The primary data page shows the detailed antibody staining in 76 different cell types for each analyzed antibody. In addition, for each cell type, a knowledge-based annotated protein expression score based on all analyzed antibodies is displayed furthest to the right. The images and annotations can be accessed by clicking on the tissue name or score bar. More information can be found in Assays & Annotation.
The tissues and cell types can be ordered by organ, cell type or alphabetically. If ordered by organ, the tissues are presented in groups according to functional features. If ordered by cell type, the cells are presented in groups related to origin.
This score describes the level of antibody staining observed in the annotated cell types as not detected (n), low (l), medium (m) or high (h). It is based on the staining intensity and fraction of stained cells. The images and annotations can be accessed by clicking on the tissue name or score bar. More information can be found in Assays & Annotation.
This score describes a knowledge-based best estimate of the protein expression in the annotated cell types as not detected (n), low (l), medium (m) or high (h). It is a result of stringent evaluation of immunohistochemical staining pattern, RNA data from internal and external sources and available protein/gene characterization data. More information can be found in Assays & Annotation.
Summarizing texts describe the staining pattern for each antibody based on staining intensity, fraction of stained cells and subcellular localization. More information can be found in Assays & Annotation.
Most normal tissues displayed moderate cytoplasmic positivity with additional membranous and nuclear staining in a few cases. A subset of renal tubules, peripheral nerve, heart and skeletal muscle cells were strongly stained. Exocrine pancreas, glial cells and lymphoid tissues were weakly stained or generally negative.
Most of the normal tissues displayed moderate cytoplasmic and basement membrane positivity with in several tissues.
The gastrointestinal tract, urothelium, fallopian tube and trophoblastic cells showed moderate to strong positivity in or in association to the basement membrane.
Strong cytoplasmic and membranous positivity was observed in placental cytotrophoblasts, urothelium and a subset of cells in seminiferous ducts. The basal layers of most squamous epithelia displayed moderate cytoplasmic staining. Remaining normal tissues were weakly stained or negative.