Protein interactions - SLC27A2 - The Human Protein Atlas

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	SLC27A2
Synonyms	ACSVL1, FACVL1, FATP2, hFACVL1, HsT17226, VLACS, VLCS
Gene descriptionⁱ Full gene name according to HGNC.	Solute carrier family 27 member 2
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s). Read more	Enzymes Metabolic proteins Transporters
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.	Membrane
Protein evidence	Evidence at protein level (all genes)

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression analysis and annotation data generated within the Human Protein Atlas project.
Single cell type expression clusterⁱ The RNA data was used to cluster genes according to their expression across single cell types. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity.	Cytotrophoblasts - Basic cellular functions (mainly)
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected.	Cell type enhanced (Conjunctival goblet cells, Cytotrophoblasts, Enterocytes, Epididymal efferent duct absorptive cells, Epididymal principal cells, Hepatocytes, Lactotrophs, Migrating cytotrophoblasts, Proximal tubule cells, Respiratory ciliated cells, Respiratory secretory cells, Retinal pigment epithelial cells)
Tissue expression cluster (RNA)ⁱ The RNA data was used to cluster genes according to their expression across tissues. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity.	Liver & Kidney - Metabolism (mainly)
Tissue specificity (RNA)ⁱ The RNA specificity category is based on mRNA expression levels in the consensus dataset which is calculated from the RNA expression levels in samples from HPA and GTEX. The categories include: tissue enriched, group enriched, tissue enhanced, low tissue specificity and not detected.	Tissue enhanced (Kidney, Liver)
Subcellular locationⁱ Main subcellular location based on data generated in the subcellular section of the Human Protein Atlas.	Not available
Secretome annotationⁱ All genes with at least one predicted secreted isoform have been annotated and classified with the aim to determine if the corresponding protein(s) are: secreted into blood locally secreted or actually being attached to membrane or retained in intracellular locations like mitochondria, endoplasmatic reticulum (ER), Golgi apparatus or lysosomes.	Not available

GENE INFORMATIONⁱ Gene information from Ensembl and Entrez, as well as links to available gene identifiers are displayed here. Information was retrieved from Ensembl if not indicated otherwise.
Chromosome	15
Cytoband	q21.2
Chromosome location (bp)	50182196 - 50236385
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	3
Ensembl	ENSG00000140284 (version 109)
Entrez gene	11001
HGNC	HGNC:10996
UniProt	O14975
GeneCards	SLC27A2

ASSAYSⁱ

Interaction

Metabolic

INTERACTIONⁱ

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e.g. Brain enriched, Localized to mitochondria, Liver & Kidney - Metabolism

Field

Cluster

Cell type

Category

Cluster

Pathway

Consensus

IntAct

BioGrid

OpenCell

BioPlex

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Number of interactions:

Interaction	# Consensus	# IntAct	# BioGrid	# OpenCell	# BioPlex
EXOC8	13	67	14	1	8
RANBP6	2	0	4	0	6
SEC61B	51	3	172	160	0

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Subcell location

Predicted location

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Number of interactions:

Interaction	# Consensus	# IntAct	# BioGrid	# OpenCell	# BioPlex
ABCD1	1	1	5	0	2
ARMC6	0	0	6	0	0
BZW2	1	1	6	5	1
DYM	0	2	1	0	17
EIF2B2	5	6	9	4	17
EXOC8	13	67	14	1	8
HEATR1	0	1	10	3	26
HEATR3	2	0	6	44	11
IPO5	19	7	51	37	0
KIF14	3	0	43	4	7
KPNB1	36	14	105	71	11
MIGA2	2	0	3	2	2
RANBP6	2	0	4	0	6
SAAL1	1	1	6	0	27
SDHA	4	7	30	2	9
SEC61B	51	3	172	160	0
SLC39A4	0	0	57	0	0
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Subcell location

Predicted location

Cell type specificity

Protein class

Number of interactions:

Interaction	# Consensus	# IntAct	# BioGrid	# OpenCell	# BioPlex
SEC61B	51	3	172	160	0

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Subcell location

Predicted location

Cell type specificity

Protein class

Number of interactions:

Interaction	# Consensus	# IntAct	# BioGrid	# OpenCell	# BioPlex
BCL2L2	7	46	9	0	2
BCL2L2-PABPN1	0	46	0	0	2
C3orf52	2	57	2	0	43
EXOC8	13	67	14	1	8
FASN	2	6	39	9	4
GPD1	0	1	0	0	4
GPR182	1	1	1	0	243
GPR45	0	0	0	0	197
KCNE4	0	2	2	0	14
KPNA2	31	37	85	43	7
LPCAT1	0	0	5	2	7
LRRC73	0	7	1	0	11
PIGH	3	2	3	0	89
RAB2B	2	12	3	2	12
RAMP3	0	7	0	0	100
RANBP6	2	0	4	0	6
RETREG3	10	91	13	0	35
SFTPA2	0	2	0	0	17
TSPAN15	2	4	3	0	122
TUBA4A	13	5	37	0	37
VAC14	19	83	25	1	12
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METABOLIC SUMMARYⁱ In this summary the pathway/subsystems to which the gene belongs is shown together with the associated cellular compartment for the reactions based on metabolite information. The number of proteins and metabolites in the pathway is shown as well as the number of reactions for the selected gene. By clicking on a pathway in the summary table the associated metabolic network map is shown, together with a gene-tissue heatmap that shows the expression of genes in that pathway in different tissues.
Gene SLC27A2 is associated with 189 reactions in 11 different subsystems, and present in the compartments: Cytosol, Endoplasmic reticulum, Extracellular, Mitochondria, Peroxisome. Provided by metabolicatlas.org
Pathway / Subsystem	Subsystem-associated compartments	# proteins	# metabolites	# reactions for this protein
Fatty acid activation (cytosolic)	Cytosol	16	137	59
Fatty acid activation (endoplasmic reticular)	Endoplasmic reticulum	10	114	55
Leukotriene metabolism	Peroxisome, Mitochondria, Cytosol, Endoplasmic reticulum, Nucleus, Extracellular	199	105	17
Bile acid biosynthesis	Peroxisome, Endoplasmic reticulum, Cytosol, Mitochondria, Extracellular	94	171	12
Eicosanoid metabolism	Cytosol, Mitochondria, Peroxisome, Endoplasmic reticulum, Golgi apparatus, Nucleus	42	82	4
Vitamin E metabolism	Mitochondria, Cytosol, Endoplasmic reticulum	55	68	13
Fatty acid oxidation	Cytosol, Endoplasmic reticulum, Peroxisome, Mitochondria, Extracellular	70	358	12
Transport reactions	Cytosol, Extracellular, Lysosome, Peroxisome, Mitochondria, Golgi apparatus, Endoplasmic reticulum, Nucleus, Inner mitochondria	563	1599	7
Arachidonic acid metabolism	Cytosol, Peroxisome, Endoplasmic reticulum, Extracellular, Nucleus, Mitochondria, Golgi apparatus	107	88	6
Bile acid recycling	Cytosol, Endoplasmic reticulum, Extracellular	16	25	1
Beta oxidation of phytanic acid (peroxisomal)	Peroxisome, Cytosol	13	37	3

PROTEIN INFORMATIONⁱ The protein information section displays alternative protein-coding transcripts (splice variants) encoded by this gene according to the Ensembl database. The Splice variant identifier links to the Ensembl website protein summary for the selected splice variant. The data in the Swissprot and TrEMBL columns links to corresponding pages in the UniProt database. The protein classes assigned to this protein are shown if expanding the data in the protein class column. Parent protein classes are in bold font and subclasses are listed under the parent class. The length of the protein (amino acid residues according to Ensembl), molecular mass (kDalton), predicted signal peptide and number of predicted transmembrane region(s) according to in-house majority decision methods based on sets of predictors are also reported.
Splice variant	SwissProt	TrEMBL	Protein class	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
SLC27A2-201	O14975		Enzymes Metabolic proteins Transporters Predicted membrane proteins Mapped to neXtProt Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	620 aa 70.3 kDa	Yes	2
SLC27A2-202	O14975		Enzymes Metabolic proteins Transporters Predicted membrane proteins Mapped to neXtProt Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	567 aa 64.6 kDa	Yes	1
SLC27A2-203		G3V1R7	Metabolic proteins Predicted membrane proteins Protein evidence (Ezkurdia et al 2014)	385 aa 44 kDa	No	1