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TISSUE PRIMARY DATA KIDNEY Show tissue menu
ADIPOSE TISSUE ADRENAL GLAND AMYGDALA APPENDIX BASAL GANGLIA BLOOD VESSEL BONE MARROW BREAST BRONCHUS CEREBELLUM CEREBRAL CORTEX CERVIX CHOROID PLEXUS COLON
DUODENUM ENDOMETRIUM EPIDIDYMIS ESOPHAGUS FALLOPIAN TUBE GALLBLADDER HEART MUSCLE HIPPOCAMPAL FORMATION HYPOTHALAMUS KIDNEY LIVER LUNG LYMPH NODE MIDBRAIN
NASOPHARYNX ORAL MUCOSA OVARY PANCREAS PARATHYROID GLAND PITUITARY GLAND PLACENTA PROSTATE RECTUM RETINA SALIVARY GLAND SEMINAL VESICLE SKELETAL MUSCLE SKIN
SMALL INTESTINE SMOOTH MUSCLE SOFT TISSUE SPINAL CORD SPLEEN STOMACH TESTIS THYMUS THYROID GLAND TONGUE TONSIL URINARY BLADDER VAGINA
ANTIBODIES
AND
VALIDATION
Dictionary
Kidney
Tissue proteome
Kidney
Tissue methods
KIDNEY - Expression summary
Protein expression
Kidneyi

On the top, protein expression in current human tissue, based on all annotated cell types, is reported with the units not detected (n), low (l), medium (m) and high (h). Underneath, protein expression in each annotated cell type are reported using the same units. Protein expression data is based on knowledge-based annotation. For genes where more than one antibody has been used, a collective score is set. If knowledge-based annotation could not be performed for a gene, no data is displayed here. View antibody staining data further down this page.

h
m
l
n
Bowman's capsule: Not detected
Cells in glomeruli: High
Collecting ducts: Not detected
Distal tubules: Not detected
Proximal tubules (cell body): Not detected
Proximal tubules (microvilli): Not detected
Protein profiling
Multiplex tissuei

A summary of the protein localization in the current human tissue based on multiplex immunohistochemistry profiling in selected tissues is shown for genes where this analysis has been performed.

Cytoplasmic and plasma membranous staining in endothelia.

RNA expressioni

A summary of mRNA expression data available for current tissue based on several datasets. The mRNA expression levels in human tissues are based on RNA-seq data generated by the Human Protein Atlas HPA, Genotype-Tissue Expression GTEx portal and CAGE data generated by the FANTOM5 consortium. Consensus normalized expression levels for human tissues was created by combining the data from HPA and GTEx datasets. The mRNA expression levels in pig brain are based on RNA-seq data generated by the Human Protein Atlas, and for mouse brain HPA data and in situ hybridization generated by the Allen brain atlas dataset are reported.

Scroll down to view mRNA expression data in more detail.

Consensus:18.4 nTPM
HPA:11.8 nTPM
GTEx:18.4 nTPM
FANTOM5:27.5 Scaled Tags Per Million
KIDNEY - SINGLE CELL RNA EXPRESSION
Explore single cell type data

KIDNEY - Multiplex stainingi

Antibody localization in the annotated cell types/states/structures of the current human tissue is reported as main/additional locations, percent overlap between the antibody and cell type/state/structure-specific markers, and, when applicable also subcellular localization. The scores are based on multiplex immunohistochemistry profiling in selected tissues.

Main locations are characterized by a high overlap between the antibody and the cell type/state-specific marker combined with strong antibody signal intensity, while additional locations are characterized by lower overlap and weaker antibody signal intensity.

The antibody of interest is reported in green, while cell types/states/structures are reported in various other colors, and DAPI (marks nucleus) is reported in blue. Colors can be toggled on and off by clicking on the name of the cell type/state of interest, “Antibody” or “DAPI”. To toggle between the different tissue samples, click on the miniature images at the right bottom corner of the main image. The miniature images appear upon hovering the mouse over that area.

- Antibody HPA012368
Main location Endothelia
Additional location Distal tubules
Podocytes
No antibody overlap
No antibody overlap
No antibody overlap
No antibody overlap
Antibody overlap>75%
LocationCytoplasm
Plasma membrane

KIDNEY - Antibody stainingi

Antibody staining in the annotated cell types in the current human tissue is reported as not detected, low, medium, or high, based on conventional immunohistochemistry profiling in selected tissues. This score is based on the combination of the staining intensity and fraction of stained cells. Each image is clickable and will lead to virtual microscopy that enables deeper exploration of all samples and also displays staining intensity scores, fraction scores and subcellular localization as well as patient and tissue information for each sample.

Ascending and descending describe two types of gradient, based on difference in staining intensity between enterocytes in crypts and apical enterocytes.

Ascending - the staining intensity is stronger in apical enterocytes (towards the lumen) compared to enterocytes in the crypts (gland based)

Descending - the staining is weaker in apical enterocytes compared to enterocytes in crypts

Antibody HPA009300Antibody HPA012368
Bowman's capsule -Not detected
Cells in glomeruli LowHigh
Cells in tubules Not detected-
Collecting ducts -Not detected
Distal tubules -Not detected
Proximal tubules (cell body) -Not detected
Proximal tubules (microvilli) -Not detected





KIDNEY - HPA RNA-seqi

The RNA-seq details section shows detailed information about the individual samples used for the transcript profiling and results of the RNA-seq analysis.

Information about each individual sample is listed below, including gender, age, a tissue section image and estimated fractions of cell types. nTPM (normalized transcripts per million) values give a quantification of the gene abundance which is comparable between different genes and samples.

Average nTPMi

Max subtype nTPM is the value for the subtype with the largest average nTPM across the subtype samples.

11.8
overview
Female, age 58
Kidney sample 55
nTPM: 9
Cell types%
Cells in tubules:
60

Cells in glomeruli:
20

Fibroblasts:
5

Other cell types:
15

overview
Female, age 67
Kidney sample 56
nTPM: 10.2
Cell types%
Cells in tubules:
70

Cells in glomeruli:
15

Fibroblasts:
10

Other cell types:
5

overview
Female, age 55
Kidney sample 57
nTPM: 14.2
Cell types%
Cells in tubules:
80

Cells in glomeruli:
10

Fibroblasts:
5

Other cell types:
5

overview
Male, age 46
Kidney sample 58
nTPM: 12.2
Cell types%
Cells in tubules:
60

Cells in glomeruli:
25

Fibroblasts:
5

Other cell types:
10

overview
Female, age 57
Kidney sample 358
nTPM: 12.7
Cell types%
Cells in tubules:
60

Cells in glomeruli:
10

Fibroblasts:
10

Other cell types:
20

overview
Male, age 78
Kidney sample 377
nTPM: 15
Cell types%
Cells in tubules:
65

Cells in glomeruli:
10

Fibroblasts:
5

Other cell types:
20

overview
Male, age 73
Kidney sample 380
nTPM: 9.7
Cell types%
Cells in tubules:
60

Cells in glomeruli:
10

Fibroblasts:
10

Other cell types:
20

overview
Female, age 59
Kidney sample 394
nTPM: 10.7
Cell types%
Cells in tubules:
65

Cells in glomeruli:
10

Fibroblasts:
10

Other cell types:
15

overview
Female, age 48
Kidney sample 414
nTPM: 12.5
Cell types%
Cells in tubules:
60

Cells in glomeruli:
5

Fibroblasts:
10

Other cell types:
25


KIDNEY - GTEx RNA-seqi

RNA-Seq data generated by the Genotype-Tissue Expression (GTEx) project from human tissues is reported as mean nTPM. More information can be found on the GTEx portal.

Distribution across the dataset is visualized with box plots, shown as median and 25th and 75th percentiles. Points are displayed as outliers if they are above or below 1.5 times the interquartile range. nTPM values of the individual samples are presented next to the box plot.

Max subtype nTPMi

Max subtype nTPM is the value for the subtype with the largest average nTPM across the subtype samples.

18.4
GTEx sample id Sample description nTPM
Kidney - Cortex
Average nTPM: 14.0
Samples: 104

Max nTPM: 44.4
Min nTPM: 1.9
Std nTPM: 6.8
Median nTPM: 12.7
GTEX-1I1GP-1926-SM-CNNQU 50-59 years, male 44.4
GTEX-1N2EF-1426-SM-EXUSH 60-69 years, male 36.2
GTEX-13O1R-2526-SM-5N9FW 60-69 years, male 33.4
GTEX-1ICLY-2026-SM-GA913 50-59 years, male 29.1
GTEX-1JMPZ-1226-SM-ARU8Y 30-39 years, male 27.4
GTEX-11TTK-1926-SM-5PNW8 60-69 years, female 23.9
GTEX-1A3MW-2226-SM-73KUX 60-69 years, female 23.9
GTEX-11GS4-2326-SM-5A5KS 60-69 years, male 23.7
GTEX-1GF9W-1326-SM-7P8PX 60-69 years, male 22.5
GTEX-1LG7Y-2726-SM-D5OVW 50-59 years, male 22.0
GTEX-1HCU7-1826-SM-A9G2A 50-59 years, male 21.5
GTEX-1PWST-2226-SM-EVR3G 70-79 years, male 21.3
GTEX-1JMLX-1526-SM-AHZ3N 50-59 years, male 20.7
GTEX-1AX8Z-2326-SM-731CR 60-69 years, male 20.2
GTEX-1H3VY-1926-SM-9JGHJ 50-59 years, male 20.2
GTEX-145MN-0326-SM-5QGQI 30-39 years, male 20.1
GTEX-1O9I2-1926-SM-F2TBQ 50-59 years, male 20.0
GTEX-1C6VQ-2326-SM-7IGN1 50-59 years, male 19.4
GTEX-15CHQ-2126-SM-6871M 60-69 years, male 19.1
GTEX-1GTWX-1826-SM-9QEHG 60-69 years, male 19.1
GTEX-1LH75-1326-SM-F2I1R 50-59 years, female 19.0
GTEX-QLQW-1626-SM-CMKFE 30-39 years, male 18.8
GTEX-1F48J-2226-SM-7MXTN 50-59 years, female 18.4
GTEX-1JJE9-1026-SM-HL9TH 70-79 years, male 18.4
GTEX-14C39-2126-SM-664OH 40-49 years, male 18.3
GTEX-1J1OQ-1426-SM-AHZ3P 40-49 years, female 18.0
GTEX-1CB4J-1926-SM-7MGX8 60-69 years, male 17.8
GTEX-16XZY-1026-SM-HAV39 70-79 years, male 17.5
GTEX-1JJ6O-2526-SM-AHZ3J 60-69 years, male 17.4
GTEX-1MUQO-2526-SM-E9TJN 60-69 years, male 17.3
GTEX-1E2YA-1626-SM-7MGXS 50-59 years, male 16.3
GTEX-16XZZ-2226-SM-HAV34 60-69 years, male 16.1
GTEX-1GN1U-2126-SM-AHZ4J 50-59 years, female 15.8
GTEX-1HB9E-1826-SM-D4P33 50-59 years, male 15.4
GTEX-1A8FM-2026-SM-7P8RN 50-59 years, female 15.1
GTEX-XPVG-0526-SM-4B65N 50-59 years, male 15.0
GTEX-1497J-0826-SM-5NQAJ 60-69 years, male 14.9
GTEX-1399S-0526-SM-5IJG8 30-39 years, female 14.7
GTEX-1GMR3-2426-SM-7MXV2 40-49 years, male 14.5
GTEX-ZYFG-1626-SM-5GZYY 60-69 years, female 14.4
GTEX-ZVZP-0926-SM-5GIDB 50-59 years, male 14.2
GTEX-ZXG5-2026-SM-HAUZV 60-69 years, male 14.2
GTEX-P4QS-1126-SM-3NMD5 60-69 years, male 14.1
GTEX-1OJC4-2326-SM-DTXA5 50-59 years, female 13.9
GTEX-13FHP-2126-SM-GIN8J 50-59 years, male 13.7
GTEX-1IKK5-0926-SM-A9G2U 60-69 years, male 13.7
GTEX-S33H-1426-SM-EZ6L7 30-39 years, male 13.2
GTEX-QDVN-1726-SM-HL9TO 50-59 years, male 13.0
GTEX-REY6-1826-SM-EAZAT 60-69 years, male 13.0
GTEX-W5X1-1626-SM-H7OGO 40-49 years, female 12.9
GTEX-1H3NZ-2126-SM-9WPQ6 60-69 years, male 12.8
GTEX-14C5O-2026-SM-5YYB1 60-69 years, male 12.7
GTEX-13RTJ-2226-SM-5S2Q1 60-69 years, male 12.6
GTEX-13O3O-1726-SM-GJ3RL 60-69 years, female 12.3
GTEX-ZLFU-0926-SM-5P9F8 40-49 years, male 12.3
GTEX-13OVI-1126-SM-5KLZF 60-69 years, female 12.2
GTEX-ZYT6-2226-SM-5GIC9 30-39 years, male 12.0
GTEX-T5JC-1526-SM-4DM68 20-29 years, male 11.9
GTEX-ZC5H-1726-SM-5HL7X 40-49 years, female 11.9
GTEX-13112-2126-SM-5GCO4 50-59 years, male 11.7
GTEX-1QAET-2126-SM-F2TBS 50-59 years, male 11.7
GTEX-147F4-2626-SM-5Q5CS 50-59 years, male 11.6
GTEX-14PJ2-1826-SM-HL9UB 50-59 years, male 11.6
GTEX-1K9T9-1826-SM-CXZK2 50-59 years, female 11.6
GTEX-13OW6-1826-SM-5N9F9 50-59 years, male 11.0
GTEX-1N2DW-1826-SM-EAZ54 50-59 years, male 11.0
GTEX-ZE9C-1426-SM-4WKGM 60-69 years, male 10.9
GTEX-1117F-2126-SM-GIN9G 60-69 years, female 10.8
GTEX-15DCD-1926-SM-HAV33 70-79 years, female 10.8
GTEX-1JMQK-1926-SM-CJI3B 60-69 years, male 10.5
GTEX-1KWVE-0826-SM-CXZKO 30-39 years, male 10.5
GTEX-12696-0926-SM-5FQTV 60-69 years, male 10.4
GTEX-16Z82-2826-SM-HAUZZ 60-69 years, male 9.8
GTEX-16MT8-1926-SM-7EPGL 60-69 years, female 9.7
GTEX-1GF9V-1926-SM-9JGHE 60-69 years, male 9.7
GTEX-1R9PO-1626-SM-E6CPT 60-69 years, female 9.7
GTEX-Y5V6-2026-SM-5IFHO 60-69 years, male 9.7
GTEX-ZDXO-0226-SM-4WKH7 60-69 years, male 9.5
GTEX-1HCVE-2126-SM-HL9UO 50-59 years, male 9.3
GTEX-17F97-1926-SM-7IGM4 50-59 years, male 9.1
GTEX-Y5V5-1226-SM-EYYVP 60-69 years, female 9.1
GTEX-1JMQJ-1726-SM-E9U4V 50-59 years, male 8.9
GTEX-11OF3-1326-SM-5N9FJ 60-69 years, male 8.7
GTEX-12WSG-0826-SM-5EQ5A 50-59 years, female 8.7
GTEX-RN64-1626-SM-48FD7 50-59 years, male 8.5
GTEX-1HBPI-2026-SM-CE6RZ 50-59 years, male 8.2
GTEX-13OVL-1826-SM-5KLZR 50-59 years, male 8.1
GTEX-17F96-1926-SM-7MGWY 70-79 years, male 8.0
GTEX-1QP6S-1526-SM-EXUSG 40-49 years, male 7.8
GTEX-15DYW-2026-SM-6AJBD 60-69 years, female 7.7
GTEX-1NV8Z-2226-SM-EXOJ2 60-69 years, male 7.5
GTEX-1BAJH-1826-SM-731DA 70-79 years, male 7.4
GTEX-1IL2V-1826-SM-ARU7R 70-79 years, male 7.2
GTEX-1RQEC-2426-SM-F2I1J 60-69 years, male 7.0
GTEX-O5YV-1226-SM-EV795 60-69 years, female 7.0
GTEX-17HHY-2326-SM-7KFSR 50-59 years, male 6.6
GTEX-1EKGG-2226-SM-7IGOA 60-69 years, male 6.4
GTEX-QDT8-1726-SM-EYYV6 30-39 years, female 6.0
GTEX-NFK9-1826-SM-HL9T3 40-49 years, male 5.8
GTEX-13NYB-1726-SM-5N9G2 40-49 years, male 5.0
GTEX-14JG1-2326-SM-HAUZ5 40-49 years, male 4.8
GTEX-WL46-1926-SM-GNIN6 50-59 years, male 3.8
GTEX-14E6D-2526-SM-5YYA9 50-59 years, male 3.4
GTEX-T6MN-1826-SM-EXOHN 50-59 years, male 1.9
Show allShow less
Kidney - Medulla
Average nTPM: 18.4
Samples: 11

Max nTPM: 54.0
Min nTPM: 1.5
Std nTPM: 14.0
Median nTPM: 13.4
GTEX-T5JC-1626-SM-EZ6KW 20-29 years, male 54.0
GTEX-QEG5-2026-SM-H6Q6I 20-29 years, male 36.6
GTEX-T6MN-1926-SM-GOQYD 50-59 years, male 19.7
GTEX-TKQ2-0626-SM-EZ6LB 50-59 years, male 19.0
GTEX-S33H-1526-SM-GQ1CB 30-39 years, male 16.0
GTEX-RU72-1926-SM-EAZ3F 50-59 years, female 13.4
GTEX-R55E-2026-SM-EZ6L1 20-29 years, male 10.9
GTEX-SIU8-1926-SM-H7OG4 50-59 years, male 10.9
GTEX-P4QS-1226-SM-HPAG8 60-69 years, male 10.6
GTEX-QEG4-1526-SM-GPRWK 30-39 years, male 10.3
GTEX-N7MS-1526-SM-HAUZP 60-69 years, male 1.5
Show allShow less

KIDNEY - FANTOM5 CAGEi

RNA expression in human tissues obtained through Cap Analysis of Gene Expression (CAGE) generated by the FANTOM5 project are reported as Scaled Tags Per Million.

Max subtype Scaled Tags Per Millioni

Max subtype Scaled Tags Per Million is the value for the subtype with the largest average Scaled Tags Per Million across the subtype samples.

27.5
FANTOM5 sample id Sample description Scaled Tags Per Million
Kidney
Scaled Tags Per Million: 27.5
FF:10017-101C8 60,62,63 years, female 27.5

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