034976 [response to endoplasmic reticulum stress] GO:0035690 [cellular response to drug] GO:0036003 [positive regulation of transcription from RNA polymerase II promoter in response to stress] GO:0036091 [positive regulation of transcription from RNA polymerase II promoter in response to oxidative stress] GO:0036499 [PERK-mediated unfolded protein response] GO:0042025 [host cell nucleus] GO:0042149 [cellular response to glucose starvation] GO:0042493 [response to drug] GO:0043161 [proteasome-mediated ubiquitin-dependent protein catabolic process] GO:0043536 [positive regulation of blood vessel endothelial cell migration] GO:0043565 [sequence-specific DNA binding] GO:0045454 [cell redox homeostasis] GO:0045766 [positive regulation of angiogenesis] GO:0045893 [positive regulation of transcription, DNA-templated] GO:0045944 [positive regulation of transcription by RNA polymerase II] GO:0045995 [regulation of embryonic development] GO:0046223 [aflatoxin catabolic process] GO:0046326 [positive regulation of glucose import] GO:0060548 [negative regulation of cell death] GO:0061419 [positive regulation of transcription from RNA polymerase II promoter in response to hypoxia] GO:0070301 [cellular response to hydrogen peroxide] GO:0071280 [cellular response to copper ion] GO:0071356 [cellular response to tumor necrosis factor] GO:0071456 [cellular response to hypoxia] GO:0071498 [cellular response to fluid shear stress] GO:0071499 [cellular response to laminar fluid shear stress] GO:1902037 [negative regulation of hematopoietic stem cell differentiation] GO:1902176 [negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway] GO:1903071 [positive regulation of ER-associated ubiquitin-dependent protein catabolic process] GO:1903206 [negative regulation of hydrogen peroxide-induced cell death] GO:1903788 [positive regulation of glutathione biosynthetic process] GO:1904385 [cellular response to angiotensin] GO:1904753 [negative regulation of vascular associated smooth muscle cell migration] GO:2000121 [regulation of removal of superoxide radicals] GO:2000352 [negative regulation of endothelial cell apoptotic process] GO:2000379 [positive regulation of reactive oxygen species metabolic process] Show all	605 aa 67.8 kDa	No	0
NFE2L2-202 ENSP00000380253 ENST00000397063	Q16236 [Direct mapping] Nuclear factor erythroid 2-related factor 2 Show all	Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Transcription factors Basic domains Cancer-related genes Mutated cancer genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Missense Mutations Disease related genes Human disease related genes Cancers Cancers of the digestive system Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Ezkurdia et al 2014) Show all	GO:0000785 [chromatin] GO:0000976 [transcription regulatory region sequence-specific DNA binding] GO:0000978 [RNA polymerase II cis-regulatory region sequence-specific DNA binding] GO:0000981 [DNA-binding transcription factor activity, RNA polymerase II-specific] GO:0001102 [RNA polymerase II activating transcription factor binding] GO:0003677 [DNA binding] GO:0003700 [DNA-binding transcription factor activity] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] GO:0005794 [Golgi apparatus] GO:0005813 [centrosome] GO:0005829 [cytosol] GO:0005886 [plasma membrane] GO:0006355 [regulation of transcription, DNA-templated] GO:0006357 [regulation of transcription by RNA polymerase II] GO:0010499 [proteasomal ubiquitin-independent protein catabolic process] GO:0010628 [positive regulation of gene expression] GO:0016032 [viral process] GO:0016567 [protein ubiquitination] GO:0019904 [protein domain specific binding] GO:0030968 [endoplasmic reticulum unfolded protein response] GO:0032993 [protein-DNA complex] GO:0034599 [cellular response to oxidative stress] GO:0036003 [positive regulation of transcription from RNA polymerase II promoter in response to stress] GO:0036499 [PERK-mediated unfolded protein response] GO:0042025 [host cell nucleus] GO:0043161 [proteasome-mediated ubiquitin-dependent protein catabolic process] GO:0043565 [sequence-specific DNA binding] GO:0045454 [cell redox homeostasis] GO:0045944 [positive regulation of transcription by RNA polymerase II] GO:0061419 [positive regulation of transcription from RNA polymerase II promoter in response to hypoxia] GO:0070301 [cellular response to hydrogen peroxide] GO:0071356 [cellular response to tumor necrosis factor] GO:0071498 [cellular response to fluid shear stress] GO:0071499 [cellular response to laminar fluid shear stress] GO:1902176 [negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway] GO:1903071 [positive regulation of ER-associated ubiquitin-dependent protein catabolic process] GO:1903206 [negative regulation of hydrogen peroxide-induced cell death] GO:2000352 [negative regulation of endothelial cell apoptotic process] Show all	589 aa 66.1 kDa	No	0
NFE2L2-203 ENSP00000412191 ENST00000421929	C9J0Y1 [Direct mapping] Nuclear factor erythroid 2-related factor 2 Show all	Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Cancer-related genes Mutated cancer genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Missense Mutations Human disease related genes Cancers Cancers of the digestive system Protein evidence (Ezkurdia et al 2014) Show all	GO:0003677 [DNA binding] GO:0003700 [DNA-binding transcription factor activity] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] GO:0005813 [centrosome] GO:0005829 [cytosol] GO:0005886 [plasma membrane] GO:0006355 [regulation of transcription, DNA-templated] GO:0034599 [cellular response to oxidative stress] Show all	234 aa 26.7 kDa	No	0
NFE2L2-204 ENSP00000410015 ENST00000423513	C9JFL6 [Direct mapping] Nuclear factor erythroid 2-related factor 2 Show all	Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Cancer-related genes Mutated cancer genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Missense Mutations Human disease related genes Cancers Cancers of the digestive system Protein evidence (Ezkurdia et al 2014) Show all	GO:0003677 [DNA binding] GO:0003700 [DNA-binding transcription factor activity] GO:0005634 [nucleus] GO:0005737 [cytoplasm] GO:0006355 [regulation of transcription, DNA-templated] GO:0034599 [cellular response to oxidative stress] Show all	141 aa 16.9 kDa	No	0
NFE2L2-205 ENSP00000391291 ENST00000430047	C9J3K4 [Direct mapping] Nuclear factor erythroid 2-related factor 2 Show all	Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Cancer-related genes Mutated cancer genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Missense Mutations Human disease related genes Cancers Cancers of the digestive system Protein evidence (Ezkurdia et al 2014) Show all	GO:0003677 [DNA binding] GO:0003700 [DNA-binding transcription factor activity] GO:0005634 [nucleus] GO:0005737 [cytoplasm] GO:0006355 [regulation of transcription, DNA-templated] GO:0034599 [cellular response to oxidative stress] Show all	68 aa 7.6 kDa	No	0
NFE2L2-206 ENSP00000411575 ENST00000446151	Q16236 [Direct mapping] Nuclear factor erythroid 2-related factor 2 Show all	Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Transcription factors Basic domains Cancer-related genes Mutated cancer genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Missense Mutations Disease related genes Human disease related genes Cancers Cancers of the digestive system Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Ezkurdia et al 2014) Show all	GO:0000785 [chromatin] GO:0000976 [transcription regulatory region sequence-specific DNA binding] GO:0000978 [RNA polymerase II cis-regulatory region sequence-specific DNA binding] GO:0000981 [DNA-binding transcription factor activity, RNA polymerase II-specific] GO:0001102 [RNA polymerase II activating transcription factor binding] GO:0003677 [DNA binding] GO:0003700 [DNA-binding transcription factor activity] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] GO:0005794 [Golgi apparatus] GO:0005813 [centrosome] GO:0005829 [cytosol] GO:0005886 [plasma membrane] GO:0006355 [regulation of transcription, DNA-templated] GO:0006357 [regulation of transcription by RNA polymerase II] GO:0010499 [proteasomal ubiquitin-independent protein catabolic process] GO:0010628 [positive regulation of gene expression] GO:0016032 [viral process] GO:0016567 [protein ubiquitination] GO:0019904 [protein domain specific binding] GO:0030968 [endoplasmic reticulum unfolded protein response] GO:0032993 [protein-DNA complex] GO:0034599 [cellular response to oxidative stress] GO:0036003 [positive regulation of transcription from RNA polymerase II promoter in response to stress] GO:0036499 [PERK-mediated unfolded protein response] GO:0042025 [host cell nucleus] GO:0043161 [proteasome-mediated ubiquitin-dependent protein catabolic process] GO:0043565 [sequence-specific DNA binding] GO:0045454 [cell redox homeostasis] GO:0045944 [positive regulation of transcription by RNA polymerase II] GO:0061419 [positive regulation of transcription from RNA polymerase II promoter in response to hypoxia] GO:0070301 [cellular response to hydrogen peroxide] GO:0071356 [cellular response to tumor necrosis factor] GO:0071498 [cellular response to fluid shear stress] GO:0071499 [cellular response to laminar fluid shear stress] GO:1902176 [negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway] GO:1903071 [positive regulation of ER-associated ubiquitin-dependent protein catabolic process] GO:1903206 [negative regulation of hydrogen peroxide-induced cell death] GO:2000352 [negative regulation of endothelial cell apoptotic process] Show all	582 aa 65.4 kDa	No	0
NFE2L2-207 ENSP00000400073 ENST00000448782	C9J1A8 [Direct mapping] Nuclear factor erythroid 2-related factor 2 Show all	Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Cancer-related genes Mutated cancer genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Missense Mutations Human disease related genes Cancers Cancers of the digestive system Protein evidence (Ezkurdia et al 2014) Show all	GO:0003677 [DNA binding] GO:0003700 [DNA-binding transcription factor activity] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] GO:0005813 [centrosome] GO:0005829 [cytosol] GO:0005886 [plasma membrane] GO:0006355 [regulation of transcription, DNA-templated] GO:0034599 [cellular response to oxidative stress] Show all	280 aa 31.7 kDa	No	0
NFE2L2-208 ENSP00000391590 ENST00000449627	C9JBM0 [Direct mapping] Nuclear factor erythroid 2-related factor 2 Show all	Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Cancer-related genes Mutated cancer genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Missense Mutations Human disease related genes Cancers Cancers of the digestive system Protein evidence (Ezkurdia et al 2014) Show all	GO:0003677 [DNA binding] GO:0003700 [DNA-binding transcription factor activity] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] GO:0005794 [Golgi apparatus] GO:0005829 [cytosol] GO:0005886 [plasma membrane] GO:0006355 [regulation of transcription, DNA-templated] GO:0034599 [cellular response to oxidative stress] GO:0042025 [host cell nucleus] Show all	265 aa 30.2 kDa	No	0
NFE2L2-209 ENSP00000416308 ENST00000458603	H7C498 [Direct mapping] Nuclear factor erythroid 2-related factor 2 Show all	Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Cancer-related genes Mutated cancer genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Missense Mutations Human disease related genes Cancers Cancers of the digestive system Protein evidence (Ezkurdia et al 2014) Show all		47 aa 5.4 kDa	No	0
NFE2L2-211 ENSP00000467401 ENST00000464747	Q16236 [Direct mapping] Nuclear factor erythroid 2-related factor 2 Show all	Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Transcription factors Basic domains Cancer-related genes Mutated cancer genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Missense Mutations Disease related genes Human disease related genes Cancers Cancers of the digestive system Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Ezkurdia et al 2014) Show all	GO:0000785 [chromatin] GO:0000976 [transcription regulatory region sequence-specific DNA binding] GO:0000978 [RNA polymerase II cis-regulatory region sequence-specific DNA binding] GO:0000981 [DNA-binding transcription factor activity, RNA polymerase II-specific] GO:0001102 [RNA polymerase II activating transcription factor binding] GO:0003677 [DNA binding] GO:0003700 [DNA-binding transcription factor activity] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] GO:0005794 [Golgi apparatus] GO:0005813 [centrosome] GO:0005829 [cytosol] GO:0005886 [plasma membrane] GO:0006355 [regulation of transcription, DNA-templated] GO:0006357 [regulation of transcription by RNA polymerase II] GO:0010499 [proteasomal ubiquitin-independent protein catabolic process] GO:0010628 [positive regulation of gene expression] GO:0016032 [viral process] GO:0016567 [protein ubiquitination] GO:0019904 [protein domain specific binding] GO:0030968 [endoplasmic reticulum unfolded protein response] GO:0032993 [protein-DNA complex] GO:0034599 [cellular response to oxidative stress] GO:0036003 [positive regulation of transcription from RNA polymerase II promoter in response to stress] GO:0036499 [PERK-mediated unfolded protein response] GO:0042025 [host cell nucleus] GO:0043161 [proteasome-mediated ubiquitin-dependent protein catabolic process] GO:0043565 [sequence-specific DNA binding] GO:0045454 [cell redox homeostasis] GO:0045944 [positive regulation of transcription by RNA polymerase II] GO:0061419 [positive regulation of transcription from RNA polymerase II promoter in response to hypoxia] GO:0070301 [cellular response to hydrogen peroxide] GO:0071356 [cellular response to tumor necrosis factor] GO:0071498 [cellular response to fluid shear stress] GO:0071499 [cellular response to laminar fluid shear stress] GO:1902176 [negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway] GO:1903071 [positive regulation of ER-associated ubiquitin-dependent protein catabolic process] GO:1903206 [negative regulation of hydrogen peroxide-induced cell death] GO:2000352 [negative regulation of endothelial cell apoptotic process] Show all	589 aa 66.1 kDa	No	0
NFE2L2-213 ENSP00000464920 ENST00000586532	K7EIW5 [Direct mapping] Nuclear factor erythroid 2-related factor 2 Show all	Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Cancer-related genes Mutated cancer genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Missense Mutations Human disease related genes Cancers Cancers of the digestive system Protein evidence (Ezkurdia et al 2014) Show all	GO:0003677 [DNA binding] GO:0003700 [DNA-binding transcription factor activity] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] GO:0005813 [centrosome] GO:0005829 [cytosol] GO:0005886 [plasma membrane] GO:0006355 [regulation of transcription, DNA-templated] GO:0034599 [cellular response to oxidative stress] Show all	265 aa 30.1 kDa	No	0
NFE2L2-214 ENSP00000468089 ENST00000588123	K7ER33 [Direct mapping] Nuclear factor erythroid 2-related factor 2 Show all	Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Cancer-related genes Mutated cancer genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Missense Mutations Human disease related genes Cancers Cancers of the digestive system Protein evidence (Ezkurdia et al 2014) Show all	GO:0003677 [DNA binding] GO:0003700 [DNA-binding transcription factor activity] GO:0005634 [nucleus] GO:0005737 [cytoplasm] GO:0006355 [regulation of transcription, DNA-templated] GO:0034599 [cellular response to oxidative stress] Show all	146 aa 16.9 kDa	No	0

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The Human Protein Atlas

The Human Protein Atlas project is funded
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