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General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene namei
Official gene symbol, which is typically a short form of the gene name, according to HGNC.
All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions.
Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached.
Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s).
The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.
Membrane, Intracellular
HUMAN PROTEIN ATLAS INFORMATION
Upregulated in disease (PEA)i
A gene is classified as upregulated in a disease if the average concentration of all samples of that disease is significantly higher (adj P-value<0.005 and NPX difference>=1) than the average concentration of samples of all diseases as measured by PEA . For gender specific diseases the analysis includes only samples corresponding to the same gender from the other diseases.
Not analyzed
Blood-based immunoassayi
The blood-based immunoassay category applies to actively secreted proteins and is based on plasma or serum protein concentrations established with enzyme-linked immunosorbent assays, compiled from a literature search. The categories include: detected and not detected, where detection refers to a concentration found in the literature search.
Not analysed since only proteins predicted to be actively secreted to blood is analysed here
Mass spectrometryi
Detection or not of the gene in blood, based on spectral count estimations from a publicly available mass spectrometry-based plasma proteomics dataset obtained from the PeptideAtlas.
Blood protein levels across diseases and healthy individuals, profiled using SomaScan.
SOMAmer (31973-16)
All
Male
Female
2356 samples across 32 cohorts. 0% below LOD.
1020 male samples across 27 cohorts. 0% below LOD.
1328 female samples across 30 cohorts. 0% below LOD.
Class
Median
Alphabetical
Show points
Hide points
THE EFFECT OF AGE, BMI AND SEX ON BLOOD PROTEIN LEVELSi
Blood protein levels by age, BMI, and sex, measured using the proximity extension assay (PEA) with the Olink Explore 1536. In the age and sex scatterplots, samples are colored by disease class.
SOMAmer (31973-16)
LONGITUDINAL ANALYSIS OF BLOOD PROTEIN LEVELS AT AGES 4, 8, 16 AND 24i
Longitudinal blood protein levels in healthy individuals measured at ages 4, 8, 16, and 24 years, shown separately for males and females. Relative protein abundances were quantified using the proximity extension assay (PEA) with the Olink Explore HT.
The Human Protein Atlas project is funded
