Protein interactions - XPO7 - The Human Protein Atlas

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	XPO7
Synonyms	EXP7, KIAA0745, RANBP16
Gene descriptionⁱ Full gene name according to HGNC.	Exportin 7
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s). Read more	Metabolic proteins Transporters
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.	Membrane, Intracellular
Protein evidence	Evidence at protein level (all genes)

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression analysis and annotation data generated within the Human Protein Atlas project.
Single cell type expression clusterⁱ The RNA data was used to cluster genes according to their expression across single cell types. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity.	Non-specific - Transcription (mainly)
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected.	Low cell type specificity
Tissue expression cluster (RNA)ⁱ The RNA data was used to cluster genes according to their expression across tissues. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity.	Non-specific - Transcription (mainly)
Tissue specificity (RNA)ⁱ The RNA specificity category is based on mRNA expression levels in the consensus dataset which is calculated from the RNA expression levels in samples from HPA and GTEX. The categories include: tissue enriched, group enriched, tissue enhanced, low tissue specificity and not detected.	Low tissue specificity
Subcellular locationⁱ Main subcellular location based on data generated in the subcellular section of the Human Protein Atlas.	Not available
Secretome annotationⁱ All genes with at least one predicted secreted isoform have been annotated and classified with the aim to determine if the corresponding protein(s) are: secreted into blood locally secreted or actually being attached to membrane or retained in intracellular locations like mitochondria, endoplasmatic reticulum (ER), Golgi apparatus or lysosomes.	Not available

GENE INFORMATIONⁱ Gene information from Ensembl and Entrez, as well as links to available gene identifiers are displayed here. Information was retrieved from Ensembl if not indicated otherwise.
Chromosome	8
Cytoband	p21.3
Chromosome location (bp)	21919662 - 22006585
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	4
Ensembl	ENSG00000130227 (version 109)
Entrez gene	23039
HGNC	HGNC:14108
UniProt	Q9UIA9
GeneCards	XPO7

ASSAYSⁱ

Interaction

Metabolic

INTERACTIONⁱ

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e.g. Brain enriched, Localized to mitochondria, Non-specific - Transcription

Field

Cluster

Cell type

Category

Cluster

Pathway

Consensus

IntAct

BioGrid

OpenCell

BioPlex

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Interaction	# Consensus	# IntAct	# BioGrid	# OpenCell	# BioPlex
RAN	32	88	75	66	11

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View all protein interaction data in IntAct

Interaction	# Consensus	# IntAct	# BioGrid	# OpenCell	# BioPlex
CUTC	0	13	0	2	0
RAN	32	88	75	66	11
USO1	1	5	13	1	0

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Interaction	# Consensus	# IntAct	# BioGrid	# OpenCell	# BioPlex
CCDC22	20	20	26	19	24
CD274	2	5	49	0	4
COIL	16	37	33	6	17
DAXX	37	79	88	0	0
EGFR	187	275	458	0	6
NUP153	13	3	50	20	1
NXF1	18	62	97	3	0
OSBP	6	3	8	17	7
PLOD2	1	1	7	4	0
POLK	0	0	7	1	0
RAN	32	88	75	66	11
RANBP17	0	0	1	0	0
SLC39A9	0	30	8	0	0
TRIM25	3	3	190	0	0
USP11	5	7	95	0	2
USP14	8	1	76	9	0
XPO1	25	7	129	29	10
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Interaction	# Consensus	# IntAct	# BioGrid	# OpenCell	# BioPlex
CUTC	0	13	0	2	0
RANBP1	4	1	9	45	0

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Interaction	# Consensus	# IntAct	# BioGrid	# OpenCell	# BioPlex
CD70	0	2	1	0	81
COMTD1	1	0	4	0	105
FPR1	0	2	0	0	49
GPR182	1	1	1	0	243
GPR45	0	0	0	0	197
HSD17B13	0	104	0	0	6
MAP7	1	4	8	3	39
MFSD4A	9	0	13	0	146
PROKR1	0	0	0	0	13

METABOLIC SUMMARYⁱ In this summary the pathway/subsystems to which the gene belongs is shown together with the associated cellular compartment for the reactions based on metabolite information. The number of proteins and metabolites in the pathway is shown as well as the number of reactions for the selected gene. By clicking on a pathway in the summary table the associated metabolic network map is shown, together with a gene-tissue heatmap that shows the expression of genes in that pathway in different tissues.
Gene XPO7 is associated with 1 reactions in 1 different subsystems, and present in the compartments: Cytosol, Golgi apparatus. Provided by metabolicatlas.org
Pathway / Subsystem	Subsystem-associated compartments	# proteins	# metabolites	# reactions for this protein
Transport reactions	Cytosol, Extracellular, Lysosome, Peroxisome, Mitochondria, Golgi apparatus, Endoplasmic reticulum, Nucleus, Inner mitochondria	563	1599	1

PROTEIN INFORMATIONⁱ The protein information section displays alternative protein-coding transcripts (splice variants) encoded by this gene according to the Ensembl database. The Splice variant identifier links to the Ensembl website protein summary for the selected splice variant. The data in the Swissprot and TrEMBL columns links to corresponding pages in the UniProt database. The protein classes assigned to this protein are shown if expanding the data in the protein class column. Parent protein classes are in bold font and subclasses are listed under the parent class. The length of the protein (amino acid residues according to Ensembl), molecular mass (kDalton), predicted signal peptide and number of predicted transmembrane region(s) according to in-house majority decision methods based on sets of predictors are also reported.
Splice variant	SwissProt	TrEMBL	Protein class	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
XPO7-201	Q9UIA9		Metabolic proteins Transporters Predicted membrane proteins Mapped to neXtProt Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	1087 aa 123.9 kDa	No	1
XPO7-202		E7ESC6	Metabolic proteins Predicted membrane proteins Protein evidence (Ezkurdia et al 2014)	1088 aa 124.1 kDa	No	1
XPO7-203		E5RIW1	Metabolic proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014)	237 aa 26.8 kDa	No	0
XPO7-208		H0YBE1	Metabolic proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014)	190 aa 21.6 kDa	No	0