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General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene namei
Official gene symbol, which is typically a short form of the gene name, according to HGNC.
Assigned HPA protein class(es) for the encoded protein(s).
CD markers Plasma proteins
Predicted locationi
All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions.
Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached.
Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s).
The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.
Gene information from Ensembl and Entrez, as well as links to available gene identifiers are displayed here. Information was retrieved from Ensembl if not indicated otherwise.
Chromosome
10
Cytoband
q26.3
Chromosome location (bp)
133262420 - 133276868
Number of transcriptsi
Number of protein-coding transcripts from the gene as defined by Ensembl.
Useful information about the protein provided by UniProt.
Possible involvement in extravasation of leukocytes....show less
Molecular function (UniProt)i
Keywords assigned by UniProt to proteins due to their particular molecular function.
Hydrolase, Metalloprotease, Protease
Ligand (UniProt)i
Keywords assigned by UniProt to proteins because they bind, are associated with, or whose activity is dependent of some molecule.
Metal-binding, Zinc
Gene summary (Entrez)i
Useful information about the gene from Entrez
This gene encodes a member of the ADAM (a disintegrin and metalloprotease domain) family. Members of this family are membrane-anchored proteins structurally related to snake venom disintegrins, and have been implicated in a variety of biological processes involving cell-cell and cell-matrix interactions, including fertilization, muscle development, and neurogenesis. The protein encoded by this gene may be involved in cell adhesion during neurodegeneration, and it is thought to be a target for allergic respiratory diseases, including asthma. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2009]...show less
PROTEIN INFORMATIONi
The protein information section displays alternative protein-coding transcripts (splice variants) encoded by this gene according to the Ensembl database.
The ENSP identifier links to the Ensembl website protein summary, while the ENST identifier links to the Ensembl website transcript summary for the selected splice variant. The data in the UniProt column can be expanded to show links to all matching UniProt identifiers for this protein.
The protein classes assigned to this protein are shown if expanding the data in the protein class column. Parent protein classes are in bold font and subclasses are listed under the parent class.
The Gene Ontology terms assigned to this protein are listed if expanding the Gene ontology column. The length of the protein (amino acid residues according to Ensembl), molecular mass (kDalton), predicted signal peptide (according to a majority of the signal peptide predictors SPOCTOPUS, SignalP 4.0, and Phobius) and the number of predicted transmembrane region(s) (according to MDM) are also reported.
P78325 [Direct mapping] Disintegrin and metalloproteinase domain-containing protein 8
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CD markers MEMSAT3 predicted membrane proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Predicted intracellular proteins Plasma proteins Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0000902[cell morphogenesis] GO:0001525[angiogenesis] GO:0002102[podosome] GO:0002523[leukocyte migration involved in inflammatory response] GO:0002675[positive regulation of acute inflammatory response] GO:0002693[positive regulation of cellular extravasation] GO:0004222[metalloendopeptidase activity] GO:0004252[serine-type endopeptidase activity] GO:0005509[calcium ion binding] GO:0005515[protein binding] GO:0005737[cytoplasm] GO:0005886[plasma membrane] GO:0006508[proteolysis] GO:0006954[inflammatory response] GO:0008233[peptidase activity] GO:0008237[metallopeptidase activity] GO:0008270[zinc ion binding] GO:0009986[cell surface] GO:0010954[positive regulation of protein processing] GO:0016020[membrane] GO:0016787[hydrolase activity] GO:0022407[regulation of cell-cell adhesion] GO:0022617[extracellular matrix disassembly] GO:0032010[phagolysosome] GO:0032127[dense core granule membrane] GO:0033089[positive regulation of T cell differentiation in thymus] GO:0035579[specific granule membrane] GO:0042581[specific granule] GO:0043406[positive regulation of MAP kinase activity] GO:0043524[negative regulation of neuron apoptotic process] GO:0043621[protein self-association] GO:0045089[positive regulation of innate immune response] GO:0045780[positive regulation of bone resorption] GO:0045785[positive regulation of cell adhesion] GO:0046872[metal ion binding] GO:0048247[lymphocyte chemotaxis] GO:0050714[positive regulation of protein secretion] GO:0050839[cell adhesion molecule binding] GO:0051044[positive regulation of membrane protein ectodomain proteolysis] GO:0051092[positive regulation of NF-kappaB transcription factor activity] GO:0051897[positive regulation of protein kinase B signaling] GO:0070245[positive regulation of thymocyte apoptotic process] GO:0070820[tertiary granule] GO:0070821[tertiary granule membrane] GO:0071133[alpha9-beta1 integrin-ADAM8 complex] GO:0071456[cellular response to hypoxia] GO:0101003[ficolin-1-rich granule membrane] GO:2000309[positive regulation of tumor necrosis factor (ligand) superfamily member 11 production] GO:2000391[positive regulation of neutrophil extravasation] GO:2000415[positive regulation of fibronectin-dependent thymocyte migration] GO:2000418[positive regulation of eosinophil migration]